The Anti-Virulence Effect of Sub-Minimal Inhibitory Concentrations of Levofloxacin on Hypervirulent Klebsiella pneumoniae

References

• Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev. 1998;11(4):589–603. doi:10.1128/CMR.11.4.589
   PubMed Web of Science ®Google Scholar
• Liu YM, Li BB, Zhang YY, et al. Clinical and molecular characteristics of emerging hypervirulent Klebsiella pneumoniae bloodstream infections in mainland China. Antimicrob Agents Chemother. 2014;58(9):5379–5385. doi:10.1128/AAC.02523-14
   PubMed Web of Science ®Google Scholar
• Li J, Ren J, Wang W, et al. Risk factors and clinical outcomes of hypervirulent Klebsiella pneumoniae induced bloodstream infections. Eur J Clin Microbiol Infect Dis. 2018;37(4):679–689. doi:10.1007/s10096-017-3160-z
   PubMed Web of Science ®Google Scholar
• Lee HC, Chuang YC, Yu WL, et al. Clinical implications of hypermucoviscosity phenotype in Klebsiella pneumoniae isolates: association with invasive syndrome in patients with community-acquired bacteraemia. J Intern Med. 2006;259(6):606–614. doi:10.1111/j.1365-2796.2006.01641.x
   PubMed Web of Science ®Google Scholar
• Cubero M, Grau I, Tubau F, et al. Hypervirulent Klebsiella pneumoniae clones causing bacteraemia in adults in a teaching hospital in Barcelona, Spain (2007–2013). Clin Microbiol Infect. 2016;22(2):154–160. doi:10.1016/j.cmi.2015.09.025
   PubMed Web of Science ®Google Scholar
• Choby JE, Howard-Anderson J, Weiss DS. Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives. J Intern Med. 2020;287(3):283–300. doi:10.1111/joim.13007
   PubMed Web of Science ®Google Scholar
• Decre D, Verdet C, Emirian A, et al. Emerging severe and fatal infections due to Klebsiella pneumoniae in two university hospitals in France. J Clin Microbiol. 2011;49(8):3012–3014. doi:10.1128/JCM.00676-11
   Web of Science ®Google Scholar
• Paczosa MK, Mecsas J. Klebsiella pneumoniae: going on the offense with a strong defense. Microbiol Mol Biol Rev. 2016;80(3):629–661. doi:10.1128/MMBR.00078-15
   PubMed Web of Science ®Google Scholar
• Cortes G, Borrell N, de Astorza B, Gomez C, Sauleda J, Alberti S. Molecular analysis of the contribution of the capsular polysaccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine model of pneumonia. Infect Immun. 2002;70(5):2583–2590. doi:10.1128/IAI.70.5.2583-2590.2002
   PubMed Web of Science ®Google Scholar
• Fang CT, Chuang YP, Shun CT, Chang SC, Wang JT. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med. 2004;199(5):697–705. doi:10.1084/jem.20030857
   PubMed Web of Science ®Google Scholar
• Jun JB. Klebsiella pneumoniae liver abscess. Infect Chemother. 2018;50(3):210–218. doi:10.3947/ic.2018.50.3.210
   PubMed Web of Science ®Google Scholar
• Jung SW, Chae HJ, Park YJ, et al. Microbiological and clinical characteristics of bacteraemia caused by the hypermucoviscosity phenotype of Klebsiella pneumoniae in Korea. Epidemiol Infect. 2013;141(2):334–340. doi:10.1017/S0950268812000933
   PubMed Web of Science ®Google Scholar
• Wacharotayankun R, Arakawa Y, Ohta M, et al. Enhancement of extracapsular polysaccharide synthesis in Klebsiella pneumoniae by RmpA2, which shows homology to NtrC and FixJ. Infect Immun. 1993;61(8):3164–3174. doi:10.1128/iai.61.8.3164-3174.1993
