Circulating miR-155 and JAK2/STAT3 Axis in Acute Ischemic Stroke Patients and Its Relation to Post-Ischemic Inflammation and Associated Ischemic Stroke Risk Factors

References

• Heron M. Deaths: leading causes for 2004. Natl Vital Stat Rep. 2007;56:1–96.
   PubMedGoogle Scholar
• Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors,2001: systematic analysis of population health data. Lancet. 2006;367(9524):1747–1757. doi:10.1016/S0140-6736(06)68770-9
   PubMed Web of Science ®Google Scholar
• Adogu POU, Ubajaka CF, Emelumadu OF, Alutu COC. Epidemiologic transition of diseases and health-related events in developing countries: a review. Am J Med Sci Med Sci. 2015;5(4):150–157.
   Google Scholar
• Bamford J, Sandercock P, Dennis M, Burn J, Warlow C. Classification and natural history of clinical identifiable subtypes of cerebral infarction. Lancet. 1991;337(8756):1521–1526. doi:10.1016/0140-6736(91)93206-O
   PubMed Web of Science ®Google Scholar
• Béjot Y, Bailly H, Durier J, Giroud M. Epidemiology of stroke in Europe and trends for the 21st century. La Presse Médicale. 2016;45:e391–e398. doi:10.1016/j.lpm.2016.10.003
   PubMed Web of Science ®Google Scholar
• Ekker MS, Boot EM, Singhal AB, et al. Epidemiology, aetiology, and management of ischaemic stroke in young adults. Lancet Neurol. 2018;17:790–801. doi:10.1016/S1474-4422(18)30233-3
   PubMed Web of Science ®Google Scholar
• Powers WJ. Acute ischemic stroke. N Engl J Med. 2020;383:252–260. doi:10.1056/NEJMcp1917030
   PubMed Web of Science ®Google Scholar
• Pearce WJ. Epigenetics: an expanding new piece of the stroke puzzle. Transl Stroke Res. 2011;2:243–247. doi:10.1007/s12975-011-0094-0
   PubMed Web of Science ®Google Scholar
• Kassis H, Shehadah A, Chopp M, Zhang ZG. Epigenetics in stroke recovery. Genes. 2017;8:89. doi:10.3390/genes8030089
   PubMed Web of Science ®Google Scholar
• Lakhan SE, Kirchgessner A, Hofer M. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med. 2009;7:97. doi:10.1186/1479-5876-7-97
   PubMed Web of Science ®Google Scholar
• Kadir RRA, Bayraktutan U. Urokinase plasminogen activator: a potential thrombolytic agent for ischaemic stroke. Cell Mol Neurobiol. 2020;40:347–355. doi:10.1007/s10571-019-00737-w
   PubMed Web of Science ®Google Scholar
• Roitbak T. Silencing a multifunctional microRNA is beneficial for stroke recovery. Front Mol Neurosci. 2018;11:58. doi:10.3389/fnmol.2018.00058
   PubMed Web of Science ®Google Scholar
• Bulygin KV, Beeraka NM, Saitgareeva AR, et al. Can miRNAs be considered as diagnostic and therapeutic molecules in ischemic stroke pathogenesis?—Current status. Int J Mol Sci. 2020;21(18):6728. doi:10.3390/ijms21186728
   PubMed Web of Science ®Google Scholar
• Vijayan M, Reddy PH. Peripheral biomarkers of stroke: focus on circulatory microRNAs. Biochim Biophys Acta (BBA)-Mol Basis Dis. 2016;1862:1984–1993. doi:10.1016/j.bbadis.2016.08.003
   PubMed Web of Science ®Google Scholar
• Khoshnam SE, Winlow W, Farbood Y, Moghaddam HF, Farzaneh M. Emerging roles of microRNAs in ischemic stroke: as possible therapeutic agents. J Stroke. 2017;19(2):166–187. doi:10.5853/jos.2016.01368
   PubMed Web of Science ®Google Scholar
• Nakka VP, Prakash-babu P, Vemuganti R. Crosstalk between endoplasmic reticulum stress, oxidative stress, and autophagy: potential therapeutic targets for acute CNS injuries. Mol Neurobiol. 2016;53:532–544. doi:10.1007/s12035-014-9029-6
   PubMed Web of Science ®Google Scholar
• O’Brien J, Hayder H, Zayed Y, Peng C. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne). 2018;9:402. doi:10.3389/fendo.2018.00402
