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Review

Risk Factors for Poor Outcomes Among Patients with Extensively Drug-Resistant Tuberculosis (XDR-TB): A Scoping Review

, , , &
Pages 5429-5448 | Published online: 16 Dec 2021

References

  • World Health Organization. Global tuberculosis report 2019. Geneva: World Health Organization; 2019. Available from: https://apps.who.int/iris/bitstream/handle/10665/329368/9789241565714-eng.pdf?ua=1. Accessed September 8, 2021.
  • World Health Organization. Tuberculosis. Newsroom. World Health Organization; 2021a. Available from: https://www.who.int/news-room/fact-sheets/detail/tuberculosis. Accessed October 13, 2021.
  • Centers for Disease Control. Highlights from the 2016 treatment of drug-susceptible tuberculosis guidelines; 2016. Available from: https://www.cdc.gov/tb/topic/treatment/guidelinehighlights.htm#:~:text=The%20preferred%20regimen%20for%20treating,months%20of%20INH%20and%20RIF. Accessed April 18, 2021.
  • MacNeil A, Glaziou P, Sismanidis C, Maloney S, Floyd K. Global epidemiology of tuberculosis and progress toward achieving global targets—2017. MMWR Morb Mortal Wkly Rep. 2019;68(11):263. doi:10.15585/mmwr.mm6811a330897077
  • World Health Organization. WHO announces updated definitions of extensively drug-resistant tuberculosis; 2021b. Available from: https://www.who.int/news/item/27-01-2021-who-announces-updated-definitions-of-extensively-drug-resistant-tuberculosis. Accessed September 8, 2021.
  • World Health Organization. Update of the WHO guidance on the treatment of drug susceptible tuberculosis; 2021c. Available from: https://www.who.int/news/item/16-04-2021-update-of-the-who-guidance-on-the-treatment-of-drug-susceptible-tuberculosis. Accessed November 1, 2021.
  • Centers for Disease Control and Prevention. Highlights from the 2016 treatment of drug-susceptible tuberculosis guidelines. Available from: https://www.cdc.gov/tb/topic/treatment/guidelinehighlights.htm. Accessed November 1, 2021.
  • Manjelievskaia J, Erck D, Piracha S, Schrager L. Drug-resistant TB: deadly, costly and in need of a vaccine. Trans R Soc Trop Med Hyg. 2016;110(3):186–191. doi:10.1093/trstmh/trw00626884499
  • Johnston JC, Shahidi NC, Sadatsafavi M, Fitzgerald JM. Treatment outcomes of multidrug-resistant tuberculosis: a systematic review and meta-analysis. PLoS One. 2009;4(9):e6914. doi:10.1371/journal.pone.000691419742330
  • Yang TW, Park HO, Jang HN, et al. Side effects associated with the treatment of multidrug-resistant tuberculosis at a tuberculosis referral hospital in South Korea: a retrospective study. Medicine. 2017;96(28). doi:10.1097/MD.0000000000007482
  • Migliori GB, De Iaco G, Besozzi G, Centis R, Cirillo DM. First tuberculosis cases in Italy resistant to all tested drugs. Weekly Release. 2007;12(20):3194. doi:10.2807/esw.12.20.03194-en
  • Velayati AA, Masjedi MR, Farnia P, et al. Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in Iran. Chest. 2009;136(2):420–425. doi:10.1378/chest.08-242719349380
  • Udwadia ZF, Amale RA, Ajbani KK, Rodrigues C. Totally drug-resistant tuberculosis in India. Clin Infect Dis. 2012b;54(4):579–581. doi:10.1093/cid/cir88922190562
  • Klopper M, Warren RM, Hayes C, et al. Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa. Emerg Infect Dis. 2013;19(3):449. doi:10.3201/eid1903.12024623622714
  • Flor de Lima B, Tavares M. Risk factors for extensively drug‐resistant tuberculosis: a review. Clin Respir J. 2014;8(1):11–23. doi:10.1111/crj.1204423875862
