Antimicrobial Stewardship: Fighting Antimicrobial Resistance and Protecting Global Public Health

References

• World Health Organization. Record number of countries contribute data revealing disturbing rates of antimicrobial resistance; 2020 Available from: https://www.who.int/news-room/detail/01-06-2020-record-number-of-countries-contribute-data-revealing-disturbing-rates-of-antimicrobial-resistance. Accessed 129, 2020.
   Google Scholar
• World Health Organization. 2020 Antibiotic resistance; 2020 Available from: https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance. Accessed 129, 2020.
   Google Scholar
• Centers for Disease Control and Prevention. Antibiotic/Antimicrobial Resistance (AR/AMR); 2020 https://www.cdc.gov/drugresistance/index.html. Accessed 129, 2020.
   Google Scholar
• World Medical Association (WMA). WMA statement on antimicrobial resistance. Available from: https://www.wma.net/policies-post/wma-statement-on-resistance-to-antimicrobial-drugs/. Accessed 129, 2020.
   Google Scholar
• World Health Organization. Turning Plans into Action for Antimicrobial Resistance (AMR). Working Paper 2.0: Implementation and Coordination. Geneva: World Health Organization; 2019.
   Google Scholar
• Public Health Group. Tackling Antimicrobial Resistance 2019–2024: The UK’s Five-Year National Action Plan. London: HM Government; 2019.
   Google Scholar
• Dadgostar P. Antimicrobial resistance: implications and costs. Infect Drug Resist. 2019;12:3903–3910. doi:10.2147/IDR.S23461031908502
   PubMed Web of Science ®Google Scholar
• Buchy P, Ascioglu S, Buisson Y, et al. Impact of vaccines on antimicrobial resistance. Int J Infect Dis. 2020;90:188–196. doi:10.1016/j.ijid.2019.10.00531622674
   PubMed Web of Science ®Google Scholar
• ISGlobal. Antimicrobial resistance. Available from: https://www.isglobal.org/en/antimicrobial-resistance. Accessed 129, 2020.
   Google Scholar
• Centers for Disease Control and Prevention. 2020 About antibiotic resistance. Available from: https://www.cdc.gov/drugresistance/about.html. Accessed 129, 2020.
   Google Scholar
• World Health Organization. Global Antimicrobial Resistance Surveillance System (GLASS) Report: Early Implementation. Geneva: World Health Organization; 2020.
   Google Scholar
• Lushniak BD. Antibiotic resistance: a public health crisis. Public Health Rep. 2014;129(4):314–316. doi:10.1177/00333549141290040224982528
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. CDC, office of infectious disease; 2020 Available from: https://www.cdc.gov/drugresistance/biggest-threats.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fdrugresistance%2Fbiggest_threats.html. Accessed 129, 2020.
   Google Scholar
• World Bank. By 2050, drug-resistant infections could cause global economic damage on par with 2008 financial crisis. World Bank; 2016 Available from: https://www.worldbank.org/en/news/press-release/2016/09/18/by-2050-drug-resistant-infections-could-cause-global-economic-damage-on-par-with-2008-financial-crisis. Accessed 129, 2020.
   Google Scholar
• Interagency Coordination Group on Antimicrobial Resistance. No time to wait: securing the future from drug-resistant infections report to the secretary-general of the United Nations; 2019 Available from: https://www.who.int/antimicrobial-resistance/interagency-coordination-group/IACG_final_report_EN.pdf?ua=1. Accessed 129, 2020.
   Google Scholar
• World Health Organization. Antimicrobial Resistance. Available from: https://www.euro.who.int/en/health-topics/disease-prevention/antimicrobial-resistance. Accessed 129, 2020.
   Google Scholar
• Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. Pharm Therap. 2015;40(4):277–283.
   Google Scholar
• Aslam B, Wang W, Arshad MI, et al. Antibiotic resistance: a rundown of a global crisis. Infect Drug Resist. 2018;11:1645–1658. doi:10.2147/IDR.S17386730349322
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States, 2019. Atlanta, GA: U.S. Department of Health and Human Services; 2019.
   Google Scholar
• Santajit S, Indrawattana N. Mechanisms of antimicrobial resistance in ESKAPE pathogens. Biomed Res Int. 2016;2016:2475067. doi:10.1155/2016/247506727274985
   PubMed Web of Science ®Google Scholar
• World Health Organization. Global Tuberculosis Report. Geneva: World Health Organization; 2019.
   Google Scholar
• World Health Organization. Global Tuberculosis Report. Geneva: World Health Organization; 2015.
   Google Scholar
• European Centre for Disease Prevention and Control & World Health Organization Regional Office for Europe. Tuberculosis Surveillance and Monitoring in Europe 2019 – 2017 Data. Copenhagen: European Centre for Disease Prevention and Control; 2019.
   Google Scholar
• World Health Organization. Clinical management of COVID-19 interim guidance - May 2020. Geneva: World Health Organization; 2020 Available from: https://www.who.int/publications-detail/clinical-management-of-covid-19. Accessed 129, 2020.
   Google Scholar
• The Guardian. World Health Organization warns overuse of antibiotics for Covid-19 will cause more deaths; 2020 Available from: https://www.theguardian.com/world/2020/jun/01/who-warns-overuse-of-antibiotics-for-covid-19-will-cause-more-deaths. Accessed 129, 2020.
   Google Scholar
• Getahun H, Smith I, Trivedi K, Paulin S, Balkhy HH. Tackling antimicrobial resistance in the COVID-19 pandemic. Bull World Health Organ. 2020;98(7):442–442A. doi:10.2471/BLT.20.26857332742026
   PubMed Web of Science ®Google Scholar
• Rawson TM, Moore LSP, Zhu N, et al. Bacterial and fungal co-infection in individuals with coronavirus: a rapid review to support COVID-19 antimicrobial prescribing. Clin Infect Dis. 2020;ciaa530. doi:10.1093/cid/ciaa530
   Web of Science ®Google Scholar
• Murray AK. The Novel Coronavirus COVID-19 outbreak: global implications for antimicrobial resistance. Front Microbiol. 2020;11:1020. doi:10.3389/fmicb.2020.0102032574253
   PubMed Web of Science ®Google Scholar
• Hsu J. How covid-19 is accelerating the threat of antimicrobial resistance. BMJ. 2020;369:m1983. doi:10.1136/bmj.m198332423901
   PubMed Web of Science ®Google Scholar
• Saleem Z, Godman B, Hassali MA, Hashmi FK, Azhar F, Rehman IU. Point prevalence surveys of health-care-associated infections: a systematic review. Pathog Glob Health. 2019;113(4):191–205. doi:10.1080/20477724.2019.163207031215326
   PubMed Web of Science ®Google Scholar
• Toner E, Adalja A, Gronvall GK, Cicero A, Inglesby TV. Antimicrobial resistance is a global health emergency. Health Secure. 2015;13(3):153–155. doi:10.1089/hs.2014.0088
   PubMed Web of Science ®Google Scholar
• Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global, multifaceted phenomenon. Pathog Glob Health. 2015;109(7):309–318. doi:10.1179/2047773215Y.000000003026343252
   PubMed Web of Science ®Google Scholar
• World Health Organization. Antibacterial Agents in Clinical Development: An Analysis of the Antibacterial Clinical Development Pipeline. Geneva: World Health Organization; 2019.
   Google Scholar
• World Health Organization. Antibacterial Agents in Preclinical Development: An Open-Access Database. Geneva: World Health Organization; 2019.
   Google Scholar
• World Health Organization. Lack of new antibiotics threatens global efforts to contain drug-resistant infections; 2020 Available from: https://www.who.int/news-room/detail/17-01-2020-17-01-2020-lack-of-new-antibiotics-threatens-global-efforts-to-contain-drug-resistant-infections. Accessed 129, 2020.
   Google Scholar
• World Intellectual Property Organization (WIPO). Standing Committee on the Law of Patents. Review of Existing Research on Patents and Access to Medical Products and Health Technologies. Geneva: Thirty-First session; 2019.
   Google Scholar
• AMR Industry Alliance. AMR Industry Alliance, 2020 Progress Report. Geneva: AMR Industry Alliance; 2020.
   Google Scholar
• Ridge KW, Hand K, Sharland M, Abubakar I, Livermore DM. Antimicrobial resistance In: Davies SC, editor. Annual Report of the Chief Medical Officer, Volume Two, 2011, Infections and the Rise of Antimicrobial Resistance. London: Department of Health; 2013.
   Google Scholar
• Dellit TH, Owens RC, McGowan JE, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007;44(2):159–177. doi:10.1086/51039317173212
   PubMed Web of Science ®Google Scholar
• Donà D, Barbieri E, Daverio M, et al. Implementation and impact of pediatric antimicrobial stewardship programs: a systematic scoping review. Antimicrob Resist Infect Control. 2020;9:3. doi:10.1186/s13756-019-0659-331911831
   PubMed Web of Science ®Google Scholar
• Dik JW, Hendrix R, Poelman R, et al. Measuring the impact of antimicrobial stewardship programs. Expert Rev Anti Infect Ther. 2016;14(6):569–575. doi:10.1080/14787210.2016.117806427077229
   PubMed Web of Science ®Google Scholar
• Rosenblatt-Farrell N. The landscape of antibiotic resistance. Environ Health Perspect. 2009;117(6):A244–A250. doi:10.1289/ehp.117-a24419590668
   PubMed Web of Science ®Google Scholar
• McGowan JE, Gerding DN. Does antibiotic restriction prevent resistance? New Horiz. 1996;4(3):370–376.8856755
   PubMedGoogle Scholar
• Shlaes DM, Gerding DN, John JF, et al. Society for Healthcare Epidemiology of America and Infectious Diseases Society of America Joint Committee on the prevention of antimicrobial resistance: guidelines for the prevention of antimicrobial resistance in hospitals. Clin Infect Dis. 1997;25(3):584–599. doi:10.1086/5137669314444
   PubMed Web of Science ®Google Scholar
• Goff DA, Kullar R, Goldstein EJC, et al. A global call from five countries to collaborate in antibiotic stewardship: united we succeed, divided we might fail. Lancet Infect Dis. 2017;17(2):e56–e63. doi:10.1016/S1473-3099(16)30386-327866945
   PubMed Web of Science ®Google Scholar
• Dyar OJ, Huttner B, Schouten J, Pulcini C; ESGAP (ESCMID Study Group for Antimicrobial stewardship). What is antimicrobial stewardship? Clin Microbiol Infect. 2017;23(11):793–798. doi:10.1016/j.cmi.2017.08.02628882725
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. Antibiotic prescribing and use in hospitals and long-term care; 2017 Available from: https://www.cdc.gov/antibiotic-use/healthcare/#:~:text=Studies%20demonstrate%20that%20improving%20prescribing,all%20while%20reducing%20healthcare%20costs. Accessed 129, 2020.
