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CASE REPORT

Pneumonia Caused by Coinfection with Cytomegalovirus and Pneumocystis jirovecii in an HIV-Negative Infant Diagnosed by Metagenomic Next-Generation Sequencing

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Pages 3417-3425 | Published online: 30 Jun 2022

References

  • Sepkowitz KA. Opportunistic infections in patients with and patients without acquired immunodeficiency syndrome. Clin Infect Dis. 2002;34(8):1098–1107. doi:10.1086/339548
  • Restrepo-Gualteros SM, Gutierrez MJ, Villamil-Osorio M, Arroyo MA, Nino G. Challenges and clinical implications of the diagnosis of cytomegalovirus lung infection in children. Curr Infect Dis Rep. 2019;21(7):24. doi:10.1007/s11908-019-0681-x
  • Rojas P, Friaza V, García E, et al. Early acquisition of pneumocystis jirovecii colonization and potential association with respiratory distress syndrome in preterm newborn infants. Clin Infect Dis. 2017;65(6):976–981. doi:10.1093/cid/cix454
  • Coclite E, Di Natale C, Nigro G. Congenital and perinatal cytomegalovirus lung infection. J Matern Fetal Neonatal Med. 2013;26(17):1671–1675. doi:10.3109/14767058.2013.794207
  • Salzer HJF, Schäfer G, Hoenigl M, et al. Clinical, diagnostic, and treatment disparities between HIV-infected and non-HIV-infected immunocompromised patients with Pneumocystis jirovecii pneumonia. Respiration. 2018;96(1):52–65. doi:10.1159/000487713
  • Qian YY, Wang HY, Zhou Y, et al. Improving pulmonary infection diagnosis with metagenomic next generation sequencing. Front Cell Infect Microbiol. 2020;10:567615. doi:10.3389/fcimb.2020.567615
  • Grumaz S, Stevens P, Grumaz C, et al. Next-generation sequencing diagnostics of bacteremia in septic patients. Genome Med. 2016;8(1):73. doi:10.1186/s13073-016-0326-8
  • Hamprecht K, Maschmann J, Jahn G, Poets CF, Goelz R. Cytomegalovirus transmission to preterm infants during lactation. J Clin Virol. 2008;41(3):198–205. doi:10.1016/j.jcv.2007.12.005
  • Aviles R, Boyce TG, Thompson DM. Pneumocystis carinii pneumonia in a 3-month-old infant receiving high-dose corticosteroid therapy for airway hemangiomas. Mayo Clin Proc. 2004;79(2):243–245. doi:10.4065/79.2.243
  • Yu Q, Jia P, Su L, Zhao H, Que C. Outcomes and prognostic factors of non-HIV patients with pneumocystis jirovecii pneumonia and pulmonary CMV co-infection: a retrospective cohort study. BMC Infect Dis. 2017;17(1):392. doi:10.1186/s12879-017-2492-8
  • Cillóniz C, Dominedò C, Álvarez-Martínez MJ, et al. Pneumocystis pneumonia in the twenty-first century: HIV-infected versus HIV-uninfected patients. Expert Rev Anti Infect Ther. 2019;17(10):787–801. doi:10.1080/14787210.2019.1671823
  • Borstnar S, Lindic J, Tomazic J, et al. Pneumocystis jirovecii pneumonia in renal transplant recipients: a national center experience. Transplant Proc. 2013;45(4):1614–1617. doi:10.1016/j.transproceed.2013.02.107
  • Del Corpo O, Butler-Laporte G, Sheppard DC, Cheng MP, McDonald EG, Lee TC. Diagnostic accuracy of serum (1-3)-β-D-glucan for Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis. Clin Microbiol Infect. 2020;26(9):1137–1143. doi:10.1016/j.cmi.2020.05.024
  • Jiang J, Bai L, Yang W, et al. Metagenomic next-generation sequencing for the diagnosis of Pneumocystis jirovecii pneumonia in non-HIV-infected patients: a retrospective study. Infect Dis Ther. 2021;10(3):1733–1745. doi:10.1007/s40121-021-00482-y
