Molecular Characteristics and Gonococcal Genetic Island Carrying Status of Thirty-Seven Neisseria gonorrhoeae Isolates in Eastern China

References

• Harrison OB, Clemence M, Dillard JP, et al. Genomic analyses of Neisseria gonorrhoeae reveal an association of the gonococcal genetic island with antimicrobial resistance. J Infect. 2016;73(6):578–587. doi:10.1016/j.jinf.2016.08.010
   Web of Science ®Google Scholar
• Harrison OB, Cehovin A, Skett J, et al. Neisseria gonorrhoeae population genomics: use of the gonococcal core genome to improve surveillance of antimicrobial resistance. J Infect Dis. 2020;222(11):1816–1825. doi:10.1093/infdis/jiaa002
   PubMed Web of Science ®Google Scholar
• Shaskolskiy B, Kravtsov D, Kandinov I, et al. Comparative whole-genome analysis of Neisseria gonorrhoeae; isolates revealed changes in the gonococcal genetic island and specific genes as a link to antimicrobial resistance. Front Cell Infect Microbiol. 2022;12:831336. doi:10.3389/fcimb.2022.831336
   Web of Science ®Google Scholar
• Callaghan MM, Heilers JH, van der Does C, Dillard JP. Secretion of chromosomal DNA by the Neisseria gonorrhoeae type IV secretion system. Curr Top Microbiol Immunol. 2017;413:323–345. doi:10.1007/978-3-319-75241-9_13
   Web of Science ®Google Scholar
• Dillard JP, Seifert HS. A variable genetic island specific for Neisseria gonorrhoeae is involved in providing DNA for natural transformation and is found more often in disseminated infection isolates. Mol Microbiol. 2001;41(1):263–277. doi:10.1046/j.1365-2958.2001.02520.x
   Web of Science ®Google Scholar
• Jores J, Rumer L, Kiessling S, Kaper JB, Wieler LH. A novel locus of enterocyte effacement (LEE) pathogenicity island inserted at pheV in bovine Shiga toxin-producing Escherichia coli strain O103:H2. FEMS Microbiol Lett. 2001;204(1):75–79. doi:10.1111/j.1574-6968.2001.tb10866.x
   Web of Science ®Google Scholar
• Carniel E. The Yersinia high-pathogenicity island: an iron-uptake island. Microbes Infect. 2001;3(7):561–569. doi:10.1016/S1286-4579(01)01412-5
   PubMed Web of Science ®Google Scholar
• Morschhäuser J, Köhler G, Ziebuhr W, et al. Evolution of microbial pathogens. Philos Trans R Soc Lond B Biol Sci. 2000;355(1397):695–704. doi:10.1098/rstb.2000.0609
   Web of Science ®Google Scholar
• Arnold DL, Pitman A, Jackson RW. Pathogenicity and other genomic islands in plant pathogenic bacteria. Mol Plant Pathol. 2003;4(5):407–420. doi:10.1046/j.1364-3703.2003.00187.x
   Web of Science ®Google Scholar
• Jackson RW, Athanassopoulos E, Tsiamis G, et al. Identification of a pathogenicity island, which contains genes for virulence and avirulence, on a large native plasmid in the bean pathogen Pseudomonas syringae pathovar phaseolicola. Proc Natl Acad Sci U S A. 1999;96(19):10875–10880. doi:10.1073/pnas.96.19.10875
   Web of Science ®Google Scholar
• Gal-Mor O, Finlay BB. Pathogenicity islands: a molecular toolbox for bacterial virulence. Cell Microbiol. 2006;8(11):1707–1719. doi:10.1111/j.1462-5822.2006.00794.x
   PubMed Web of Science ®Google Scholar
• Rivas LA, Mansfield J, Tsiamis G, Jackson RW, Murillo J. Changes in race-specific virulence in Pseudomonas syringae pv. phaseolicola are associated with a chimeric transposable element and rare deletion events in a plasmid-borne pathogenicity island. Appl Environ Microbiol. 2005;71(7):3778–3785. doi:10.1128/AEM.71.7.3778-3785.2005
   Web of Science ®Google Scholar
• Hacker J, Bender L, Ott M, et al. Deletions of chromosomal regions coding for fimbriae and hemolysins occur in vitro and in vivo in various extraintestinal Escherichia coli isolates. Microb Pathog. 1990;8(3):213–225. doi:10.1016/0882-4010(90)90048-U
   Web of Science ®Google Scholar
• Novick RP, Fischetti VA, Novick RP. Pathogenicity islands and their role in staphylococcal biology. Microbiol Spectr. 2019;7(3). doi:10.1128/microbiolspec.GPP3-0062-2019
   Web of Science ®Google Scholar
• Noto JM, Peek RM. The helicobacter pylori cag pathogenicity island. Methods Mol Biol. 2012;921:41–50.
