Five-Year Survey of Asymptomatic Colonization with Multidrug-Resistant Organisms in a Romanian Tertiary Care Hospital

References

• UN Ad hoc Interagency Coordinating Group on Antimicrobial Resistance. New report calls for urgent action to avert antimicrobial resistance crisis. Available from: https://www.who.int/news/item/29-04-2019-new-report-calls-for-urgent-action-to-avert-antimicrobial-resistance-crisis. Accessed March 22, 2022.
   Google Scholar
• Rice LB. Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. J Infect Dis. 2008;197:1079–1081. doi:10.1086/533452
   PubMed Web of Science ®Google Scholar
• World Health Organization. WHO priority pathogens list for R&D of new antibiotics. Available from: https://www.who.int/news/item/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed. Accessed March 22, 2022.
   Google Scholar
• Cassini A, Högberg LD, Plachouras D, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis. 2019;19:56–66. doi:10.1016/S1473-3099(18)30605-4
   PubMed Web of Science ®Google Scholar
• Arbune M, Gurau G, Niculet E, et al. Prevalence of antibiotic resistance of ESKAPE pathogens over five years in an infectious diseases hospital from south-east of Romania. Infect Drug Resist. 2021;14:2369–2378. doi:10.2147/IDR.S312231
   Web of Science ®Google Scholar
• Orosz L, Lengyel G, Ánosi N, et al. Changes in resistance pattern of ESKAPE pathogens between 2010 and 2020 in the clinical center of University of Szeged, Hungary. Acta Microbiol Immunol Hung. 2022;69(1):27–34. doi:10.1556/030.2022.01640
   Web of Science ®Google Scholar
• Mutters NT, Tacconelli E. Infection prevention and control in Europe – the picture in the mosaic. Clin Microbiol Infect. 2015;21:1045–1046. doi:10.1016/j.cmi.2015.06.012
   Web of Science ®Google Scholar
• Tacconelli E, Cataldo MA, Dancer SJ, et al. ESCMID guidelines for the management of the infection control measures to reduce transmission of multidrug-resistant Gram-negative bacteria in hospitalized patients. Clin Microbiol Infect. 2014;20(Suppl. 1):1–55. doi:10.1111/1469-0691.12427
   PubMed Web of Science ®Google Scholar
• Centers of Disease Control and Prevention. Management of multidrug-resistant organisms in healthcare settings; 2017:1–74. Available from: https://www.cdc.gov/infectioncontrol/guidelines/mdro/. Accessed August 31, 2021.
   Google Scholar
• Magiorakos AP, Burns K, Rodríguez Baño J, et al. Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: guidance from the European Centre for Disease Prevention and Control. Antimicrob Resist Infect Control. 2017;6:113.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa in health care facilities. World Health Organization; 2017. Available from: https://apps.who.int/iris/handle/10665/259462. Accessed August 31, 2021.
   Google Scholar
• European Centre for Disease Prevention and Control. Carbapenem-resistant Enterobacteriaceae. Stockholm: ECDC; 2019:1–17.
   Google Scholar
• Biehl LM, Bertz H, Bogner J, et al. Screening and contact precautions – a survey on infection control measures for multidrug-resistant bacteria in German university hospitals. Antimicrob Resist Infect Control. 2017;6:37. doi:10.1186/s13756-017-0191-2
   Web of Science ®Google Scholar
• Surleac M, Czobor Barbu IC, Paraschiv S, et al. Whole genome sequencing snapshot of multidrug resistant Klebsiella pneumoniae strains from hospitals and receiving wastewater treatment plants in Southern Romania. PLoS One. 2020;15(1):e0228079. doi:10.1371/journal.pone.0228079
   Web of Science ®Google Scholar
• Gheorghe I, Czobor Barbu I, Surleac M, et al. Subtypes, resistance and virulence platforms in extended-drug resistant Acinetobacter baumannii Romanian isolates. Springer Nature. 2021;11:13288. doi:10.1038/s41598-021-92590-5
   Web of Science ®Google Scholar
• Székely E, Damjanova I, Jánvári L, et al. First description of blaNDM-1, blaOXA-48, blaOXA-181 producing Enterobacteriaceae strains in Romania. Int J Med Microbiol. 2013;303(8):697–700. doi:10.1016/j.ijmm.2013.10.001
   Web of Science ®Google Scholar
• Lixandru EL, Cotar AI, Straut M, et al. Carbapenemase-producing Klebsiella pneumoniae in Romania: a six-month survey. PLoS One. 2015;10(11):e0143214. doi:10.1371/journal.pone.0143214
   Web of Science ®Google Scholar
• Rafila A, Talapan D, Dorobăț OM, et al. Emergence of carbapenemase-producing Enterobacteriaceae, a public health threat: a Romanian infectious disease hospital based study. Rev Romana Med Lab. 2015;23(3):295–301.