   PubMed Web of Science ®Google Scholar
• Eyileten C, Wicik Z, De Rosa S, et al. MicroRNAs as diagnostic and prognostic biomarkers in ischemic stroke—A comprehensive review and bioinformatic analysis. Cells. 2018;7:249. doi:10.3390/cells7120249
   PubMed Web of Science ®Google Scholar
• Vijayan M, Reddy PH. Non-coding RNAs based molecular links in type 2 diabetes, ischemic stroke, and vascular dementia. J Alzheimers Dis. 2020;75:353–383. doi:10.3233/JAD-200070
   PubMed Web of Science ®Google Scholar
• Vijayan M, Kumar S, Yin X, et al. Identification of novel circulatory microRNA signatures linked to patients with ischemic stroke. Hum Mol Genet. 2018;27(13):2318–2329. doi:10.1093/hmg/ddy136
   PubMed Web of Science ®Google Scholar
• Faraoni I, Antonetti FR, Cardone J, Bonmassar E. miR-155 gene: a typical multifunctional microRNA. Biochim Biophys Acta. 2009;1792:497–505. doi:10.1016/j.bbadis.2009.02.013
   PubMed Web of Science ®Google Scholar
• Cardoso AL, Guedes JR, Pedroso de Lima MC. miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production. Immunology. 2012;135:73–88. doi:10.1111/j.1365-2567.2011.03514.x
   PubMed Web of Science ®Google Scholar
• Lim KY, Chua JH, Tan JR, et al. MicroRNAs in cerebral ischemia. Transl Stroke Res. 2010;1:287–303. doi:10.1007/s12975-010-0035-3
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang J, Han R, Liu H, Sun D, Liu X. Downregulation of serum brain specific microRNA is associated with inflammation and infarct volume in acute ischemic stroke. J Clin Neurosci. 2015;22:291. doi:10.1016/j.jocn.2014.05.042
   PubMed Web of Science ®Google Scholar
• Zhu N, Zhang D, Chen S, et al. Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration. Atherosclerosis. 2011;215:286–293. doi:10.1016/j.atherosclerosis.2010.12.024
   PubMed Web of Science ®Google Scholar
• Tian FJ, An LN, Wang GK, et al. Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis. Cardiovasc Res. 2014;103:100–110. doi:10.1093/cvr/cvu070
   PubMed Web of Science ®Google Scholar
• Nazari-Jahantigh M, Wei Y, Noels H, et al. MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J Clin Invest. 2012;122:4190–4202. doi:10.1172/JCI61716
   PubMed Web of Science ®Google Scholar
• Yao R, Ma YL, Liang W, et al. MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1. PLoS One. 2012;7:e46082. doi:10.1371/journal.pone.0046082
   PubMed Web of Science ®Google Scholar
• Sun H-X, Zeng D-Y, Li R-T, et al. Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase. Hypertension. 2012;60:1407–1414. doi:10.1161/HYPERTENSIONAHA.112.197301
   PubMed Web of Science ®Google Scholar
• Guedes JR, Custodia CM, Silva RJ, de Almeida LP, de Lima MCP, Cardoso AL. Early miR-155 upregulation contributes to neuroinflammation in Alzheimer’s disease triple transgenic mouse model. Hum Mol Genet. 2014;23:6286–6301. doi:10.1093/hmg/ddu348
   PubMed Web of Science ®Google Scholar
• Lopez‐Ramirez MA, Wu D, Pryce G, et al. MicroRNA‐155 negatively affects blood–brain barrier function during neuroinflammation. FASEB J. 2014;28(6):2551–2565. doi:10.1096/fj.13-248880
   PubMed Web of Science ®Google Scholar
• Pena-Philippides JC, Caballero-Garrido E, Lordkipanidze T. In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response. J Neuroinflammation. 2016;13:1–16. doi:10.1186/s12974-016-0753-x
   PubMed Web of Science ®Google Scholar
• Zhang L, Liu C, Huang C, Xiaohui X, Teng J. miR-155 knockdown protects against cerebral ischemia and reperfusion injury by targeting MafB. Biomed Res Int. 2020;2020:11.