  • Cohen T, Colijn C, Wright A, Zignol M, Pym A, Murray M. Challenges in estimating the total burden of drug-resistant tuberculosis. Am J Respir Crit Care Med. 2008;177(12):1302–1306. doi:10.1164/rccm.200801-175PP18369201
  • Kompala T, Shenoi SV, Friedland G. Transmission of tuberculosis in resource-limited settings. Curr HIV/AIDS Rep. 2013;10(3):264–272. doi:10.1007/s11904-013-0164-x23824469
  • Luepke KH, Suda KJ, Boucher H, et al. Past, present, and future of antibacterial economics: increasing bacterial resistance, limited antibiotic pipeline, and societal implications. Pharmacotherapy. 2017;37(1):71–84. doi:10.1002/phar.186827859453
  • Sprigg K, Pietrangeli CE. Bacterial antibiotic resistance: on the Cusp of a post-antibiotic world. Curr Treat Options Infect Dis. 2019;11:42–57. doi:10.1007/s40506-019-0181-4
  • Dheda K, Gumbo T, Gandhi NR, et al. Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis. Lancet Respir Med. 2014;2(4):321–338. doi:10.1016/S2213-2600(14)70031-124717628
  • Gandhi NR, Nunn P, Dheda K, et al. Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis. Lancet. 2010a;375(9728):1830–1843. doi:10.1016/S0140-6736(10)60410-220488523
  • World Health Organization. Multidrug- and extensively drug-resistant TB (M/XDR-TB); 2021d. Available from: https://www.euro.who.int/en/health-topics/communicable-diseases/tuberculosis/data-and-statistics/multidrug-and-extensively-drug-resistant-tb-mxdr-tb. Accessed November 2, 2021.
  • Sotgiu G, Ferrara G, Matteelli A, et al. Epidemiology and clinical management of XDR-TB: a systematic review by TBNET. Eur Respir J. 2009;33(4):871–881. doi:10.1183/09031936.0016800819251779
  • Alemu A, Bitew ZW, Worku T, Gamtesa DF, Alebel A, Sabol I. Predictors of mortality in patients with drug-resistant tuberculosis: a systematic review and meta-analysis. PLoS One. 2021;16(6):e0253848. doi:10.1371/journal.pone.025384834181701
  • Tricco AC, Lillie E, Zarin W, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–473. doi:10.7326/M18-085030178033
  • Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews BMJ. 2021;372:n71. doi:10.1136/bmj.n7133782057
  • Cox H, Hughes J, Black J, Nicol MP. Precision medicine for drug-resistant tuberculosis in high-burden countries: is individualised treatment desirable and feasible? Lancet Infect Dis. 2018;18(9):e282–e287. doi:10.1016/S1473-3099(18)30104-X29548923
  • Jibrin YB, Ali AB, Saad ST, Kolo PM. Prevalence of treatment failure among pulmonary tuberculosis patients in federal medical centre, Gombe, Northeastern Nigeria. ISRN Infect Dis. 2013;2013:1–4. doi:10.5402/2013/461704
  • Ankrah AO, van der Werf TS, de Vries EF, Dierckx RA, Sathekge MM, Glaudemans AW. PET/CT imaging of Mycobacterium tuberculosis infection. Clin Transl Imaging. 2016;4(2):131–144. doi:10.1007/s40336-016-0164-027077068
  • Koul AN. MDRTB Then, XMDRTB Now and Then……… Totally. JMS. 2016;19(1):12–17. doi:10.33883/jms.v19i1.275
  • Tabarsi P, Mardani M. Extensively drug-resistant tuberculosis: a review article. Arch Clin Infect Dis. 2012;7(3):81–84. doi:10.5812/archcid.14773
  • Keshavjee S, Farmer PE. Tuberculosis, drug resistance, and the history of modern medicine. N Engl J Med. 2012;367(10):931–936. doi:10.1056/NEJMra120542922931261
  • Abilleira F, Brum C, von Groll A, da Silva PE. Evaluation of direct microplate nitrate reductase assay as a rapid method for the detection of multiple and extensively tuberculosis drug resistance. Biomédica. 2015;35(2):285–291. doi:10.1590/S0120-4157201500020001726535551
