Progress in Multidisciplinary Treatment of Fournier’s Gangrene

References

• Shyam DC, Rapsang AG. Fournier’s gangrene. Surgeon. 2013;11(4):222–232. doi:10.1016/j.surge.2013.02.001
   Web of Science ®Google Scholar
• Fournier JA. Gangrene foudroyante de la verge. Semaine Medicale. 1883;3:345–348.
   Google Scholar
• Wilson B. Necrotizing fasciitis. Am Surg. 1952;18(4):416–431.
   Google Scholar
• Thwaini A, Khan A, Malik A, et al. Fournier’s gangrene and its emergency management. Postgrad Med J. 2006;82(970):516–519. doi:10.1136/pgmj.2005.042069
   Web of Science ®Google Scholar
• Sorensen MD, Krieger JN, Rivara FP, et al. Fournier’s Gangrene: population based epidemiology and outcomes. J Urol. 2009;181(5):2120–2126. doi:10.1016/j.juro.2009.01.034
   Web of Science ®Google Scholar
• Sorensen MD, Krieger JN. Fournier’s Gangrene: epidemiology and outcomes in the general US population. Urol Int. 2016;97(3):249–259. doi:10.1159/000445695
   Web of Science ®Google Scholar
• Eke N. Fournier’s gangrene: a review of 1726 cases. Br J Surg. 2000;87(6):718–728. doi:10.1046/j.1365-2168.2000.01497.x
   PubMed Web of Science ®Google Scholar
• Furr J, Watts T, Street R, et al. Contemporary trends in the inpatient management of Fournier’s Gangrene: predictors of length of stay and mortality based on population-based sample. Urology. 2017;102:79–84. doi:10.1016/j.urology.2016.09.021
   Web of Science ®Google Scholar
• Beecroft NJ, Jaeger CD, Rose JR, et al. Fournier’s Gangrene in females: presentation and management at a tertiary center. Urology. 2021;151:113–117. doi:10.1016/j.urology.2020.05.056
   Web of Science ®Google Scholar
• Ballard DH, Raptis CA, Guerra J, et al. Preoperative CT findings and interobserver reliability of Fournier Gangrene. AJR Am J Roentgenol. 2018;211(5):1051–1057. doi:10.2214/AJR.18.19683
   Web of Science ®Google Scholar
• Ugwumba FO, Nnabugwu I, Ozoemena OF. Fournier’s gangrene – analysis of management and outcome in south-eastern Nigeria. S Afr J Surg. 2012;50(1):16–19.
   Web of Science ®Google Scholar
• Radcliffe RS, Khan MA. Mortality associated with Fournier’s gangrene remains unchanged over 25 years. BJU Int. 2020;125(4):610–616. doi:10.1111/bju.14998
   Web of Science ®Google Scholar
• Bowen D, Juliebø-Jones P, Somani BK. Global outcomes and lessons learned in the management of Fournier’s gangrene from high-volume centres: findings from a literature review over the last two decades. World J Urol. 2022;40(10):2399–2410. doi:10.1007/s00345-022-04139-4
   Web of Science ®Google Scholar
• Yilmaz Baser H, Zumrutbas AE, Yilmaz A, et al. Importance of emergency department waiting period in Fournier’s Gangrene; 10 years of experience. Int J Clin Pract. 2021;75(9):e14361. doi:10.1111/ijcp.14361
   Web of Science ®Google Scholar
• Goh T, Goh LG, Ang CH, et al. Early diagnosis of necrotizing fasciitis. Br J Surg. 2014;101(1):e119–e125. doi:10.1002/bjs.9371
   PubMed Web of Science ®Google Scholar
• El-Qushayri AE, Khalaf KM, Dahy A, et al. Fournier’s gangrene mortality: a 17-year systematic review and meta-analysis. Int J Infect Dis. 2020;92:218–225. doi:10.1016/j.ijid.2019.12.030
   Web of Science ®Google Scholar
