83
Views
9
CrossRef citations to date
0
Altmetric
Original Research

The effects of diet-induced obesity on hepatocyte insulin signaling pathways and induction of non-alcoholic liver damage

, , , &
Pages 211-219 | Published online: 15 Mar 2011

References

  • DeFronzoRAFerranniniEInsulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular diseaseDiabetes Care1991141731942044434
  • HotamisligilGSMechanisms of TNF-alpha-induced insulin resistanceExp Clin Endocrinol Diabetes199910711912510320052
  • SteppanCMBaileySTBhatSThe hormone resistin links obesity to diabetesNature200140930731211201732
  • BjorntorpP“Portal” adipose tissue as a generator of risk factors for cardiovascular disease and diabetesArteriosclerosis1990104934962196039
  • BodenGRole of fatty acids in the pathogenesis of insulin resistance and NIDDMDiabetes1997463108971073
  • WilliamsonJRMechanism for the stimulation in vivo of hepatic gluconeogenesis by glucagonBiochem J196610111C14C
  • XuJNakamuraMTChoHPClarkeSDSterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fatsJ Biol Chem1999274235772358310438539
  • OakesNDBellKSFurlerSMDiet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoADiabetes199746202220289392490
  • MittlemanSDVan CittersGWKimSPLongitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell responseDiabetes2000492116212511118015
  • MichaelMDKulkarniRNPosticCLoss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunctionMol Cell20006879710949030
  • MarchesiniGBabiniMNon-alcoholic fatty liver disease and metabolic syndromeMinerva Cardioangiol20065422923916778754
  • ImhofAKratzerWBoehmBPrevalence of non-alcoholic fatty liver and characteristics in overweight adolescents in the general populationEur J Epidemiol20072288989717896181
  • BruntEMJanneyCGDi BisceglieAMNeuschwander-TetriBABaconBRNonalcoholic steatohepatitis: a proposal for grading and staging the histological lesionsAm J Gastroenterol1999942467247410484010
  • SparksJDSparksCEInsulin regulation of triacylglycerol-rich lipoprotein synthesis and secretionBiochim Biophys Acta199412159327948013
  • ZammitVAUse of in vivo and in vitro techniques for the study of the effects of insulin on hepatic triacylglycerol secretion in different insulinaemic statesBiochem Soc Trans20002810310910816109
  • StarzlTEWatanabeKPorterKAPutnamCWEffects of insulin, glucagon, and insulin/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogsLancet1976182182556646
  • AnaiMFunakiMOgiharaTAltered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty ratsDiabetes19984713239421369
  • FriedmanJEIshizukaTLiuSReduced insulin receptor signaling in the obese spontaneously hypertensive Koletsky ratAm J Physiol1997273E1014E10239374689
  • SaadMJArakiEMiralpeixMRothenbergPlWhiteMFKahnCRRegulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistanceJ Clin Invest199290183918491331176
  • SestiGFedericiMHribalMLLauroDSbracciaPLauroRDefects of the insulin receptor substrate (IRS) system in human metabolic disordersFASEB J2001152099211111641236
  • RotherKIImaiYCarusoMBeguinotFFormisanoPAcciliDEvidence that IRS-2 phosphorylation is required for insulin action in hepatocytesJ Biol Chem199827317491174979651339
  • ValverdeAMBurksDJFabregatIMolecular mechanisms of insulin resistance in IRS-2-deficient hepatocytesDiabetes2003522239224812941762
  • KimYBPeroniODFrankeTFKahnBBDivergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker ratsDiabetes20004984785610905496
  • LiJBilliarTRNitric Oxide. IV. Determinants of nitric oxide protection and toxicity in liverAm J Physiol1999276G1069G107310329995
  • McNaughtonLPuttaguntaLMartinez-CuestaMADistribution of nitric oxide synthase in normal and cirrhotic human liverProc Natl Acad Sci U S A200299171611716612482944
  • FataniSHNaderaliEKPanchianiSShahSWongCThe effects of dietary obesity on protein expressions of insulin signaling pathway in rat aortaDrug Discov Ther20082254261
  • McCurdyCEDavidsonRTCarteeGDBrief calorie restriction increases AKt2 phosphorylation in insulin-stimulated rat skeletal muscleAm J Physiol Endocrinol Metab2003285693700
  • GauthierMSFavierRLavoieJMTime course of the development of non-alcoholic hepatic steatosis in response to high-fat diet-induced obesity in ratsBr J Nutr20069527328116469142
  • LiZYangSLinHProbiotics and antibodies to TNF inhibit inflammatory activity and improve non-alcoholic fatty liver diseaseHepatology20033734335012540784
  • UchiharaMIzumiNHigh-sensitivity C-reactive protein (hs-CRP): a promising biomarker for the screening of nonalcoholic steatohepatitis (NASH)Nippon Rinsho2006641133113816768121
  • YangSQLinHZMandalAKHuangJDiehlAMDisrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiologyHepatology2001344 Pt 169470611584365
  • YangSQLiYLinHZGabriesonKTrushMADiehlAMMitochondrial adaptations to obesity-related oxidant stressArch Biochem Biophys200037825926810860543
  • LeeFYLiYZhuHTumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating rat liverHepatology19992967768710051468
  • BostFMcKayRDeanNMercolaDThe JnK kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cellsJ Biol Chem199727233422334299407138
  • SaxenaNKTitusMADingXLeptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk and Akt phosphorylation)FASEB J2004181612161415319373
  • NaderaliEKFataniSTellesMHunterLThe effects of physiological and pharmacological weight loss on adiponectin and leptin mRNA levels in the rat epididymal adipose tissueEur J Pharmacol200857943343818155694
  • PalmerMSchaffnerFEffect of weight reduction on hepatic abnormalities in overweight patientsGastroenterology199099140814132210247
  • HickmanIJJonssonJRPrinsJBModest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of lifeGut20045341341914960526
  • IpEFarrellGCRobertsonGHallPKirschRLeclercqICentral role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in miceHepatology20033812313212829994
  • NagasawaTInadaYNakanoSEffects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient dietEur J Pharmacol200653618219116574099