  • Kumwenda G, Chipungu G, Sloan D, Kaimila Y, Chiumya K, Pangani H. The occurrence and frequency of genomic mutations that mediate Isoniazid and Rifampicin resistance in Mycobacterium tuberculosis isolates from untreated pulmonary Tuberculosis cases in urban Blantyre, Malawi. Malawi Med J. 2018;30(1):1–5. doi:10.4314/mmj.v30i1.129868151
  • Dara M, Sotgiu G, Zaleskis R, Migliori GB. Untreatable tuberculosis: is surgery the answer? Eur Respir J. 2015;45(3):577–582. doi:10.1183/09031936.0022951425726530
  • Banin E, Hughes D, Kuipers OP. Bacterial pathogens, antibiotics and antibiotic resistance. FEMS Microbiol Rev. 2017;41(3):450–452. doi:10.1093/femsre/fux01628486583
  • Duffy ST. The power of detention in the management of non-compliance with tuberculosis treatment: a survey of Irish practitioners and analysis of potential legal liability. Public Health. 2009;123(1):81–85. doi:10.1016/j.puhe.2008.09.00119091360
  • Migliori GB, Centis R, D’Ambrosio L, et al. Totally drug-resistant and extremely drug-resistant tuberculosis: the same disease? Clin Infect Dis. 2012;54(9):1379–1380. doi:10.1093/cid/cis12822492321
  • Amaral L, Molnar J. Potential therapy of multidrug-resistant and extremely drug-resistant tuberculosis with thioridazine. In Vivo. 2012;26(2):231–236.22351663
  • Therese KL, Gayathri R, Madhavan HN. Molecular biological techniques for detection of multidrug resistant tuberculosis (MDR) and extremely drug resistant tuberculosis (XDR) in clinical isolates of Mycobacterium tuberculosis. In: Understanding Tuberculosis—global Experiences and Innovative Approaches to the Diagnosis. Rijeka, Croatia: InTech; 2012:455–470.
  • Dheda K, Limberis JD, Pietersen E, et al. Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study. Lancet Respir Med. 2017b;5(4):269–281. doi:10.1016/S2213-2600(16)30433-728109869
  • Nathavitharana RR, Lederer P, Tierney DB, Nardell E. Treatment as prevention and other interventions to reduce transmission of multidrug-resistant tuberculosis. Int J Tuberc Lung Dis. 2019;23(4):396–404. doi:10.5588/ijtld.18.027631064617
  • Farnia P, Mohammad RM, Merza MA, et al. Growth and cell-division in extensive (XDR) and extremely drug resistant (XXDR) tuberculosis strains: transmission and atomic force observation. Int J Clin Exp Med. 2010;3(4):308.21072265
  • Joanna Briggs Institute. Critical appraisal tools; n.d. Available from: https://jbi.global/critical-appraisal-tools. Accessed November 2, 2021.
  • Bowring AL, Veronese V, Doyle JS, Stoove M, Hellard M. HIV and sexual risk among men who have sex with men and women in Asia: a systematic review and meta-analysis. AIDS Behav. 2016;20(10):2243–2265. doi:10.1007/s10461-015-1281-x26781871
  • Xu Y, Chen X, Wang K. Global prevalence of hypertension among people living with HIV: a systematic review and meta-analysis. J Am Soc Hypertens. 2017;11(8):530–540. doi:10.1016/j.jash.2017.06.00428689734
  • Adalbert JR, Varshney K, Tobin R, Pajaro R. Clinical outcomes in patients co-infected with COVID-19 and Staphylococcus aureus: a scoping review. BMC Infect Dis. 2021;21(1):1–17. doi:10.1186/s12879-021-06616-433390160
  • Balabanova Y, Ignatyeva O, Fiebig L, et al. Survival of patients with multidrug-resistant TB in Eastern Europe: what makes a difference? Thorax. 2016;71(9):854–861. doi:10.1136/thoraxjnl-2015-20763827012887
  • Balabanova Y, Nikolayevskyy V, Ignatyeva O, et al. Survival of civilian and prisoner drug-sensitive, multi- and extensive drug- resistant tuberculosis cohorts prospectively followed in Russia. PLoS One. 2011;6(6):e20531. doi:10.1371/journal.pone.002053121695213