   Google Scholar
• Davey P, Marwick CA, Scott CL, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2017;2(2):CD003543. doi:10.1002/14651858.CD003543.pub428178770
   PubMed Web of Science ®Google Scholar
• Gregory JR, Suleyman S, Barnes MN. A review of the opportunities and shortcomings of antibiotic stewardship. US Pharm. 2018;43(4):HS-7-HS-12.
   Web of Science ®Google Scholar
• Pollack LA, van Santen KL, Weiner LM, Dudeck MA, Edwards JR, Srinivasan A. Antibiotic stewardship programs in U.S. acute care hospitals: findings from the 2014 national healthcare safety network annual hospital survey. Clin Infect Dis. 2016;63(4):443–449. doi:10.1093/cid/ciw32327199462
   PubMed Web of Science ®Google Scholar
• Joint Commission on Hospital Accreditation. APPROVED: new antimicrobial stewardship standard. J Comm Perspect. 2016;36(7):1,3–4, 8.
   Google Scholar
• Oberjé EJM, Tanke MAC, Jeurissen PPT. Antimicrobial stewardship initiatives throughout europe: proven value for money. Infect Dis Rep. 2017;9(1):6800. doi:10.4081/idr.2017.680028458794
   PubMed Web of Science ®Google Scholar
• European Commission. EU guidelines for the prudent use of antimicrobials in human health (2017/C 212/01). ECDC. Brussels: European Commission Available from: https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:52017XC0701(01)&from=EN. Accessed 129, 2020.
   Google Scholar
• European Centre for Disease Prevention and Control. Proposals for EU guidelines on the prudent use of antimicrobials in humans. Stockholm: ECDC; 2017 Available from: https://www.ecdc.europa.eu/sites/portal/files/media/en/publications/Publications/EU-guidelines-prudent-use-antimicrobials.pdf. Accessed 129, 2020.
   Google Scholar
• Saam M, Huttner B, Harbarth S Evaluation of antibiotic awareness campaigns. WHO collaborating centre on patient safety. Geneva, Switzerland: The University of Geneva Hospitals and Faculty of Medicine; 2017 Available from: https://www.who.int/selection_medicines/committees/expert/21/applications/s6_antibiotic_awareness_campaigns.pdf?ua=1. Accessed 129, 2020.
   Google Scholar
• Kpokiri EE, Taylor DG, Smith FJ. Development of antimicrobial stewardship programmes in low and middle-income countries: a mixed-methods study in Nigerian hospitals. Antibiotics (Basel). 2020;9(4):204. doi:10.3390/antibiotics9040204
   Web of Science ®Google Scholar
• Cox JA, Vlieghe E, Mendelson M, et al. Antibiotic stewardship in low- and middle-income countries: the same but different? Clin Microbiol Infect. 2017;23(11):812–818. doi:10.1016/j.cmi.2017.07.01028712667
   PubMed Web of Science ®Google Scholar
• Van Dijck C, Vlieghe E, Cox JA. Antibiotic stewardship interventions in hospitals in low-and middle-income countries: a systematic review. Bull World Health Organ. 2018;96(4):266–280. doi:10.2471/BLT.17.20344829695883
   PubMed Web of Science ®Google Scholar
• Wilkinson A, Ebata A, MacGregor H. Interventions to reduce antibiotic prescribing in LMICs: a scoping review of evidence from human and animal health systems. Antibiotics (Basel). 2018;8(1):2. doi:10.3390/antibiotics8010002
   Web of Science ®Google Scholar
• Septimus EJ, Owens RC. Need and potential of antimicrobial stewardship in community hospitals. Clin Infect Dis. 2011;53(Suppl 1):S8–S14. doi:10.1093/cid/cir36321795728
   PubMed Web of Science ®Google Scholar
• United Nations. Political declaration of the high-level meeting of the general assembly on antimicrobial resistance; 2016 Available from: https://digitallibrary.un.org/record/842813?ln=en. Accessed 129, 2020.
   Google Scholar
• World Health Organization. Global action plan on antimicrobial resistance. 20 Avenue Appia, 1211 Geneva 27, Switzerland: World Health Organization. WHO Press, World Health Organization; 2015 Available from: https://apps.who.int/iris/bitstream/handle/10665/193736/9789241509763_eng.pdf?sequence=1. Accessed 129, 2020.
   Google Scholar
• World Health Organization. Antimicrobial stewardship programs in health-care facilities in low- and middle-income countries: a WHO practical toolkit. World Health Organization; 2019 Available from: https://apps.who.int/iris/bitstream/handle/10665/329404/9789241515481-eng.pdf?sequence=1&isAllowed=y. Accessed 129, 2020.
   Google Scholar
• MacDougall C, Polk RE. Antimicrobial stewardship programs in health care systems. Clin Microbiol Rev. 2005;18(4):638–656. doi:10.1128/CMR.18.4.638-656.200516223951
   PubMed Web of Science ®Google Scholar
• Liaskou M, Duggan C, Joynes R. Pharmacy’s role in antimicrobial resistance and stewardship. Clin Pharm. 2018;10:6. doi:10.1211/CP.2018.20204885
   Google Scholar
• Society for Healthcare Epidemiology of America; Infectious Diseases Society of America; Pediatric Infectious Diseases Society. Policy statement on antimicrobial stewardship by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), and the Pediatric Infectious Diseases Society (PIDS). Infect Control Hosp Epidemiol. 2012;33(4):322–327. doi:10.1086/665010.22418625
   PubMed Web of Science ®Google Scholar
• Lloyd DH, Page SW. Antimicrobial stewardship in veterinary medicine. Microbiol Spectr. 2018;6(3). doi:10.1128/microbiolspec.ARBA-0023-2017
   Web of Science ®Google Scholar
• The Society for Healthcare Epidemiology of America. Infection prevention and control programs are essential to antibiotic stewardship efforts; 2018 Available from: https://www.shea-online.org/index.php/journal-news/press-room/press-release-archives/581-infection-prevention-and-control-programs-are-essential-to-antibiotic-stewardship-efforts#:~:text=Antimicrobial%20stewardship%20programs%20encourage%20the,preserve%20the%20efficacy%20of%20antibiotics. Accessed 129, 2020.
   Google Scholar
• Global Alliance for Infections in Surgery for Infections in Surgery. Core elements of antibiotic stewardship. Available from: https://infectionsinsurgery.org/core-elements-of-antibiotic-stewardship/. Accessed 129, 2020.
   Google Scholar
• Bondarenka CM, Bosso JA. Successful implementation of an antimicrobial stewardship program at an academic medical center. Hosp Pharm. 2017;52(7):508–513. doi:10.1177/001857871772153529276281
   PubMedGoogle Scholar
• Centers for Disease Control and Prevention. CDC, the core elements of hospital antibiotic stewardship programs; 2019 Available from:https://www.cdc.gov/antibiotic-use/core-elements/hospital.html. Accessed 129, 2020.
   Google Scholar
• Tang K, Heil EL Antimicrobial stewardship: a primer for hospital pharmacists. Pharmacy Times; 2016 Available from: https://www.pharmacytimes.com/publications/health-system-edition/2016/march2016/antimicrobial-stewardship-a-primer-for-hospital-pharmacists. Accessed 129, 2020.
   Google Scholar
• Ostrowsky B, Banerjee R, Bonomo RA, et al. Infectious Diseases Society of America, Pediatric Infectious Diseases Society, and the Society for Healthcare Epidemiology of America. Infectious diseases physicians: leading the way in antimicrobial stewardship. Clin Infect Dis. 2018;66(7):995–1003. doi:10.1093/cid/cix109329444247
   PubMed Web of Science ®Google Scholar
• Trivedi KK, Pollack LA. The role of public health in antimicrobial stewardship in healthcare. Clin Infect Dis. 2014;59(Suppl 3):S101–S103. doi:10.1093/cid/ciu54425261535
   PubMed Web of Science ®Google Scholar
• Anderson M, Clift C, Schulze K, et al. Averting the AMR crisis: what are the avenues for policy action for countries in Europe? [Internet] Copenhagen (Denmark): European Observatory on Health Systems and Policies; 2019 Available from: https://www.ncbi.nlm.nih.gov/books/NBK543407/. Accessed 129, 2020.
