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Original Research

Molecular Mechanism of Polymyxin Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli Isolates from Henan Province, China: A Multicenter Study

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Pages 2657-2666 | Published online: 12 Jul 2021

References

  • Sun J, Zhang H, Liu YH, Feng Y. Towards understanding MCR-like colistin resistance. Trends Microbiol. 2018;26(9):794–808.29525421
  • Giamarellou H. Epidemiology of infections caused by polymyxin-resistant pathogens. Int J Antimicrob Agents. 2016;48(6):614–621.27865627
  • Nordmann P, Poirel L. Plasmid-mediated colistin resistance: an additional antibiotic resistance menace. Clin Microbiol Infect. 2016;22(5):398–400.27021419
  • Liu YY, Wang Y, Walsh TR, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):161–168.26603172
  • Li X, Liu B, Dong P, Li F, Yuan L, Hu G. The prevalence of mcr-1 and resistance characteristics of Escherichia coli isolates from diseased and healthy pigs. Diagn Microbiol Infect Dis. 2018;91(1):63–65.29395711
  • Li Y, Sun Q, Shen Y, et al. Rapid Increase in prevalence of carbapenem-resistant Enterobacteriaceae (CRE) and emergence of colistin resistance gene mcr-1 in CRE in a hospital in Henan, China. J Clin Microbiol. 2018;56(4):e01932–17.29386265
  • Qin S, Zhang C, Schwarz S, et al. Identification of a novel conjugative mcr-8.2-bearing plasmid in an almost pan-resistant hypermucoviscous Klebsiella pneumoniae ST11 isolate with enhanced virulence. J Antimicrob Chemother. 2020;75(9):2696–2699.32591807
  • Pitt ME, Elliott A, Cao MD, et al. Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae. Microb Genom. 2018;4(3):e000158.
  • Poirel L, Jayol A, Bontron S, et al. The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae. J Antimicrob Chemother. 2015;70(1):75–80.25190723
  • Hamel M, Chatzipanagiotou S, Hadjadj L, et al. Inactivation of mgrB gene regulator and resistance to colistin is becoming endemic in carbapenem-resistant Klebsiella pneumoniae in Greece: a nationwide study from 2014 to 2017. Int J Antimicrob Agents. 2020;55(4):105930.32130981
  • European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters, Version 9.0; 2019. Available from: https://www.eucast.org/clinical_breakpoints/. Accessed 72, 2021.
  • Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing. 29th ed. Wayne (PA): CLSI supplement M100 Clinical and Laboratory Standards Institute; 2019.
  • Dallenne C, Da Costa A, Decré D, Favier C, Arlet G. Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae. J Antimicrob Chemother. 2010;65(3):490–495.20071363
  • Queenan AM, Bush K. Carbapenemases: the versatile beta-lactamases. Clin Microbiol Rev. 2007;20(3):440–458.17630334
  • Wang X, Wang Y, Zhou Y, et al. Emergence of a novel mobile colistin resistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae. Emerg Microbes Infect. 2018;7(1):122.29970891
  • Haeili M, Javani A, Moradi J, Jafari Z, Feizabadi MM, Babaei E. MgrB alterations mediate colistin resistance in Klebsiella pneumoniae isolates from Iran. Front Microbiol. 2017;8:2470.29326662
  • Cannatelli A, Di Pilato V, Giani T, et al. In vivo evolution to colistin resistance by PmrB sensor kinase mutation in KPC-producing Klebsiella pneumoniae is associated with low-dosage colistin treatment. Antimicrob Agents Chemother. 2014;58(8):4399–4403.24841267
  • Cannatelli A, D’Andrea MM, Giani T, et al. In vivo emergence of colistin resistance in Klebsiella pneumoniae producing KPC-type carbapenemases mediated by insertional inactivation of the PhoQ/PhoP mgrB regulator. Antimicrob Agents Chemother. 2013;57(11):5521–5526.23979739
  • He J, Jia X, Yang S, et al. Heteroresistance to carbapenems in invasive Pseudomonas aeruginosa infections. Int J Antimicrob Agents. 2018;51(3):413–421.29127047