• Laor E, Palmer LS, Tolia BM, et al. Outcome prediction in patients with Fournier’s gangrene. J Urol. 1995;154(1):89–92. doi:10.1016/S0022-5347(01)67236-7
   Web of Science ®Google Scholar
• Bozkurt O, Sen V, Demir O, et al. Evaluation of the utility of different scoring systems (FGSI, LRINEC and NLR) in the management of Fournier’s gangrene. Int Urol Nephrol. 2015;47(2):243–248. doi:10.1007/s11255-014-0897-5
   Web of Science ®Google Scholar
• Elsaket AE, Maharajh S, Urry RJ. The presentation, management and outcomes of Fournier’s gangrene at a tertiary urology referral centre in South Africa. S Afr Med J. 2018;108(8):671–676. doi:10.7196/SAMJ.2018.v108i8.13100
   Web of Science ®Google Scholar
• Ghodoussipour SB, Gould D, Lifton J, et al. Surviving Fournier’s gangrene: multivariable analysis and a novel scoring system to predict length of stay. J Plast Reconstr Aesthet Surg. 2018;71(5):712–718. doi:10.1016/j.bjps.2017.12.005
   Web of Science ®Google Scholar
• Vick R, Carson CC. Fournier’s disease. Urol Clin North Am. 1999;26(4):841–849. doi:10.1016/S0094-0143(05)70224-X
   Web of Science ®Google Scholar
• Smith GL, Bunker CB, Dinneen MD. Fournier’s gangrene. Br J Urol. 1998;81(3):347–355. doi:10.1046/j.1464-410x.1998.00532.x
   PubMedGoogle Scholar
• Esposito S, Bassetti M, Concia E, et al. Diagnosis and management of skin and soft-tissue infections (SSTI). A literature review and consensus statement: an update. J Chemother. 2017;29(4):197–214. doi:10.1080/1120009X.2017.1311398
   PubMed Web of Science ®Google Scholar
• Stevens DL, Bryant AE. Necrotizing soft-tissue infections. N Engl J Med. 2018;378(10):971. doi:10.1056/NEJMc1800049
   Web of Science ®Google Scholar
• Elliott D, Kufera JA, Myers RA. The microbiology of necrotizing soft tissue infections. Am J Surg. 2000;179(5):361–366. doi:10.1016/S0002-9610(00)00360-3
   PubMed Web of Science ®Google Scholar
• Goodell KH, Jordan MR, Graham R, et al. Rapidly advancing necrotizing fasciitis caused by Photobacterium (Vibrio) damsela: a hyperaggressive variant. Crit Care Med. 2004;32(1):278–281. doi:10.1097/01.CCM.0000104920.01254.82
   Web of Science ®Google Scholar
• Morgan MS. Diagnosis and management of necrotising fasciitis: a multiparametric approach. J Hosp Infect. 2010;75(4):249–257. doi:10.1016/j.jhin.2010.01.028
   PubMed Web of Science ®Google Scholar
• Garcia NM, Cai J. Aggressive Soft Tissue Infections. Surg Clin North Am. 2018;98(5):1097–1108. doi:10.1016/j.suc.2018.05.001
   PubMed Web of Science ®Google Scholar
• Tang LM, Su YJ, Lai YC. The evaluation of microbiology and prognosis of Fournier’s gangrene in past five years. Springerplus. 2015;4(1):14. doi:10.1186/s40064-014-0783-8
   Google Scholar
• Castillejo Becerra CM, Jaeger CD, Rose JR, et al. Microorganisms and antibiogram patterns in Fournier’s Gangrene: contemporary experience from a single tertiary care center. J Urol. 2020;204(6):1249–1255. doi:10.1097/JU.0000000000001194
   Web of Science ®Google Scholar
• Thayer J, Mailey BA. Two-stage neoscrotum reconstruction using porcine bladder extracellular Matrix after Fournier’s Gangrene. Plast Reconstr Surg Glob Open. 2020;8(8):e3034. doi:10.1097/GOX.0000000000003034
