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Original Research

Molecular Epidemiology and Mechanisms of Carbapenem-Resistant Acinetobacter baumannii Isolates from ICU and Respiratory Department Patients of a Chinese University Hospital

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Pages 743-755 | Published online: 25 Feb 2021

References

  • Perez F, Hujer AM, Hujer KM, Decker BK, Rather PN, Bonomo RA. Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2007;51(10):3471–3484. doi:10.1128/AAC.01464-0617646423
  • Giamarellou H, Antoniadou A, Kanellakopoulou K. Acinetobacter baumannii: a universal threat to public health? Int J Antimicrob Agents. 2008;32(2):106–119. doi:10.1016/j.ijantimicag.2008.02.01318571905
  • Kim YJ, Kim SI, Hong K-W, Kim YR, Park YJ, Kang M-W. Risk factors for mortality in patients with carbapenem-resistant Acinetobacter baumannii bacteremia: impact of appropriate antimicrobial therapy. J Korean Med Sci. 2012;27(5):471–475. doi:10.3346/jkms.2012.27.5.47122563209
  • Nhu NTK, Lan NPH, Campbell JI, et al. Emergence of carbapenem-resistant Acinetobacter baumannii as the major cause of ventilator-associated pneumonia in intensive care unit patients at an infectious disease hospital in southern Vietnam. J Med Microbiol. 2014;63(Pt10):1386–1394. doi:10.1099/jmm.0.076646-025038137
  • Qureshi ZA, Hittle LE, O’Hara JA, et al. Colistin-resistant Acinetobacter baumannii: beyond carbapenem resistance. Clin Infect Dis. 2015;60(9):1295–1303. doi:10.1093/cid/civ04825632010
  • Rafei R, Dabboussi F, Hamze M, et al. Molecular analysis of Acinetobacter baumannii strains isolated in Lebanon using four different typing methods. PLoS One. 2014;9(12):e115969. doi:10.1371/journal.pone.011596925541711
  • Evans BA, Hamouda A, Amyes SGB. The rise of carbapenem-resistant Acinetobacter baumannii. Curr Pharm Des. 2013;19(2):223–238. doi:10.2174/13816121380407028522894617
  • Higgins PG, Dammhayn C, Hackel M, Seifert H. Global spread of carbapenem-resistant Acinetobacter baumannii. J Antimicrob Chemother. 2010;65(2):233–238. doi:10.1093/jac/dkp42819996144
  • Lee CR, Lee JH, Park M, et al. Biology of acinetobacter baumannii: pathogenesis, antibiotic resistance mechanisms, and prospective treatment options. Front Cell Infect Microbiol. 2017;7:55.28348979
  • Piana A, Palmieri A, Deidda S, et al. Molecular typing of XDR Acinetobacter baumannii strains in an Italian ICU. Epidemiol Prev. 2015;39(4Suppl 1):129–133.
  • Liu X, Zhao M, Chen Y, Bian X, Li Y, Shi J. Synergistic killing by meropenem and colistin combination of carbapenem-resistant Acinetobacter baumannii isolates from Chinese patients in an in vitro pharmacokinetic/pharmacodynamic model. Int J Antimicrob Agents. 2016;48(5):559–563. doi:10.1016/j.ijantimicag.2016.07.01827670371
  • Martinez T, Martinez I, Vazquez GJ, Aquino EE, Robledo IE. Genetic environment of the KPC gene in Acinetobacter baumannii ST2 clone from Puerto Rico and genomic insights into its drug resistance. J Med Microbiol. 2016;65(8):784. doi:10.1099/jmm.0.00028927259867
  • Higgins PG, Pérezllarena FJ, Zander E, Fernández A, Bou G, Seifert H. OXA-235, a novel class D β-lactamase involved in resistance to carbapenems in Acinetobacter baumannii. Antimicrob Agents Chemother. 2013;57(5):2121–2126. doi:10.1128/AAC.02413-1223439638
  • Liu L, Ji S, Ruan Z, et al. Dissemination of blaOXA-23 in Acinetobacter spp. in China: main roles of conjugative plasmid pAZJ221 and transposon Tn2009. Antimicrob Agents Chemother. 2015;59(4):1998–2005. doi:10.1128/AAC.04574-1425605357
  • Mussi MA, Limansky AS, Viale AM. Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of β-barrel outer membrane proteins. Antimicrob Agents Chemother. 2005;49(4):1432–1440. doi:10.1128/AAC.49.4.1432-1440.200515793123
  • Tomaschek F, Higgins PG, Stefanik D, Wisplinghoff H, Seifert H, Gao F. Head-to-head comparison of two Multi-Locus Sequence Typing (MLST) schemes for characterization of Acinetobacter baumannii outbreak and sporadic isolates. PLoS One. 2016;11(4):e0153014. doi:10.1371/journal.pone.015301427071077
  • Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing, 28th Ed. CLSI Supplement M100. Wayne, PA: Clinical and Laboratory Standards Institute; 2018.
