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Original Research

Carbonyl Cyanide 3-Chlorophenylhydrazone (CCCP) Exhibits Direct Antibacterial Activity Against Mycobacterium abscessus

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Pages 1199-1208 | Published online: 23 Mar 2021

References

  • Johansen MD, Herrmann JL, Kremer L. Non-tuberculous mycobacteria and the rise of mycobacterium abscessus. Nat Rev Microbiol. 2020;18(7):392–407. doi:10.1038/s41579-020-0331-132086501
  • Cowman S, van Ingen J, Griffith DE, Loebinger MR. Non-tuberculous mycobacterial pulmonary disease. Eur Respir J. 2019;54(1):1900250. doi:10.1183/13993003.00250-201931221809
  • Koh WJ, Chang B, Jeong BH, et al. Increasing recovery of nontuberculous mycobacteria from respiratory specimens over a 10-year period in a tertiary referral hospital in south korea. Tuberc Respir Dis (Seoul). 2013;75(5):199–204. doi:10.4046/trd.2013.75.5.19924348667
  • Griffith DE. Mycobacterium abscessus and antibiotic resistance: same as it ever was. Clin Infect Dis. 2019;69(10):1687–1689. doi:10.1093/cid/ciz07130689764
  • Chen J, Zhao L, Mao Y, et al. Clinical efficacy and adverse effects of antibiotics used to treat mycobacterium abscessus pulmonary disease. Front Microbiol. 2019;10:1977. doi:10.3389/fmicb.2019.0197731507579
  • Kwak N, Dalcolmo MP, Daley CL, et al. Mycobacterium abscessus pulmonary disease: individual patient data meta-analysis. Eur Respir J. 2019;54(1):1801991. doi:10.1183/13993003.01991-201830880280
  • Nessar R, Cambau E, Reyrat JM, Murray A, Gicquel B. Mycobacterium abscessus: a new antibiotic nightmare. J Antimicrob Chemother. 2012;67(4):810–818. doi:10.1093/jac/dkr57822290346
  • Ardebili A, Talebi M, Azimi L, Rastegar Lari A. Effect of efflux pump inhibitor carbonyl cyanide 3-chlorophenylhydrazone on the minimum inhibitory concentration of ciprofloxacin in acinetobacter baumannii clinical isolates. Jundishapur J Microbiol. 2014;7(1):e8691. doi:10.5812/jjm.869125147654
  • Park YK, Ko KS. Effect of carbonyl cyanide 3-chlorophenylhydrazone (CCCP) on killing acinetobacter baumannii by colistin. J Microbiol. 2015;53(1):53–59. doi:10.1007/s12275-015-4498-525557480
  • Wang Y, Venter H, Ma S. Efflux pump inhibitors: a novel approach to combat efflux-mediated drug resistance in bacteria. Curr Drug Targets. 2016;17(6):702–719. doi:10.2174/138945011666615100110394826424403
  • Rodrigues L, Parish T, Balganesh M, Ainsa JA. Antituberculosis drugs: reducing efflux=increasing activity. Drug Discov Today. 2017;22(3):592–599. doi:10.1016/j.drudis.2017.01.00228089787
  • Guo Q, Chen J, Zhang S, et al. Efflux pumps contribute to intrinsic clarithromycin resistance in clinical, mycobacterium abscessus isolates. Infect Drug Resist. 2020;13:447–454. doi:10.2147/IDR.S23985032104016
  • Rindi L. Efflux pump inhibitors against nontuberculous mycobacteria. Int J Mol Sci. 2020;21(12):4191. doi:10.3390/ijms21124191
  • CLSI. Susceptibility Testing of Mycobacteria, Nocardia, and Other Aerobic Actinomycetes; Approved Standard, 2nd. Clsi Document M24-A2. CLSI; 2011.
  • Zhang S, Zou Y, Guo Q, et al. Ar-12 exhibits direct and host-targeted antibacterial activity toward mycobacterium abscessus. Antimicrob Agents Chemother. 2020;64(8). doi:10.1128/AAC.00236-20.
  • Viljoen A, Raynaud C, Johansen MD, et al. Verapamil improves the activity of bedaquiline against mycobacterium abscessus in vitro and in macrophages. Antimicrob Agents Chemother. 2019;63(9). doi:10.1128/AAC.00705-19.