   Google Scholar
• El-Shazly M, Aziz M, Aboutaleb H, et al. Management of equivocal (early) Fournier’s gangrene. Ther Adv Urol. 2016;8(5):297–301. doi:10.1177/1756287216655673
   Google Scholar
• Sarkis P, Farran F, Khoury R, et al. Gangrène de Fournier : revue de la littérature récente[Fournier’s gangrene: a review of the recent literature]. Prog Urol. 2009;19(2):75–84. French. doi:10.1016/j.purol.2008.09.050
   Web of Science ®Google Scholar
• Xiu F, Stanojcic M, Diao L, et al. Stress hyperglycemia, insulin treatment, and innate immune cells. Int J Endocrinol. 2014;2014:486403. doi:10.1155/2014/486403
   PubMed Web of Science ®Google Scholar
• Trevelin SC, Carlos D, Beretta M, et al. Diabetes mellitus and sepsis: a challenging association. Shock. 2017;47(3):276–287. doi:10.1097/SHK.0000000000000778
   Web of Science ®Google Scholar
• Hatanaka E, Monteagudo PT, Marrocos MS, et al. Neutrophils and monocytes as potentially important sources of proinflammatory cytokines in diabetes. Clin Exp Immunol. 2006;146(3):443–447. doi:10.1111/j.1365-2249.2006.03229.x
   Web of Science ®Google Scholar
• Voelzke BB, Hagedorn JC. Presentation and Diagnosis of Fournier Gangrene. Urology. 2018;114:8–13. doi:10.1016/j.urology.2017.10.031
   Web of Science ®Google Scholar
• Martinschek A, Evers B, Lampl L, et al. Prognostic aspects, survival rate, and predisposing risk factors in patients with Fournier’s gangrene and necrotizing soft tissue infections: evaluation of clinical outcome of 55 patients. Urol Int. 2012;89(2):173–179. doi:10.1159/000339161
   Web of Science ®Google Scholar
• Ferretti M, Saji AA, Phillips J. Fournier’s Gangrene: a review and outcome comparison from 2009 to 2016. Adv Wound Care. 2017;6(9):289–295. doi:10.1089/wound.2017.0730
   Web of Science ®Google Scholar
• Hatipoglu E, Demiryas S, Şimşek O, et al. Fournier’s gangrene: five years’ experience from a single center in Turkey. Ulus Travma Acil Cerrahi Derg. 2020;26(2):235–241. doi:10.14744/tjtes.2020.66805
   Web of Science ®Google Scholar
• David R, Traeger L, Kahokehr A, et al. A prospective case series of Fournier’s gangrene at a tertiary centre involving adjacent organs. ANZ J Surg. 2021;91(12):2817–2823. doi:10.1111/ans.17005
   Web of Science ®Google Scholar
• Montrief T, Long B, Koyfman A, et al. Fournier Gangrene: a review for emergency clinicians. J Emerg Med. 2019;57(4):488–500. doi:10.1016/j.jemermed.2019.06.023
   Web of Science ®Google Scholar
• Herrera Ortiz AF, Arámbula JG, Del Castillo V, et al. Fournier’s Gangrene with retroperitoneal extension as the first manifestation of the Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS). Cureus. 2021;13(12):e20517. doi:10.7759/cureus.20517
   Web of Science ®Google Scholar
• Çalışkan S, Özsoy E, Sungur M, et al. Fournier’s gangrene: review of 36 cases. Ulus Travma Acil Cerrahi Derg. 2019;25(5):479–483. doi:10.14744/tjtes.2019.30232
   Web of Science ®Google Scholar
• Koyama M, Kitazawa M, Ehara T, et al. 直腸癌に対する化学療法中に発症した会陰部壊疽性筋膜炎の2 例 [Two cases of Fournier’s gangrene that occurred during chemotherapy for rectal cancer]. Gan To Kagaku Ryoho. 2017;44(2):169–171. Japanese.
