Clinical and Microbiological Characteristics of Klebsiella pneumoniae Bloodstream Infection in a Chinese Hospital: Hypervirulent and Multiclonal

References

• Li W, Sun G, Yu Y, et al. Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China. Clin Infect Dis. 2014;58:225–232. doi:10.1093/cid/cit675
   PubMed Web of Science ®Google Scholar
• Liu YM, Li BB, Zhang YY, et al. Clinical and molecular characteristics of emerging hypervirulent Klebsiella pneumoniae bloodstream infections in mainland China. Antimicrob Agents Chemother. 2014;58:5379–5385. doi:10.1128/AAC.02523-14
   PubMed Web of Science ®Google Scholar
• Russo TA, Olson R, MacDonald U, et al. Aerobactin, but not yersiniabactin, salmochelin, or enterobactin, enables the growth/survival of hypervirulent (Hypermucoviscous) Klebsiella pneumoniae ex vivo and in vivo. Infect Immun. 2015;83:3325–3333. doi:10.1128/IAI.00430-15
   PubMed Web of Science ®Google Scholar
• Russo TA, Olson R, Macdonald U, et al. Aerobactin mediates virulence and accounts for increased siderophore production under iron-limiting conditions by hypervirulent (hypermucoviscous) Klebsiella pneumoniae.. Infect Immun. 2014;82:2356–2367. doi:10.1128/IAI.01667-13
   PubMed Web of Science ®Google Scholar
• Shi Q, Lan P, Huang D, et al. Diversity of virulence level phenotype of hypervirulent Klebsiella pneumoniae from different sequence type lineage. BMC Microbiol. 2018;18:94. doi:10.1186/s12866-018-1236-2
   Web of Science ®Google Scholar
• Russo TA, Marr CM. Hypervirulent Klebsiella pneumoniae. Clin Microbiol Rev. 2019;32:e00001–e00019. doi:10.1128/CMR.00001-19
   PubMed Web of Science ®Google Scholar
• Li J, Ren J, Wang W, et al. Risk factors and clinical outcomes of hypervirulent Klebsiella pneumoniae induced bloodstream infections. Eur J Clin Microbiol Infect Dis. 2018;37:679–689. doi:10.1007/s10096-017-3160-z
   Web of Science ®Google Scholar
• Zhang Y, Zhao C, Wang Q, et al. High prevalence of hypervirulent Klebsiella pneumoniae infection in China: geographic distribution, clinical characteristics, and antimicrobial resistance. Antimicrob Agents Chemother. 2016;60(10):6115–6120. doi:10.1128/AAC.01127-16
   PubMed Web of Science ®Google Scholar
• Liu C, Shi J, Guo J. High prevalence of hypervirulent Klebsiella pneumoniae infection in the genetic background of elderly patients in two teaching hospitals in China. Infect Drug Resist. 2018;11:1031–1041. doi:10.2147/IDR.S161075
   PubMed Web of Science ®Google Scholar
• Lan Y, Zhou M, Jian Z, et al. Prevalence of pks gene cluster and characteristics of Klebsiella pneumoniae -induced bloodstream infections. J Clin Lab Anal. 2019;33:e22838. doi:10.1002/jcla.22838
   PubMed Web of Science ®Google Scholar
• Wu H, Li D, Zhou H, et al. Bacteremia and other body site infection caused by hypervirulent and classic Klebsiella pneumoniae.. Microb Pathog. 2017;104:254–262. doi:10.1016/j.micpath.2017.01.049
   PubMed Web of Science ®Google Scholar
• Shi Q, Quan J, Lan P, et al. Prevalence and characteristics of pks gene cluster harbouring Klebsiella pneumoniae from bloodstream infection in China. Epidemiol Infect. 2020;148:e69. doi:10.1017/S0950268820000655
   Web of Science ®Google Scholar
• CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 30th ed. CLSI supplement M100. Wayne, PA: CLSI; 2020.
