368
Views
35
CrossRef citations to date
0
Altmetric
Review

Profile of isavuconazole and its potential in the treatment of severe invasive fungal infections

&
Pages 163-174 | Published online: 22 Oct 2013

References

  • GirmeniaCNew generation azole antifungals in clinical investigationExpert Opin Investig Drugs200918912791295
  • LivermoreJHopeWEvaluation of the pharmacokinetics and clinical utility of isavuconazole for treatment of invasive fungal infectionsExpert Opin Drug Metab Toxicol20128675976522530880
  • PasqualottoACDenningDWNew and emerging treatments for fungal infectionsJ Antimicrob Chemother200861Suppl 1i19i3018063600
  • KagoshimaYMoriMSuzukiEDesign, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazoleBioorg Med Chem Lett200313219119612482421
  • WarnPASharpAMosqueraJComparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavusJ Antimicrob Chemother20065861198120717071636
  • DenningDWHopeWWTherapy for fungal diseases: opportunities and prioritiesTrends Microbiol201018519520420207544
  • ChowdharyAKathuriaSRandhawaHSGaurSNKlaassenCHMeisJFIsolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the CYP51A gene in IndiaJ Antimicrob Chemother201267236236622028200
  • HowardSJCerarDAndersonMJFrequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failureEmerg Infect Dis20091571068107619624922
  • GuineaJBouzaEIsavuconazole: a new and promising antifungal triazole for the treatment of invasive fungal infectionsFuture Microbiol20083660361519072177
  • Schmitt-HoffmannARoosBHeepMSingle-ascending-dose pharmacokinetics and safety of the novel broad-spectrum antifungal triazole BAL4815 after intravenous infusions (50, 100, and 200 milligrams) and oral administrations (100, 200, and 400 milligrams) of its prodrug, BAL8557, in healthy volunteersAntimicrob Agents Chemother200650127928516377698
  • Ostrosky-ZeichnerLInurriaNRodriguezJChenEPaetznickVComparative in vitro activity of isavuconazole (ISA) against medically important yeasts and mouldsPaper presented at: Programs and Abstracts of the 49th Annual; Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)2009San Francisco, CA
  • Schmitt-HoffmannARoosBMaaresJMultiple-dose pharmacokinetics and safety of the new antifungal triazole BAL4815 after intravenous infusion and oral administration of its prodrug, BAL8557, in healthy volunteersAntimicrob Agents Chemother200650128629316377699
  • Schmitt-HoffmannARoosBSauerJEffect of rifampicin on the pharmacokinetics of BAL4815 at steady state after multiple oral doses of BAL8557 (WSA) and rifampicinPaper presented at: Abstracts of the Sixteenth Congress of the International Society for Human and Animal Mycology (ISHAM)2006Paris, France
  • Schmitt-HoffmannARoosBSauerJEffect of BAL8557, a water-soluble azole pro-drug (WSA), on the pharmacokinetics of S- and R-warfarinPaper presented at: Abstracts of the Sixteenth Congress of the International Society for Human and Animal Mycology (ISHAM)2006Paris, France
  • Schmitt-HoffmannARoosBSauerJEffect of BAL8557, a water-soluble azole pro-drug (WSA), on the pharmacokinetics of ciclosporinPaper presented at: Abstracts of the Sixteenth Congress of the International Society for Human and Animal Mycology (ISHAM)2006Paris, France
  • Schmitt-HoffmannARoosBSpickermannJEffect of mild and moderate liver disease on the pharmacokinetics of isavuconazole after intravenous and oral administration of a single dose of the prodrug BAL8557Antimicrob Agents Chemother200953114885489019667286
  • Schmitt-HoffmanARoosBSpickermanJNo relevant food effect in man on isavuconazole oral pharmacokinetics preliminary dataPaper presented at: 48th Annual International Conference on Antimicrobial Agents and Chemotherapy (ICAAC)2008Washington, DC
  • ThompsonGRIIIWiederholdNPIsavuconazole: a comprehensive review of spectrum of activity of a new triazoleMycopathologia2010170529131320524153
  • SeifertHAurbachUStefanikDCornelyOIn vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolatesAntimicrob Agents Chemother20075151818182117307977
