412
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Central Nervous System Toxicity of Voriconazole: Risk Factors and Threshold – A Retrospective Cohort Study

, ORCID Icon, , , , , , , , , & ORCID Icon show all
Pages 7475-7484 | Received 24 Sep 2022, Accepted 02 Dec 2022, Published online: 16 Dec 2022

References

  • Theuretzbacher U, Ihle F, Derendorf H. Pharmacokinetic/pharmacodynamic profile of voriconazole. Clin Pharmacokinet. 2006;45(7):649–663. doi:10.2165/00003088-200645070-00002
  • Wang T, Sun JY, Chen SY, et al. Population pharmacokinetics study of voriconazole and dosing regimen optimization in patients with invasive fungus infections. Chin Pharm J. 2014;24:227–233.
  • Boyd AE, Modi S, Howard SJ, et al. Adverse reactions to voriconazole. Clin Infect Dis. 2004;39(8):1241–1244. doi:10.1086/424662
  • Imhof A, Schaer DJ, Schanz U, et al. Neurological adverse events to voriconazole: evidence for therapeutic drug monitoring. Swiss Med Wkly. 2006;136(45–46):739–742.
  • Luong ML, Hosseini-Moghaddam SM, Singer LG, et al. Risk factors for voriconazole hepatotoxicity at 12 weeks in lung transplant recipients. Am J Transplant. 2012;12(7):1929–1935. doi:10.1111/j.1600-6143.2012.04042.x
  • Saito T, Fujiuchi S, Tao Y, et al. Efficacy and safety of voriconazole in the treatment of chronic pulmonary aspergillosis: experience in Japan. Infection. 2012;40(6):661–667. doi:10.1007/s15010-012-0322-x
  • Zonios DI, Gea-Banacloche J, Childs R, et al. Hallucinations during voriconazole therapy. Clin Infect Dis. 2008;47:1. doi:10.1086/588844
  • Eiden C, Peyrière H, Cociglio M, et al. Adverse effects of voriconazole: analysis of the French pharmacovigilance database. Ann Pharmacother. 2007;41(5):755–763. doi:10.1345/aph.1H671
  • Dolton MJ, McLachlan AJ. Voriconazole pharmacokinetics and exposure-response relationships: assessing the links between exposure, efficacy and toxicity. Int J Antimicrob Agents. 2014;44(3):183–193. doi:10.1016/j.ijantimicag.2014.05.019
  • Lutsar I, Hodges MR, Tomaszewski K, et al. Safety of voriconazole and dose individualization. Clin Infect Dis. 2003;36(8):1087–1088. doi:10.1086/374248
  • Chu HY, Jain R, Xie H, et al. Voriconazole therapeutic drug monitoring: retrospective cohort study of the relationship to clinical outcomes and adverse events. BMC Infect Dis. 2013;13:105. doi:10.1186/1471-2334-13-105
  • Heo ST, Aitken SL, Tverdek FP, et al. How common is subsequent central nervous system toxicity in asymptomatic patients with haematologic malignancy and supratherapeutic voriconazole serum levels? Clin Microbiol Infect. 2017;23(6):387–390. doi:10.1016/j.cmi.2016.12.031
  • Koselke E, Kraft S, Smith J, et al. Evaluation of the effect of obesity on voriconazole serum concentrations. J Antimicrob Chemother. 2012;67(12):2957–2962. doi:10.1093/jac/dks312
  • Patterson TF, Thompson GR, Denning DW, et al. Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the infectious diseases society of America. Clin Infect Dis. 2016;63:4. doi:10.1093/cid/ciw326
  • World Health Organization. The Uppsala monitoring centre. The use of the WHO-UMC system for standardised case causality assessment, 2018; 2020.
  • Cancer. NIo. Common Terminology Criteria for Adverse Events (CTCAE). Waltham, MA. UpToDate; 2017:1–9.
  • Wang T, Zhu H, Sun J, et al. Efficacy and safety of voriconazole and CYP2C19 polymorphism for optimised dosage regimens in patients with invasive fungal infections. Int J Antimicrob Agents. 2014;44(5):436–442. doi:10.1016/j.ijantimicag.2014.07.013
