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ORIGINAL RESEARCH

Predictive Value of Combination of Procalcitonin and Predisposition, Infection, Response, and Organ Dysfunction (PIRO) System in Septic Patients with Positive Blood Cultures in the Emergency Department

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Pages 6189-6202 | Received 10 Aug 2022, Accepted 13 Oct 2022, Published online: 26 Oct 2022

References

  • Hagel S, Pletz MW, Brunkhorst FM, Seifert H, Kern WV. Bakteriämie und Sepsis. Internist. 2013;54:399–407. doi:10.1007/s00108-012-3185-4
  • Lee -C-C, Chen S-Y, Chang I-J, Chen S-C, S-C W. Comparison of clinical manifestations and outcome of community-acquired bloodstream infections among the oldest old, elderly, and adult patients. Medicine. 2007;86:138–144. doi:10.1097/SHK.0b013e318067da56
  • Weinstein MP, Towns ML, Quartey SM, et al. The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis. 1997;24:584–602. doi:10.1093/clind/24.4.584
  • Long B, Koyfman A. Best clinical practice: blood culture utility in the emergency department. J Emerg Med. 2016;51:529–539. doi:10.1016/j.jemermed.2016.07.003
  • Girard TD, Ely EW. Bacteremia and sepsis in older adults. Clin Geriatr Med. 2007;23:633–647. doi:10.1016/j.cger.2007.05.003
  • Kethireddy S, Bilgili B, Sees A, et al. Culture-negative septic shock compared with culture-positive septic shock: a retrospective cohort study. Crit Care Med. 2018;46:506–512. doi:10.1097/CCM.0000000000002924
  • Coburn B, Morris AM, Tomlinson G, Detsky AS. Does this adult patient with suspected bacteremia require blood cultures? JAMA. 2012;308:502–511. doi:10.1001/jama.2012.8262.
  • Weinstein MP, Reller LB, Murphy JR, Lichtenstein KA. The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. I. Laboratory and epidemiologic observations. Rev Infect Dis. 1983;5:35–53. doi:10.1093/clinids/5.1.35
  • Berild D, Mohseni A, Diep LM, Jensenius M, Ringertz SH. Adjustment of antibiotic treatment according to the results of blood cultures leads to decreased antibiotic use and costs. J Antimicrob Chemother. 2006;57:326–330. doi:10.1093/jac/dki463
  • Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med. 2003;31:1250–1256. doi:10.1097/01.CCM.0000050454.01978.3B
  • Chen Y-X, C-S L. Risk stratification and prognostic performance of the predisposition, infection, response, and organ dysfunction (PIRO) scoring system in septic patients in the emergency department: a cohort study. Crit Care. 2014;18:R74. doi:10.1186/cc13832
  • Howell MD, Talmor D, Schuetz P, Hunziker S, Jones AE, Shapiro NI. Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit Care Med. 2011;39:322–327. doi:10.1097/CCM.0b013e3182037a8e
  • Gai L, Tong Y, Yan B-Q. Research on the diagnostic effect of PCT level in serum on patients with sepsis due to different pathogenic causes. Eur Rev Med Pharmacol Sci. 2018;22:4238–4242. doi:10.26355/eurrev_201807_15418
  • Shokripour M, Omidifar N, Salami K, Moghadami M, Samizadeh B, Tornesello ML. Diagnostic accuracy of immunologic biomarkers for accurate diagnosis of bloodstream infection in patients with malignancy: procalcitonin in comparison with C-reactive protein. Can J Infect Dis Med Microbiol. 2020;2020:8362109. doi:10.1155/2020/8362109
  • Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801–810. doi:10.1001/jama.2016.0287
  • Tafelski S, Nachtigall I, Stengel S, Wernecke K, Spies C. Comparison of three models for sepsis patient discrimination according to PIRO: predisposition, infection, response and organ dysfunction. Minerva Anestesiol. 2015;81:264–271.
  • Peker N, Couto N, Sinha B, Rossen JW. Diagnosis of bloodstream infections from positive blood cultures and directly from blood samples: recent developments in molecular approaches. Clin Microbiol Infect. 2018;24:944–955. doi:10.1016/j.cmi.2018.05.007