   Google Scholar
• Gai Z, Samodelov SL, Kullak-Ublick GA, Visentin M. Molecular mechanisms of colistin-induced nephrotoxicity. Molecules. 2019;24(3):653. doi:10.3390/molecules24030653
   Web of Science ®Google Scholar
• Mulani MS, Kamble EE, Kumkar SN, Tawre MS, Pardesi KR. Emerging strategies to combat ESKAPE pathogens in the era of antimicrobial resistance: a review. Front Microbiol. 2019;10:539. doi:10.3389/fmicb.2019.0053930988669
   PubMed Web of Science ®Google Scholar
• Rice LB. Progress and challenges in implementing the research on ESKAPE pathogens. Infect Control Hosp Epidemiol. 2010;31(Suppl 1):S7–S10. doi:10.1086/65599520929376
   PubMed Web of Science ®Google Scholar
• Doron S, Davidson LE. Antimicrobial stewardship. Mayo Clin Proc. 2011;86(11):1113–1123. doi:10.4065/mcp.2011.035822033257
   PubMed Web of Science ®Google Scholar
• Joseph J, Rodvold KA. The role of carbapenems in the treatment of severe nosocomial respiratory tract infections. Expert Opin Pharmacother. 2008;9(4):561–575. doi:10.1517/14656566.9.4.56118312158
   PubMed Web of Science ®Google Scholar
• Public Health Foundation. Public health antibiotic stewardship driver diagram; 2013 Available from: http://www.phf.org/resourcestools/Documents/Antibiotic_Stewardship_Driver_Diagram.pdf. Accessed 129, 2020.
   Google Scholar
• Centers for Disease Control and Prevention. The 10 essential public health services; 2020 Available from: https://phnci.org/uploads/resource-files/EPHS-English.pdf. Accessed 129, 2020.
   Google Scholar
• Talbot GH, Das A, Cush S, et al. Foundation for the National Institutes of Health Biomarkers Consortium HABP/VABP Project Team. Evidence-based study design for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. J Infect Dis. 2019;219(10):1536–1544. doi:10.1093/infdis/jiy57830649434
   PubMed Web of Science ®Google Scholar
• Bertollo LG, Lutkemeyer DS, Levin AS. Are antimicrobial stewardship programs effective strategies for preventing antibiotic resistance? A systematic review. Am J Infect Control. 2018;46(7):824–836. doi:10.1016/j.ajic.2018.01.00229472107
   PubMed Web of Science ®Google Scholar
• Standiford HC, Chan S, Tripoli M, Weekes E, Forrest GN. Antimicrobial stewardship at a large tertiary care academic medical center: cost analysis before, during, and after a 7-year program. Infect Control Hosp Epidemiol. 2012;33(4):338–345. doi:10.1086/66490922418628
   PubMed Web of Science ®Google Scholar
• Combes JR, Arespacochaga E, Appropriate use of medical resources. Chicago, IL: American Hospital Association’s Physician Leadership Forum; 2013 Available from: http://www.ahaphysicianforum.org/files/pdf/appropusewhiteppr.pdf. Accessed 129, 2020.
   Google Scholar
• File TM, Srinivasan A, Bartlett JG. Antimicrobial stewardship: importance for patient and public health. Clin Infect Dis. 2014;59(Suppl 3):S93–S96. doi:10.1093/cid/ciu54325261547
   PubMed Web of Science ®Google Scholar
• Forde C, Stierman B, Ramon-Pardo P, Dos Santos T, Singh N. Carbapenem-resistant Klebsiella pneumoniae in Barbados: driving change in practice at the national level. PLoS One. 2017;12(5):e0176779. doi:10.1371/journal.pone.017677928542162
   PubMed Web of Science ®Google Scholar
• Cassini A, Högberg LD, Plachouras D, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modeling analysis. Lancet Infect Dis. 2019;19(1):56–66. doi:10.1016/S1473-3099(18)30605-430409683
   PubMed Web of Science ®Google Scholar
• Holmes EAF, Hughes DA. Challenges for economic evaluation of health care strategies to contain antimicrobial resistance. Antibiotics (Basel). 2019;8(4):166. doi:10.3390/antibiotics8040166
   Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States 2013. Atlanta, GA: U.S. Department of Health and Human Services Available from: https://www.cdc.gov/drugresistance/Threat-Report-2013/pdf/ar-Threats-2013-508.pdf. Accessed 129, 2020.
   Google Scholar
• Nagpal R, Mainali R, Ahmadi S, et al. Gut microbiome and aging: physiological and mechanistic insights. Nutr Healthy Aging. 2018;4(4):267–285. doi:10.3233/NHA-17003029951588
   PubMedGoogle Scholar
• World Health Organization. Global antimicrobial resistance surveillance system (‎GLASS)‎: technical meeting on the early implementation phase: 22–23 October 2015. WHO Regional Office for Europe Copenhagen, Denmark: meeting report. World Health Organization Available from: https://apps.who.int/iris/handle/10665/204117. Accessed 129, 2020.
   Google Scholar
• World Health Organization. GLASS report: early implementation, 2017–2018; 2018 Geneva: World Health Organization Available from: https://apps.who.int/iris/bitstream/handle/10665/279656/9789241515061-eng.pdf?ua=1. Accessed 129, 2020.
   Google Scholar
• McLeod M, Ahmad R, Shebl NA, Micallef C, Sim F, Holmes A. A whole-health-economy approach to antimicrobial stewardship: analysis of current models and future direction. PLoS Med. 2019;16(3):e1002774. doi:10.1371/journal.pmed.100277430925166
   PubMed Web of Science ®Google Scholar
• Aldeyab MA, Harbarth S, Vernaz N, et al. The impact of antibiotic use on the incidence and resistance pattern of extended-spectrum beta-lactamase-producing bacteria in primary and secondary healthcare settings. Br J Clin Pharmacol. 2012;74(1):171–179. doi:10.1111/j.1365-2125.2011.0416122150975
   PubMed Web of Science ®Google Scholar
• World Health Organization. One health. In: World Health Organization [Internet]. World Health Organization; 2017 Available from: http://www.who.int/features/qa/one-health/en/. Accessed 129, 2020.
   Google Scholar
• Hardefeldt LY, Gilkerson JR, Billman-Jacobe H, et al. Barriers to and enablers of implementing antimicrobial stewardship programs in veterinary practices. J Vet Intern Med. 2018;32(3):1092–1099. doi:10.1111/jvim.1508329573053
   PubMed Web of Science ®Google Scholar
• Charani E, Edwards R, Sevdalis N, et al. Behavior change strategies to influence antimicrobial prescribing in acute care: a systematic review. Clin Infect Dis. 2011;53(7):651–662. doi:10.1093/cid/cir44521890770
   PubMed Web of Science ®Google Scholar
• Charani E, Castro-Sanchez E, Sevdalis N, et al. Understanding the determinants of antimicrobial prescribing within hospitals: the role of “prescribing etiquette”. Clin Infect Dis. 2013;57(2):188–196. doi:10.1093/cid/cit21223572483
   PubMed Web of Science ®Google Scholar
• MacFadden DR, McGough SF, Fisman D, Santillana M, Brownstein JS. Antibiotic resistance increases with local temperature. Nat Clim Chang. 2018;8(6):510–514. doi:10.1038/s41558-018-0161-630369964
   PubMed Web of Science ®Google Scholar
• Ohl CA, Luther VP. Health care provider education as a tool to enhance antibiotic stewardship practices. Infect Dis Clin North Am. 2014;28(2):177–193. doi:10.1016/j.idc.2014.02.00124857387
   PubMed Web of Science ®Google Scholar
• British Society for Antimicrobial Chemotherapy. Antimicrobial stewardship from principles to practice. Birmingham, UK: British Society for Antimicrobial Chemotherapy, BSAC; 2018 Available from: http://www.bsac.org.uk/antimicrobialstewardshipebook/BSAC-AntimicrobialStewardship-FromPrinciplestoPractice-eBook.pdf. Accessed 129, 2020.
   Google Scholar
• Leekha S, Terrell CL, Edson RS. General principles of antimicrobial therapy. Mayo Clin Proc. 2011;86(2):156–167. doi:10.4065/mcp.2010.063921282489
   PubMed Web of Science ®Google Scholar
• Melander RJ, Zurawski DV, Melander C. Narrow-spectrum antibacterial agents. Medchemcomm. 2018;9(1):12–21. doi:10.1039/C7MD00528H29527285
   PubMed Web of Science ®Google Scholar
• Hembach N, Schmid F, Alexander J, Hiller C, Rogall ET, Schwartz T. Occurrence of the mcr-1 colistin resistance gene and other clinically relevant antibiotic resistance genes in microbial populations at different municipal wastewater treatment plants in Germany. Front Microbiol. 2017;8:1282. doi:10.3389/fmicb.2017.0128228744270
   PubMed Web of Science ®Google Scholar
• Wright GD. Antibiotic adjuvants: rescuing antibiotics from resistance. Trends Microbiol. 2016;24(11):928. doi:10.1016/j.tim.2016.07.00827522372
   PubMed Web of Science ®Google Scholar
• Laws M, Shaaban A, Rahman KM. Antibiotic resistance breakers: current approaches and future directions. FEMS Microbiol Rev. 2019;43(5):490–516. doi:10.1093/femsre/fuz01431150547
   PubMed Web of Science ®Google Scholar
• Liu Y, Li R, Xiao X, Wang Z. Antibiotic adjuvants: an alternative approach to overcome multi-drug resistant Gram-negative bacteria. Crit Rev Microbiol. 2019;45(3):301–314. doi:10.1080/1040841X.2019.159981330985240
   PubMed Web of Science ®Google Scholar
• Tang H, Zhao W, Yu J, Li Y, Zhao C. Recent development of pH-responsive polymers for cancer nanomedicine. Molecules. 2018;24(1):4. doi:10.3390/molecules24010004
   PubMed Web of Science ®Google Scholar
• González-Bello C. Antibiotic adjuvants - A strategy to unlock bacterial resistance to antibiotics. Bioorg Med Chem Lett. 2017;27(18):4221–4228. doi:10.1016/j.bmcl.2017.08.02728827113
   PubMed Web of Science ®Google Scholar
• Douafer H, Andrieu V, Phanstiel O, Brunel JM. Antibiotic adjuvants: make antibiotics great again! J Med Chem. 2019;62(19):8665–8681. doi:10.1021/acs.jmedchem.8b0178131063379
   PubMed Web of Science ®Google Scholar
• Gill EE, Franco OL, Hancock RE. Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens. Chem Biol Drug Des. 2015;85(1):56–78. doi:10.1111/cbdd.1247825393203
   PubMed Web of Science ®Google Scholar
• Hawkey PM, Warren RE, Livermore DM, et al. Treatment of infections caused by multidrug-resistant Gram-negative bacteria: report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party. J Antimicrob Chemother. 2018;73(Suppl_3):iii2–iii78. doi:10.1093/jac/dky02729514274
   PubMed Web of Science ®Google Scholar
• Nathwani D, Sneddon J. Practical Guide to Antimicrobial Stewardship in Hospitals. Durham, USA: Biomerieux Inc; 2015.
