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Infection and Drug Resistance Volume 14, 2021 - Issue
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Case Report

Osteoarticular Cryptococcosis Successfully Treated with High-Dose Liposomal Amphotericin B Followed by Oral Fluconazole

Guillem Deus1 Infectious Diseases Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, Barcelona, Spain
,
Silvia Gómez-Zorrilla1 Infectious Diseases Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, Barcelona, SpainCorrespondence[email protected]
,
Daniel Echeverria-Esnal2 Pharmacy Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
,
Ana Siverio3 Microbiology Service, Laboratori de Referència de Catalunya, Hospital del Mar, Barcelona, Spain
,
Robert Güerri-Fernandez1 Infectious Diseases Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, Barcelona, Spain
,
Jesús Ares4 Department of Radiology, Hospital del Mar, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
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Nuria Campillo2 Pharmacy Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
,
Emili Letang1 Infectious Diseases Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, Barcelona, Spain;5 ISGlobal, Barcelona Institute for Global, Universitat de BarcelonaHealth, Barcelona, Spain
,
Hernando Knobel1 Infectious Diseases Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, Barcelona, Spain
,
Santiago Grau2 Pharmacy Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
&
Juan Pablo Horcajada1 Infectious Diseases Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, Barcelona, Spain
 show all
Pages 719-722 | Published online: 24 Feb 2021

References

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  • Chayakulkeeree M, Perfect JR. Cryptococcosis. Infect Dis Clin North Am. 2006;20(3):507–544.16984867
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  • Li Z, Liang J, Shen J, Qiu G, Weng X. Thoracolumbar scoliosis due to cryptococcal osteomyelitis: a case report and review of the literature. Medicine. 2016;95(5):e2613.26844472
  • Jarvis JN, Leeme TB, Mooketsi M, et al. Short-course high-dose liposomal amphotericin b for human immunodeficiency virus–associated cryptococcal meningitis: a phase 2 randomized controlled trial. Clin Infect Dis. 2019;68(3):393–401.29945252
  • Perfect JR, Dismukes WE, Dromer F, et al. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of America. Clin Infect Dis. 2010;50(3):291–322.20047480
  • Molloy SF, Kanyama C, Heyderman RS, et al. Antifungal combinations for treatment of cryptococcal meningitis in Africa. N Engl J Med. 2018;378(11):1004–1017.29539274
  • Chesdachai S, Rajasingham R, Nicol MR, et al. Minimum inhibitory concentration distribution of fluconazole against cryptococcus species and the fluconazole exposure prediction model. Open Forum Infect Dis. 2019;6(10):ofz369.31420668

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