  • Kasperbauer SH, De Groote MA. The treatment of rapidly growing mycobacterial infections. Clin Chest Med. 2015;36(1):67–78. doi:10.1016/j.ccm.2014.10.00425676520
  • Ramis IB, Vianna JS, Silva Junior L, et al. In silico and in vitro evaluation of tetrahydropyridine compounds as efflux inhibitors in mycobacterium abscessus. Tuberculosis (Edinb). 2019;118:101853. doi:10.1016/j.tube.2019.07.00431430699
  • Koh WJ, Jeon K, Lee NY, et al. Clinical significance of differentiation of mycobacterium massiliense from mycobacterium abscessus. Am J Respir Crit Care Med. 2011;183(3):405–410. doi:10.1164/rccm.201003-0395OC20833823
  • Mougari F, Guglielmetti L, Raskine L, et al. Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. Expert Rev Anti Infect Ther. 2016;14(12):1139–1154. doi:10.1080/14787210.2016.123830427690688
  • Catherinot E, Roux AL, Macheras E, et al. Acute respiratory failure involving an r variant of mycobacterium abscessus. J Clin Microbiol. 2009;47(1):271–274. doi:10.1128/JCM.01478-0819020061
  • Nessar R, Reyrat JM, Davidson LB, Byrd TF. Deletion of the mmpl4b gene in the mycobacterium abscessus glycopeptidolipid biosynthetic pathway results in loss of surface colonization capability, but enhanced ability to replicate in human macrophages and stimulate their innate immune response. Microbiology (Reading). 2011;157(4):1187–1195. doi:10.1099/mic.0.046557-021292749
  • Pawlik A, Garnier G, Orgeur M, et al. Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent mycobacterium abscessus. Mol Microbiol. 2013;90(3):612–629. doi:10.1111/mmi.1238723998761
  • Rhoades ER, Archambault AS, Greendyke R, et al. Mycobacterium abscessus glycopeptidolipids mask underlying cell wall phosphatidyl-myo-inositol mannosides blocking induction of human macrophage TNF-α by preventing interaction with TLR2. J Immunol. 2009;183(3):1997–2007. doi:10.4049/jimmunol.080218119596998
  • Li B, Ye M, Zhao L, et al. Glycopeptidolipid genotype correlates with the severity of mycobacterium abscessus lung disease. J Infect Dis. 2020;221(Supplement_2):S257–S262. doi:10.1093/infdis/jiz47532176786
  • Rottman M, Catherinot E, Hochedez P, et al. Importance of t cells, gamma interferon, and tumor necrosis factor in immune control of the rapid grower mycobacterium abscessus in c57bl/6 mice. Infect Immun. 2007;75(12):5898–5907. doi:10.1128/IAI.00014-0717875636
  • Clary G, Sasindran SJ, Nesbitt N, et al. Mycobacterium abscessus smooth and rough morphotypes form antimicrobial-tolerant biofilm phenotypes but are killed by acetic acid. Antimicrob Agents Chemother. 2018;62(3). doi:10.1128/AAC.01782-17.
  • Ruger K, Hampel A, Billig S, et al. Characterization of rough and smooth morphotypes of mycobacterium abscessus isolates from clinical specimens. J Clin Microbiol. 2014;52(1):244–250. doi:10.1128/JCM.01249-1324197890
  • Ni W, Li Y, Guan J, et al. Effects of efflux pump inhibitors on colistin resistance in multidrug-resistant gram-negative bacteria. Antimicrob Agents Chemother. 2016;60(5):3215–3218. doi:10.1128/AAC.00248-1626953203
  • Mlejnek P. Caspase-3 activity and carbonyl cyanide m-chlorophenylhydrazone-induced apoptosis in HL-60. Altern Lab Anim. 2001;29(3):243–249. doi:10.1177/02611929010290031311387021
  • Soutar MPM, Kempthorne L, Annuario E, et al. FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy. Autophagy. 2019;15(11):2002–2011. doi:10.1080/15548627.2019.160354931060423