   Google Scholar
• Imamura S, Ogura N, Aoki Y, et al. 二次治療IRIS+Bevacizumab 投与中にフルニエ壊疽を発症した直腸肛門管癌の1 例 [A case of Fournier’s gangrene during second-line IRIS plus bevacizumab chemotherapy for rectal and anal canal cancer]. Gan To Kagaku Ryoho. 2022;49(5):597–599. Japanese.
   Google Scholar
• Joury A, Mahendra A, Alshehri M, et al. Extensive necrotizing fasciitis from Fournier’s gangrene. Urol Case Rep. 2019;26:100943. doi:10.1016/j.eucr.2019.100943
   Web of Science ®Google Scholar
• García-García A, Galeano-Valle F, Nuevo-González JA, et al. Fournier’s gangrene and SGLT2 inhibitors: a case study. Endocrinol Diabetes Nutr. 2020;67(6):423–425. doi:10.1016/j.endinu.2019.12.007
   Web of Science ®Google Scholar
• Bersoff-Matcha SJ, Chamberlain C, Cao C, et al. Fournier Gangrene associated with sodium-glucose cotransporter-2 inhibitors: a review of spontaneous postmarketing cases. Ann Intern Med. 2019;170(11):764–769. doi:10.7326/M19-0085
   PubMed Web of Science ®Google Scholar
• Taylor L, Asmar O, Mandal A, et al. Perspectives from a regional plastic surgery centre on evidence for the purported link between SGLT2 inhibitors and Fournier’s Gangrene. Front Surg. 2021;8:754101. doi:10.3389/fsurg.2021.754101
   Web of Science ®Google Scholar
• Duarte I, Outerelo C, Santana A, et al. Fournier Gangrene as a complication of a perinephric abscess after kidney transplant: a case report. Transplant Proc. 2021;53(4):1281–1283. doi:10.1016/j.transproceed.2021.02.009
   Web of Science ®Google Scholar
• Santucci RA, Joyce GF, Wise M. Male urethral stricture disease. J Urol. 2007;177(5):1667–1674. doi:10.1016/j.juro.2007.01.041
   PubMed Web of Science ®Google Scholar
• Fialkov JM, Watkins K, Fallon B, et al. Fournier’s gangrene with an unusual urologic etiology. Urology. 1998;52(2):324–327. doi:10.1016/S0090-4295(98)00195-2
   Web of Science ®Google Scholar
• Mundy AR, Andrich DE. Urethral strictures. BJU Int. 2011;107(1):6–26. doi:10.1111/j.1464-410X.2010.09800.x
   PubMed Web of Science ®Google Scholar
• Louro JM, Albano M, Baltazar J, et al. Fournier’s Gangrene: 10-year experience of a plastic surgery and burns department at a tertiary hospital. Acta Med Port. 2019;32(5):368–374. doi:10.20344/amp.11003
   Web of Science ®Google Scholar
• Yücel M, Özpek A, Başak F, et al. Fournier’s gangrene: a retrospective analysis of 25 patients. Ulus Travma Acil Cerrahi Derg. 2017;23(5):400–404. doi:10.5505/tjtes.2017.01678
   Web of Science ®Google Scholar
• Numoto S, Kurahashi H, Azuma Y, et al. Fournier’s gangrene during ACTH therapy. Brain Dev. 2017;39(5):435–438. doi:10.1016/j.braindev.2016.11.012
   Web of Science ®Google Scholar
• Ameh EA, Dauda MM, Sabiu L, et al. Fournier’s gangrene in neonates and infants. Eur J Pediatr Surg. 2004;14(6):418–421. doi:10.1055/s-2004-821138
   Web of Science ®Google Scholar
• Fukui K, Fujioka M, Ishiyama S. Sacral pressure ulcer-induced Fournier’s Gangrene extending to the retroperitoneum: a case report. Wounds. 2018;30(1):E5–E8.