   Web of Science ®Google Scholar
• Palacios M, Miner TA, Frederick DR, et al. Identification of two regulators of virulence that are conserved in Klebsiella pneumoniae classical and hypervirulent strains. Mbio. 2018;9(4). doi:10.1128/mBio.01443-18
   Web of Science ®Google Scholar
• Namikawa H, Oinuma KI, Sakiyama A, et al. Discovery of anti-mucoviscous activity of rifampicin and its potential as a candidate antivirulence agent against hypervirulent Klebsiella pneumoniae. Int J Antimicrob Agents. 2019;54(2):167–175. doi:10.1016/j.ijantimicag.2019.05.018
   Web of Science ®Google Scholar
• Lin TL, Yang FL, Yang AS, et al. Amino acid substitutions of MagA in Klebsiella pneumoniae affect the biosynthesis of the capsular polysaccharide. PLoS One. 2012;7(10):e46783. doi:10.1371/journal.pone.0046783
   Web of Science ®Google Scholar
• Domenico P, Schwartz S, Cunha BA. Reduction of capsular polysaccharide production in Klebsiella pneumoniae by sodium salicylate. Infect Immun. 1989;57(12):3778–3782. doi:10.1128/iai.57.12.3778-3782.1989
   Web of Science ®Google Scholar
• Blumenkrantz N, Asboe-Hansen G. New method for quantitative determination of uronic acids. Anal Biochem. 1973;54(2):484–489. doi:10.1016/0003-2697(73)90377-1
   PubMed Web of Science ®Google Scholar
• Shang D, Liang H, Wei S, Yan X, Yang Q, Sun Y. Effects of antimicrobial peptide L-K6, a temporin-1CEb analog on oral pathogen growth, Streptococcus mutans biofilm formation, and anti-inflammatory activity. Appl Microbiol Biotechnol. 2014;98(20):8685–8695. doi:10.1007/s00253-014-5927-9
   Web of Science ®Google Scholar
• Linares JF, Gustafsson I, Baquero F, Martinez JL. Antibiotics as intermicrobial signaling agents instead of weapons. Proc Natl Acad Sci U S A. 2006;103(51):19484–19489. doi:10.1073/pnas.0608949103
   PubMed Web of Science ®Google Scholar
• Brook I, Hausfeld JN. In vitro effects of penicillin and telithromycin on the expression of Streptococcus pneumoniae capsule. J Antimicrob Chemother. 2006;58(3):678–679. doi:10.1093/jac/dkl261
   Web of Science ®Google Scholar
• Nomura S, Murata K, Nagayama A. Effects of sub-minimal inhibitory concentrations of antimicrobial agents on the cell surface of Klebsiella pneumoniae and phagocytic killing activity. J Chemother. 1995;7(5):406–413. doi:10.1179/joc.1995.7.5.406
   PubMed Web of Science ®Google Scholar
• Liu YC, Cheng DL, Lin CL. Klebsiella pneumoniae liver abscess associated with septic endophthalmitis. Arch Intern Med. 1986;146(10):1913–1916. doi:10.1001/archinte.1986.00360220057011
   PubMedGoogle Scholar
• Wang JH, Liu YC, Lee SS, et al. Primary liver abscess due to Klebsiella pneumoniae in Taiwan. Clin Infect Dis. 1998;26(6):1434–1438. doi:10.1086/516369
   PubMed Web of Science ®Google Scholar
• Siu LK, Fung CP, Chang FY, et al. Molecular typing and virulence analysis of serotype K1 Klebsiella pneumoniae strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan. J Clin Microbiol. 2011;49(11):3761–3765. doi:10.1128/JCM.00977-11
   PubMed Web of Science ®Google Scholar
• Shu HY, Fung CP, Liu YM, et al. Genetic diversity of capsular polysaccharide biosynthesis in Klebsiella pneumoniae clinical isolates. Microbiology. 2009;155(Pt 12):4170–4183. doi:10.1099/mic.0.029017-0