   Google Scholar
• Zhou C, Wu Q, He L, et al. Clinical and molecular characteristics of carbapenem-resistant hypervirulent Klebsiella pneumoniae Isolates in a tertiary hospital in Shanghai, China. Infect Drug Resist. 2021;14:2697–2706. doi:10.2147/IDR.S321704
   PubMed Web of Science ®Google Scholar
• Fang CT, Lai SY, Yi WC, et al. Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Clin Infect Dis. 2007;45:284–293. doi:10.1086/519262
   PubMed Web of Science ®Google Scholar
• Ye M, Tu J, Jiang J, et al. Clinical and genomic analysis of liver abscess-causing Klebsiella pneumoniae identifies new liver abscess-associated virulence genes. Front Cell Infect Microbiol. 2016;6:165. doi:10.3389/fcimb.2016.00165
   PubMed Web of Science ®Google Scholar
• Yeh KM, Kurup A, Siu LK, et al. Capsular serotype K1 or K2, rather than magA and rmpA, is a major virulence determinant for Klebsiella pneumoniae liver abscess in Singapore and Taiwan. J Clin Microbiol. 2007;45:466–471. doi:10.1128/JCM.01150-06
   PubMed Web of Science ®Google Scholar
• Turton JF, Baklan H, Siu LK, et al. Evaluation of a multiplex PCR for detection of serotypes K1, K2 and K5 in Klebsiella sp. and comparison of isolates within these serotypes. FEMS Microbiol Lett. 2008;284:247–252. doi:10.1111/j.1574-6968.2008.01208.x
   PubMed Web of Science ®Google Scholar
• Bachman MA, Oyler JE, Burns SH, et al. Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2. Infect Immun. 2011;79:3309–3316. doi:10.1128/IAI.05114-11
   Web of Science ®Google Scholar
• Yu WL, Ko WC, Cheng KC, et al. Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. Clin Infect Dis. 2006;42:1351–1358. doi:10.1086/503420
   PubMed Web of Science ®Google Scholar
• Luo Y, Wang Y, Ye L, et al. Molecular epidemiology and virulence factors of pyogenic liver abscess causing Klebsiella pneumoniae in China. Clin Microbiol Infect. 2014;20:O818–O824. doi:10.1111/1469-0691.12664
   PubMed Web of Science ®Google Scholar
• Harada S, Aoki K, Yamamoto S, et al. Clinical and molecular characteristics of Klebsiella pneumoniae isolates causing bloodstream infections in Japan: occurrence of hypervirulent infections in health care. J Clin Microbiol. 2019;57:e01206–e01219. doi:10.1128/JCM.01206-19
   Web of Science ®Google Scholar
• Kim D, Park BY, Choi MH, et al. Antimicrobial resistance and virulence factors of Klebsiella pneumoniae affecting 30 day mortality in patients with bloodstream infection. J Antimicrob Chemother. 2019;74:190–199. doi:10.1093/jac/dky397
   Web of Science ®Google Scholar
• Johnson JR, Johnston B, Kuskowski MA, et al. Molecular Epidemiology and Phylogenetic Distribution of the Escherichia coli pks Genomic Island. J Clin Microbiol. 2008;46:3906–3911. doi:10.1128/JCM.00949-08
   PubMed Web of Science ®Google Scholar
• Putze J, Hennequin C, Nougayrede JP, et al. Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae. Infect Immun. 2009;77:4696–4703. doi:10.1128/IAI.00522-09
   PubMed Web of Science ®Google Scholar
• Chen YT, Lai YC, Tan MC, et al. Prevalence and characteristics of pks genotoxin gene cluster-positive clinical Klebsiella pneumoniae isolates in Taiwan. Sci Rep. 2017;7:43120. doi:10.1038/srep43120
   Web of Science ®Google Scholar
• Wu X, Shi Q, Shen S, et al. Clinical and bacterial characteristics of Klebsiella pneumoniae affecting 30-day mortality in patients with bloodstream infection. Front Cell Infect Microbiol. 2021;11:688989. doi:10.3389/fcimb.2021.688989
   Web of Science ®Google Scholar
• Zhang Y, Jin L, Ouyang P, et al. Evolution of hypervirulence in carbapenem-resistant Klebsiella pneumoniae in China: a multicentre, molecular epidemiological analysis. J Antimicrob Chemother. 2020;75:327–336. doi:10.1093/jac/dkz446
   PubMed Web of Science ®Google Scholar
• Yao H, Qin S, Chen S, et al. Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae.. Lancet Infect Dis. 2018;18:25. doi:10.1016/S1473-3099(17)30628-X
   PubMed Web of Science ®Google Scholar
• Gu D, Dong N, Zheng Z, et al. A fatal outbreak of ST11 carbapenem- resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018;18:37–46. doi:10.1016/S1473-3099(17)30489-9
   PubMed Web of Science ®Google Scholar
• Choby JE, Howard-Anderson J, Weiss DS. Hypervirulent Klebsiella pneumoniae-clinical and molecular perspectives. J Intern Med. 2020;287:283–300. doi:10.1111/joim.13007
   PubMed Web of Science ®Google Scholar
• Hwang JH, Handigund M, Hwang JH, et al. Clinical features and risk factors associated with 30-day mortality in patients with pneumonia caused by hypervirulent Klebsiella pneumoniae (hvKP). Ann Lab Med. 2020;40:481–487. doi:10.3343/alm.2020.40.6.481
   Web of Science ®Google Scholar
• Chan KS, Shelat VG. Klebsiella pneumoniae bacteremia is associated with higher mortality in acute calculous cholangitis as compared to Escherichia coli bacteremia. World J Surg. 2022;46:1678–1685. doi:10.1007/s00268-022-06559-0
   Web of Science ®Google Scholar