   Google Scholar
• Bloomfield SF, Cookson B, Falkiner F, Griffith C, Cleary V. Methicillin-resistant Staphylococcus aureus, Clostridium difficile, and extended-spectrum beta-lactamase-producing Escherichia coli in the community: assessing the problem and controlling the spread. Am J Infect Control. 2007;35(2):86–88. doi:10.1016/j.ajic.2006.10.00317327186
   PubMed Web of Science ®Google Scholar
• Matsuura GT, Garrison MW. Antibiotic collateral damage: resistance and antibiotic-associated diarrhea. Hosp Pharm. 2011;46:758–768.
   Google Scholar
• Laplante K, Cunha C, Morrill H, Rice L, Mylonakis E. Antimicrobial Stewardship: Principles and Practice. Boston: CAB International; 2017.
   Google Scholar
• de Jong LAW, van der Linden PD, Roukens MMB, van de Garde EMW, van der Velden AW, Natsch S. Consecutive antibiotic use in the outpatient setting: an extensive, longitudinal descriptive analysis of antibiotic dispensing data in the Netherlands. BMC Infect Dis. 2019;19(1):84. doi:10.1186/s12879-019-3732-x30678645
   PubMed Web of Science ®Google Scholar
• Cunha BA. Effective antibiotic-resistance control strategies. Lancet. 2001;357(9265):1307–1308. doi:10.1016/S0140-6736(00)04527-X11343730
   PubMed Web of Science ®Google Scholar
• Gasparetto J, Tuon FF, Dos Santos Oliveira D. Intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units. BMC Infect Dis. 2019;19(1):650. doi:10.1186/s12879-019-4280-031331272
   PubMed Web of Science ®Google Scholar
• Vogtländer NP, Van Kasteren ME, Natsch S, Kullberg BJ, Hekster YA, Van Der Meer JW. Improving the process of antibiotic therapy in daily practice: interventions to optimize timing, dosage adjustment to renal function, and switch therapy. Arch Intern Med. 2004;164(11):1206–1212. doi:10.1001/archinte.164.11.120615197046
   PubMedGoogle Scholar
• Barlam TF, Cosgrove SE, Abbo LM, et al. Executive summary: implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016;62(10):1197–1202. doi:10.1093/cid/ciw21727118828
   PubMed Web of Science ®Google Scholar
• Cunha CB. Antimicrobial stewardship programs: principles and practice. Med Clin North Am. 2018;102(5):797–803. doi:10.1016/j.mcna.2018.04.00330126571
   PubMed Web of Science ®Google Scholar
• Simoens S. Factors affecting the cost-effectiveness of antibiotics. Chemother Res Pract. 2011;2011:249867. doi:10.1155/2011/24986722312550
   PubMedGoogle Scholar
• Saliba-Gustafsson EA, Dunberger Hampton A, Zarb P, Orsini N, Borg MA, Stålsby Lundborg C. Factors associated with antibiotic prescribing in patients with acute respiratory tract complaints in Malta: a 1-year repeated cross-sectional surveillance study. BMJ Open. 2019;9(12):e032704. doi:10.1136/bmjopen-2019-032704
   Web of Science ®Google Scholar
• Institute for Healthcare Improvement, Centers for Disease Control. Antibiotic stewardship drivers and change package [Internet]. Atlanta, GA: US Department of Health and Human Services, CDC; 2012 Available from: http://www.cdc.gov/getsmart/healthcare/pdfs/antibiotic_stewardship_change_package.pdf. Accessed 129, 2020.
   Google Scholar
• Septimus E Get smart for healthcare. Clinician guide for collecting cultures. Atlanta, GA: US Department of Health and Human Services. CDC; 2015 Available from: http://www.cdc.gov/getsmart/healthcare/implementation/clinicianguide.html. Accessed 129, 2020.
   Google Scholar
• Waters CD. Pharmacist-driven antimicrobial stewardship program in an institution without infectious diseases physician support. Am J Health Syst Pharm. 2015;72(6):466–468. doi:10.2146/ajhp14038125736941
   PubMed Web of Science ®Google Scholar
• Bowater RJ, Stirling SA, Lilford RJ. Is antibiotic prophylaxis in surgery a generally effective intervention? Testing a generic hypothesis over a set of meta-analyses. Ann Surg. 2009;249(4):551–556. doi:10.1097/SLA.0b013e318199f20219300236
   PubMed Web of Science ®Google Scholar
• Bratzler DW, Dellinger EP, Olsen KM, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm. 2013;70(3):195–283. doi:10.2146/ajhp12056823327981
   PubMedGoogle Scholar
• Roberts JA, Norris R, Paterson DL, Martin JH. Therapeutic drug monitoring of antimicrobials. Br J Clin Pharmacol. 2012;73(1):27–36. doi:10.1111/j.1365-2125.201121831196
   PubMed Web of Science ®Google Scholar
• Rybak MJ, Lomaestro BM, Rotschafer JC, et al. Vancomycin therapeutic guidelines: a summary of consensus recommendations from the infectious diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists. Clin Infect Dis. 2009;49(3):325–327. doi:10.1086/60087719569969
   PubMed Web of Science ®Google Scholar
• Flanders SA, Saint S. Why does antimicrobial overuse in hospitalized patients persist? JAMA Intern Med. 2014;174(5):661–662. doi:10.1001/jamainternmed.2014.89724595627
   PubMed Web of Science ®Google Scholar
• Hughes SJ, Moore LS. Antimicrobial stewardship. Br J Hosp Med (Lond). 2019;80(3):C42–C45. doi:10.12968/hmed.2019.80.3.C4230860917
   PubMed Web of Science ®Google Scholar
• Kim J, Craft DW, Katzman M. Building an antimicrobial stewardship program: cooperative roles for pharmacists, infectious diseases specialists, and clinical microbiologists. Lab Med. 2015;46(3):e65–e71. doi:10.1309/LMC0SHRJBY0ONHI926283698
   PubMed Web of Science ®Google Scholar
• Mas-Morey P, Valle M. A systematic review of inpatient antimicrobial stewardship programs involving clinical pharmacists in small-to-medium-sized hospitals. Eur J Hosp Pharm. 2018;25(e1):e69–e73. doi:10.1136/ejhpharm-2017-00138131157071
   PubMedGoogle Scholar
• Ladenheim D. Role of nurses in supporting antimicrobial stewardship. Nurs Stand. 2018;33(6):55–58. doi:10.7748/ns30156793
   PubMedGoogle Scholar
• Shaukat A, Al-Wali W, Nawash E, Sonallah H. Antimicrobial stewardship: a shared responsibility among primary prescribers, pharmacists, infectious disease physicians, and microbiologists. J Infect Dis Ther. 2020;8:420.
   Google Scholar
• Kullar R, Yang H, Grein J, Murthy R. A roadmap to implementing antimicrobial stewardship principles in Long-term Care Facilities (LTCFs): collaboration between an acute-care hospital and LTCFs. Clin Infect Dis. 2018;66(8):1304–1312. doi:10.1093/cid/cix104129182743
   PubMed Web of Science ®Google Scholar
• Bouza E, Muñoz P, Burillo A. Role of the clinical microbiology laboratory in antimicrobial stewardship. Med Clin North Am. 2018;102(5):883–898. doi:10.1016/j.mcna.2018.05.00330126578
   PubMed Web of Science ®Google Scholar
• Ha TV, Nguyen AMT, Nguyen HST. Public awareness about antibiotic use and resistance among residents in highland areas of Vietnam. Biomed Res Int. 2019;2019:9398536. doi:10.1155/2019/939853631223624
   PubMed Web of Science ®Google Scholar
• Li B, Webster TJ. Bacteria antibiotic resistance: new challenges and opportunities for implant-associated orthopedic infections. J Orthop Res. 2018;36(1):22–32. doi:10.1002/jor.2365628722231
   PubMed Web of Science ®Google Scholar
• Maurer FP, Christner M, Hentschke M, Rohde H. Advances in rapid identification and susceptibility testing of bacteria in the clinical microbiology laboratory: implications for patient care and antimicrobial stewardship programs. Infect Dis Rep. 2017;9(1):6839. doi:10.4081/idr.2017.683928458798
   PubMed Web of Science ®Google Scholar
• Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fourth Informational Supplement. CLSI Document M100-S24, Wayne; 2014.