   Web of Science ®Google Scholar
• Popa LI, Gheorghe I, Barbu IC, et al. Multidrug resistant Klebsiella pneumoniae ST101 clone survival chain from inpatients to hospital effluent after chlorine treatment. Front Microbiol. 2021;11:610296. doi:10.3389/fmicb.2020.610296
   Web of Science ®Google Scholar
• Lupșe M, Flonta M, Herbel L, et al. Is carriage of multidrug-resistant organisms a risk factor for nosocomial infections in an infectious diseases ICU? [abstract]. Critical Care. 2015;19(Suppl 1):S32 (P93). doi:10.1186/cc14173
   Google Scholar
• Timofte D, Panzaru CV, Maciuca IE, et al. Active surveillance scheme in three Romanian hospitals reveals a high prevalence and variety of carbapenemase-producing Gram-negative bacteria: a pilot study, December 2014 to May 2015. Euro Surveil. 2016;21(25):30262. doi:10.2807/1560-7917.ES.2016.21.25.30262
   Google Scholar
• Nedelcu NI, Iacob CP. Predictors for MDRO carriage in adult patients of a infectious diseases clinic from Bucharest, Romania. Int J Infect Dis. 2020;101(1):25–26. doi:10.1016/j.ijid.2020.09.103
   Web of Science ®Google Scholar
• Magiorakos AP, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18:268–281. doi:10.1111/j.1469-0691.2011.03570.x
   PubMed Web of Science ®Google Scholar
• The European Committee on Antimicrobial Susceptibility Testings. Breakpoint tables for interpretation of MICs and zone diameters. EUCAST, version 5.0-9.0, 2015-2019. Available from: https://www.eucast.org/ast_of_bacteria/previous_versions_of_documents/. Accessed September 9, 2021.
   Google Scholar
• The European Committee on Antimicrobial Susceptibility Testing. EUCAST guidelines for detection of resistance mechanisms and specific resistance of clinical and/or epidemiological importance. EUCAST, version 2.0; 2017. Available from: https://www.eucast.org/resistance_mechanisms/. Accessed September 9, 2021.
   Google Scholar
• Matuschek E, Brown DFJ, Kahlmeter G. Development of the EUCAST disk diffusion antimicrobial susceptibility testing method and its implementation in routine microbiology laboratories. Clin Microbiol Infect. 2014;20:255–266. doi:10.1111/1469-0691.12373
   PubMed Web of Science ®Google Scholar
• van Hout D, Bruijning-Verhagen P, Blok H, Troelstra A, Bonten M. Universal risk assessment upon hospital admission for screening of carriage with multidrug-resistant microorganisms (MDRO) in a Dutch tertiary care centre (2016–2019). J Hosp Infect. 2021;109:32–39. doi:10.1016/j.jhin.2020.12.007
   Web of Science ®Google Scholar
• Monecke S, Müller E, Dorneanu OS, Vremera T, Ehricht R. Molecular typing of MRSA and of clinical Staphylococcus aureus isolates from Iași, Romania. PLoS One. 2014;9(5):e97833. doi:10.1371/journal.pone.0097833
   Web of Science ®Google Scholar
• Hidron AI, Kourbatova EV, Halvosa JS, et al. Risk factors for colonization with methicillin-resistant Staphylococcus aureus (MRSA) in patients admitted to an urban hospital: emergence of community-associated MRSA nasal carriage. Clin Infect Dis. 2005;41:159–166. doi:10.1086/430910
   PubMed Web of Science ®Google Scholar
• Cunha BA, Schoch P, Abruzzo ED. Clinical- and cost-ineffectiveness of targeted methicillin-resistant Staphylococcus aureus screening of high-risk patients admitted to a low-prevalence teaching hospital. Am J Infect Control. 2013;41:1136–1146. doi:10.1016/j.ajic.2013.03.297
   Web of Science ®Google Scholar
• Otter JA, Herdman MT, Williams B, Tosas O, Edgeworth JD, French GL. Low prevalence of methicillin-resistant Staphylococcus aureus carriage at hospital admission: implications for risk-factor-based vs universal screening. J Hosp Infect. 2013;83:114–121. doi:10.1016/j.jhin.2012.10.008
   Web of Science ®Google Scholar