   PubMedGoogle Scholar
• Schubert S, Rakin A, Heesemann J. The Yersinia high-pathogenicity island (HPI): evolutionary and functional aspects. Int J Med Microbiol. 2004;294(2–3):83–94. doi:10.1016/j.ijmm.2004.06.026
   Web of Science ®Google Scholar
• Lou L, Zhang P, Piao R, Wang Y. Salmonella pathogenicity island 1 (SPI-1) and its complex regulatory network. Front Cell Infect Microbiol. 2019;9:270. doi:10.3389/fcimb.2019.00270
   PubMed Web of Science ®Google Scholar
• Harrison EM, Carter ME, Luck S, et al. Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14. Infect Immun. 2010;78(4):1437–1446. doi:10.1128/IAI.00621-09
   PubMed Web of Science ®Google Scholar
• Murphy RA, Boyd EF. Three pathogenicity islands of Vibrio cholerae can excise from the chromosome and form circular intermediates. J Bacteriol. 2008;190(2):636–647. doi:10.1128/JB.00562-07
   Web of Science ®Google Scholar
• van Ulsen P, Tommassen J. Protein secretion and secreted proteins in pathogenic Neisseriaceae. FEMS Microbiol Rev. 2006;30(2):292–319. doi:10.1111/j.1574-6976.2006.00013.x
   Web of Science ®Google Scholar
• Callaghan MM, Klimowicz AK, Shockey AC, Kane J, Pepperell CS, Dillard JP. Transcriptional and translational responsiveness of the Neisseria gonorrhoeae type IV secretion system to conditions of host infections. Infect Immun. 2021;89(12):e0051921. doi:10.1128/IAI.00519-21
   Web of Science ®Google Scholar
• Mavroidi A, Tzelepi E, Siatravani E, et al. Analysis of emergence of quinolone-resistant gonococci in Greece by combined use of Neisseria gonorrhoeae multiantigen sequence typing and multilocus sequence typing. J Clin Microbiol. 2011;49(4):1196–1201. doi:10.1128/JCM.02233-10
   Web of Science ®Google Scholar
• Yoon SH, Park YK, Lee S, et al. Towards pathogenomics: a web-based resource for pathogenicity islands. Nucleic Acids Res. 2007;35:D395–D400. doi:10.1093/nar/gkl790
   Web of Science ®Google Scholar
• CLSI. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing. CLSI Supplement M100. 30th ed. Wayne, PA: Clinical and Laboratory Standards Institute; 2020.
   Google Scholar
• Wan C, Li Y, Le W, et al. Increasing resistance to azithromycin in Neisseria gonorrhoeae in Eastern Chinese cities: resistance mechanisms and genetic diversity among isolates from Nanjing. Antimicrob Agents Chemother. 2018;62(5). doi:10.1128/AAC.02499-17
   Web of Science ®Google Scholar
• Allen VG, Farrell DJ, Rebbapragada A, et al. Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. Antimicrob Agents Chemother. 2011;55(2):703–712. doi:10.1128/AAC.00788-10
   PubMed Web of Science ®Google Scholar
• Zheng Z, Chen H, Deng T, et al.Drug resistance mechanism and molecular characteristics of tetracycline-resistant Neisseria gonorrhoeae clinical isolates from a tertiary hospital. Chin J Microbiol Immunol. 2019;39(2):2.
   Google Scholar
• Zheng Z, Liu L, Shen X, et al. Antimicrobial resistance and molecular characteristics among Neisseria gonorrhoeae Clinical isolates in A Chinese Tertiary Hospital. Infect Drug Resist. 2019;12:3301–3309. doi:10.2147/IDR.S221109
   Web of Science ®Google Scholar
• Unemo M, Seifert HS, Hook EW, et al. Gonorrhoea. Nat Rev Dis Primers. 2019;5(1):79. doi:10.1038/s41572-019-0128-6
   PubMed Web of Science ®Google Scholar
• Unemo M. Current and future antimicrobial treatment of gonorrhoea – the rapidly evolving Neisseria gonorrhoeae continues to challenge. BMC Infect Dis. 2015;15(1):364. doi:10.1186/s12879-015-1029-2
   PubMed Web of Science ®Google Scholar
• Hochhut B, Dobrindt U, Hacker J. Pathogenicity islands and their role in bacterial virulence and survival. Contrib Microbiol. 2005;12:234–254.
   Google Scholar
• Nieto PA, Pardo-Roa C, Salazar-Echegarai FJ, et al. New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence. Microbes Infect. 2016;18(5):302–309. doi:10.1016/j.micinf.2016.02.001
   Web of Science ®Google Scholar
• Zhang J, van der Veen S. Neisseria gonorrhoeae 23S rRNA A2059G mutation is the only determinant necessary for high-level azithromycin resistance and improves in vivo biological fitness. J Antimicrob Chemother. 2019;74(2):407–415. doi:10.1093/jac/dky438
   PubMed Web of Science ®Google Scholar
• Zola TA, Strange HR, Dominguez NM, Dillard JP, Cornelissen CN. Type IV secretion machinery promotes ton-independent intracellular survival of Neisseria gonorrhoeae within cervical epithelial cells. Infect Immun. 2010;78(6):2429–2437. doi:10.1128/IAI.00228-10
   Web of Science ®Google Scholar
• Ortiz Á, Santander M, E. P, Lugo PJ. Neisseria gonorrhoeae: un patógeno díscolo. Conceptos microbiológicos, resistencia a antimicrobianos y su vigilancia epidemiológica en Chile [Neisseria gonorrhoeae: a wayward pathogen. Microbiological concepts, antimicrobial resistance and its epidemiological surveillance in Chile]. Rev Chilena Infectol. 2021;38(4):512–522. Spanish. doi:10.4067/S0716-10182021000400512
   Web of Science ®Google Scholar
• Aitolo GL, Adeyemi OS, Afolabi BL, Owolabi AO. Neisseria gonorrhoeae antimicrobial resistance: past to present to future. Curr Microbiol. 2021;78(3):867–878. doi:10.1007/s00284-021-02353-8
   PubMed Web of Science ®Google Scholar
• Unemo M, Golparian D, Eyre DW. Antimicrobial Resistance in Neisseria gonorrhoeae and Treatment of Gonorrhea. Methods Mol Biol. 2019;1997:37–58.
   Google Scholar
• Tang C, Holden D. Pathogen virulence genes--implications for vaccines and drug therapy. Br Med Bull. 1999;55(2):387–400. doi:10.1258/0007142991902448
   Web of Science ®Google Scholar