Microbiological Profiles of Ocular Fungal Infection at an Ophthalmic Referral Hospital in Southern China: A Ten-Year Retrospective Study

References

• Ong HS, Fung SS, Macleod D, et al. Altered patterns of fungal keratitis at a London ophthalmic referral hospital: an eight-year retrospective observational study. Am J Ophthalmol. 2016;168:227–236. doi:10.1016/j.ajo.2016.05.021
   PubMed Web of Science ®Google Scholar
• Tanure MA, Cohen EJ, Sudesh S, et al. Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania. Cornea. 2000;19:307–312. doi:10.1097/00003226-200005000-00010
   PubMed Web of Science ®Google Scholar
• Ritterband DC, Seedor JA, Shah MK, et al. Fungal keratitis at the New York eye and ear infirmary. Cornea. 2006;25:264–267. doi:10.1097/01.ico.0000177423.77648.8d
   PubMed Web of Science ®Google Scholar
• Iselin KC, Baenninger PB, Schmittinger-Zirm A, et al. Fungal keratitis: a six-year review at a tertiary referral centre. Klin Monbl Augenheilkd. 2017;234:419–425. doi:10.1055/s-0042-123233
   Web of Science ®Google Scholar
• Tuft SJ, Tullo AB. Fungal keratitis in the United Kingdom 2003–2005. Eye. 2009;23:1308–1313. doi:10.1038/eye.2008.298
   PubMed Web of Science ®Google Scholar
• Xie L, Zhai H, Zhao J, et al. Antifungal susceptibility for common pathogens of fungal keratitis in Shandong Province, China. Am J Ophthalmol. 2008;146:260–265. doi:10.1016/j.ajo.2008.04.019
   PubMed Web of Science ®Google Scholar
• Sharma S, Taneja M, Gupta R, et al. Comparison of clinical and microbiological profiles in smear-positive and smear-negative cases of suspected microbial keratitis. Indian J Ophthalmol. 2007;55:21–25. doi:10.4103/0301-4738.29490
   Google Scholar
• Shah A, Sachdev A, Coggon D, et al. Geographic variations in microbial keratitis: an analysis of the peer-reviewed literature. Br J Ophthalmol. 2011;95:762–767. doi:10.1136/bjo.2009.169607
   PubMed Web of Science ®Google Scholar
• Leck AK, Thomas PA, Hagan M, et al. Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis. Br J Ophthalmol. 2002;86:1211–1215. doi:10.1136/bjo.86.11.1211
   PubMed Web of Science ®Google Scholar
• Xie L, Zhong W, Shi W, et al. Spectrum of fungal keratitis in north China. Ophthalmology. 2006;113:1943–1948. doi:10.1016/j.ophtha.2006.05.035
   PubMed Web of Science ®Google Scholar
• Durand ML. Bacterial and fungal endophthalmitis. Clin Microbiol Rev. 2017;30:597–613. doi:10.1128/CMR.00113-16
   PubMed Web of Science ®Google Scholar
• Manikandan P, Abdel-Hadi A, Randhir Babu Singh Y, et al. Fungal keratitis: epidemiology, rapid detection, and antifungal susceptibilities of fusarium and aspergillus isolates from corneal scrapings. Biomed Res Int. 2019;2019:6395840. doi:10.1155/2019/6395840
   PubMed Web of Science ®Google Scholar
• Kredics L, Narendran V, Shobana CS, et al. Filamentous fungal infections of the cornea: a global overview of epidemiology and drug sensitivity. Mycoses. 2015;58:243–260. doi:10.1111/myc.12306
   PubMed Web of Science ®Google Scholar
• Garg P, Roy A, Roy S. Update on fungal keratitis. Curr Opin Ophthalmol. 2016;27:333–339. doi:10.1097/ICU.0000000000000272
   PubMed Web of Science ®Google Scholar
• Homa M, Shobana CS, Singh YR, et al. Fusarium keratitis in South India: causative agents, their antifungal susceptibilities and a rapid identification method for the Fusarium solani species complex. Mycoses. 2013;56:501–511. doi:10.1111/myc.12062
   PubMed Web of Science ®Google Scholar
