References
- O’SullivanBPFreedmanSDCystic fibrosisLancet20093731891190419403164
- HarrisonFMicrobial ecology of the cystic fibrosis lungMicrobiology200715391792317379702
- LyczakJBCannonCLPierGBLung infections associated with cystic fibrosisClin Microbiol Rev20021519422211932230
- StruelensMJSchwamVDeplanoABaranDGenome macrorestriction analysis of diversity and variability of Pseudomonas aeruginosa strains infecting cystic fibrosis patientsJ Clin Microbiol199331232023268408549
- BreitensteinSWalterSBosshammerJRömlingUTummlerBDirect sputum analysis of Pseudomonas aeruginosa macrorestriction fragment genotypes in patients with cystic fibrosisMed Microbiol Immunol199718693999403836
- SmithEEBuckleyDGWuZGenetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patientsProc Natl Acad Sci U S A20061038487849216687478
- HuseHKKwonTZlosnikJEParallel evolution in Pseudomonas aeruginosa over 39,000 generations in vivoMBio201014e0019920856824
- GovanJRDereticVMicrobial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepaciaMicrobiol Rev1996605395748840786
- KirisitsMJProstLStarkeyMParsekMRCharacterization of colony morphology variants isolated from Pseudomonas aeruginosa biofilmsAppl Environ Microbiol2005714809482116085879
- HäusslerSZieglerILöttelAHighly adherent small-colony variants of Pseudomonas aeruginosa in cystic fibrosis lung infectionJ Med Microbiol20035229530112676867
- ByrdMSPangBHongWDirect evaluation of Pseudomonas aeruginosa biofilm mediators in a chronic infection modelInfect Immun2011793087309521646454
- MaloneJGJaegerTSpanglerCYfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosaPLoS Pathog20106e100080420300602
- MulcahyHO’CallaghanJO’GradyEPPseudomonas aeruginosa RsmA plays an important role during murine infection by influencing colonization, virulence, persistence, and pulmonary inflammationInfect Immun20087663263818025099
- ReinhardtAKöhlerTWoodPDevelopment and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patientsAntimicrob Agents Chemother2007511341135017261619
- MurphyTFBrauerALSethiSHaemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzaeJ Infect Dis2007195818917152011
- SpoeringALLewisKBiofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobialsJ Bacteriol20011836746675111698361
- HäusslerSTummlerBWeissbrodtHRohdeMSteinmetzISmall-colony variants of Pseudomonas aeruginosa in cystic fibrosisClin Infect Dis19992962162510530458
- BurkeVRobinsonJORichardsonCJBundellCSLongitudinal studies of virulence factors of Pseudomonas aeruginosa in cystic fibrosisPathology1991231451481745565
- ZierdtCHSchmidtPJDissociation in Pseudomonas aeruginosaJ Bacteriol196487100310104959790
- ThomassenMJDemkoCABoxerbaumBSternRCKuchenbrodPJMultiple isolates of Pseudomonas aeruginosa with differing antimicrobial susceptibility patterns from patients with cystic fibrosisJ Infect Dis1979140873880120383
- DrenkardEAusubelFMPseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variationNature200241674074311961556
- D’ArgenioDACalfeeMWRaineyPBPesciECAutolysis and auto-aggregation in Pseudomonas aeruginosa colony morphology mutantsJ Bacteriol20021846481648912426335
- WeiQTarighiSDötschAPhenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosaPLoS One20116e2927622195037
- HoffmanLRD’ArgenioDAMacCossMJAminoglycoside antibiotics induce bacterial biofilm formationNature20054361171117516121184
- StarkeyMHickmanJHMaLPseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lungJ Bacteriol20091913492350319329647
- MaloneJGJaegerTManfrediPThe YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airwaysPLoS Pathog20128e100276022719254
- FriedmanLKolterRTwo genetic loci produce distinct carbohydrate-rich structural components of the Pseudomonas aeruginosa biofilm matrixJ Bacteriol20041864457446515231777
- MowatEPatersonSFothergillJLPseudomonas aeruginosa population diversity and turnover in cystic fibrosis chronic infectionsAm J Respir Crit Care Med20111831674167921297072
- WorkentineMLSibleyCDGlezersonBPhenotypic heterogeneity of Pseudomonas aeruginosa populations in a cystic fibrosis patientPLoS One20138e6022523573242
- SabraWHaddadAMZengAPComparative physiological study of the wild type and the small colony variant of Pseudomonas aeruginosa 20265 under controlled growth conditionsWorld J Microbiol Biotechnol2014301027103624129697
- von GotzFHäusslerSJordanDExpression analysis of a highly adherent and cytotoxic small colony variant of Pseudomonas aeruginosa isolated from a lung of a patient with cystic fibrosisJ Bacteriol20041863837384715175297