   Google Scholar
• Schulz LT, Fox BC, Polk RE. Can the antibiograms be used to assess microbiologic outcomes after antimicrobial stewardship interventions? A critical review of the literature. Pharmacotherapy. 2012;32(8):668–676. doi:10.1002/j.1875-9114.2012.0116323307516
   PubMed Web of Science ®Google Scholar
• Pakyz AL. The utility of hospital antibiograms as tools for guiding empiric therapy and tracking resistance. Insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy. 2007;27(9):1306–1312. doi:10.1592/phco.27.9.130617723084
   PubMed Web of Science ®Google Scholar
• Kållberg C, Årdal C, Salvesen Blix H, Klein E. Introduction and geographic availability of new antibiotics approved between 1999 and 2014. PLoS One. 2018;13(10):e0205166. doi:10.1371/journal.pone.020516630325963
   PubMed Web of Science ®Google Scholar
• Morency-Potvin P, Schwartz DN, Weinstein RA. Antimicrobial stewardship: how the microbiology laboratory can right the ship. Clin Microbiol Rev. 2016;30(1):381–407. doi:10.1128/CMR.00066-1627974411
   PubMed Web of Science ®Google Scholar
• Reed EE, Stevenson KB, West JE, Bauer KA, Goff DA. Impact of formulary restriction with prior authorization by an antimicrobial stewardship program. Virulence. 2013;4(2):158–162. doi:10.4161/viru.2165723154323
   PubMed Web of Science ®Google Scholar
• LaRosa LA, Fishman NO, Lautenbach E, Koppel RJ, Morales KH, Linkin DR. Evaluation of antimicrobial therapy orders circumventing an antimicrobial stewardship program: investigating the strategy of “stealth dosing”. Infect Control Hosp Epidemiol. 2007;28(5):551–556. doi:10.1086/51353517464914
   PubMed Web of Science ®Google Scholar
• Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34(6):1589–1596. doi:10.1097/01.CCM.000021796116625125
   PubMed Web of Science ®Google Scholar
• Kumar A. Optimizing antimicrobial therapy in sepsis and septic shock. Crit Care Clin. 2009;25(4):733–51, viii. doi:10.1016/j.ccc.2009.08.00419892250
   PubMed Web of Science ®Google Scholar
• World Organization for Animal Health (OIE). OIE list of antimicrobials of veterinary importance; 2015 Available from: http://www.oie.int/fileadmin/Home/eng/Our_scientific_expertise/docs/pdf/Eng_OIE_List_antimicrobials_May2015.pdf. Accessed 129, 2020.
   Google Scholar
• Horikoshi Y, Suwa J, Higuchi H, et al. Sustained pediatric antimicrobial stewardship program with consultation to infectious diseases reduced carbapenem resistance and infection-related mortality. Int J Infect Dis. 2017;64:69–73. doi:10.1016/j.ijid.2017.09.01228941633
   PubMed Web of Science ®Google Scholar
• Wang H, Wang H, Yu X, et al. Impact of antimicrobial stewardship managed by clinical pharmacists on antibiotic use and drug resistance in a Chinese hospital, 2010–2016: a retrospective observational study. BMJ Open. 2019;9(8):e026072. doi:10.1136/bmjopen-2018-026072
   PubMed Web of Science ®Google Scholar
• Wu JH, Langford BJ, Daneman N, Friedrich JO, Garber G. Antimicrobial stewardship programs in long-term care settings: a meta-analysis and systematic review. J Am Geriatr Soc. 2019;67(2):392–399. doi:10.1111/jgs.1567530517765
   PubMed Web of Science ®Google Scholar
• Nathwani D, Varghese D, Stephens J, Ansari W, Martin S, Charbonneau C. Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review. Antimicrob Resist Infect Control. 2019;8:35. doi:10.1186/s13756-019-0471-030805182
   PubMed Web of Science ®Google Scholar
• Akpan MR, Isemin NU, Udoh AE, Ashiru-Oredope D. Implementation of antimicrobial stewardship programs in African countries: a systematic literature review. J Glob Antimicrob Resist. 2020;22:317–324. doi:10.1016/j.jgar.2020.03.00932247077
   PubMed Web of Science ®Google Scholar
• Lee CF, Cowling BJ, Feng S, et al. Impact of antibiotic stewardship programs in Asia: a systematic review and meta-analysis. J Antimicrob Chemother. 2018;73(4):844–851. doi:10.1093/jac/dkx49229340609
   PubMed Web of Science ®Google Scholar
• Xiao Y, Shen P, Zheng B, Zhou K, Luo Q, Li L. Change in antibiotic use in secondary and tertiary hospitals nationwide after a national antimicrobial stewardship campaign was launched in China, 2011–2016: an observational study. J Infect Dis. 2020;221(Supplement_2):S148–S155. doi:10.1093/infdis/jiz55632176788
   PubMed Web of Science ®Google Scholar
• Mardani M, Abolghasemi S, Shabani S. Impact of an antimicrobial stewardship program in the antimicrobial-resistant and prevalence of clostridioides difficile infection and amount of antimicrobial consumed in cancer patients. BMC Res Notes. 2020;13(1):246. doi:10.1186/s13104-020-05085-332430059
   PubMed Web of Science ®Google Scholar
• Onorato L, Macera M, Calò F, et al. The effect of an antimicrobial stewardship program in two intensive care units of a teaching hospital: an interrupted time series analysis. Clin Microbiol Infect. 2020;26(6):782.e1–782.e6. doi:10.1016/j.cmi.2019.10.021
   Web of Science ®Google Scholar
• Savoldi A, Foschi F, Kreth F, et al. Impact of implementing a non-restrictive antibiotic stewardship program in an emergency department: a four-year quasi-experimental prospective study. Sci Rep. 2020;10(1):8194. doi:10.1038/s41598-020-65222-732424172
   PubMed Web of Science ®Google Scholar
• Singh S, Menon VP, Mohamed ZU, et al. Implementation and impact of an antimicrobial stewardship program at a tertiary care center in South India. Open Forum Infect Dis. 2018;6(4):ofy290. doi:10.1093/ofid/ofy29031024967
   PubMed Web of Science ®Google Scholar
• Wee LE, Chung SJ, Tang SLS, et al. Who listens, and who doesn’t? Factors associated with adherence to antibiotic stewardship intervention in a Singaporean tertiary hospital. J Glob Antimicrob Resist. 2020;22:391–397. doi:10.1016/j.jgar.2020.04.00632311504
   PubMed Web of Science ®Google Scholar
• Abubakar U, Syed Sulaiman SA, Adesiyun AG. Impact of pharmacist-led antibiotic stewardship interventions on compliance with surgical antibiotic prophylaxis in obstetric and gynecologic surgeries in Nigeria. PLoS One. 2019;14(3):e0213395. doi:10.1371/journal.pone.021339530845240
   PubMed Web of Science ®Google Scholar
• Brink AJ, Messina AP, Feldman C, Richards GA, van den Bergh D. Netcare Antimicrobial Stewardship Study Alliance. From guidelines to practice: a pharmacist-driven prospective audit and feedback improvement model for perioperative antibiotic prophylaxis in 34 South African hospitals. J Antimicrob Chemother. 2017;72(4):1227–1234. doi:10.1093/jac/dkw52327999061
   PubMed Web of Science ®Google Scholar
• D’Agata EMC, Lindberg CC, Lindberg CM, et al. The positive effects of an antimicrobial stewardship program targeting outpatient hemodialysis facilities. Infect Control Hosp Epidemiol. 2018;39(12):1400–1405. doi:10.1017/ice.2018.23730253815
   PubMed Web of Science ®Google Scholar
• Majumder MAA, Singh K, Hilaire MG, Rahman S, Sa B, Haque M. Tackling antimicrobial resistance by promoting antimicrobial stewardship in medical and allied health professional curricula. Expert Rev Anti Infect Ther. 2020;1–14. doi:10.1080/14787210.2020.1796638
   Web of Science ®Google Scholar
• Minen MT, Duquaine D, Marx MA, Weiss D. A survey of knowledge, attitudes, and beliefs of medical students concerning antimicrobial use and resistance. Microb Drug Resist. 2010;16(4):285–289. doi:10.1089/mdr.2010.000920624097
   PubMed Web of Science ®Google Scholar
• Castro-Sánchez E, Drumright LN, Gharbi M, Farrell S, Holmes AH. Mapping antimicrobial stewardship in undergraduate medical, dental, pharmacy, nursing, and veterinary education in the United Kingdom. PLoS One. 2016;11(2):e0150056. doi:10.1371/journal.pone.015005626928009
   PubMed Web of Science ®Google Scholar
• Abbo LM, Cosgrove SE, Pottinger PS, et al. Medical students’ perceptions and knowledge about antimicrobial stewardship: how are we educating our future prescribers? Clin Infect Dis. 2013;57(5):631–638. doi:10.1093/cid/cit37023728148
   PubMed Web of Science ®Google Scholar
• Pulcini C, Wencker F, Frimodt-Møller N, et al. European survey on principles of prudent antibiotic prescribing teaching in undergraduate students. Clin Microbiol Infect. 2015;21(4):354–361. doi:10.1016/j.cmi.2014.11.01525658523
   PubMed Web of Science ®Google Scholar
• MacDougall C, Schwartz BS, Kim L, Nanamori M, Shekarchian S, Chin-Hong PV. An interprofessional curriculum on antimicrobial stewardship improves knowledge and attitudes toward appropriate antimicrobial use and collaboration. Open Forum Infect Dis. 2017;4(1):ofw225. doi:10.1093/ofid/ofw22528480231
   PubMedGoogle Scholar
• Australian Commission on Safety and Quality in Health Care. Antimicrobial Stewardship in Australian Health Care. Sydney: ACSQHC; 2018.
