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ORIGINAL RESEARCH

A Pilot Study of 0.4% Povidone-Iodine Nasal Spray to Eradicate SARS-CoV-2 in the Nasopharynx

, ORCID Icon, & ORCID Icon
Pages 7529-7536 | Received 04 Oct 2022, Accepted 09 Dec 2022, Published online: 21 Dec 2022

References

  • Wang H, Paulson KR, Pease SA; COVID-19 Excess Mortality Collaborators. Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21. Lancet. 2022;399(10334):1513–1536. doi:10.1016/S0140-6736(21)02796-3
  • Badu K, Oyebola K, Zahouli JZB, et al. SARS-CoV-2 viral shedding and transmission dynamics: implications of WHO COVID-19 discharge guidelines. Front Med. 2021;8:648660. doi:10.3389/fmed.2021.648660
  • Casey-Bryars M, Griffin J, McAloon C, et al. Presymptomatic transmission of SARS-CoV-2 infection: a secondary analysis using published data. BMJ Open. 2021;11:e041240. doi:10.1136/bmjopen-2020-041240
  • Pelletier JS, Miller D, Liang B, Capriotti JA. In vitro efficacy of a povidone-iodine 0.4% and dexamethasone 0.1% suspension against ocular pathogens. J Cataract Refract Surg. 2011;37:763–766. doi:10.1016/j.jcrs.2010.11.028
  • Anderson DE, Sivalingam V, Kang AEZ, et al. Povidone-iodine demonstrates rapid in vitro virucidal activity against SARS-CoV-2, the virus causing COVID-19 disease. Infect Dis Ther. 2020;9:669–675. doi:10.1007/s40121-020-00316-3
  • Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Rapid in-vitro inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using povidone-iodine oral antiseptic rinse. J Prosthodont. 2020;29(6):529–533. doi:10.1111/jopr.13209
  • Shet M, Hong R, Igo D, Cataldo M, Bhaskar S. In vitro evaluation of the virucidal activity of different povidone-iodine formulations against murine and human coronaviruses. Infect Dis Ther. 2021;10:2777–2790. doi:10.1007/s40121-021-00536-1
  • Nagatake T, Ahmed K, Oishi K. Prevention of respiratory infections by povidone-iodine gargle. Dermatology. 2002;204(Suppl 1):32–36. doi:10.1159/000057722
  • Ghaddara HA, Kumar JA, Cadnum JL, Ng-Wong YK, Donskey CJ. Efficacy of a povidone iodine preparation in reducing nasal methicillin-resistant Staphylococcus aureus in colonized patients. Am J Infect Control. 2020;48:456–459. doi:10.1016/j.ajic.2019.09.014
  • Peng HM, Wang LC, Zhai JL, Weng XS, Feng B, Wang W. Effectiveness of preoperative decolonization with nasal povidone iodine in Chinese patients undergoing elective orthopedic surgery: a prospective cross-sectional study. Braz J Med Biol Res. 2017;51:e6736. doi:10.1590/1414-431x20176736
  • Krajewska Wojciechowska J, Krajewski W, Zub K, Zatoński T. Review of practical recommendations for otolaryngologists and head and neck surgeons during the COVID-19 pandemic. Auris Nasus Larynx. 2020;47:544–558. doi:10.1016/j.anl.2020.05.022
  • Seneviratne CJ, Balan P, Ko KKK, et al. Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. Infection. 2021;49:305–311. doi:10.1007/s15010-020-01563-9
  • Elzein R, Abdel-Sater F, Fakhreddine S, et al. In vivo evaluation of the virucidal efficacy of Chlorhexidine and Povidone-iodine mouthwashes against salivary SARS-CoV-2. A randomized-controlled clinical trial. J Evid Based Dent Pract. 2021;21:101584. doi:10.1016/j.jebdp.2021.101584
  • Guenezan J, Garcia M, Strasters D, et al. Povidone iodine mouthwash, gargle, and nasal spray to reduce nasopharyngeal viral load in patients with COVID-19: a randomized clinical trial. JAMA Otolaryngol Head Neck Surg. 2021;147:400–401. doi:10.1001/jamaoto.2020.5490
  • Zarabanda D, Vukkadala N, Phillips KM, et al. The effect of povidone-iodine nasal spray on nasopharyngeal SARS-CoV-2 viral load: a randomized control trial. Laryngoscope. 2021;132:2089–2095. doi:10.1002/lary.29935
  • Ferrer MD, Barrueco ÁS, Martinez-Beneyto Y, et al. Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2. Sci Rep. 2021;11:24392. doi:10.1038/s41598-021-03461-y
  • Wang H, Tan W, Tan W, Tan W. Summary of the detection kits for SARS-CoV-2 approved by the national medical products administration of China and their application for diagnosis of COVID-19. Virol Sin. 2020;35:699–712. doi:10.1007/s12250-020-00331-1
  • Sasaki M, Uemura K, Sato A, et al. SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells. PLoS Pathog. 2021;17:e1009233. doi:10.1371/journal.ppat.1009233
  • Dhand NK, Khatkar MS. Statulator: an online statistical calculator. sample size calculator for comparing two paired proportions. Available from: http://statulator.com/SampleSize/ss2PP.html. Accessed July 25, 2022.
  • Schulz KF, Altman DG, Moher D, for the CONSORT Group. CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. PLoS Med. 2010;7(3): e1000251. Copyright: © 2010 Schulz et al. Creative Commons Attribution License.
  • Friedland P, Tucker S, Goodall S, et al. In vivo (human) and in vitro inactivation of SARS-CoV-2 with 0.5% povidone-iodine nasal spray. Aust J Otolaryngol. 2022;5:2. doi:10.21037/ajo-21-40
  • Seikai T, Takada A, Hasebe A, et al. Gargling with povidone iodine has a short-term inhibitory effect on SARS-CoV-2 in patients with COVID-19. J Hosp Infect. 2022;123:179–181. doi:10.1016/j.jhin.2022.01.001
  • Kunno J, Supawattanabodee B, Sumanasrethakul C, Wiriyasivaj B, Kuratong S, Kaewchandee C. Comparison of different waves during the COVID-19 pandemic: retrospective descriptive study in Thailand. Adv Prev Med. 2021;2021:5807056. doi:10.1155/2021/5807056