- Roy-BurmanASavelRHRacineSType III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infectionsJ Infect Dis20011831767177411372029
- IrieYStarkeyMEdwardsANPseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post-transcriptionally by RsmAMol Microbiol20107815817220735777
- WehmhonerDHäusslerSTümmlerBInter- and intraclonal diversity of the Pseudomonas aeruginosa proteome manifests within the secretomeJ Bacteriol20031855807581413129952
- MenaAMaciáMDBorrellNInactivation of the mismatch repair system in Pseudomonas aeruginosa attenuates virulence but favors persistence of oropharyngeal colonization in cystic fibrosis miceJ Bacteriol20071893665366817307847
- LujanAMMoyanoAJSeguraIArgaranaCESmaniaAMQuorum-sensing-deficient (lasR) mutants emerge at high frequency from a Pseudomonas aeruginosa mutS strainMicrobiology200715322523717185551
- OliverACantonRCampoPBaqueroFBlazquezJHigh frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infectionScience20002881251125410818002
- SchneiderMMühlemannKDrozSClinical characteristics associated with isolation of small-colony variants of Staphylococcus aureus and Pseudomonas aeruginosa from respiratory secretions of patients with cystic fibrosisJ Clin Microbiol2008461832183418322058
- HarrisonFMuruliAHigginsSDiggleSPDevelopment of an ex vivo porcine lung model for studying growth, virulence, and signaling of Pseudomonas aeruginosaInfect Immun2014823312332324866798
- MeissnerAWildVSimmRPseudomonas aeruginosa cupA-encoded fimbriae expression is regulated by a GGDEF and EAL domain-dependent modulation of the intracellular level of cyclic diguanylateEnviron Microbiol200792475248517803773
- HickmanJWTifreaDFHarwoodCSA chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levelsProc Natl Acad Sci U S A2005102144221442716186483
- BlankaADüvelJDötschAConstitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosawith altered membrane compositionSci Signal20158ra3625872871
- HenggeRPrinciples of c-di-GMP signalling in bacteriaNat Rev Microbiol2009726327319287449
- JenalUMaloneJMechanisms of cyclicdi-GMP signaling in bacteriaAnnu Rev Genet20064038540716895465
- RossPWeinhouseHAloniYRegulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acidNature198732527928118990795
- SchmidtAJRyjenkovDAGomelskyMThe ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domainsJ Bacteriol20051874774478115995192
- PaulRWeiserSAmiotNCCell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domainGenes Dev20041871572715075296
- ChristenMChristenBFolcherMSchauerteAJenalUIdentification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTPJ Biol Chem2005280308293083715994307
- RyanRPFouhyYLuceyJFCell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnoverProc Natl Acad Sci U S A20061036712671716611728
- GalperinMYA census of membrane-bound and intracellular signal transduction proteins in bacteria: bacterial IQ, extroverts and introvertsBMC Microbiol200553515955239
- KulasakaraHLeeVBrencicAAnalysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′–5′)-cyclic-GMP in virulenceProc Natl Acad Sci U S A20061032839284416477007
- MerighiMLeeVTHyodoMHayakawaYLorySThe second messenger bis-(3′–5′)-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosaMol Microbiol20076587689517645452
- LeeSYMatewishJMKesslerJLA cyclic-di-GMP receptor required for bacterial exopolysaccharide productionMol Microbiol2007651474148417824927
- HickmanJWHarwoodCSIdentification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factorMol Microbiol20086937638918485075
- KulasekaraHDVentreIKulasekaraBRA novel two-component system controls the expression of Pseudomonas aeruginosa fimbrial cup genesMol Microbiol20055536838015659157
- BorleeBRGoldmanADMurakamiKPseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrixMol Microbiol20107582784220088866
- AnSWuJZhangLHModulation of Pseudomonas aeruginosa biofilm dispersal by a cyclic-di-GMP phosphodiesterase with a putative hypoxia-sensing domainAppl Environ Microbiol2010768160817320971871
- KuchmaSLConnollyJPO’TooleGAA three-component regulatory system regulates biofilm maturation and type III secretion in Pseudomonas aeruginosaJ Bacteriol20051871441145415687209
- MoscosoJAMikkelsenHHeebSWilliamsPFillouxAThe Pseudomonas aeruginosa sensor RetS switches Type III and Type VI secretion via c-di-GMP signallingEnviron Microbiol2011133128313821955777
- MoscosoJAJaegerTValentiniMThe diguanylate cyclase SadC is a central player in Gac/Rsm-mediated biofilm formation in Pseudomonas aeruginosaJ Bacteriol20141964081408825225264
