A Case of Meningitis in an Infant Due to Hypervirulent Klebsiella pneumoniae Transmission Within a Family

References

• Liu Z, Gu Y, Li X, et al. Identification and characterization of NDM-1-producing Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae in China. Ann Lab Med. 2019;39(2):167–175. doi:10.3343/alm.2019.39.2.167
   PubMed Web of Science ®Google Scholar
• Hu D, Li Y, Ren P, et al. Molecular epidemiology of hypervirulent carbapenemase-producing Klebsiella pneumoniae. Front Cell Infect Microbiol. 2021;11:661218. doi:10.3389/fcimb.2021.661218
   Web of Science ®Google Scholar
• Bingen E, Levy C, de la Rocque F, et al. Bacterial meningitis in children: a French prospective study. Clin Infect Dis. 2005;41(7):1059–1063. doi:10.1086/432944
   Web of Science ®Google Scholar
• Peng X, Zhu Q, Liu J, et al. Prevalence and antimicrobial resistance patterns of bacteria isolated from cerebrospinal fluid among children with bacterial meningitis in China from 2016 to 2018: a multicenter retrospective study. Antimicrob Resist Infect Control. 2021;10(1):24. doi:10.1186/s13756-021-00895-x
   Web of Science ®Google Scholar
• Sundaram V, Agrawal S, Chacham S, Mukhopadhyay K, Dutta S, Kumar P. Klebsiella pneumoniae brain abscess in neonates: a report of 2 cases. J Child Neurol. 2010;25(3):379–382. doi:10.1177/0883073809338326
   Web of Science ®Google Scholar
• Biswas B, Mondal M, Thapa R, Mallick D, Datta AK. Neonatal brain abscess due to extended-spectrum beta-lactamase producing Klebsiella pneumoniae. J Clin Diagnostic Res. 2014;8(11):Pd01–02. doi:10.7860/JCDR/2014/10160.5198
   Google Scholar
• Khaneja M, Naprawa J, Kumar A, Piecuch S. Successful treatment of late-onset infection due to resistant Klebsiella pneumoniae in an extremely low birth weight infant using ciprofloxacin. J Perinatol. 1999;19(4):311–314. doi:10.1038/sj.jp.7200084
   Google Scholar
• CLSI M100-Ed31. Performance Standards for Antimicrobial Susceptibility Testing. Washington DC: Clinical and Laboratory Standards Institute; 2021.
   Google Scholar
• Yu VL, Hansen DS, Ko WC, et al. Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections. Emerg Infect Dis. 2007;13(7):986–993. doi:10.3201/eid1307.070187
   PubMed Web of Science ®Google Scholar
• Russo TA, Olson R, Fang CT, et al. Identification of biomarkers for differentiation of hypervirulent Klebsiella pneumoniae from classical K. pneumoniae. J Clin Microbiol. 2018;56(9). doi:10.1128/JCM.00776-18
   PubMed Web of Science ®Google Scholar
• Turton JF, Perry C, Elgohari S, Hampton CV. PCR characterization and typing of Klebsiella pneumoniae using capsular type-specific, variable number tandem repeat and virulence gene targets. J Med Microbiol. 2010;59(Pt 5):541–547. doi:10.1099/jmm.0.015198-0
   PubMed Web of Science ®Google Scholar
• Diancourt L, Passet V, Verhoef J, Grimont PA, Brisse S. Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J Clin Microbiol. 2005;43(8):4178–4182. doi:10.1128/JCM.43.8.4178-4182.2005
   PubMed Web of Science ®Google Scholar
• Martin RM, Bachman MA. Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae. Front Cell Infect Microbiol. 2018;8:4. doi:10.3389/fcimb.2018.00004
   PubMed Web of Science ®Google Scholar
• Dorman MJ, Short FL. Genome watch: Klebsiella pneumoniae: when a colonizer turns bad. Nat Rev Microbiol. 2017;15(7):384. doi:10.1038/nrmicro.2017.64
   Web of Science ®Google Scholar
• Casewell M, Phillips I. Hands as route of transmission for Klebsiella species. Br Med J. 1977;2(6098):1315–1317. doi:10.1136/bmj.2.6098.1315
   PubMed Web of Science ®Google Scholar
• Jarvis WR, Munn VP, Highsmith AK, Culver DH, Hughes JM. The epidemiology of nosocomial infections caused by Klebsiella pneumoniae. Infect Control. 1985;6(2):68–74. doi:10.1017/S0195941700062639
   Google Scholar