   Google Scholar
• Zakariya-Yousef Breval I, Trujillo Díaz N, De La Herranz Guerrero P. [Fournier’s gangrene secondary to inguinoperineal abscess caused by Acidaminococcus intestini and Streptococcus gallolyticus spp. pasteurianus]. Rev Esp Quimioter. 2021;34(6):679–681. Spanish. doi:10.37201/req/070.2021
   Web of Science ®Google Scholar
• Sihombing AT, Palgunadi IN, Stefanus D. Complete urethral disruption as a complication of urethral catheterization presenting as scrotal mass: a rare case. Urol Case Rep. 2020;33:101378. doi:10.1016/j.eucr.2020.101378
   Web of Science ®Google Scholar
• López Pacios JC, Sánchez Merino JM, Piñeiro Fernández MC, et al. Gangrena de Fournier secundaria a cateterismo uretral [Fournier’s gangrene secondary to urethral catheterization]. Arch Esp Urol. 2005;58(2):167–170. Spanish. doi:10.4321/s0004-06142005000200012
   Google Scholar
• Kumagai A, Ogawa D, Koyama T, et al. 経直腸的前立腺生検後にフルニエ壊疽を発症した管理不良な糖尿病患者の1例 [A case report of Fournier’s gangrene in a diabetic patient induced by transrectal prostate biopsy (TRPB)]. Nihon Hinyokika Gakkai Zasshi. 2002;93(5):648–651. Japanese. doi:10.5980/jpnjurol1989.93.648
   Google Scholar
• Zingaro MD, Boni A, Vermandois JAR, et al. Fournier’s Gangrene and intravenous drug abuse: an unusual case report and review of the literature. Open Med. 2019;14:694–710. doi:10.1515/med-2019-0114
   Web of Science ®Google Scholar
• Ghazanfar H, Espinosa PV, Zeana C, et al. Penile necrosis associated with local intravenous injection of cocaine. Am J Case Rep. 2022;23:e935250. doi:10.12659/AJCR.935250
   Web of Science ®Google Scholar
• Ferreira PC, Reis JC, Amarante JM, et al. Fournier’s gangrene: a review of 43 reconstructive cases. Plast Reconstr Surg. 2007;119(1):175–184. doi:10.1097/01.prs.0000244925.80290.57
   Web of Science ®Google Scholar
• Erickson BA, Miller AC, Warner HL, et al. Understanding the prodrome of necrotizing soft tissue infections of the genitalia (Fournier’s Gangrene) and the incidence, duration, and risk factors associated with potential missed opportunities for an earlier diagnosis: a population-based longitudinal study. J Urol. 2022;25:10–97.
   Google Scholar
• Lahouar R, Naouar S, Ben Khalifa B, et al. Isolated Penile Fournier’s gangrene: a very rare entity. Urol Case Rep. 2021;37:101608.
   Web of Science ®Google Scholar
• Abass-Shereef J, Kovacs M, Simon EL. Fournier’s Gangrene masking as perineal and scrotal cellulitis. Am J Emerg Med. 2018;36(9):1719.e1–1719.e2. doi:10.1016/j.ajem.2018.05.067
   Web of Science ®Google Scholar
• Singh A, Ahmed K, Aydin A, et al. Fournier’s gangrene. A clinical review. Arch Ital Urol Androl. 2016;88(3):157–164. doi:10.4081/aiua.2016.3.157
   Google Scholar
• Moussa M, Abou Chakra M. Isolated Penile Fournier’s gangrene: a case report and literature review. Int J Surg Case Rep. 2019;62:65–68. doi:10.1016/j.ijscr.2019.08.012
   Web of Science ®Google Scholar
• Fernando SM, Tran A, Cheng W, et al. Necrotizing soft tissue infection: diagnostic accuracy of physical examination, imaging, and LRINEC score: a systematic review and meta-analysis. Ann Surg. 2019;269(1):58–65. doi:10.1097/SLA.0000000000002774
   PubMed Web of Science ®Google Scholar
• Zacharias N, Velmahos GC, Salama A, et al. Diagnosis of necrotizing soft tissue infections by computed tomography. Arch Surg. 2010;145(5):452–455. doi:10.1001/archsurg.2010.50
   Google Scholar
• Ballard DH, Mazaheri P, Raptis CA, et al. Fournier Gangrene in men and women: appearance on CT, Ultrasound, and MRI and what the surgeon wants to know. Can Assoc Radiol J. 2020;71(1):30–39. doi:10.1177/0846537119888396
   Web of Science ®Google Scholar
• Mcgillicuddy EA, Lischuk AW, Schuster KM, et al. Development of a computed tomography-based scoring system for necrotizing soft-tissue infections. J Trauma. 2011;70(4):894–899. doi:10.1097/TA.0b013e3182134a76
   Google Scholar
• Yoneda A, Fujita F, Tokai H, et al. MRI can determine the adequate area for debridement in the case of Fournier’s gangrene. Int Surg. 2010;95(1):76–79.