- KazmierczakBILebronMBMurrayTSAnalysis of FimX, a phospho-diesterase that governs twitching motility in Pseudomonas aeruginosaMol Microbiol2006601026104316677312
- AlmRABoderoAJFreePDMattickJSIdentification of a novel gene, pilZ, essential for type 4 fimbrial biogenesis in Pseudomonas aeruginosaJ Bacteriol199617846538550441
- BaraquetCHarwoodCSCyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQProc Natl Acad Sci U S A2013110184781848324167275
- KulasekaraBRKamischkeCKulasekaraHDc-di-GMP heterogeneity is generated by the chemotaxis machinery to regulate flagellar motilityElife20132e0140224347546
- KuchmaSLDelalezNJFilkinsLMCyclic Di-GMP-mediated repression of swarming motility by Pseudomonas aeruginosa PA14 requires the MotAB statorJ Bacteriol201519742043025349157
- RyanRPTolker-NielsenTDowJMWhen the PilZ don’t work: effectors for cyclic di-GMP action in bacteriaTrends Microbiol20122023524222444828
- BoydCDO’TooleGASecond messenger regulation of biofilm formation: breakthroughs in understanding c-di-GMP effector systemsAnnu Rev Cell Dev Biol20122843946223057745
- LeeVTMatewishJMKesslerJLA cyclic-di-GMP receptor required for bacterial exopolysaccharide productionMol Microbiol2007651474148417824927
- BaraquetCMurakamiKParsekMRHarwoodCSThe FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response to c-di-GMPNucleic Acids Res201240157207721822581773
- BrencicALorySDetermination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmAMol Microbiol20097261263219426209
- HäusslerSBiofilm formation by the small colony variant phenotype of Pseudomonas aeruginosaEnviron Microbiol2004654655115142242
- ChambersJRSauerKSmall RNAs and their role in biofilm formationTrends Microbiol201321394923178000
- BrencicAMcFarlandKAMcManusHRThe GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAsMol Microbiol20097343444519602144
- GoodmanALMerighiMHyodoMDirect interaction between sensor kinase proteins mediates acute and chronic disease phenotypes in a bacterial pathogenGenes Dev20092324925919171785
- RauMHHansenSKJohansenHKEarly adaptive developments of Pseudomonas aeruginosa after the transition from life in the environment to persistent colonization in the airways of human cystic fibrosis hostsEnviron Microbiol2010121643165820406284
- ScottFWPittTLIdentification and characterization of transmissible Pseudomonas aeruginosa strains in cystic fibrosis patients in England and WalesJ Med Microbiol20045360961515184530
- HogardtMHeesemannJAdaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lungInt J Med Microbiol201030055756220943439
- BantinakiEKassenRKnightCGAdaptive divergence in experimental populations of Pseudomonas fluorescens. III. Mutational origins of wrinkly spreader diversityGenetics200717644145317339222
- HogardtMHobothCSchmoldtSStage-specific adaptation of hypermutable Pseudomonas aeruginosa isolates during chronic pulmonary infection in patients with cystic fibrosisJ Infect Dis2007195708017152010
- SmaniaAMSeguraIPezzaRJEmergence of phenotypic variants upon mismatch repair disruption in Pseudomonas aeruginosaMicrobiology20041501327133815133095
- MukherjeeACuiYMaWLiuYChatterjeeAKhexA of Erwinia carotovora ssp carotovora strain Ecc71 negatively regulates production of RpoS and rsmB RNA, a global regulator of extracellular proteins, plant virulence and the quorum-sensing signal, N-(3-oxohexanoyl)-L-homoserine lactoneEnviron Microbiol2000220321511220306
- MenaASmithEEBurnsJLGenetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutationJ Bacteriol20081907910791718849421
- RömlingUSchmidtKDTummlerBLarge chromosomal inversions occur in Pseudomonas aeruginosa clone C strains isolated from cystic fibrosis patientsFEMS Microbiol Lett19971501491569163919
- KresseAUDineshSDLarbigKRömlingUImpact of large chromosomal inversions on the adaptation and evolution of Pseudomonas aeruginosa chronically colonizing cystic fibrosis lungsMol Microbiol20034714515812492860
- CuiLNeohHMIwamotoAHiramatsuKCoordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteriaProc Natl Acad Sci U S A2012109E1647E165622645353
- EckweilerDBunkBSproerCOvermannJHäusslerSComplete genome sequence of highly adherent Pseudomonas aeruginosa small-colony variant SCV20265Genome Announc201421e0123224459283
- TielenPWibbergDBlomJGenome sequence of the small-colony variant Pseudomonas aeruginosa MH27, isolated from a chronic urethral catheter infectionGenome Announc201421e0117424459261