  • Opota O, Croxatto A, Prod’hom G, Greub G. Blood culture-based diagnosis of bacteraemia: state of the art. Clin Microbiol Infect. 2015;21:313–322. doi:10.1016/j.cmi.2015.01.003
  • Rutanga JP, Nyirahabimana T. Clinical significance of molecular diagnostic tools for bacterial bloodstream infections: a systematic review. Interdiscip Perspect Infect Dis. 2016;2016:6412085. doi:10.1155/2016/6412085
  • Loonen AJM, Wolffs PFG, Bruggeman CA, van den Brule AJC. Developments for improved diagnosis of bacterial bloodstream infections. Eur J Clin Microbiol Infect Dis. 2014;33:1687–1702. doi:10.1007/s10096-014-2153-4
  • Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41:580–637. doi:10.1097/CCM.0b013e31827e83af
  • Dubourg G, Raoult D. Emerging methodologies for pathogen identification in positive blood culture testing. Expert Rev Mol Diagn. 2016;16:97–111. doi:10.1586/14737159.2016.1112274
  • Heron M. Deaths: leading Causes for 2014. Natl Vital Stat Rep. 2016;65:1–96.
  • GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117–171. doi:10.1016/S0140-6736(14)61682-2
  • Reinhart K, Daniels R, Kissoon N, Machado FR, Schachter RD, Finfer S. Recognizing sepsis as a global health priority - a WHO resolution. N Engl J Med. 2017;377:414–417. doi:10.1056/NEJMp1707170
  • Kaukonen K-M, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA. 2014;311:1308–1316. doi:10.1001/jama.2014.2637
  • Bearman GML, Wenzel RP. Bacteremias: a leading cause of death. Arch Med Res. 2005;36:646–659. doi:10.1016/j.arcmed.2005.02.005
  • Kumar A, Zarychanski R, Light B, et al. Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis. Crit Care Med. 2010;38:1773–1785. doi:10.1097/CCM.0b013e3181eb3ccd.
  • Sivayoham N, Hussain AN, Shabbo L, Christie D. An observational cohort study of the performance of the REDS score compared to the SIRS criteria, NEWS2, CURB65, SOFA, MEDS and PIRO scores to risk-stratify emergency department suspected sepsis. Ann Med. 2021;53:1863–1874. doi:10.1080/07853890.2021.1992495
  • Valentania V, Somasetia DH, Hilmanto D, Setiabudi D, Nataprawira HMN. Modified PIRO (predisposition, insult, response, organ dysfunction) severity score as a predictor for mortality of children with pneumonia in Hasan Sadikin Hospital, Bandung, Indonesia. Multidiscip Respir Med. 2021;16(1):735. doi:10.4081/mrm.2021.735
  • Cardoso T, Rodrigues PP, Nunes C, et al. Prospective international validation of the predisposition, infection, response and organ dysfunction (PIRO) clinical staging system among intensive care and general ward patients. Ann Intensive Care. 2021;11:180. doi:10.1186/s13613-021-00966-7
  • Rao H, Dutta S, Menon P, Attri S, Sachdeva N, Malik M. Procalcitonin and C-reactive protein for diagnosing post-operative sepsis in neonates. J Paediatr Child Health. 2022;58:593–599. doi:10.1111/jpc.15774
  • Tambo M, Taguchi S, Nakamura Y, Okegawa T, Fukuhara H. Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definitions in obstructive acute pyelonephritis. BMC Urol. 2020;20:23. doi:10.1186/s12894-020-00596-4
  • Zhai G-H, Zhang W, Xiang Z, et al. Diagnostic value of sIL-2R, TNF-α and PCT for sepsis infection in patients with closed abdominal injury complicated with severe multiple abdominal injuries. Front Immunol. 2021;12:741268. doi:10.3389/fimmu.2021.741268
  • Moreno RP, Metnitz B, Adler L, et al. Sepsis mortality prediction based on predisposition, infection and response. Intensive Care Med. 2008;34:496–504. doi:10.1007/s00134-007-0943-1
  • Padkin A, Goldfrad C, Brady AR, Young D, Black N, Rowan K. Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med. 2003;31:2332–2338. doi:10.1097/01.CCM.0000085141.75513.2B