   Web of Science ®Google Scholar
• Sweet DE, Feldman MK, Remer EM. Imaging of the acute scrotum: keys to a rapid diagnosis of acute scrotal disorders. Abdom Radiol. 2020;45(7):2063–2081. doi:10.1007/s00261-019-02333-4
   Web of Science ®Google Scholar
• Lee PC, Turnidge J, Mcdonald PJ. Fine-needle aspiration biopsy in diagnosis of soft tissue infections. J Clin Microbiol. 1985;22(1):80–83. doi:10.1128/jcm.22.1.80-83.1985
   PubMed Web of Science ®Google Scholar
• Avery LL, Scheinfeld MH. Imaging of penile and scrotal emergencies. Radiographics. 2013;33(3):721–740. doi:10.1148/rg.333125158
   Web of Science ®Google Scholar
• Auerbach J, Bornstein K, Ramzy M, et al. Fournier Gangrene in the emergency department: diagnostic dilemmas, treatments and current perspectives. Open Access Emerg Med. 2020;12:353–364. doi:10.2147/OAEM.S238699
   Web of Science ®Google Scholar
• Johnson LJ, Crisologo PA, Sivaganesan S, et al. Evaluation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score for detecting necrotizing soft tissue infections in patients with diabetes and lower extremity infection. Diabetes Res Clin Pract. 2021;171:108520. doi:10.1016/j.diabres.2020.108520
   Web of Science ®Google Scholar
• Wong CH, Khin LW, Heng KS, et al. The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med. 2004;32(7):1535–1541.
   PubMed Web of Science ®Google Scholar
• Abdullah M, Mcwilliams B, Khan SU. Reliability of the Laboratory Risk Indicator in Necrotising Fasciitis (LRINEC) score. Surgeon. 2019;17(5):309–318.
   Web of Science ®Google Scholar
• García-Tarriño R, Ballesteros-Betancourt J, Soriano-Viladomiu A, et al. Necrotizing fasciitis: usefulness of the LRINEC score in a third-level hospital. Injury. 2021;52(Suppl 4):S8–S15.
   Web of Science ®Google Scholar
• Van Stigt S, Knubben M, Schrooten T, et al. Prognostic factors for mortality in 123 severe cases of necrotizing fasciitis in 5 hospitals in the Netherlands between 2003 and 2017. Eur J Trauma Emerg Surg. 2022;48(2):1189–1195.
   Web of Science ®Google Scholar
• Bakker J, Kattan E, Annane D, et al. Current practice and evolving concepts in septic shock resuscitation. Intensive Care Med. 2022;48(2):148–163.
   Web of Science ®Google Scholar
• Berlin DA, Bakker J. Understanding venous return. Intensive Care Med. 2014;40(10):1564–1566.
   Web of Science ®Google Scholar
• Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181–1247.
   PubMed Web of Science ®Google Scholar
• Levy MM, Dellinger RP, Townsend SR, et al. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med. 2010;36(2):222–231.
   PubMed Web of Science ®Google Scholar
• Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: international Guidelines for Management of Sepsis and Septic Shock: 2016. Crit Care Med. 2017;45(3):486–552.
   PubMed Web of Science ®Google Scholar
• Nawijn F, Smeeing DPJ, Houwert RM, et al. Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis. World J Emerg Surg. 2020;15:4.