• Miqueleiz Zapatero A, Hernando C, Barba J, et al. [First report of a case of fungal keratitis due to Curvularia hominis in Spain]. Rev Iberoam Micol. 2018;35:155–158. Spanish. doi:10.1016/j.riam.2018.03.004
   Web of Science ®Google Scholar
• Li Z, Breitwieser FP, Lu J, et al. Identifying corneal infections in formalin-fixed specimens using next generation sequencing. Invest Ophthalmol Vis Sci. 2018;59:280–288. doi:10.1167/iovs.17-21617
   PubMed Web of Science ®Google Scholar
• Mahmoudi S, Masoomi A, Ahmadikia K, et al. Fungal keratitis: an overview of clinical and laboratory aspects. Mycoses. 2018;61:916–930. doi:10.1111/myc.12822
   PubMed Web of Science ®Google Scholar
• Bharathi MJ, Ramakrishnan R, Meenakshi R, et al. Microbiological diagnosis of infective keratitis: comparative evaluation of direct microscopy and culture results. Br J Ophthalmol. 2006;90:1271–1276. doi:10.1136/bjo.2006.096230
   PubMed Web of Science ®Google Scholar
• Zhang W, Yang H, Jiang L, et al. Use of potassium hydroxide, Giemsa and calcofluor white staining techniques in the microscopic evaluation of corneal scrapings for diagnosis of fungal keratitis. J Int Med Res. 2010;38:1961–1967. doi:10.1177/147323001003800609
   PubMed Web of Science ®Google Scholar
• Heuer C, Bahnemann J, Scheper T, et al. Paving the way to overcome antifungal drug resistance: current practices and novel developments for rapid and reliable antifungal susceptibility testing. Small Methods. 2021;5:e2100713. doi:10.1002/smtd.202100713
   Web of Science ®Google Scholar
• Al-Hatmi AM, Normand AC, Ranque S, et al. Comparative evaluation of Etest, EUCAST, and CLSI methods for amphotericin B, voriconazole, and posaconazole against clinically relevant fusarium species. Antimicrob Agents Chemother. 2016;61. doi:10.1128/AAC.01671-16
   Web of Science ®Google Scholar
• Meletiadis J, Geertsen E, Curfs-Breuker I, et al. Intra- and interlaboratory agreement in assessing the in vitro activity of micafungin against common and rare candida species with the EUCAST, CLSI, and Etest methods. Antimicrob Agents Chemother. 2016;60:6173–6178. doi:10.1128/AAC.01027-16
   Web of Science ®Google Scholar
• Behrens-Baumann WJ, Hofmuller W, Tammer I, et al. Keratomycosis due to Tintelnotia destructans refractory to common therapy treated successfully with systemic and local terbinafine in combination with polyhexamethylene biguanide. Int Ophthalmol. 2018;39:1379–1385. doi:10.1007/s10792-018-0930-2
   Web of Science ®Google Scholar
• Lin L, Duan F, Yang Y, et al. Nine-year analysis of isolated pathogens and antibiotic susceptibilities of microbial keratitis from a large referral eye center in southern China. Infect Drug Resist. 2019;12:1295–1302. doi:10.2147/IDR.S206831
   PubMed Web of Science ®Google Scholar
• Lin L, Mei F, Liao J, et al. Nine-year analysis of isolated pathogens and antibiotic susceptibilities of infectious endophthalmitis from a large referral eye center in Southern China. Infect Drug Resist. 2020;13:493–500. doi:10.2147/IDR.S235954
   PubMed Web of Science ®Google Scholar
• Wang N, Yang Q, Tan Y, et al. Bacterial spectrum and antibiotic resistance patterns of ocular infection: differences between external and intraocular diseases. J Ophthalmol. 2015;2015:813979. doi:10.1155/2015/813979
   Web of Science ®Google Scholar
• Hua GO, Yiwei TA, Xiangming GO, Jiahui LI, Zhiwei CA. Spectrum of fungal keratitis change in South China. Chin J Exp Ophthalmol. 2017;2017:161–164.
   Google Scholar
• Kumar A, Pandya S, Kavathia G, et al. Microbial keratitis in Gujarat, Western India: findings from 200 cases. Pan Afr Med J. 2011;10:48.