   PubMed Web of Science ®Google Scholar
• Cheng HY, Chen YS, Wu CY, Chang HY, Lai YC, Peng HL. RmpA regulation of capsular polysaccharide biosynthesis in Klebsiella pneumoniae CG43. J Bacteriol. 2010;192(12):3144–3158. doi:10.1128/JB.00031-10
   PubMed Web of Science ®Google Scholar
• Fang CT, Lai SY, Yi WC, Hsueh PR, Liu KL, Chang SC. Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Clin Infect Dis. 2007;45(3):284–293. doi:10.1086/519262
   PubMed Web of Science ®Google Scholar
• Yeh KM, Lin JC, Yin FY, et al. Revisiting the importance of virulence determinant magA and its surrounding genes in Klebsiella pneumoniae causing pyogenic liver abscesses: exact role in serotype K1 capsule formation. J Infect Dis. 2010;201(8):1259–1267. doi:10.1086/606010
   Web of Science ®Google Scholar
• Russo TA, Olson R, Macdonald U, et al. Aerobactin mediates virulence and accounts for increased siderophore production under iron-limiting conditions by hypervirulent (hypermucoviscous) Klebsiella pneumoniae. Infect Immun. 2014;82(6):2356–2367. doi:10.1128/IAI.01667-13
   PubMed Web of Science ®Google Scholar
• Russo TA, Olson R, Fang CT, et al. Identification of biomarkers for differentiation of hypervirulent Klebsiella pneumoniae from classical K. pneumoniae. J Clin Microbiol. 2018;56(9). doi:10.1128/JCM.00776-18
   PubMed Web of Science ®Google Scholar
• Russo TA, Olson R, MacDonald U, Beanan J, Davidson BA, Camilli A. Aerobactin, but not yersiniabactin, salmochelin, or enterobactin, enables the growth/survival of hypervirulent (hypermucoviscous) Klebsiella pneumoniae ex vivo and in vivo. Infect Immun. 2015;83(8):3325–3333. doi:10.1128/IAI.00430-15
   PubMed Web of Science ®Google Scholar
• Russo TA, Gulick AM. Aerobactin synthesis proteins as antivirulence targets in hypervirulent Klebsiella pneumoniae. Acs Infect Dis. 2019;5(7):1052–1054. doi:10.1021/acsinfecdis.9b00117
   PubMed Web of Science ®Google Scholar
• Lam M, Wyres KL, Judd LM, et al. Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in Klebsiella pneumoniae. Genome Med. 2018;10(1):77. doi:10.1186/s13073-018-0587-5
   PubMed Web of Science ®Google Scholar
• Sahly H, Podschun R, Oelschlaeger TA, et al. Capsule impedes adhesion to and invasion of epithelial cells by Klebsiella pneumoniae. Infect Immun. 2000;68(12):6744–6749. doi:10.1128/IAI.68.12.6744-6749.2000
   Web of Science ®Google Scholar
• Lin JC, Chang FY, Fung CP, et al. High prevalence of phagocytic-resistant capsular serotypes of Klebsiella pneumoniae in liver abscess. Microbes Infect. 2004;6(13):1191–1198. doi:10.1016/j.micinf.2004.06.003
   PubMed Web of Science ®Google Scholar
• Domenico P, Salo RJ, Cross AS, Cunha BA. Polysaccharide capsule-mediated resistance to opsonophagocytosis in Klebsiella pneumoniae. Infect Immun. 1994;62(10):4495–4499. doi:10.1128/iai.62.10.4495-4499.1994
   PubMed Web of Science ®Google Scholar
• Kobayashi SD, Porter AR, Freedman B, et al. Antibody-mediated killing of carbapenem-resistant ST258 Klebsiella pneumoniae by human neutrophils. Mbio. 2018;9(2). doi:10.1128/mBio.00297-18
   Web of Science ®Google Scholar