  • Bei C, Fu M, Zhang Y, et al. Mortality and associated factors of patients with extensive drug-resistant tuberculosis: an emerging public health crisis in China. BMC Infect Dis. 2018;18(1):261. doi:10.1186/s12879-018-3169-729879908
  • Bhering M, Duarte R, Kritski A. Predictive factors for unfavourable treatment in MDR-TB and XDR-TB patients in Rio de Janeiro State, Brazil, 2000–2016. PLoS One. 2019;14(11):e0218299. doi:10.1371/journal.pone.021829931747405
  • Blöndal K, Viiklepp P, Guomundsson LJ, Altraj A. Predictors of recurrence of multidrug-resistant and extensively drug-resistant tuberculosis. Int J Tuberc Lung Dis. 2012;16(9):1228–1233. doi:10.5588/ijtld.12.003722748131
  • Chingonzoh R, Manesen MR, Madlavu MJ, et al. Risk factors for mortality among adults registered on the routine drug resistant tuberculosis reporting database in the Eastern Cape Province, South Africa, 2011 to 2013. PLoS One. 2018;13(8):e0202469. doi:10.1371/journal.pone.020246930133504
  • Frank M, Adamashvili N, Lomtadze N, et al. Long-term follow-up reveals high post-treatment mortality among patients with extensively drug-resistant (XDR) tuberculosis in the country of Georgia. Open Forum Infect Dis. 2019;6. doi:10.1093/ofid/ofz152
  • Gandhi NR, Andrews JR, Brust JC, et al. Risk factors for mortality among MDR-and XDR-TB patients in a high HIV prevalence setting. Int J Tuberc Lung Dis. 2012;16(1):90–97. doi:10.5588/ijtld.11.015322236852
  • Gandhi NR, Shah NS, Andrews JR, et al. HIV coinfection in multidrug- and extensively drug-resistant tuberculosis results in high early mortality. Am J Respir Crit Care Med. 2010b;181(1):80–86. doi:10.1164/rccm.200907-0989OC19833824
  • James P, Gupta R, Christopher DJ, Thankagunam B, Veeraraghavan B. MDR-and XDR-TB among suspected drug‐resistant TB patients in a tertiary care hospital in India. Clin Respir J. 2011;5(1):19–25. doi:10.1111/j.1752-699X.2009.00184.x21159137
  • Javaid A, Ullah I, Masud H, et al. Predictors of poor treatment outcomes in multidrug-resistant tuberculosis patients: a retrospective cohort study. Clin Microbiol Infect. 2018;24(6):612–617. doi:10.1016/j.cmi.2017.09.01228970158
  • Kuksa L, Riekstina V, Leimane V, et al. Multi-and extensively drug-resistant tuberculosis in Latvia: trends, characteristics and treatment outcomes. Public Health Action. 2014;4(2):S47–S53. doi:10.5588/pha.14.004126393098
  • Kvasnovsky CL, Cegielski JP, Erasmus R, Siwisa NO, Thomas K, der Walt ML. Extensively drug-resistant TB in Eastern Cape, South Africa: high mortality in HIV-negative and HIV-positive patients. J Acquir Immune Defic Syndr. 2011;57(2):146–152. doi:10.1097/QAI.0b013e31821190a321297482
  • Liu CH, Li L, Chen Z, et al. Characteristics and treatment outcomes of patients with MDR and XDR tuberculosis in a TB referral hospital in Beijing: a 13-year experience. PLoS One. 2011;6(4):e19399. doi:10.1371/journal.pone.001939921559362
  • O’Donnell MR, Padayatchi N, Kvasnovsky C, Werner L, Master I, Horsburgh CR Jr. Treatment outcomes for extensively drug-resistant tuberculosis and HIV co-infection. Emerg Infect Dis. 2013;19(3):416–424. doi:10.3201/eid1903.12099823622055
  • O’Donnell MR, Pillay M, Pillay M, et al. Primary capreomycin resistance is common and associated with early mortality in patients with extensively drug-resistant tuberculosis in KwaZulu-natal, South Africa. J Acquir Immune Defic Syndr. 2015;69(5):536–543. doi:10.1097/QAI.000000000000065025886924
  • Olayanju O, Limberis J, Esmail A, et al. Long-term bedaquiline-related treatment outcomes in patients with extensively drug-resistant tuberculosis from South Africa. Eur Respir J. 2018;51(5):1800544. doi:10.1183/13993003.00544-201829700106