• Weterings V, Veenemans J, van Rijen M, Kluytmans J. Prevalence of nasal carriage of methicillin-resistant Staphylococcus aureus in patients at hospital admission in The Netherlands, 2010–2017: an observational study. Clin Microbiol Infect. 2019;25:1428e1–1428e5. doi:10.1016/j.cmi.2019.03.012
   Web of Science ®Google Scholar
• Parascandalo FA, Zarb P, Tartari E, et al. Carriage of multidrug-resistant organisms in a tertiary university hospital in Albania – a point prevalence survey. Antimicrob Resist Infect Control. 2016;5:29. doi:10.1186/s13756-016-0128-1
   Web of Science ®Google Scholar
• Joachim A, Moyo SJ, Nkinda L, et al. Prevalence of methicillin-resistant Staphylococcus aureus carriage on admission among patients attending regional hospitals in Dar es Salaam, Tanzania. BMC Res Notes. 2017;10:417. doi:10.1186/s13104-017-2668-8
   Google Scholar
• Wilson HJ, Khokhar F, Enoch DA, et al. Point-prevalence survey of carbapenemase-producing Enterobacteriaceae and vancomycin-resistant enterococci in adult inpatients in a university teaching hospital in the UK. J Hosp Infect. 2018;100:35–39. doi:10.1016/j.jhin.2018.06.024
   Web of Science ®Google Scholar
• Chhatwal P, Ebadi E, Thol F, et al. Prospective infection surveillance and systematic screening for vancomycin-resistant enterococci in hematologic and oncologic patients – findings of a German tertiary care center. J Glob Antimicrob Resist. 2020;22:102–105. doi:10.1016/j.jgar.2020.02.012
   Web of Science ®Google Scholar
• Vidal-Navarro L, Pfeiffer C, Bouziges N, Sotto A, Lavigne JP. Faecal carriage of multidrug-resistant Gram-negative bacilli during a non-outbreak situation in a French university hospital. J Antimicrob Chemother. 2010;65:2455–2458. doi:10.1093/jac/dkq333
   Web of Science ®Google Scholar
• Platteel TN, Leverstein-van Hall MA, Cohen Stuart JW, et al. Predicting carriage with extended-spectrum beta-lactamase-producing bacteria at hospital admission: a cross-sectional study. Clin Microbiol Infect. 2015;21:141–146. doi:10.1016/j.cmi.2014.09.014
   Web of Science ®Google Scholar
• Isendahl J, Turlej-Rogacka A, Manjuba C, Rodrigues A, Giske CG, Nauclér P. Fecal carriage of ESBL-producing E. coli and K. pneumoniae in children in Guinea-Bissau: a hospital-based cross-sectional study. PLoS One. 2012;7(12):e51981. doi:10.1371/journal.pone.0051981
   Web of Science ®Google Scholar
• Girlich D, Bouihat N, Poirel L, Benouda A, Nordmann P. High rate of faecal carriage of extended-spectrum β-lactamase and OXA-48 carbapenemase-producing Enterobacteriaceae at a university hospital in Morocco. Clin Microbiol Infect. 2014;20:350–354. doi:10.1111/1469-0691.12325
   PubMed Web of Science ®Google Scholar
• Rodríguez-Molina D, Berglund F, Blaak H, et al. Carriage of ESBL-producing Enterobacterales in wastewater treatment plant workers and surrounding residents – the AWARE Study. Eur J Clin Microbiol Infect Dis. 2021:1–16. doi:10.1007/s10096-021-04387-z
   Web of Science ®Google Scholar
• López-González L, Viñuela-Prieto JM, Rodriguez-Avial I, Manzano R, Candel FJ. Description of carbapenemase-producing Enterobacteriaceae isolates in a Spanish tertiary hospital. Epidemiological analysis and clinical impact. Rev Esp Quimioter. 2019;32(3):254–262.
   Web of Science ®Google Scholar
• Dijkshoorn L, van Aken E, Shunburne L, et al. Prevalence of Acinetobacter baumannii and other Acinetobacter spp. in faecal samples from non-hospitalised individuals. Clin Microbiol Infect. 2005;11:329–332. doi:10.1111/j.1469-0691.2005.01093.x
   PubMed Web of Science ®Google Scholar
• Corbella X, Pujol M, Ayats J, et al. Relevance of digestive tract colonization in the epidemiology of nosocomial infections due to multiresistant Acinetobacter baumannii. Clin Infect Dis. 1996;23:329–334. doi:10.1093/clinids/23.2.329
   PubMed Web of Science ®Google Scholar