  • Deng M, Zhu M-H, Li J-J, et al. Molecular epidemiology and mechanisms of tigecycline resistance in clinical isolates of Acinetobacter baumannii from a Chinese University Hospital. Antimicrob Agents Chemother. 2014;58(1):297–303. doi:10.1128/AAC.01727-1324165187
  • Zhao Y, Hu K, Zhang J, et al. Outbreak of carbapenem-resistant Acinetobacter baumannii carrying the carbapenemase OXA-23 in ICU of the eastern Heilongjiang Province, China. BMC Infect Dis. 2019;19(1):452. doi:10.1186/s12879-019-4073-531113374
  • Pournaras S, Gogou V, Giannouli M, et al. Single-locus-sequence-based typing of blaOXA-51-like genes for rapid assignment of Acinetobacter baumannii clinical isolates to international clonal lineages. J Clin Microbiol. 2014;52:1653–1657. doi:10.1128/JCM.03565-1324622099
  • Woodford N, Ellington MJ, Coelho JM, et al. Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int J Antimicrob Agents. 2006;27(4):351–353. doi:10.1016/j.ijantimicag.2006.01.00416564159
  • Karah N, Jolley KA, Hall RM, Uhlin BE, Gao F. Database for the ampC alleles in Acinetobacter baumannii. PLoS One. 2017;12(5):e0176695. doi:10.1371/journal.pone.017669528459877
  • Mirshekar M, Shahcheraghi F, Azizi O, Solgi H, Badmasti F. Diversity of class 1 integrons, and disruption of carO and dacD by insertion sequences among Acinetobacter baumannii Isolates in Tehran, Iran. Microb Drug Resist. 2018;24(4):359–366. doi:10.1089/mdr.2017.015228972863
  • Piran A, Shahcheraghi F, Solgi H, Rohani M, Badmasti F. A reliable combination method to identification and typing of epidemic and endemic clones among clinical isolates of Acinetobacter baumannii. Infect Genet Evol. 2017;54:501–507. doi:10.1016/j.meegid.2017.08.01828827174
  • El-Shazly S, Dashti A, Vali L, Bolaris M, Ibrahim AS. Molecular epidemiology and characterization of multiple drug-resistant (MDR) clinical isolates of Acinetobacter baumannii. Int J Infect Dis. 2015;41:42–49. doi:10.1016/j.ijid.2015.10.01626518066
  • Sun F, Ou Q, Wang Q, et al. The resistance and transmission mechanism of Acinetobacter baumannii isolates in a tertiary care hospital, China. J Chemother. 2016;28(6):476‐481. doi:10.1080/1120009X.2016.1139335
  • Turton JF, Ward ME, Woodford N, et al. The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol Lett. 2010;258(1):72–77. doi:10.1111/j.1574-6968.2006.00195.x
  • Bartual SG, Seifert H, Hippler C, et al. Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii. J Clin Microbiol. 2005;43(9):4382–4390. doi:10.1128/JCM.43.9.4382-4390.200516145081
  • Durmaz R, Otlu B, Koksal F. The optimization of a rapid pulsed-field gel electrophoresis protocol for the typing of Acinetobacter baumannii, Escherichia coli and Klebsiella spp. Jpn J Infect Dis. 2009;62(5):372–377.19762987
  • Tenover FC, Arbeit RD, Goering RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995;33(9):2233. doi:10.1128/JCM.33.9.2233-2239.19957494007
  • Chang -Y-Y, Chen H-P, Lin C-W, et al. Implementation and outcomes of an antimicrobial stewardship program: effectiveness of education. J Chin Med Assoc. 2017;80(6):353–359. doi:10.1016/j.jcma.2016.09.01228411959
  • Warde E, Davies E, Ward A. Control of a multidrug-resistant Acinetobacter baumannii outbreak. Br J Nurs. 2019;28(4):242–248. doi:10.12968/bjon.2019.28.4.24230811227