   Web of Science ®Google Scholar
• Kabay S, Yucel M, Yaylak F, et al. The clinical features of Fournier’s gangrene and the predictivity of the Fournier’s Gangrene Severity Index on the outcomes. Int Urol Nephrol. 2008;40(4):997–1004.
   Web of Science ®Google Scholar
• Perry TL, Kranker LM, Mobley EE, et al. Outcomes in Fournier’s Gangrene using skin and soft tissue sparing flap preservation surgery for wound closure: an alternative approach to wide radical debridement. Wounds. 2018;30(10):290–299.
   Web of Science ®Google Scholar
• Hagedorn JC, Wessells H. A contemporary update on Fournier’s gangrene. Nat Rev Urol. 2017;14(4):205–214.
   Web of Science ®Google Scholar
• Erickson BA, Flynn KJ. Management of necrotizing soft tissue infections (Fournier’s Gangrene) and surgical reconstruction of debridement wound defects. Urol Clin North Am. 2022;49(3):467–478.
   Web of Science ®Google Scholar
• Chawla SN, Gallop C, Mydlo JH. Fournier’s Gangrene: an analysis of repeated surgical debridement. Eur Urol. 2003;43(5):572–575.
   Web of Science ®Google Scholar
• Tarasconi A, Perrone G, Davies J, et al. Anorectal emergencies: WSES-AAST guidelines. World J Emerg Surg. 2021;16(1):48.
   Web of Science ®Google Scholar
• Urbina T, Razazi K, Ourghanlian C, et al. Antibiotics in necrotizing soft tissue infections. Antibiotics. 2021;10(9):1104.
   Web of Science ®Google Scholar
• Arulkumaran N, Routledge M, Schlebusch S, et al. Antimicrobial-associated harm in critical care: a narrative review. Intensive Care Med. 2020;46(2):225–235.
   PubMed Web of Science ®Google Scholar
• Tutino R, Colli F, Rizzo G, et al. Which role for hyperbaric oxygen therapy in the treatment of Fournier’s Gangrene? A retrospective study. Front Surg. 2022;9:850378.
   Web of Science ®Google Scholar
• Tanaka T, Minami A, Uchida J, et al. Potential of hyperbaric oxygen in urological diseases. Int J Urol. 2019;26(9):860–867.
   PubMed Web of Science ®Google Scholar
• Raizandha MA, Hidayatullah F, Kloping YP, et al. The role of hyperbaric oxygen therapy in Fournier’s Gangrene: a systematic review and meta-analysis of observational studies. Int Braz J Urol. 2022;48(5):771–781.
   Web of Science ®Google Scholar
• Schneidewind L, Anheuser P, Schönburg S, et al. Hyperbaric oxygenation in the treatment of Fournier’s gangrene: a systematic review. Urol Int. 2021;105(3–4):247–256.
   Web of Science ®Google Scholar
• Creta M, Longo N, Arcaniolo D, et al. Hyperbaric oxygen therapy reduces mortality in patients with Fournier’s Gangrene. Results from a multi-institutional observational study. Minerva Urol Nefrol. 2020;72(2):223–228.
   Web of Science ®Google Scholar
• Syllaios A, Davakis S, Karydakis L, et al. Treatment of Fournier’s Gangrene with vacuum-assisted closure therapy as enhanced recovery treatment modality. In Vivo. 2020;34(3):1499–1502.
   Web of Science ®Google Scholar
• Silberstein J, Grabowski J, Parsons JK. Use of a vacuum-assisted device for Fournier’s gangrene: a new paradigm. Rev Urol. 2008;10(1):76–80.
   Google Scholar
• Iacovelli V, Cipriani C, Sandri M, et al. The role of vacuum-assisted closure (VAC) therapy in the management of FOURNIER’S gangrene: a retrospective multi-institutional cohort study. World J Urol. 2021;39(1):121–128.
