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Infection and Drug Resistance Volume 14, 2021 - Issue
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Case Report

Talaromyces marneffei and Burkholderia cepacia Co-Infection in a HIV-Uninfected Patient with Anti-Interferon-γ Autoantibodies

Wen Zeng1 Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong, 518000, People’s Republic of China;2 Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of China
,
Ye Qiu1 Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong, 518000, People’s Republic of China;2 Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of China
,
Mengxin Tang1 Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong, 518000, People’s Republic of China;2 Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of China
,
Hui Zhang2 Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of China
,
Mianluan Pan1 Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong, 518000, People’s Republic of China
,
Shudan Tang2 Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-3656-3895
ORCID Icon &
Jianquan Zhang1 Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong, 518000, People’s Republic of ChinaCorrespondence[email protected]
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Pages 2173-2177 | Published online: 10 Jun 2021

References

  • Zeng W, Qiu Y, Tang S, Zhang J, Pan M, Zhong X. Characterization of anti-interferon-γ antibodies in HIV negative patients infected with disseminated Talaromyces marneffei and cryptococcosis. Open Forum Infect Dis. 2019;6:ofz208. doi:10.1093/ofid/ofz20831660325
  • Hammoud M, Fares Y, Atoui R, Dabboucy B. Burkholderia cepacia as a cause of pyogenic spondylodiscitis in immunocompetent patients: a single-institution case series and literature review. J Spine Surg. 2019;5:372–377. doi:10.21037/jss.2019.07.0231663049
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  • Chi CY, Lin CH, Ho MW, et al. Clinical manifestations, course, and outcome of patients with neutralizing anti-interferon-γ autoantibodies and disseminated nontuberculous mycobacterial infections. Medicine (Baltimore). 2016;95:e3927. doi:10.1097/MD.000000000000392727336882
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  • Qiu Y, Feng X, Zeng W, Zhang H, Zhang J. Immunodeficiency disease spectrum in HIV-negative individuals with Talaromycosis. J Clin Immunol. 2021;41:221–223. doi:10.1007/s10875-020-00869-532996007
  • Chi CY, Chu CC, Liu JP, et al. Anti-IFN-γ autoantibodies in adults with disseminated nontuberculous mycobacterial infections are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02 and the reactivation of latent varicella-zoster virus infection. Blood. 2013;121:1357–1366. doi:10.1182/blood-2012-08-45248223243276
  • Lin CH, Chi CY, Shih HP, et al. Identification of a major epitope by anti-interferon-γ autoantibodies in patients with mycobacterial disease. Nat Med. 2016;22:994–1001. doi:10.1038/nm.415827525523
  • Tang BS, Chan JF, Chen M, et al. Disseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon. Clin Vaccine Immunol. 2010;17:1132–1138. doi:10.1128/CVI.00053-1020445006
  • Laisuan W, Pisitkun P, Ngamjanyaporn P, Suangtamai T, Rotjanapan P. Prospective pilot study of cyclophosphamide as an adjunct treatment in patients with adult-onset immunodeficiency associated with anti-interferon-γ autoantibodies. Open Forum Infect Dis. 2020;7:ofaa035. doi:10.1093/ofid/ofaa03532099846
  • Browne SK, Zaman R, Sampaio EP, et al. Anti-CD20 (rituximab) therapy for anti-IFN-γ autoantibody-associated nontuberculous mycobacterial infection. Blood. 2012;119:3933–3939. doi:10.1182/blood-2011-12-39570722403254

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