  • Muñoz-Price LS, Carling P, Clearly T, et al. Control of a two-decade endemic situation with carbapenem-resistant Acinetobacter baumannii: electronic dissemination of a bundle of interventions. Am J Infect Control. 2014;42:466–471. doi:10.1016/j.ajic.2013.12.02424773784
  • Yamada K, Yanagihara K, Araki N, et al. Clinical characteristics of tertiary hospital patients from whom Acinetobacter calcoaceticus-Acinetobacter baumannii complex strains were isolated. Intern Med. 2012;51(1):51–57. doi:10.2169/internalmedicine.51.601822214623
  • Molter G, Seifert H, Mandraka F, et al. Outbreak of carbapenem-resistant Acinetobacter baumannii in the intensive care unit: a multi-level strategic management approach. J Hosp Infect. 2016;92(2):194–198. doi:10.1016/j.jhin.2015.11.00726778130
  • Silva GJD, Domingues S. Insights on the horizontal gene transfer of carbapenemase determinants in the opportunistic pathogen Acinetobacter baumannii. Microorganisms. 2016;4(3):29. doi:10.3390/microorganisms4030029
  • Tsiatsiou O, Iosifidis E, Katragkou A, et al. Successful management of an outbreak due to carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit. Eur J Pediatr. 2015;174(1):65–74. doi:10.1007/s00431-014-2365-824985124
  • Zowawi HM, Sartor AL, Sidjabat HE, et al. Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii isolates in the gulf cooperation council states: dominance of OXA-23-type producers. J Clin Microbiol. 2015;53(3):896. doi:10.1128/JCM.02784-1425568439
  • He C, Xie Y, Zhang L, et al. Increasing imipenem resistance and dissemination of the ISAba1-associated blaOXA-23 gene among Acinetobacter baumannii isolates in an intensive care unit. J Med Microbiol. 2011;60:337–341. doi:10.1099/jmm.0.022681-021127157
  • Martínez P, Mattar S. Imipenem-resistant Acinetobacter baumannii carrying the ISAba1-bla OXA-23,51 and ISAba1-bla ADC-7 genes in Monteria, Colombia. Braz J Microbiol. 2012;43:1274‑1280. doi:10.1590/S1517-83822012000400006
  • Shahcheraghi F, Abbasalipour M, Feizabadi M, Ebrahimipour G, Akbari N. Isolation and genetic characterization of metallo-β-lactamase and carbapenamase producing strains of Acinetobacter baumannii from patients at Tehran hospitals. Iran J Microbiol. 2011;3:68.22347585
  • Mugnier PD, Poirel L, Naas T, Nordmann P. Worldwide dissemination of the blaOXA-23 carbapenemase gene of Acinetobacter baumannii. Emerg Infect Dis. 2010;16:35. doi:10.3201/eid1601.09085220031040
  • Thomas CM, Nielsen KM. Mechanisms of, and barriers to, horizontal gene transfer between bacteria. Nat Rev Microbiol. 2005;3(9):711–721. doi:10.1038/nrmicro123416138099
  • Hua X, Zhou Z, Yang Q, et al. Evolution of Acinetobacter baumannii in vivo: international clone II, more resistance to ceftazidime, mutation in ptk. Front Microbiol. 2017;8:1256.28740486
  • Savard P, Gopinath R, Zhu W, et al. First NDM‑positive Salmonella sp. strain identified in the United States. Antimicrob Agents Chemother. 2011;55:5957‑5958. doi:10.1128/AAC.05719-11
  • Armin S, Fallah F, Azimi L, et al. Warning: spread of NDM-1 in two border towns of Iran. Cell Mol Biol. 2018;64:125–129. doi:10.14715/cmb/2018.64.10.2030084804
  • Xiao S-Z, Chu H-Q, Han L-Z, et al. Resistant mechanisms and molecular epidemiology of imipenem-resistant Acinetobacter baumannii. Mol Med Rep. 2016;14(3):2483–2488. doi:10.3892/mmr.2016.553827485638
  • Huang L, Sun L, Yan Y. Clonal spread of carbapenem resistant Acinetobacter baumannii ST92 in a Chinese Hospital during a 6-year period. J Microbiol. 2013;51(1):113–117. doi:10.1007/s12275-013-2341-423456719