Advanced search
Publication Cover
Infection and Drug Resistance Volume 15, 2022 - Issue
Submit an article Journal homepage
271
Views
2
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Rapid Detection of Carbapenem-Resistant Klebsiella pneumoniae Using Machine Learning and MALDI-TOF MS Platform

Jinyu WangDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-6636-7831
ORCID Icon,
Cuiping XiaDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
,
Yue WuDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
,
Xin TianDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
,
Ke ZhangDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
&
Zhongxin WangDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of ChinaCorrespondence[email protected]
Pages 3703-3710 | Published online: 12 Jul 2022

References

  • Wu X, Shi Q, Shen S, Huang C, Wu H. Clinical and bacterial characteristics of Klebsiella pneumoniae affecting 30-day mortality in patients with bloodstream infection. Front Cell Infect Microbiol. 2021;11:688989. doi:10.3389/fcimb.2021.688989
  • Karampatakis T, Antachopoulos C, Iosifidis E, et al. Molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in Greece. Future Microbiol. 2016;11:809–823. doi:10.2217/fmb-2016-0042
  • Ventola CL. The antimicrobials resistance crisis: part 1: causes and threats. Pharm Ther. 2015;40:277–283.
  • Haigh JD, Green IM, Ball D, et al. Rapid identification of bacteria from bioMérieux BacT/ALERT blood culture bottles by MALDI-TOF MS. Br J Biomed Sci. 2013;70:149–155. doi:10.1080/09674845.2013.11669949
  • Sakarikou C, Ciotti M, Dolfa C, et al. Rapid detection of carbapenemase-producing Klebsiella pneumoniae strains derived from blood cultures by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS). BMC Microbiol. 2017;17(1):54. doi:10.1186/s12866-017-0952-3
  • Fangous M-S, Mougari F, Gouriou S, et al. Classification algorithm for subspecies identification within the Mycobacterium abscessus species, based on matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol. 2014;52:3362–3369. doi:10.1128/JCM.00788-14
  • Mather CA, Werth BJ, Sivagnanam S, et al. Rapid detection of vancomycin-intermediate Staphylococcus aureus by Matrix-assisted laser desorption ionization-time of flight massspectrometry. J Clin Microbiol. 2016;54(4):883–890. doi:10.1128/JCM.02428-15
  • CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 28th ed. CLSI document M100-S27. Wayne, PA: CLSI; 2018.
  • Pena I, Pena-Vina E, Rodriguez-Avial I, et al. Comparison of performance of MALDI-TOF MS and MLST for biotyping carbapenemase-producing Klebsiella pneumoniae sequence types ST11 and ST101 isolates [published online ahead of print, 2020 Dec 15]. Enferm Infecc Microbiol Clin. 2020;40(4):172–178.
  • Hussein K, Raz-Pasteur A, Finkelstein R. Impact of carbapenem resistance on the outcome of patients’ hospital-acquired bacteraemia caused by Klebsiellapneumoniae. J Hosp Infect. 2013;83(83):307–313. doi:10.1016/j.jhin.2012.10.012
  • Li C, Wen X, Ren N, et al. Point-prevalence of healthcare-associated infection in China in 2010: a large multicenter epidemiological survey. Infect Control Hosp Epidemiol. 2014;35(11):1436–1437. doi:10.1086/678433
  • Meng X, Liu S, Duan J, et al. Risk factors and medical costs for healthcare-associated carbapenem-resistant Escherichia coli infection among hospitalized patients in a Chinese teaching hospital. BMC Infect Dis. 2017;17(1):82. doi:10.1186/s12879-016-2176-9
  • Arato V, Raso MM, Gasperini G, et al. Prophylaxis and treatment against Klebsiella pneumoniae: current insights on this emerging anti-microbial resistant global threat. Int J Mol Sci. 2021;22(8):4042. doi:10.3390/ijms22084042
  • Wang G, Song G, Xu Y. A rapid antimicrobial susceptibility test for Klebsiella pneumoniae using a broth micro-dilution combined with MALDI TOF MS. Infect Drug Resist. 2021;14:1823–1831. doi:10.2147/IDR.S305280
  • Liu X, Su T, Hsu YS, et al. Rapid identification and discrimination of methicillin-resistant Staphylococcus aureus strains via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2021;35(2):e8972. doi:10.1002/rcm.8972
  • Huang TS, Lee SS, Lee CC, et al. Detection of carbapenem-resistant Klebsiella pneumoniae on the basis of matrix-assisted laser desorption ionization time-of-flight mass spectrometry by using supervised machine learning approach. PLoS One. 2020;15(2):e0228459. doi:10.1371/journal.pone.0228459
  • Esener N, Green MJ, Emes RD, et al. Discrimination of contagious and environmental strains of Streptococcus uberis in dairy herds by means ofmass spectrometry and machine-learning. Sci Rep. 2018;8:17517. doi:10.1038/s41598-018-35867-6
  • Pérez-Sancho M, Vela AI, Horcajo P, et al. Rapid differentiation of Staphylococcus aureus subspecies based on MALDI-TOF MS profiles. J Vet Diagn Invest. 2018;30:813–820. doi:10.1177/1040638718805537

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.