   Google Scholar
• Rocha-Pereira N, Lafferty N, Nathwani D. Educating healthcare professionals in antimicrobial stewardship: can online-learning solutions help? J Antimicrob Chemother. 2015;70(12):3175–3177. doi:10.1093/jac/dkv33626429566
   PubMed Web of Science ®Google Scholar
• Lucas B. G7 and G20 Commitments on Health. K4D Helpdesk Report 673. Brighton, UK: Institute of Development Studies; 2019.
   Google Scholar
• World Health Organization. Additional global, regional, and national strategies and plans to address antimicrobial resistance; 2014 Available from: https://www.who.int/antimicrobial-resistance/global-action-plan/General_and_national_plans_amr_Dec_2014.pdf?ua=1. Accessed 129, 2020.
   Google Scholar
• Centers for Disease Control and Prevention. U.S. national action plan for combating antibiotic-resistant bacteria (National Action Plan); 2015 Available from: https://www.cdc.gov/drugresistance/us-activities/national-action-plan.html. Accessed 129, 2020.
   Google Scholar
• European Commission. EU action on antimicrobial resistance. Available from: https://ec.europa.eu/health/antimicrobial-resistance/eu-action-on-antimicrobial-resistance_en. Accessed 129, 2020.
   Google Scholar
• World Health Organization. Countries step up to tackle antimicrobial resistance; 2018 Available from: https://www.who.int/news-room/detail/18-07-2018-countries-step-up-to-tackle-antimicrobial-resistance. Accessed 129, 2020.
   Google Scholar
• Madero CM, Navas AL, Leon EP, Alvarez SS. Use of antibiotics with ONE HEALTH perspective: Spanish strategic action plan to reduce the risk of selection and dissemination of antibiotic resistance. Small Rumin Res. 2016;142:44–47.
   Web of Science ®Google Scholar
• Lammie SL, Hughes JM. Antimicrobial resistance, food safety, and one health: the need for convergence. Annu Rev Food Sci Technol. 2016;7:287–312. doi:10.1146/annurev-food-041715-03325126772408
   PubMed Web of Science ®Google Scholar
• Shariff M. Antimicrobial resistance: challenges and the way forward. Indian J Chest Dis Allied Sci. 2016;58(3):157–159.30152647
   PubMedGoogle Scholar
• Holmes AH, Moore LS, Sundsfjord A, et al. Understanding the mechanisms and drivers of antimicrobial resistance. Lancet. 2016;387(10014):176–187. doi:10.1016/S0140-6736(15)00473-026603922
   PubMed Web of Science ®Google Scholar
• Jacobs TG, Robertson J, van den Ham HA, Iwamoto K, Bak Pedersen H, Mantel-Teeuwisse AK. Assessing the impact of law enforcement to reduce over-the-counter (OTC) sales of antibiotics in low- and middle-income countries; a systematic literature review. BMC Health Serv Res. 2019;19(1):536. doi:10.1186/s12913-019-4359-831366363
   PubMed Web of Science ®Google Scholar
• Zhao Y, Li G, Chen Y, Lu Y. Challenges and advances in genome editing technologies in streptomyces. Biomolecules. 2020;10(5):734.
   Web of Science ®Google Scholar
• Gholizadeh P, Köse Ş, Dao S, et al. How CRISPR-Cas system could be used to combat antimicrobial resistance. Infect Drug Resist. 2020;13:1111–1121. doi:10.2147/IDR.S24727132368102
   PubMed Web of Science ®Google Scholar
• Goren M, Yosef I, Qimron U. Sensitizing pathogens to antibiotics using the CRISPR-Cas system. Drug Resist Updates. 2017;30:1–6. doi:10.1016/j.drup.2016.11.003
   PubMed Web of Science ®Google Scholar
• Yao R, Liu D, Jia X, Zheng Y, Liu W, Xiao Y. CRISPR-Cas9/Cas12a biotechnology and application in bacteria. Synth Syst Biotechnol. 2018;3(3):135–149. doi:10.1016/j.synbio.2018.09.00430345399
   PubMed Web of Science ®Google Scholar
• Aslam B, Rasool M, Idris A, et al. CRISPR-Cas system: a potential alternative tool to cope antibiotic resistance. Antimicrob Resis Infect Control. 2020;9:131. doi:10.1186/s13756-020-00795-6
   Web of Science ®Google Scholar
• Barrangou R, Fremaux C, Deveau H, et al. CRISPR provides acquired resistance against viruses in prokaryotes. Science. 2007;315(5819):1709–1712.17379808
   PubMed Web of Science ®Google Scholar
• Müller V, Rajer F, Frykholm K, et al. Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping. Sci Rep. 2016;6:37938. doi:10.1038/srep3793827905467
   PubMed Web of Science ®Google Scholar
• Touchon M, Charpentier S, Pognard D, et al. Antibiotic resistance plasmids spread among natural isolates of Escherichia coli in spite of CRISPR elements. Microbiology. 2012;158(12):2997–3004. doi:10.1099/mic.0.060814-0
   Web of Science ®Google Scholar
• Bikard D, Euler CW, Jiang W, et al. Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials. Nat Biotechnol. 2014;32:1146. doi:10.1038/nbt.304325282355
   PubMed Web of Science ®Google Scholar
• Hale Caryn R, Majumdar S, Elmore J, et al. Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs. Mol Cell. 2012;45(3):292–302. doi:10.1016/j.molcel.2011.10.02322227116
   PubMed Web of Science ®Google Scholar
• Cui L, Bikard D. Consequences of Cas9 cleavage in the chromosome of Escherichia coli. Nucleic Acids Res. 2016;44(9):4243–4251.27060147
   PubMed Web of Science ®Google Scholar
• Law BJC, Zhuo Y, Winn M, et al. A vitamin K-dependent carboxylase orthologue is involved in antibiotic biosynthesis. Nat Catalysis. 2018;1(12):977–984. doi:10.1038/s41929-018-0178-2
   Web of Science ®Google Scholar
• Van Der Oost J, Westra ER, Jackson RN, Wiedenheft B. Unravelling the structural and mechanistic basis of CRISPR–Cas systems. Nat Rev Microbiol. 2014;12(7):479–492.24909109
   PubMed Web of Science ®Google Scholar
• Citorik RJ, Mimee M, Lu TK. Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. Nat Biotechnol. 2014;32:1141. doi:10.1038/nbt.301125240928
   PubMed Web of Science ®Google Scholar
• Vercoe RB, Chang JT, Dy RL, et al. Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands. PLoS Genet. 2013;9(4):e1003454. doi:10.1371/journal.pgen.100345423637624
   PubMed Web of Science ®Google Scholar
• Harmsen IA, Mollema L, Ruiter RA, Paulussen TG, de Melker HE, Kok G. Why parents refuse childhood vaccination: a qualitative study using online focus groups. BMC Public Health. 2013;13:1183. doi:10.1186/1471-2458-13-118324341406
   PubMed Web of Science ®Google Scholar
• Jansen KU, Anderson AS. The role of vaccines in fighting antimicrobial resistance (AMR). Hum Vaccin Immunother. 2018;14(9):2142–2149. doi:10.1080/21645515.2018.147681429787323
   PubMed Web of Science ®Google Scholar
• Lima T, Domingues S, DaSilva GJ. Plasmid-medicated colistin resistance in samonella enterica: a review. Microorganisms. 2019;7(2):55. doi:10.3390/microorganisms7020055
   Web of Science ®Google Scholar
• World Health Organization. World Health Organization list of critically important antimicrobials (CIA), 3rd revision; 2011 Available from: http://www.who.int/foodsafety/publications/antimicrobials-third/en. Accessed 129, 2020.
   Google Scholar
• Mshana SE, Matee M, Rweyemamu M. Antimicrobial resistance in human and animal pathogens in Zambia, Democratic Republic of Congo, Mozambique, and Tanzania: an urgent need of a sustainable surveillance system. Ann Clin Microbiol Antimicrob. 2013;12:28. doi:10.1186/1476-0711-12-2824119299
   PubMed Web of Science ®Google Scholar
• Davis ME, Liu TL, Taylor YJ, et al. Exploring patient awareness and perceptions of the appropriate use of antibiotics: a mixed-methods study. Antibiotics (Basel). 2017;6(4):23. doi:10.3390/antibiotics6040023
   Web of Science ®Google Scholar
• Pearson M, Chandler C. Knowing antimicrobial resistance in practice: a multi-country qualitative study with human and animal healthcare professionals. Glob Health Action. 2019;12(1):1599560. doi:10.1080/16549716.2019.159956031294679
   PubMed Web of Science ®Google Scholar
• Michael CA, Dominey-Howes D, Labbate M. The antimicrobial resistance crisis: causes, consequences, and management. Front Public Health. 2014;2:145. doi:10.3389/fpubh.2014.0014525279369
   PubMedGoogle Scholar
• Lomazzi M, Moore M, Johnson A, Balasegaram M, Borisch B. Antimicrobial resistance - moving forward? BMC Public Health. 2019;19(1):858. doi:10.1186/s12889-019-7173-731266477
   PubMed Web of Science ®Google Scholar
• Founou RC, Founou LL, Essack SY. Clinical and economic impact of antibiotic resistance in developing countries: a systematic review and meta-analysis. PLoS One. 2017;12(12):e0189621. doi:10.1371/journal.pone.018962129267306
   PubMed Web of Science ®Google Scholar
• Alsan M, Schoemaker L, Eggleston K, Kammili N, Kolli P, Bhattacharya J. Out-of-pocket health expenditures and antimicrobial resistance in low-income and middle-income countries: an economic analysis. Lancet Infect Dis. 2015;15(10):1203–1210. doi:10.1016/S1473-309926164481
   PubMed Web of Science ®Google Scholar
• O’Neill J Review on antimicrobial resistance antimicrobial resistance: tackling a crisis for the health and wealth of nations. London: Review on Antimicrobial Resistance; 2014 Available from: https://amr-review.org/sites/default/files/AMR%20Review%20Paper%20-%20Tackling%20a%20crisis%20for%20the%20health%20and%20wealth%20of%20nations_1.pdf. Accessed 129, 2020.