  • Pascual A, Csajka C, Buclin T, et al. Challenging recommended oral and intravenous voriconazole doses for improved efficacy and safety: population pharmacokinetics-based analysis of adult patients with invasive fungal infections. Clin Infect Dis. 2012;55(3):381–390. doi:10.1093/cid/cis437
  • Pascual A, Calandra T, Bolay S, et al. Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomes. Clin Infect Dis. 2008;46(2):201–211. doi:10.1086/524669
  • Hamada Y, Ueda T, Miyazaki Y, et al. Effects of antifungal stewardship using therapeutic drug monitoring in voriconazole therapy on the prevention and control of hepatotoxicity and visual symptoms: a multicentre study conducted in Japan. Mycoses. 2020;63(8):779–786. doi:10.1111/myc.13129
  • Ashley ESD, Lewis R, Lewis JS, et al. Pharmacology of systemic antifungal agents. Clin Infect Dis. 2006;43(Supplement_1):S28–S39. doi:10.1086/504492
  • Hyland R, Jones BC, Smith DA. Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole. Drug Metab Dispos. 2003;31(5):540–547. doi:10.1124/dmd.31.5.540
  • Johnson LB, Kauffman CA. Voriconazole: a new triazole antifungal agent. Clin Infect Dis. 2003;36(5):630–637. doi:10.1086/367933
  • Walsh TJ, Karlsson MO, Driscoll T, et al. Pharmacokinetics and safety of intravenous voriconazole in children after single- or multiple-dose administration. Antimicrob Agents Chemother. 2004;48(6):2166–2172. doi:10.1128/AAC.48.6.2166-2172.2004
  • Seyedmousavi S, Mouton JW, Verweij PE, et al. Therapeutic drug monitoring of voriconazole and posaconazole for invasive aspergillosis. Expert Rev Anti Infect Ther. 2013;11(9):931–941. doi:10.1586/14787210.2013.826989
  • Mikus G, Scholz IM, Weiss J. Pharmacogenomics of the triazole antifungal agent voriconazole. Pharmacogenomics. 2011;12(6):861–872. doi:10.2217/pgs.11.18
  • Wang G, Lei H-P, Li Z, et al. The CYP2C19 ultra-rapid metabolizer genotype influences the pharmacokinetics of voriconazole in healthy male volunteers. Eur J Clin Pharmacol. 2009;65(3):281–285. doi:10.1007/s00228-008-0574-7
  • Weiss J, Ten Hoevel MM, Burhenne J, et al. CYP2C19 genotype is a major factor contributing to the highly variable pharmacokinetics of voriconazole. J Clin Pharmacol. 2009;49(2):196–204. doi:10.1177/0091270008327537
  • Sienkiewicz B, Urbaniak-Kujda D, Dybko J, et al. Influence of CYP2C19 genotypes on the occurrence of adverse drug reactions of voriconazole among hematological patients after Allo-HSCT. Pathology & Oncology Research. 2018;24(3):541–545. doi:10.1007/s12253-017-0264-9
  • Moriyama B, Obeng AO, Barbarino J, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for CYP2C19 and voriconazole therapy. Clin Pharmacol Ther. 2017;102(1):45–51. doi:10.1002/cpt.583
  • Matsumoto K, Ikawa K, Abematsu K, et al. Correlation between voriconazole trough plasma concentration and hepatotoxicity in patients with different CYP2C19 genotypes. Int J Antimicrob Agents. 2009;34(1):91–94. doi:10.1016/j.ijantimicag.2009.01.008
  • Zhang L, Xu MA, Wang Y, et al. Analysis of genetic polymorphisms and metabolic phenotype of CYP2C19 in 604 senile patients with coronary heart disease. J Cardiovasc and Pulmonary Dis. 2015;23: 6186–6192.
  • Jin H, Wang T, Falcione BA, et al. Trough concentration of voriconazole and its relationship with efficacy and safety: a systematic review and meta-analysis. J Antimicrob Chemother. 2016;71(7):1772–1785. doi:10.1093/jac/dkw045
  • Gómez-López A. Antifungal therapeutic drug monitoring: focus on drugs without a clear recommendation. Clin Microbiol Infect. 2020;26(11):1481–1487. doi:10.1016/j.cmi.2020.05.037
  • Xiong W-H, Brown RL, Reed B, et al. Voriconazole, an antifungal triazol that causes visual side effects, is an inhibitor of TRPM1 and TRPM3 channels. Invest Ophthalmol Vis Sci. 2015;56(2):1367–1373. doi:10.1167/iovs.14-15270