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Infection and Drug Resistance Volume 15, 2022 - Issue
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ORIGINAL RESEARCH

Metagenomic Next-Generation Sequencing for the Diagnosis of Suspected Opportunistic Infections in People Living with HIV

Jingying XuDepartment of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310023, People’s Republic of ChinaView further author information
,
Qian HuangDepartment of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310023, People’s Republic of ChinaView further author information
,
Jianhua YuDepartment of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310023, People’s Republic of ChinaView further author information
,
Shourong LiuDepartment of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310023, People’s Republic of ChinaView further author information
,
Zongxing YangDepartment of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310023, People’s Republic of ChinaView further author information
,
Fei WangDepartment of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310023, People’s Republic of ChinaView further author information
,
Yue ShiDepartment of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310023, People’s Republic of ChinaView further author information
,
Er LiDepartment of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310023, People’s Republic of ChinaView further author information
,
Zhaoyi LiDepartment of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310023, People’s Republic of ChinaView further author information
&
Yunlei XiaoDepartment of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310023, People’s Republic of ChinaCorrespondence[email protected] [email protected]
View further author information
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Pages 1767-1775 | Published online: 11 Apr 2022

References

  • UNAIDS. Homepage. Available from: http://unaids.org/en. Accessed March 28, 2022.
  • Lefterova MI, Suarez CJ, Banaei N, et al. Next-Generation Sequencing for Infectious Disease Diagnosis and Management. J Mol Diagnostics. 2015;17(6):623–634.
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  • Thakur KT. Application of Pathogen Discovery/Metagenomic Sequencing in CNS HIV. Curr HIV/AIDS Rep. 2020;17(5):507–513.
  • Fang M, Weng X, Chen L, et al. Fulminant central nervous system varicella-zoster virus infection unexpectedly diagnosed by metagenomic next-generation sequencing in an HIV-infected patient: a case report. BMC Infect Dis. 2020;20(1):159.
  • Goldberg B, Sichtig H, Geyer C, et al. Making the Leap from Research Laboratory to Clinic: challenges and Opportunities for Next-Generation Sequencing in Infectious Disease Diagnostics. mBio. 2015;6(6):e01888–01815.
  • Jiang J, Bai L, Yang W, et al. Metagenomic Next-Generation Sequencing for the Diagnosis of Pneumocystis jirovecii Pneumonia in Non-HIV-Infected Patients: a Retrospective Study. Infect Dis Therapy. 2021;10(3):1733–1745.
  • Xing XW, Zhang JT, Ma YB, et al. Apparent performance of metagenomic next-generation sequencing in the diagnosis of cryptococcal meningitis: a descriptive study. J Medicalmicrobiol. 2019;68(8):1204–1210.
  • Tan IL, Smith BR, von Geldern G, et al. HIV-associated opportunistic infections of the CNS. Lancet Neurol. 2012;11(7):605–617.
  • Yang R, Zhang H, Xiong Y, et al. Molecular diagnosis of central nervous system opportunistic infections and mortality in HIV-infected adults in Central China. AIDS Res Ther. 2017;14:24.

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