   Google Scholar
• de Kraker ME, Stewardson AJ, Harbarth S. Will 10 million people die a year due to antimicrobial resistance by 2050? PLoS Med. 2016;13(11):e1002184. doi:10.1371/journal.pmed.100218427898664
   PubMed Web of Science ®Google Scholar
• Wilson K, Gardam M, McDougall C, Attaran A, Upshur R. WHO’s response to global public health threats: XDR-TB. PLoS Med. 2007;4(7):e246. doi:10.1371/journal.pmed.004024617676989
   PubMed Web of Science ®Google Scholar
• Laxminarayan R, Bhutta Z, Duse A, et al. Drug Resistance Jamison DT, Breman JG, Measham AR, et al. editors. Disease Control Priorities in Developing Countries. 2nd Washington (DC):The International Bank for Reconstruction and Development/The World Bank; 2006
   Google Scholar
• Abadi TBA, Rizvanov AA, Haertlé T, et al. World Health Organization report: current crisis of antibiotic resistance. BioNanoSci. 2019;9:778–788. doi:10.1007/s12668-019-00658-4
   Web of Science ®Google Scholar
• Rather IA, Kim BC, Bajpai VK, Park YH. Self-medication and antibiotic resistance: crisis, current challenges, and prevention. Saudi J Biol Sci. 2017;24(4):808–812. doi:10.1016/j.sjbs.2017.01.00428490950
   PubMed Web of Science ®Google Scholar
• Ayukekbong JA, Ntemgwa M, Atabe AN. The threat of antimicrobial resistance in developing countries: causes and control strategies. Antimicrob Resist Infect Control. 2017;6:47. doi:10.1186/s13756-017-0208-x28515903
   PubMed Web of Science ®Google Scholar
• Kelesidis T, Falagas ME. Substandard/counterfeit antimicrobial drugs. Clin Microbiol Rev. 2015;28(2):443–464. doi:10.1128/CMR.00072-1425788516
   PubMed Web of Science ®Google Scholar
• Almuzaini T, Choonara I, Sammons H. Substandard and counterfeit medicines: a systematic review of the literature. BMJ Open. 2013;3(8):e002923. doi:10.1136/bmjopen-2013-002923
   PubMed Web of Science ®Google Scholar
• Ozawa S, Evans DR, Bessias S, et al. Prevalence and estimated economic burden of substandard and falsified medicines in low- and middle-income countries: a systematic review and meta-analysis. JAMA Netw Open. 2018;1(4):e181662. doi:10.1001/jamanetworkopen.2018.166230646106
   PubMed Web of Science ®Google Scholar
• Fayzrakhmanov NF. Fighting trafficking of falsified and substandard medicinal products in Russia. Int J Risk Saf Med. 2015;27(Suppl 1):S37–S40. doi:10.3233/JRS-15068126639702
   PubMedGoogle Scholar
• Mackey TK. Prevalence of substandard and falsified essential medicines: still an incomplete picture. JAMA Netw Open. 2018;1(4):e181685. doi:10.1001/jamanetworkopen.2018.168530646099
   PubMed Web of Science ®Google Scholar
• Mathur P, Singh S. Multidrug resistance in bacteria: a serious patient safety challenge for India. J Lab Physicians. 2013;5(1):5–10. doi:10.4103/0974-2727.11589824014960
   PubMedGoogle Scholar
• Steinig EJ, Duchene S, Robinson DA, et al. Evolution and global transmission of a multidrug-resistant, community-associated methicillin-resistant staphylococcus aureus lineage from the indian subcontinent. mBio. 2019;10(6):e01105–e01119. doi:10.1128/mBio.01105-1931772058
   PubMed Web of Science ®Google Scholar
• Tarai B, Das P, Kumar D. Recurrent challenges for clinicians: emergence of methicillin-resistant staphylococcus aureus, vancomycin resistance, and current treatment options. J Lab Physicians. 2013;5(2):71–78. doi:10.4103/0974-2727.11984324701097
   PubMedGoogle Scholar
• Conly J, Johnston B. Where are all the new antibiotics? The new antibiotic paradox. Can J Infect Dis Med Microbiol. 2005;16(3):159–160. doi:10.1155/2005/89205818159536
   PubMedGoogle Scholar
• Institute of Medicine (US) Forum on Emerging Infections; Knobler SL, Lemon SM, Najafi M, et al. The resistance phenomenon in microbes and infectious disease vectors: implications for human health and strategies for containment: workshop summary. 7. Strategies to contain the development and consequences of resistance. Washington (DC): National Academies Press (US); 2003 Available from: https://www.ncbi.nlm.nih.gov/books/NBK97144/. Accessed 129, 2020.
   Google Scholar
• Dhingra S, Rahman NAA, Peile E, et al. Microbial resistance movements: an overview of global public health threats posed by antimicrobial resistance, and how best to counter. Front Public Health. 2020. doi:10.3389/fpubh.2020.535668
   Web of Science ®Google Scholar
• Cosgrove SE. The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stays, and health care costs. Clin Infect Dis. 2006;42(Suppl 2):S82–S89. doi:10.1086/49940616355321
   PubMed Web of Science ®Google Scholar
• Maragakis LL, Perencevich EN, Cosgrove SE. Clinical and economic burden of antimicrobial resistance. Expert Rev Anti Infect Ther. 2008;6(5):751–763. doi:10.1586/14787210.6.5.75118847410
   PubMed Web of Science ®Google Scholar
• Frost I, Van Boeckel TP, Pires J, Craig J, Laxminarayan R. Global geographic trends in antimicrobial resistance: the role of international travel. J Travel Med. 2019;26(8):taz036. doi:10.1093/jtm/taz03631115466
   PubMed Web of Science ®Google Scholar
• Ebrahim M, Gravel D, Thabet C, Abdesselam K, Paramalingam S, Hyson C. Antimicrobial use and antimicrobial resistance trends in Canada: 2014. Can Commun Dis Rep. 2016;42(11):227–231. doi:10.14745/ccdr29769991
   PubMedGoogle Scholar
• Woon SA, Fisher D. Antimicrobial agents - optimizing the ecological balance. BMC Med. 2016;14(1):114. doi:10.1186/s12916-016-0661-z27495926
   PubMed Web of Science ®Google Scholar
• Luepke KH, Suda KJ, Boucher H, et al. 3rd. past, present, and future of antibacterial economics: increasing bacterial resistance, limited antibiotic pipeline, and societal implications. Pharmacotherapy. 2017;37(1):71–84. doi:10.1002/phar.186827859453
   PubMed Web of Science ®Google Scholar
• World Health Organization. Antimicrobial resistance. Key Facts; 2020 Available from: https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance#:~:text=Antimicrobial%20resistance%20(AMR)%20threatens%20the,all%20government%20sectors%20and%20society. Accessed 129, 2020.
   Google Scholar
• Centers for Disease Control and Prevention. Antibiotic prescribing and use in hospitals and long-term care. Core elements of hospital antibiotic stewardship programs; 2017 Available from: www.cdc.gov/antibiotic-use/healthcare/implementation/core-elements.html#_ENREF_57. Accessed 129, 2020.
   Google Scholar
• Pollack LA, Srinivasan A. Core elements of hospital antibiotic stewardship programs from the centers for disease control and prevention. Clin Infect Dis. 2014;59(Suppl 3):S97–S100. doi:10.1093/cid/ciu54225261548
   PubMed Web of Science ®Google Scholar
• Ohl CA, Dodds Ashley ES. Antimicrobial stewardship programs in community hospitals: the evidence base and case studies. Clin Infect Dis. 2011;53(Suppl 1):S23–S28; quiz S29–S30. doi:10.1093/cid/cir365
   Web of Science ®Google Scholar
• File TM, Solomkin JS, Cosgrove SE. Strategies for improving antimicrobial use and the role of antimicrobial stewardship programs. Clin Infect Dis. 2011;53(Suppl 1):S15–S22. doi:10.1093/cid/cir36421795724
   PubMed Web of Science ®Google Scholar
• Haque M, McKimm J, Sartelli M, et al. Strategies to prevent healthcare-associated infections: a narrative overview. Risk Manag Healthc Policy. 2020;13:1765–1780. doi:10.2147/RMHP.S26931533061710
   PubMed Web of Science ®Google Scholar
• Baroudi R, Flaugher M, Grace E, Zakria D. The importance of an antimicrobial stewardship program. Fed Pract. 2015;32(9):20–24.
   Google Scholar
• Rhee SM, Stone ND. Antimicrobial stewardship in long-term care facilities. Infect Dis Clin North Am. 2014;28(2):237–246. doi:10.1016/j.idc.2014.01.00124857390
   PubMed Web of Science ®Google Scholar
• Goldman JL, Newland JG. New horizons for pediatric antibiotic stewardship. Infect Dis Clin North Am. 2015;29(3):503–511. doi:10.1016/j.idc.2015.05.00326154663
   PubMed Web of Science ®Google Scholar
• Barlam TF, Cosgrove SE, Abbo LM, et al. Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016;62(10):e51–e77. doi:10.1093/cid/ciw11827080992
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. Core elements of hospital antibiotic stewardship programs. Atlanta, GA: US Department of Health and Human Services, CDC; 2019 Available from: https://www.cdc.gov/antibiotic-use/core-elements/hospital.html. Accessed 129, 2020.
