Antibiotic therapy and Clostridium difficile infection – primum non nocere – first do no harm

References

• RevelesKRLeeGCBoydNKFreiCRThe rise in Clostridium difficile infection incidence among hospitalized adults in the United States: 2001–2010Am J Infect Control201442101028103225278388
   PubMed Web of Science ®Google Scholar
• HallICO’TooleEIntestinal flora in new-born infants: with a description of a new pathogenic anaerobe, Bacillus difficilisAm J Dis Child193549390402
   Google Scholar
• BartlettJGClostridium difficile: history of its role as an enteric pathogen and the current state of knowledge about the organismClin Infect Dis199418Suppl 4S265S2728086574
   PubMed Web of Science ®Google Scholar
• DethlefsenLHuseSSoginMLRelmanDAThe pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencingPLoS Biol2008611e28019018661
   PubMed Web of Science ®Google Scholar
• DethlefsenLRelmanDAIncomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbationProc Natl Acad Sci U S A2011108Suppl 14554456120847294
   PubMed Web of Science ®Google Scholar
• JakobssonHEJernbergCAnderssonAFSjolund-KarlssonMJanssonJKEngstrandLShort-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiomePLoS One201053e983620352091
   PubMed Web of Science ®Google Scholar
• FreemanJBauerMPBainesSDThe changing epidemiology of Clostridium difficile infectionsClin Microbiol Rev201023352954920610822
   PubMed Web of Science ®Google Scholar
• GuptaAKhannaSCommunity-acquired Clostridium difficile infection: an increasing public health threatInfect Drug Resist20147637224669194
   PubMed Web of Science ®Google Scholar
• PeeryAFDellonESLundJBurden of gastrointestinal disease in the United States: 2012 updateGastroenterology20121435e1171e1173
   Web of Science ®Google Scholar
• WiegandPNNathwaniDWilcoxMHStephensJShelbayaAHaiderSClinical and economic burden of Clostridium difficile infection in Europe: a systematic review of healthcare-facility-acquired infectionJ Hosp Infect201281111422498638
   PubMed Web of Science ®Google Scholar
• ChitnisASHolzbauerSMBelflowerRMEpidemiology of community-associated Clostridium difficile infection, 2009 through 2011JAMA Intern Med2013173141359136723780507
   PubMed Web of Science ®Google Scholar
• KuntzJLPolgreenPMThe importance of considering different healthcare settings when estimating the burden of Clostridium difficileClin Infect Dis201460683183625477426
   PubMed Web of Science ®Google Scholar
• DaviesKALongshawCMDavisGLUnderdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID)Lancet Infect Dis201414121208121925455988
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and PreventionAntibiotic Resistance Threats in the United States, 2013 Available from: http://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508.pdfAccessed December 26, 2014
   Google Scholar
• ClasenerHAVollaardEJvan SaeneHKLong-term prophylaxis of infection by selective decontamination in leukopenia and in mechanical ventilationRev Infect Dis1987922953283296099
   PubMedGoogle Scholar
• VollaardEJClasenerHAColonization resistanceAntimicrob Agents Chemother19943834094148203832
   PubMed Web of Science ®Google Scholar
• MonaghanTMNew perspectives in Clostridium difficile disease pathogenesisInfect Dis Clin North Am201529111125573674
   PubMed Web of Science ®Google Scholar
• HensgensMPGoorhuisADekkersOMKuijperEJTime interval of increased risk for Clostridium difficile infection after exposure to antibioticsJ Antimicrob Chemother201267374274822146873
   PubMed Web of Science ®Google Scholar
• BaxterRRayGTFiremanBHCase-control study of antibiotic use and subsequent Clostridium difficile-associated diarrhea in hospitalized patientsInfect Control Hosp Epidemiol2008291445018171186
   PubMed Web of Science ®Google Scholar
• SettleCDWilcoxMHFawleyWNCorradoOJHawkeyPMProspective study of the risk of Clostridium difficile diarrhoea in elderly patients following treatment with cefotaxime or piperacillin-tazobactamAliment Pharmacol Ther19981212121712239882029
   PubMed Web of Science ®Google Scholar
• WilcoxMHShettyNFawleyWNChanging epidemiology of Clostridium difficile infection following the introduction of a national ribotyping-based surveillance scheme in EnglandClin Infect Dis20125581056106322784871
   PubMed Web of Science ®Google Scholar
• WilcoxMHFreemanJFawleyWLong-term surveillance of cefotaxime and piperacillin-tazobactam prescribing and incidence of Clostridium difficile diarrhoeaJ Antimicrob Chemother200454116817215163654
   PubMed Web of Science ®Google Scholar
• StevensVDumyatiGFineLSFisherSGvan WijngaardenECumulative antibiotic exposures over time and the risk of Clostridium difficile infectionClin Infect Dis2011531424821653301
   PubMed Web of Science ®Google Scholar
• DellitTHOwensRCMcGowanJEJrInfectious Diseases Society of AmericaSociety for Healthcare Epidemiology of AmericaInfectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardshipClin Infect Dis200744215917717173212