  • Liu X, Wang Y, Cui L, et al. A retrospective study on mcr-1 in clinical Escherichia coli and Klebsiella pneumoniae isolates in China from 2007 to 2016. J Antimicrob Chemother. 2018;73(7):1786–1790.29912359
  • Quan J, Li X, Chen Y, et al. Prevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China: a multicentre longitudinal study. Lancet Infect Dis. 2017;17(4):400–410.28139430
  • China Antimicrobial Resistance Surveillance System. National Bacterial Resistance Surveillance Report. Short Version (in Chinese); 2019. Available from: http://www.carss.cn/Report/Details?aId=770. Accessed 1119, 2020.
  • Yang TY, Wang SF, Lin JE, et al. Contributions of insertion sequences conferring colistin resistance in Klebsiella pneumoniae. Int J Antimicrob Agents. 2020;55(3):105894.31923567
  • Nordmann P, Jayol A, Poirel L. Rapid detection of polymyxin resistance in Enterobacteriaceae. Emerg Infect Dis. 2016;22(6):1038–1043.27191712
  • Cannatelli A, Giani T, D’Andrea MM, et al. MgrB inactivation is a common mechanism of colistin resistance in KPC-producing Klebsiella pneumoniae of clinical origin. Antimicrob Agents Chemother. 2014;58(10):5696–5703.25022583
  • Zhang R, Liu L, Zhou H, et al. Nationwide surveillance of clinical carbapenem-resistant Enterobacteriaceae (CRE) strains in China. EBioMedicine. 2017;19:98–106.28479289
  • Shen Z, Hu Y, Sun Q, et al. Emerging carriage of NDM-5 and MCR-1 in Escherichia coli from healthy people in multiple regions in China: a cross sectional observational study. EClinicalMedicine. 2018;6:11–20.31193653
  • Le L, Tran LK, Le-ha TD, et al. Coexistence of plasmid-mediated mcr-1 and blaNDM-4 genes in a clinical strain in a Klebsiella pneumoniae clinical strain in Vietnam. Infect Drug Resist. 2019;12:3703–3707.31819552
  • Park JY, Heo ST, Kwon KT, Song DY, Lee KJ, Choi JA. MCR1 and KPC2 co-producing Klebsiella pneumoniae bacteremia: first case in Korea. Infect Chemother. 2019;51(4):399–404.31668026
  • Nukui Y, Ayibieke A, Taniguchik M, et al. Whole-genome analysis of EC129, an NDM-5-, CTX-M-14-, OXA-10- and MCR-1-co-producing Escherichia coli ST167 strain isolated from Japan. J Glob Antimicrob Resist. 2019;18:148–150.31295582
  • Wang Q, Wang X, Wang J, et al. Phenotypic and genotypic characterization of carbapenem-resistant Enterobacteriaceae: data from a longitudinal large-scale CRE study in China (2012–2016). Clin Infect Dis. 2018;67(Suppl 2):S196–S205.30423057
  • Huang H, Dong N, Shu L, et al. Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014–2019. Emerg Microbes Infect. 2020;9(1):237–245.31996107
  • Xu L, Wang P, Cheng J, Qin S, Xie W. Characterization of a novel blaNDM-5-harboring IncFII plasmid and an mcr-1-bearing IncI2 plasmid in a single Escherichia coli ST167 clinical isolate. Infect Drug Resist. 2019;12:511–519.30881056
  • Fu P, Tang Y, Li G, et al. Pandemic spread of blaKPC-2 among Klebsiella pneumoniae ST11 in China is associated with horizontal transfer mediated by IncFII-like plasmids. Int J Antimicrob Agents. 2019;54:117–124.30885806
  • Shamina OV, Kryzhanovskaya OA, Lazareva AV, et al. The comparison of methods for determination of colistin susceptibility in carbapenem-resistant Klebsiella pneumoniae. Klin Lab Diagn. 2018;63(10):646–650.30768888
  • Chew KL, La MV, Lin RTP, et al. Colistin and Polymyxin B Susceptibility testing for carbapenem-resistant and mcr-Positive Enterobacteriaceae: comparison of Sensititre, MicroScan, Vitek 2, and Etest with Broth microdilution. J Clin Microbiol. 2017;55(9):2609–2616.28592552
  • Wang Y, Berglund B, Zhu Y, et al. Performance of different methods for testing polymyxin B: comparison of broth microdilution, agar dilution and MIC test strip in mcr-1 positive and negative Escherichia coli. Lett Appl Microbiol. 2021.