  • GuineaJPelaezTRecioSTorres-NarbonaMBouzaEIn vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium speciesAntimicrob Agents Chemother20085241396140018212101
  • Curfs-BrekuerIMMoutonJDebets-OssenkppYJEndtzHPVerweijPEMeisJFIn vitro activity of isavuconazole (BAL4815) compared with seven other antifungal agents against 309 prospectively collected clinical Candida isolates from The NetherlandsPaper presented at: Programs and Abstracts of the 17th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)2007Munich, Germany
  • Cuenca-EstrellaAGomez-LopezABuitragoMJMelladoERodrigues-TudelaJLBAL4815 a new antifungal agent: determination of quality control limits for susceptibility testing by methods of the european committee on antimicrobial susceptibility testing (EUCAST)Paper presented at: Programs and Abstracts of the 46th Annual International Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Annual Meeting2006San Francisco, CA
  • HeepMGroverPBrownNPPillarCMJonesMESahmDFEvaluation of isavuconazole e-test compared to broth microdilution antifungal susceptibility testing against quality control strains and clinical Candida isolatesPaper presented at: Programs and Abstracts of the 17th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)2007Munich, Germany
  • SanglardDIscherFCosteARerrariSComparison between isavuconazole (ISA) and other azoles against characterized clinical isolates and yeast model systemsPaper presented at: Abstracts of the 18th Annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)2008Barcelona, Spain
  • MajithiyaJSharpAParmarADenningDWWarnPAEfficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida kruseiJ Antimicrob Chemother200963116116619008255
  • WarnPASharpAParmarAMajithiyaJDenningDWHopeWWPharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: mathematical modeling, importance of tissue concentrations, and impact of immune status on antifungal effectAntimicrob Agents Chemother20095383453346119451288
  • ViljoenJMithaIHeepMGhannoumMAEfficacy, safety, and tolerability of three different dosing regimens of BAL8557 vs fluconazole in a double-blind, randomized, multicenter trials for the treatment of esophageal candididasis in immunocompromissed adultsPaper presented at: Abstracts of the 45th Conference on Antimicrobial Agents and Chemotherapy (ICAAC)2005Washington, DC
  • National Institutes of HealthIsavuconazole (BAL8557) in the treatment of candidemia and other invasive Candida infectionsClinicalTrials.gov [website on the Internet]Bethesda, MDUS National Library of Medicine2013 Available from: http://www.clinicaltrials.gov/ct2/show/NCT0413218?term=00413218&rank=1. NLM identifer: NCT0413218Accessed August 16, 2013
  • National Institutes of HealthEfficacy and pharmacokinetics of an antifungal in patients undergoing chemotherapyClinicalTrials.gov [website on the Internet]Bethesda, MDUS National Library of Medicine2011 Available from: http://www.clinicaltrials.gov/ct2/show/NCT0413439?term=00413439&rank=1. NLM identifier: NCT0413439Accessed August 16, 2013
  • WarnPASharpADenningDWIn vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus sppJ Antimicrob Chemother200657113513816284102
  • RudramurthySMChakrabartiAGeertsenEMoutonJWMeisJFIn vitro activity of isavuconazole against 208 Aspergillus flavus isolates in comparison with 7 other antifungal agents: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility TestingDiagn Microbiol Infect Dis201171437037721937186
  • ShivaprakashMRGeertsenEChakrabartiAMoutonJWMeisJFIn vitro susceptibility of 188 clinical and environmental isolates of Aspergillus flavus for the new triazole isavuconazole and seven other antifungal drugsMycoses2011545e583e58921518026
  • National Institutes of HealthIsavuconazole (BAL8557) for primary treatment of invasive AspergillosisClinicalTrials.gov [website on the Internet]Bethesda, MDUS National Library of Medicine2013 Available from: http://www.clinicaltrials.gov/ct2/show/NCT0412893?term=00412893&rank=1. NLM identfier: NCT0412893Accessed August 16, 2013