  • Pietersen E, Ignatius E, Streicher EM, et al. Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study. Lancet. 2014;383(9924):1230–1239. doi:10.1016/S0140-6736(13)62675-624439237
  • Pietersen E, Peter J, Streicher E, et al. High frequency of resistance, lack of clinical benefit, and poor outcomes in capreomycin treated South African patients with extensively drug-resistant tuberculosis. PLoS One. 2015;10(4):e0123655. doi:10.1371/journal.pone.012365525909847
  • Shean K, Streicher E, Pieterson E, et al. Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa. PLoS One. 2013;8(5):e63057. doi:10.1371/journal.pone.006305723667572
  • Shin SS, Keshavjee S, Gelmanova IY, et al. Development of extensively drug-resistant tuberculosis during multidrug-resistant tuberculosis treatment. Am J Respir Crit Care Med. 2010;182(3):426–432. doi:10.1164/rccm.200911-1768OC20413630
  • Tang S, Tan S, Yao L, et al. Risk factors for poor treatment outcomes in patients with MDR-TB and XDR-TB in China: retrospective multi-center investigation. PLoS One. 2013;8(12):e82943. doi:10.1371/journal.pone.008294324349402
  • Te Riele JB, Buser V, Calligaro G, et al. Relationship between chest radiographic characteristics, sputum bacterial load, and treatment outcomes in patients with extensively drug-resistant tuberculosis. Int J Infect Dis. 2019;79:65–71. doi:10.1016/j.ijid.2018.10.02630395979
  • Yuengling KA, Padayatchi N, Wolf A, et al. Effect of antiretroviral therapy on treatment outcomes in a prospective study of extensively drug-resistant tuberculosis (XDR-TB) HIV coinfection treatment in KwaZulu-Natal, South Africa. J Acquir Immune Defic Syndr. 2018;79(4):474–480. doi:10.1097/QAI.000000000000183330212394
  • Zhang L, Meng Q, Chen S, et al. Treatment outcomes of multidrug-resistant tuberculosis patients in Zhejiang, China, 2009–2013. Clin Microbiol Infect. 2018;24(4):381–388. doi:10.1016/j.cmi.2017.07.00828712668
  • Syakiratin Q, Wibowo A, Febriani E. Psychological challenges faced by multidrug-resistant tuberculosis patients: a systematic review. Berita Kedokteran Masyarakat. 2019;35(5):155–161.
  • Madhav B, Iyer A, Jayalakshmi TK. Side effect profile of 2nd line drugs in multi drug resistant (MDR) and extensively drug resistant (XDR) tuberculosis. Eur Respir J. 2015;46:PA2708. doi:10.1183/13993003.congress-2015.PA2708
  • Tola HH, Tol A, Shojaeizadeh D, Garmaroudi G. Tuberculosis treatment non-adherence and lost to follow up among TB patients with or without HIV in developing countries: a systematic review. Iran J Public Health. 2015;44(1):1–11.26060770
  • Widjanarko B, Gompelman M, Dijkers M, van der Werf MJ. Factors that influence treatment adherence of tuberculosis patients living in Java, Indonesia. Patient Prefer Adherence. 2009;3:231–238. doi:10.2147/ppa.s602019936166
  • Gebremariam MK, Bjune GA, Frich JC. Barriers and facilitators of adherence to TB treatment in patients on concomitant TB and HIV treatment: a qualitative study. BMC Public Health. 2010;10(1):651. doi:10.1186/1471-2458-10-65121029405
  • Chimbindi N, Bor J, Newell ML, et al. Time and money: the true costs of health care utilization for patients receiving ”Free” HIV/tuberculosis care and treatment in rural KwaZulu-Natal. J Acquir Immune Defic Syndr. 2015;70(2):e52–e60. doi:10.1097/QAI.000000000000072826371611
  • Central Intelligence Agency (CIA). HIV/AIDS – people living with HIV/AIDS. CIAWorld Factbook; 2020. Available from: https://www.cia.gov/the-world-factbook/field/hiv-aids-people-living-with-hiv-aids/country-comparison. Accessed December 7, 2021.