  • Fillaux J, Berry A. Real-time PCR assay for the diagnosis of Pneumocystis jirovecii pneumonia. Methods Mol Biol. 2013;943:159–170. doi:10.1007/978-1-60327-353-4_11
  • Zhang F, Chen J, Huang H, et al. Application of metagenomic next-generation sequencing in the diagnosis and treatment guidance of Pneumocystis jirovecii pneumonia in renal transplant recipients. Eur J Clin Microbiol Infect Dis. 2021;40(9):1933–1942. doi:10.1007/s10096-021-04254-x
  • Yan G, Liu J, Chen W, et al. Metagenomic next-generation sequencing of bloodstream microbial cell-free nucleic acid in children with suspected sepsis in pediatric intensive care unit. Front Cell Infect Microbiol. 2021;11:665226. doi:10.3389/fcimb.2021.665226
  • Xie Y, Ruan B, Jin L, Zhu B. Case report: next-generation sequencing in diagnosis of pneumonia due to Pneumocystis jirovecii and cytomegalovirus in a patient with HIV infection. Front Med. 2021;8:653294. doi:10.3389/fmed.2021.653294
  • Wang J, Han Y, Feng J. Metagenomic next-generation sequencing for mixed pulmonary infection diagnosis. BMC Pulm Med. 2019;19(1):252. doi:10.1186/s12890-019-1022-4
  • Zhang Y, Ai JW, Cui P, Zhang WH, Wu HL, Ye MZ. A cluster of cases of pneumocystis pneumonia identified by shotgun metagenomics approach. J Infect. 2019;78(2):158-169. doi:10.1016/j.jinf.2018.08.013
  • Xie D, Xian Y, You J, et al. Co-Infection Pneumonia with Mycobacterium abscessus and Pneumocystis jiroveci in a Patient without HI V Infection Diagnosed by Metagenomic Next-Generation Sequencing. Infect Drug Resist. 2021;14:879-888. doi:10.2147/IDR.S292768
  • Huang. S. H, Meng. X. Y, Bai. Z. J, Li. Y, Wu. S. Y. X-Linked Hyper IgM Syndrome Manifesting as Recurrent Pneumocystis jirovecii Pneumonia: A Case Report. J Trop Pediatr. 2020;66 (6), 648-654. doi:10.1093/tropej/fmaa023
  • Chiu CY, Miller SA. Clinical metagenomics. Nat Rev Genet. 2019;20(6):341-355. doi:10.1038/s41576-019-0113-7
  • Wen SH, Lin L, Yu G, et al. Pseudomembranous laryngotracheobronchitis due to coinfection with human bocavirus 1 and Mycoplasma pn pneumonia: a case report. Transl Pediatr. 2021;10(3):673–678. doi:10.21037/tp-20-278
  • Qin L, Zhang FZ, Yang TY, Tao XF, Tang LF. Pulmonary Nocardia infection in a child with idiopathic pulmonary hemosiderosis. BMC Pulm Med. 2021;21(1):182. doi:10.1186/s12890-021-01544-0
  • Liu YR, Ai T. Plastic bronchitis associated with Botrytis cinerea infection in a child: a case report. World J Clin Cases. 2020;8(20):5019–5024. doi:10.12998/wjcc.v8.i20.5019
  • Ba H, Peng H, Cheng L, et al. Case report: talaromyces marneffei infection in a Chinese child with a complex heterozygous CARD9 mutation. Front Immunol. 2021;12:685546. doi:10.3389/fimmu.2021.685546
  • Lin Y, Wang BX, Zhang NN, et al. Metagenomic analysis identified Stenotrophomonas maltophilia pneumonia in an infant suffering from unexplained very severe pneumonia. Front Pediatr. 2019;7:380. doi:10.3389/fped.2019.00380
  • Chen Y, Ai L, Zhou Y, et al. Rapid and precise diagnosis of pneumonia coinfected by Pneumocystis jirovecii and Aspergillus fumigatus assisted by next-generation sequencing in a patient with systemic lupus erythematosus: a case report. Ann Clin Microbiol Antimicrob. 2021;20(1):47. doi:10.1186/s12941-021-00448-5