   Google Scholar
• Buckel WR, Veillette JJ, Vento TJ, Stenehjem E. Antimicrobial stewardship in community hospitals. Med Clin North Am. 2018;102(5):913–928. doi:10.1016/j.mcna.2018.05.00530126580
   PubMed Web of Science ®Google Scholar
• Shallcross LJ, Howard SJ, Fowler T, Davies SC. Tackling the threat of antimicrobial resistance: from policy to sustainable action. Philos Trans R Soc Lond B Biol Sci. 2015;370(1670):20140082. doi:10.1098/rstb.2014.008225918440
   PubMed Web of Science ®Google Scholar
• Hegewisch-Taylor J, Dreser-Mansilla A, Romero-Mónico J, Levy-Hara G. Antimicrobial stewardship in hospitals in Latin America and the Caribbean: a scoping review. Rev Panam Salud Publica. 2020;44:e68. doi:10.26633/RPSP.2020.6832973908
   PubMed Web of Science ®Google Scholar
• Resman F. Antimicrobial stewardship programs; a two-part narrative review of step-wise design and issues of controversy Part I: step-wise design of an antimicrobial stewardship program. Ther Adv Infect Dis. 2020;7:2049936120933187. doi:10.1177/204993612093318732612826
   PubMed Web of Science ®Google Scholar
• Leuthner KD, Doern GV. Antimicrobial stewardship programs. J Clin Microbiol. 2013;51(12):3916–3920. doi:10.1128/JCM.01751-1323926165
   PubMed Web of Science ®Google Scholar
• Ho PL, Cheng JC, Ching PT, et al. Optimizing antimicrobial prescription in hospitals by introducing an antimicrobial stewardship program in Hong Kong: a consensus statement. Hong Kong Med J. 2006;12(2):141–148.16603782
   PubMedGoogle Scholar
• Lee CR, Cho IH, Jeong BC, Lee SH. Strategies to minimize antibiotic resistance. Int J Environ Res Public Health. 2013;10(9):4274–4305. doi:10.3390/ijerph1009427424036486
   PubMed Web of Science ®Google Scholar
• Lee CR, Lee JH, Kang LW, Jeong BC, Lee SH. Educational effectiveness, target, and content for prudent antibiotic use. Biomed Res Int. 2015;2015:214021. doi:10.1155/2015/21402125945327
   PubMed Web of Science ®Google Scholar
• Goff DA. Antimicrobial stewardship: bridging the gap between quality care and cost. Curr Opin Infect Dis. 2011;24(Suppl 1):S11–S20. doi:10.1097/01.qco.0000393484.17894.0521200180
   PubMed Web of Science ®Google Scholar
• Collignon PJ, McEwen SA. One health-its importance in helping to better control antimicrobial resistance. Trop Med Infect Dis. 2019;4(1):22. doi:10.3390/tropicalmed4010022
   Google Scholar
• Lipsitch M, Siber GR. How can vaccines contribute to solving the antimicrobial resistance problem? mBio. 2016;7(3):e00428–e00416. doi:10.1128/mBio.00428-1627273824
   PubMed Web of Science ®Google Scholar
• Kelly R, Zoubiane G, Walsh D, Ward R, Goossens H. Public funding for research on antibacterial resistance in the JPIAMR countries, the European Commission, and related European Union agencies: a systematic observational analysis. Lancet Infect Dis. 2016;16(4):431–440. doi:10.1016/S1473-3099(15)00350-326708524
   PubMed Web of Science ®Google Scholar
• Bragginton EC, Piddock LJ. UK and European Union public and charitable funding from 2008 to 2013 for bacteriology and antibiotic research in the UK: an observational study. Lancet Infect Dis. 2014;14(9):857–868. doi:10.1016/S1473-3099(14)70825-425065509
   PubMed Web of Science ®Google Scholar
• Joint Programming Initiative on Antimicrobial Resistance, JPIAMR. Strategic research and innovation agenda on antimicrobial resistance. Available from: https://www.jpiamr.eu/wp-content/uploads/2019/05/JPIAMR_SRIA_final.pdf. Accessed 129, 2020.
   Google Scholar
• Carrico RM, Garrett H, Balcom D, Glowicz JB. Infection prevention and control core practices: a roadmap for nursing practice. Nursing. 2018;48(8):28–29. doi:10.1097/01.NURSE.0000544318
   Google Scholar
• Rogers Van Katwyk S, Jones SL, Hoffman SJ. Mapping educational opportunities for healthcare workers on antimicrobial resistance and stewardship around the world. Hum Resour Health. 2018;16(1):9. doi:10.1186/s12960-018-0270-329402327
   PubMed Web of Science ®Google Scholar
• Haque M, Rahman NAA, McKimm J, et al. Self-medication of antibiotics: investigating practice among university students at the Malaysian National Defence University. Infect Drug Resist. 2019;12:1333–1351. doi:10.2147/IDR.S20336431190922
   PubMed Web of Science ®Google Scholar
• Haque M, Rahman NAA, McKimm J, et al. A cross-sectional study evaluating the knowledge and beliefs about and the use of antibiotics amongst Malaysian university students. Expert Rev Anti Infect Ther. 2019;17(4):275–284. doi:10.1080/14787210.2019.158160730761920
   PubMed Web of Science ®Google Scholar
• Woolf SH, Grol R, Hutchinson A, Eccles M, Grimshaw J. Clinical guidelines: potential benefits, limitations, and harms of clinical guidelines. BMJ. 1999;318(7182):527–530. doi:10.1136/bmj.318.7182.52710024268
   PubMed Web of Science ®Google Scholar
• Weisz G, Cambrosio A, Keating P, Knaapen L, Schlich T, Tournay VJ. The emergence of clinical practice guidelines. Milbank Q. 2007;85(4):691–727. doi:10.1111/j.1468-0009.200718070334
   PubMed Web of Science ®Google Scholar
• Anderson AD, McClellan J, Rossiter S, et al.Public health consequences of use of antimicrobial agents in agriculture Knobler SL, Lemon SM, Najafi M, et al. editors. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington (DC):National Academies Press (US); 2003
   Google Scholar
• Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf. 2014;5(6):229–241. doi:10.1177/204209861455491925436105
   PubMedGoogle Scholar
• Pulcini C, Gyssens IC. How to educate prescribers in antimicrobial stewardship practices? Virulence. 2013;4(2):192–202. doi:10.4161/viru.2370623361336
   PubMed Web of Science ®Google Scholar
• Silverberg SL, Zannella VE, Countryman D, et al. A review of antimicrobial stewardship training in medical education. Int J Med Educ. 2017;8:353–374. doi:10.5116/ijme.59ba.2d4729035872
   PubMed Web of Science ®Google Scholar
• Gyssens IC. Role of education in antimicrobial stewardship. Med Clin North Am. 2018;102(5):855–871. doi:10.1016/j.mcna.2018.05.01130126576
   PubMed Web of Science ®Google Scholar
• Marshall BM, Levy SB. Food animals and antimicrobials: impacts on human health. Clin Microbiol Rev. 2011;24(4):718–733. doi:10.1128/CMR.00002-1121976606
   PubMed Web of Science ®Google Scholar
• Economou V, Gousia P. Agriculture, and food animals as a source of antimicrobial-resistant bacteria. Infect Drug Resist. 2015;8:49–61. doi:10.2147/IDR.S5577825878509
   PubMed Web of Science ®Google Scholar
• McDermott PF, Zhao S, Wagner DD, Simjee S, Walker RD, White DG. The food safety perspective of antibiotic resistance. Anim Biotechnol. 2002;13(1):71–84. doi:10.1081/ABIO-12000577112212946
   PubMed Web of Science ®Google Scholar
• Mathew AG, Cissell R, Liamthong S. Antibiotic resistance in bacteria associated with food animals: a United States perspective of livestock production. Foodborne Pathog Dis. 2007;4(2):115–133. doi:10.1089/fpd.2006.006617600481
   PubMed Web of Science ®Google Scholar
• Moralejo D, El Dib R, Prata RA, Barretti P, Corrêa I. Improving adherence to Standard Precautions for the control of healthcare-associated infections. Cochrane Database Syst Rev. 2018;2(2):CD010768. doi:10.1002/14651858.CD010768.pub229481693
   PubMed Web of Science ®Google Scholar
• WHO Guidelines on hand hygiene in health care: first global patient safety challenge clean care is safer care. Geneva: World Health Organization; 2009 Available from: https://www.ncbi.nlm.nih.gov/books/NBK144005/. Accessed 129, 2020.
   Google Scholar
• Houghton C, Meskell P, Delaney H, et al. Barriers and facilitators to healthcare workers’ adherence with infection prevention and control (IPC) guidelines for respiratory infectious diseases: a rapid qualitative evidence synthesis. Cochrane Database Syst Rev. 2020;4(4):CD013582. doi:10.1002/14651858.CD01358232315451
   PubMed Web of Science ®Google Scholar
• Verbeek JH, Rajamaki B, Ijaz S, et al. Personal protective equipment for preventing highly infectious diseases due to exposure to contaminated body fluids in healthcare staff. Cochrane Database Syst Rev. 2020;5:CD011621. doi:10.1002/14651858.CD011621.pub532412096
   PubMed Web of Science ®Google Scholar
• Haque M, Sartelli M, McKimm J, Abu Bakar M. Healthcare-associated infections - an overview. Infect Drug Resist. 2018;11:2321–2333. doi:10.2147/IDR.S17724730532565
   PubMed Web of Science ®Google Scholar
• Haque M. Handwashing in averting infectious diseases: relevance to COVID-19. J Popul Ther Clin Pharmacol. 2020;27(SPt 1):e37–e52. doi:10.15586/jptcp.v27SP1.71132757544
   PubMed Web of Science ®Google Scholar