• Chiu CH, Su LH, Wu TL, Hung IJ. Liver abscess caused by Klebsiella pneumoniae in siblings. J Clin Microbiol. 2001;39(6):2351–2353. doi:10.1128/JCM.39.6.2351-2353.2001
   Web of Science ®Google Scholar
• Harada S, Tateda K, Mitsui H, et al. Familial spread of a virulent clone of Klebsiella pneumoniae causing primary liver abscess. J Clin Microbiol. 2011;49(6):2354–2356. doi:10.1128/JCM.00034-11
   Web of Science ®Google Scholar
• Lee CH, Chae JD, Choe W, et al. Osteomyelitis caused by hypervirulent Klebsiella pneumoniae: the first Korean case with family spread. Ann Lab Med. 2021;41(2):250–254. doi:10.3343/alm.2021.41.2.250
   PubMed Web of Science ®Google Scholar
• Gu D, Dong N, Zheng Z, et al. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018;18(1):37–46. doi:10.1016/S1473-3099(17)30489-9
   PubMed Web of Science ®Google Scholar
• Lin TL, Lee CZ, Hsieh PF, Tsai SF, Wang JT. Characterization of integrative and conjugative element ICEKp1-associated genomic heterogeneity in a Klebsiella pneumoniae strain isolated from a primary liver abscess. J Bacteriol. 2008;190(2):515–526. doi:10.1128/JB.01219-07
   PubMed Web of Science ®Google Scholar
• Chen YT, Chang HY, Lai YC, Pan CC, Tsai SF, Peng HL. Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43. Gene. 2004;337:189–198. doi:10.1016/j.gene.2004.05.008
   PubMed Web of Science ®Google Scholar
• Bulger J, MacDonald U, Olson R, Beanan J, Russo TA. Metabolite transporter PEG344 is required for full virulence of hypervirulent Klebsiella pneumoniae strain hvKP1 after pulmonary but not subcutaneous challenge. Infect Immun. 2017;85(10). doi:10.1128/IAI.00093-17
   PubMed Web of Science ®Google Scholar
• Lev AI, Astashkin EI, Kislichkina AA, et al. Comparative analysis of Klebsiella pneumoniae strains isolated in 2012–2016 that differ by antibiotic resistance genes and virulence genes profiles. Pathog Glob Health. 2018;112(3):142–151. doi:10.1080/20477724.2018.1460949
   PubMed Web of Science ®Google Scholar
• Lery LM, Frangeul L, Tomas A, et al. Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor. BMC Biol. 2014;12:41. doi:10.1186/1741-7007-12-41
   PubMed Web of Science ®Google Scholar
• Li P, Liang Q, Liu W, et al. Convergence of carbapenem resistance and hypervirulence in a highly-transmissible ST11 clone of K. pneumoniae: an epidemiological, genomic and functional study. Virulence. 2021;12(1):377–388. doi:10.1080/21505594.2020.1867468
   PubMed Web of Science ®Google Scholar
• Yang X, Dong N, Chan EW, Zhang R, Chen S. Carbapenem resistance-encoding and virulence-encoding conjugative plasmids in Klebsiella pneumoniae. Trends Microbiol. 2021;29(1):65–83. doi:10.1016/j.tim.2020.04.012
   PubMed Web of Science ®Google Scholar
• Lin YT, Siu LK, Lin JC, et al. Seroepidemiology of Klebsiella pneumoniae colonizing the intestinal tract of healthy Chinese and overseas Chinese adults in Asian countries. BMC Microbiol. 2012;12:13. doi:10.1186/1471-2180-12-13
   PubMed Web of Science ®Google Scholar
• Liao CH, Huang YT, Chang CY, Hsu HS, Hsueh PR. Capsular serotypes and multilocus sequence types of bacteremic Klebsiella pneumoniae isolates associated with different types of infections. Eur J Clin Microbiol Infect Dis. 2014;33(3):365–369. doi:10.1007/s10096-013-1964-z
   PubMed Web of Science ®Google Scholar
• Ku YH, Chuang YC, Yu WL. Clinical spectrum and molecular characteristics of Klebsiella pneumoniae causing community-acquired extrahepatic abscess. J Microbiol Immunol Infect. 2008;41(4):311–317.
   Google Scholar
• Lin JC, Koh TH, Lee N, et al. Genotypes and virulence in serotype K2 Klebsiella pneumoniae from liver abscess and non-infectious carriers in Hong Kong, Singapore and Taiwan. Gut Pathog. 2014;6:21. doi:10.1186/1757-4749-6-21
   PubMed Web of Science ®Google Scholar