  • Astellas Pharma IncAstellas reports positive topline phase 3 results for antifungal isavuconazolewww.astellas.com/en [website on the Internet]Tokyo, Japan2013 Available from: http://www.astellas.com/en/corporate/news/pdf/130930_2_Eg.pdfAccessed September 30, 2013
  • National Institutes of HealthIsavuconazole in the treatment of renally impaired aspergillosis and rare fungiClinicalTrials.gov [website on the Internet]Bethesda, MDUS National Library of Medicine2013 Available from: http://www.clinicaltrials.gov/ct2/show/NCT0634049?term=isavuconazole+renal+impairment&rank=2. NLM identifier: NCT0634049Accessed August 16, 2013
  • Alastruey-IzquierdoACastelliMVCuestaIIn vitro activity of antifungals against ZygomycetesClin Microbiol Infect200915Suppl 5717619754762
  • AlmyroudisNGSuttonDAFothergillAWRinaldiMGKusneSIn vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agentsAntimicrob Agents Chemother20075172587259017452481
  • SunQNNajvarLKBocanegraRLoebenbergDGraybillJRIn vivo activity of posaconazole against Mucor spp. in an immuno-suppressed-mouse modelAntimicrob Agents Chemother20024672310231212069997
  • EnochDAAliyuSHSuleOLewisSJKarasJAPosaconazole for the treatment of mucormycosisInt J Antimicrob Agents201138646547321782392
  • VerweijPEGonzálezGMWiedrholdNPLass-FlörlCIn vitro antifungal activity of isavuconazole against 345 Mucorales isolates collected at study centers in eight countriesJ Chemother200921327228119567347
  • Illnait-ZaragoziMTMartinezGFCurfs-BreukerIFernandezCMBoekhoutTMeisJFIn Vitro activity of the new azole isavuconazole (BAL4815) compared with six other antifungal agents against 162 Cryptococcus neoformans isolates from CubaAntimicrob Agents Chemother20085241580158218212095
  • ThompsonGRIIIFothergillAWWiederholdNPVallorACWickesBLPattersonTFEvaluation of Etest method for determining isavuconazole MICs against Cryptococcus gattii and Cryptococcus neoformansAntimicrob Agents Chemother20085282959296118559645
  • ThompsonGRIIIWiederholdNPFothergillAWVallorACWickesBLPattersonTFAntifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformansAntimicrob Agents Chemother200953130931118955539
  • ThompsonGRIIIWiederholdNPSuttonDAFothergillAPattersonTFIn vitro activity of isavuconazole against Trichosporon, Rhodotorula, Geotrichum, Saccharomyces and Pichia speciesJ Antimicrob Chemother2009641798319406849
  • GonzalezGMIn vitro activities of isavuconazole against opportunistic filamentous and dimorphic fungiMed Mycol2009471717619101837
  • KloezenWMeisJFCurfs-BreukerIFahalAHvan de SandeWWIn vitro antifungal activity of isavuconazole against Madurella mycetomatisAntimicrob Agents Chemother201256116054605622964246
  • GuineaJRecioSEscribanoPPelaezTGamaBBouzaEIn vitro antifungal activities of isavuconazole and comparators against rare yeast pathogensAntimicrob Agents Chemother20105494012401520566770
  • BrammerKWFarrowPRFaulknerJKPharmacokinetics and tissue penetration of fluconazole in humansRev Infect Dis199012Suppl 3S318S3262184510
  • CourtneyRPaiSLaughlinMLimJBatraVPharmacokinetics, safety, and tolerability of oral posaconazole administered in single and multiple doses in healthy adultsAntimicrob Agents Chemother20034792788279512936975
  • LevequeDNivoixYJehlFHerbrechtRClinical pharmacokinetics of voriconazoleInt J Antimicrob Agents200627427428416563707
  • MotonAKrishnaGMaLPharmacokinetics of a single dose of the antifungal posaconazole as oral suspension in subjects with hepatic impairmentCurr Med Res Opin20102611719886860
  • PatelKRobertsJALipmanJTettSEDeldotMEKirkpatrickCMPopulation pharmacokinetics of fluconazole in critically ill patients receiving continuous venovenous hemodiafiltration: using Monte Carlo simulations to predict doses for specified pharmacodynamic targetsAntimicrob Agents Chemother201155125868587321930888