   PubMed Web of Science ®Google Scholar
• SandiumengeADiazERodriguezAImpact of diversity of antibiotic use on the development of antimicrobial resistanceJ Antimicrob Chemother20065761197120416565158
   PubMed Web of Science ®Google Scholar
• Abel zur WieschPKouyosRAbelSViechtbauerWBonhoefferSCycling empirical antibiotic therapy in hospitals: meta-analysis and modelsPLoS Pathog2014106e100422524968123
   PubMed Web of Science ®Google Scholar
• AlonsoCDTreadwaySBHannaDBEpidemiology and outcomes of Clostridium difficile infections in hematopoietic stem cell transplant recipientsClin Infect Dis20125481053106322412059
   PubMed Web of Science ®Google Scholar
• AlonsoCDMarrKAClostridium difficile infection among hematopoietic stem cell transplant recipients: beyond colitisCurr Opin Infect Dis201326432633123806895
   PubMed Web of Science ®Google Scholar
• NeofytosDKobayashiKAlonsoCDEpidemiology, risk factors, and outcomes of Clostridium difficile infection in kidney transplant recipientsTrans Infect Dis2013152134141
   PubMed Web of Science ®Google Scholar
• DebastSBBauerMPKuijperEJEuropean Society of Clinical Microbiology and Infectious DiseasesEuropean Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infectionClin Microbiol Infect201420Suppl 212624118601
   PubMed Web of Science ®Google Scholar
• JohnsonSLouieTJGerdingDNPolymer Alternative for CDI Treatment (PACT) investigatorsVancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trialsClin Infect Dis201459334535424799326
   PubMed Web of Science ®Google Scholar
• VenugopalAAJohnsonSFidaxomicin: a novel macrocyclic antibiotic approved for treatment of Clostridium difficile infectionClin Infect Dis201254456857422156854
   PubMed Web of Science ®Google Scholar
• SearsPIchikawaYRuizNGorbachSAdvances in the treatment of Clostridium difficile with fidaxomicin: a narrow spectrum antibioticAnn N Y Acad Sci20131291334123672600
   PubMed Web of Science ®Google Scholar
• LouieTJMillerMAMullaneKMOPT-80-003 Clinical Study GroupFidaxomicin versus vancomycin for Clostridium difficile infectionN Engl J Med2011364542243121288078
   PubMed Web of Science ®Google Scholar
• CornelyOACrookDWEspositoROPT-80-004 Clinical Study GroupFidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trialLancet201212428128922321770
   PubMed Web of Science ®Google Scholar
• CrookDWWalkerASKeanYStudy 003/004 TeamsFidaxomicin versus vancomycin for Clostridium difficile infection: meta-analysis of pivotal randomized controlled trialsClin Infect Dis201255Suppl 2S93S10322752871
   PubMed Web of Science ®Google Scholar
• WilcoxMHHawkeyPMPatelBPlancheTStoneSUpdated guidance on the management and treatment of Clostridium difficile infection; 2015 Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/321891/Clostridium_difficile_management_and_treatment.pdf2013Accessed January 17, 2015
   Google Scholar
• SurawiczCMBrandtLJBinionDGGuidelines for diagnosis, treatment, and prevention of Clostridium difficile infectionsAm J Gastroenterol20131084478498 quiz 49923439232
   PubMed Web of Science ®Google Scholar
• IvarssonMELerouxJCastagnerBInvestigational new treatments for Clostridium difficile infectionDrug Discov Today20152060260825499664
   PubMed Web of Science ®Google Scholar
• TarkkanenAMHeinonenTJõgiRP1A recombinant beta-lactamase prevents emergence of antimicrobial resistance in gut micro-flora of healthy subjects during intravenous administration of ampicillinAntimicrob Agents Chemother20095362455246219307374
   PubMed Web of Science ®Google Scholar
• BhansaliSGMullaneKTingLSLeedsJDabovicKPraestgaardJPharmacokinetics of LFF571 and vancomycin in patients with moderate Clostridium difficile infectionsAntimicrob Agents Chemother20145919
   Web of Science ®Google Scholar
• ChangJYAntonopoulosDAKalraADecreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrheaJ Infect Dis2008197343543818199029
   PubMed Web of Science ®Google Scholar
• LowyIMolrineDCLeavBATreatment with monoclonal antibodies against Clostridium difficile toxinsN Engl J Med2010362319720520089970
   PubMed Web of Science ®Google Scholar
• SafdarATreatment with monoclonal antibodies against Clostridium difficile toxinsN Engl J Med20103621514441445 author reply 1445–144620397289
   PubMed Web of Science ®Google Scholar
• GensKDElshabouryRHHoltJSFecal microbiota transplantation and emerging treatments for Clostridium difficile infectionJ Pharm Prac2013265498505
   PubMedGoogle Scholar
• ZhaoSGhose-PaulCZhangKTziporiSSunXImmune-based treatment and prevention of Clostridium difficile infectionHum Vaccin Immunother201410123522353025668664
   PubMed Web of Science ®Google Scholar
• GerdingDNJohnsonSManagement of Clostridium difficile infection: thinking inside and outside the boxClin Infect Dis201051111306131320979491
   PubMed Web of Science ®Google Scholar