   Web of Science ®Google Scholar
• Yanaral F, Balci C, Ozgor F, et al. Comparison of conventional dressings and vacuum-assisted closure in the wound therapy of Fournier’s gangrene. Arch Ital Urol Androl. 2017;89(3):208–211.
   Google Scholar
• Czymek R, Schmidt A, Eckmann C, et al. Fournier’s gangrene: vacuum-assisted closure versus conventional dressings. Am J Surg. 2009;197(2):168–176.
   Web of Science ®Google Scholar
• Franco-Buenaventura D, Garcia-Perdomo HA. Vacuum-assisted closure device in the postoperative wound care for Fournier’s gangrene: a systematic review. Int Urol Nephrol. 2021;53(4):641–653.
   Web of Science ®Google Scholar
• Cipriani C, Iacovelli V, Sandri M, et al. The microbiological profile of patients with Fournier’s gangrene: a retrospective multi-institutional cohort study. Urologia. 2022;89(3):437–443.
   Web of Science ®Google Scholar
• Ozturk E, Sonmez Y, Yilmazlar T. What are the indications for a stoma in Fournier’s gangrene? Colorectal Dis. 2011;13(9):1044–1047.
   Web of Science ®Google Scholar
• Sarofim M, Di RA, Descallar J, et al. Relationship between diversional stoma and mortality rate in Fournier’s gangrene: a systematic review and meta-analysis. Langenbecks Arch Surg. 2021;406(8):2581–2590.
   Web of Science ®Google Scholar
• Sherman KL, Wexner SD. Considerations in Stoma Reversal. Clin Colon Rectal Surg. 2017;30(3):172–177.
   PubMed Web of Science ®Google Scholar
• Li YD, Zhu WF, Qiao JJ, et al. Enterostomy can decrease the mortality of patients with Fournier gangrene. World J Gastroenterol. 2014;20(24):7950–7954.
   Web of Science ®Google Scholar
• Padmanabhan A, Stern M, Wishin J, et al. Clinical evaluation of a flexible fecal incontinence management system. Am J Crit Care. 2007;16(4):384–393.
   PubMed Web of Science ®Google Scholar
• Goh M, Chew MH, Au-Yong PS, et al. Nonsurgical faecal diversion in the management of severe perianal sepsis: a retrospective evaluation of the flexible faecal management system. Singapore Med J. 2014;55(12):635–639.
   Web of Science ®Google Scholar
• Page BP, Boyce SA, Deans C, et al. Significant rectal bleeding as a complication of a fecal collecting device: report of a case. Dis Colon Rectum. 2008;51(9):1427–1429.
   PubMed Web of Science ®Google Scholar
• Kühbacher A, Burger-Kentischer A, Rupp S. Interaction of candida species with the skin. Microorganisms. 2017;5(2):32.
   Web of Science ®Google Scholar
• De Groot T, Janssen T, Faro D, et al. Antifungal activity of a medical-grade honey formulation against candida auris. J Fungi. 2021;7(1):50.
   Web of Science ®Google Scholar
• Sufya N, Matar N, Kaddura R, et al. Evaluation of bactericidal activity of Hannon honey on slowly growing bacteria in the chemostat. Drug Healthc Patient Saf. 2014;6:139–144.
   Google Scholar
• Sandberg JM, Warner HL, Flynn KJ, et al. Favorable outcomes with early component separation, primary closure of necrotizing soft tissue infections of the genitalia (Fournier’s Gangrene) debridement wound defects. Urology. 2022;166:250–256.
   Web of Science ®Google Scholar
• Insua-Pereira I, Ferreira PC, Teixeira S, et al. Fournier’s gangrene: a review of reconstructive options. Cent European J Urol. 2020;73(1):74–79.
   Web of Science ®Google Scholar
• Karian LS, Chung SY, Lee ES. Reconstruction of defects after Fournier gangrene: a systematic review. Eplasty. 2015;15:e18.
   Google Scholar
• Michael P, Peiris B, Ralph D, et al. Genital reconstruction following Fournier’s Gangrene. Sex Med Rev. 2022;10(4):800–812.
   Google Scholar