  • World Health Organization. Drug-resistant TB: totally drug-resistant TB FAQ. Areas of work: World Health Organization; 2020. Available from: https://www.who.int/tb/areas-of-work/drug-resistant-tb/totally-drug-resistant-tb-faq/en/. Accessed April 22, 2020.
  • World Health Organization. Drug-resistant TB: XDR-TB FAQ. World Health Organization; 2020. Available from: https://www.who.int/tb/areas-of-work/drug-resistant-tb/xdr-tb-faq/en/. Accessed June 3, 2020.
  • de Almeida CPB, Ziegelmann PK, Couban R, Wang L, Busse JW, Silva DR. Predictors of in-hospital mortality among patients with pulmonary tuberculosis: a systematic review and meta-analysis. Sci Rep. 2018;8(1):1–8. doi:10.1038/s41598-018-25409-529311619
  • Waitt CJ, Squire SB. A systematic review of risk factors for death in adults during and after tuberculosis treatment. Int J Tuberc Lung Dis. 2010;15:871–885. doi:10.5588/ijtld.10.0352
  • World Health Organization. Addressing TB comorbidities and health-related risk factors; 2021e. Available from: https://www.who.int/activities/addressing-tb-comorbidities-and-health-related-risk-factors. Accessed November 2, 2021.
  • Stockbridge EL, Kabani FA, Gallups JS, Miller TL. Ramadan and culturally competent care: strengthening tuberculosis protections for recently resettled Muslim refugees. J Public Health Manag Pract. 2020;26(5):E13–E16. doi:10.1097/PHH.000000000000089332732732
  • Hoke T, Bateganya M, Toyo O, et al. How home delivery of antiretroviral drugs ensured uninterrupted HIV treatment during COVID-19: experiences from Indonesia, Laos, Nepal, and Nigeria. Global Health: Science and Practice; 2021.
  • Mash R, Christian C, Chigwanda RV. Alternative mechanisms for delivery of medication in South Africa: a scoping review. S Afr Fam Pract. 2021;63(1). doi:10.4102/safp.v63i1.5274
  • Pasha A, Siddiqui H, Ali S, Brooks MB, Maqbool NR, Khan AJ. Impact of integrating mental health services within existing tuberculosis treatment facilities. Med Access Point Care. 2021;5:23992026211011314. doi:10.1177/23992026211011314
  • World Health Organization. Tuberculosis patient cost surveys: a handbook. Geneva: World Health Organization; 2017. Available from: https://apps.who.int/iris/handle/10665/259701. Accessed November 2, 2021.
  • Gurung SC, Dixit K, Rai B, et al. The role of active case finding in reducing patient incurred catastrophic costs for tuberculosis in Nepal. Infect Dis Poverty. 2019;8:99. doi:10.1186/s40249-019-0603-z31791412
  • World Health Organization. Mozambique – a comprehensive community-based delivery intervention for TB. Available from: https://apps.who.int/iris/bitstream/handle/10665/337105/9789240013575-eng.pdf. Accessed November 2, 2021.
  • Vo LNQ, Forse RJ, Codlin AJ, et al. Socio-protective effects of active case finding on catastrophic costs from tuberculosis in Ho Chi Minh City, Viet Nam: a longitudinal patient cost survey. BMC Health Serv Res. 2021;21(1):1–11. doi:10.1186/s12913-021-06984-233388053
  • Boccia D, Hargreaves J, Lönnroth K, et al. Cash transfer and microfinance interventions for tuberculosis control: review of the impact evidence and policy implications. Int J Tuberc Lung Dis. 2011;15(Suppl2):37–49. doi:10.5588/ijtld.10.043821740658