   Google Scholar
• Keshav BR, Zacheria G, Ideculla T, Bhat V, Joseph M. Epidemiological characteristics of corneal ulcers in South Sharqiya region. Oman Med J. 2008;23:34–39.
   Google Scholar
• Zhu M, Cheng C, Yi H, et al. Quantitative analysis of the bacteria in blepharitis with demodex infestation. Front Microbiol. 2018;9:1719. doi:10.3389/fmicb.2018.01719
   PubMed Web of Science ®Google Scholar
• Wang L, Sun S, Jing Y, et al. Spectrum of fungal keratitis in central China. Clin Experiment Ophthalmol. 2009;37:763–771. doi:10.1111/j.1442-9071.2009.02155.x
   PubMed Web of Science ®Google Scholar
• Sun RL, Jones DB, Wilhelmus KR. Clinical characteristics and outcome of Candida keratitis. Am J Ophthalmol. 2007;143:1043–1045. doi:10.1016/j.ajo.2007.02.016
   PubMed Web of Science ®Google Scholar
• He D, Hao J, Gao S, et al. Etiological analysis of fungal keratitis and rapid identification of predominant fungal pathogens. Mycopathologia. 2016;181:75–82. doi:10.1007/s11046-015-9950-x
   PubMed Web of Science ®Google Scholar
• Ghosh AK, Gupta A, Rudramurthy SM, et al. Fungal keratitis in North India: spectrum of agents, risk factors and treatment. Mycopathologia. 2016;181:843–850. doi:10.1007/s11046-016-0042-3
   PubMed Web of Science ®Google Scholar
• Sharma S, Kunimoto DY, Gopinathan U, et al. Evaluation of corneal scraping smear examination methods in the diagnosis of bacterial and fungal keratitis: a survey of eight years of laboratory experience. Cornea. 2002;21:643–647. doi:10.1097/00003226-200210000-00002
   PubMed Web of Science ®Google Scholar
• Watson SL, Cabrera-Aguas M, Keay L, et al. The clinical and microbiological features and outcomes of fungal keratitis over 9 years in Sydney, Australia. Mycoses. 2019;63:43–51. doi:10.1111/myc.13009
   Web of Science ®Google Scholar
• Gopinathan U, Sharma S, Garg P, et al. Review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade. Indian J Ophthalmol. 2009;57:273–279. doi:10.4103/0301-4738.53051
   PubMed Web of Science ®Google Scholar
• Kibret T, Bitew A. Fungal keratitis in patients with corneal ulcer attending Minilik II Memorial Hospital, Addis Ababa, Ethiopia. BMC Ophthalmol. 2016;16:148. doi:10.1186/s12886-016-0330-1
   PubMed Web of Science ®Google Scholar
• Zbiba W, Baba A, Bouayed E, et al. A 5-year retrospective review of fungal keratitis in the region of Cap Bon. J Francais d’ophtalmologie. 2016;39:843–848. doi:10.1016/j.jfo.2016.09.006
   Web of Science ®Google Scholar
• Cheikhrouhou F, Makni F, Neji S, et al. Epidemiological profile of fungal keratitis in Sfax (Tunisia). J Mycol Med. 2014;24:308–312. doi:10.1016/j.mycmed.2014.06.047
   PubMed Web of Science ®Google Scholar
• Verma S, Sharma V, Kanga A, et al. Current spectrum of oculomycosis in North India: a 5-year retrospective evaluation of clinical and microbiological profile. Indian J Med Microbiol. 2016;34:72–75. doi:10.4103/0255-0857.174104
   Web of Science ®Google Scholar
• Zhang Y, Wang ZQ, Sun XG. [Analysis of etiology and in vitro drug susceptibility of fungal keratitis in northern China]. Zhonghua Yan Ke Za Zhi. 2018;54:432–436. Chinese. doi:10.3760/cma.j.issn.0412-4081.2018.06.009
   Google Scholar
• Ho JW, Fernandez MM, Rebong RA, et al. Microbiological profiles of fungal keratitis: a 10-year study at a tertiary referral center. J Ophthalmic Inflamm Infect. 2016;6:5. doi:10.1186/s12348-016-0071-6
   Google Scholar
• Cho CH, Lee SB. Clinical analysis of microbiologically proven fungal keratitis according to prior topical steroid use: a retrospective study in South Korea. BMC Ophthalmol. 2019;19:207. doi:10.1186/s12886-019-1212-0
   PubMed Web of Science ®Google Scholar
• Bunya VY, Hammersmith KM, Rapuano CJ, et al. Topical and oral voriconazole in the treatment of fungal keratitis. Am J Ophthalmol. 2007;143:151–153. doi:10.1016/j.ajo.2006.07.033
   PubMed Web of Science ®Google Scholar
• Al-Badriyeh D, Leung L, Davies GE, et al. Successful use of topical voriconazole 1% alone as first-line antifungal therapy against Candida albicans keratitis. Ann Pharmacother. 2009;43:2103–2107. doi:10.1345/aph.1M318
   PubMed Web of Science ®Google Scholar
• Wang LY, Xu ZZ, Zhang JJ, et al. [Topical voriconazole as an effective treatment for fungal keratitis]. Zhonghua Yan Ke Za Zhi. 2016;52:657–662. Chinese. doi:10.3760/cma.j.issn.0412-4081.2016.09.005
   Google Scholar
• Marangon FB, Miller D, Giaconi JA, et al. In vitro investigation of voriconazole susceptibility for keratitis and endophthalmitis fungal pathogens. Am J Ophthalmol. 2004;137:820–825. doi:10.1016/j.ajo.2003.11.078
   PubMed Web of Science ®Google Scholar
• Hariprasad SM, Mieler WF, Holz ER, et al. Determination of vitreous, aqueous, and plasma concentration of orally administered voriconazole in humans. Arch Ophthalmol. 2004;122:42–47. doi:10.1001/archopht.122.1.42
   PubMed Web of Science ®Google Scholar
• Al-Badriyeh D, Neoh CF, Stewart K, et al. Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis. Clin Ophthalmol. 2010;4:391–405. doi:10.2147/opth.s6374
   PubMedGoogle Scholar
• Tuli SS. Fungal keratitis. Clin Ophthalmol. 2011;5:275–279. doi:10.2147/OPTH.S10819
   PubMedGoogle Scholar
• Oliveira Dos Santos C, Kolwijck E, van der Lee HA, et al. In vitro activity of chlorhexidine compared with seven antifungal agents against 98 fusarium isolates recovered from fungal keratitis patients. Antimicrob Agents Chemother. 2019;63. doi:10.1128/AAC.02669-18
   Web of Science ®Google Scholar
• Prajna NV, Mascarenhas J, Krishnan T, et al. Comparison of natamycin and voriconazole for the treatment of fungal keratitis. Arch Ophthalmol. 2010;128:672–678. doi:10.1001/archophthalmol.2010.102
   PubMedGoogle Scholar
• Prajna NV, Krishnan T, Rajaraman R, et al. Adjunctive oral voriconazole treatment of fusarium keratitis: a secondary analysis from the mycotic ulcer treatment trial II. JAMA Ophthalmol. 2017;135:520–525. doi:10.1001/jamaophthalmol.2017.0616
   PubMed Web of Science ®Google Scholar
• Alastruey-Izquierdo A, Cuenca-Estrella M, Monzon A, et al. Antifungal susceptibility profile of clinical Fusarium spp. isolates identified by molecular methods. J Antimicrob Chemother. 2008;61:805–809. doi:10.1093/jac/dkn022
   PubMed Web of Science ®Google Scholar
• Nayak N, Satpathy G, Prasad S, et al. Molecular characterization of drug-resistant and drug-sensitive Aspergillus isolates causing infectious keratitis. Indian J Ophthalmol. 2011;59:373–377. doi:10.4103/0301-4738.83614
   Web of Science ®Google Scholar
• Wagner L, de Hoog S, Alastruey-Izquierdo A, et al. A revised species concept for opportunistic mucor species reveals species-specific antifungal susceptibility profiles. Antimicrob Agents Chemother. 2019;63. doi:10.1128/AAC.00653-19
   Web of Science ®Google Scholar