   Web of Science ®Google Scholar
• Chen Q, Lv J, Yang W, et al. Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis. Theranostics. 2019;9(22):6424–6442. doi:10.7150/thno.35528
   PubMed Web of Science ®Google Scholar
• Liang Z, Wu G, Fan C, et al. The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke. Prog Neurobiol. 2016;137:1–16. doi:10.1016/j.pneurobio.2015.11.001
   PubMed Web of Science ®Google Scholar
• Tian YS, Zhong D, Liu QQ, et al. Upregulation of miR-216a exerts neuroprotective effects against ischemic injury through negatively regulating JAK2/STAT3-involved apoptosis and inflammatory pathways. J Neurosurg. 2018;130(3):977–988. doi:10.3171/2017.5.JNS163165
   PubMed Web of Science ®Google Scholar
• Wu Y, Xu J, Xu J, Zheng W, Chen Q, Jiao D. Study on the mechanism of JAK2/STAT3 signaling pathway-mediated inflammatory reaction after cerebral ischemia. Mol Med Rep. 2018;17(4):5007–5012. doi:10.3892/mmr.2018.8477
   PubMed Web of Science ®Google Scholar
• Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470–475. doi:10.1093/clinchem/20.4.470
   PubMed Web of Science ®Google Scholar
• Lopes-virella ME, Stone P, Elliss S. Cholesterol determination in high density lipoprotein separated by three different methods. Clin Chem. 1977;23:882–884. doi:10.1093/clinchem/23.5.882
   PubMed Web of Science ®Google Scholar
• Neri BP, Frings CS. Improved method for determination of triglycerides in serum. Clin Chem. 1973;19(10):1201–1202. doi:10.1093/clinchem/19.10.1201
   PubMed Web of Science ®Google Scholar
• Friedewald WT, Levy RL, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502. doi:10.1093/clinchem/18.6.499
   PubMed Web of Science ®Google Scholar
• Virtue A, Mai J, Yin Y, et al. Structural evidence of anti-atherogenic microRNAs. Front Biosci. 2011;16:3133–3145. doi:10.2741/3901
   Web of Science ®Google Scholar
• Tsai PC, Liao YC, Wang YS, Lin HF, Lin RT, Juo SH. Serum microRNA-21and microRNA-221 as potential biomarkers for cerebrovascular disease. J Vasc Res. 2013;50:346–354. doi:10.1159/000351767
   PubMed Web of Science ®Google Scholar
• Graff JW, Dickson AM, Clay G, McCaffrey AP, Wilson ME. Identifying functional microRNAs in macrophages with polarized phenotypes. J Biol Chem. 2012;287:21816–21825. doi:10.1074/jbc.M111.327031
   PubMed Web of Science ®Google Scholar
• Yao Y, Li G, Wu J, Zhang X, Wang J. Inflammatory response of macrophages cultured with Helicobacter pylori strains was regulated by miR-155. Int J Clin Exp Pathol. 2015;8:4545–4554.
   PubMed Web of Science ®Google Scholar
• Liu H, Yao YM, Yu Y, Dong N, Yin HN, Sheng ZY. Role of Janus kinase/signal transducer and activator of transcription pathway in regulation of expression and inflammation-promoting activity of high mobility group box protein 1 in rat peritoneal macrophages. Shock. 2007;27:55–60. doi:10.1097/01.shk.0000233197.40989.31
   PubMed Web of Science ®Google Scholar
• Pan J, Meijie Q, Yongfang L, et al. MicroRNA-126-3p/-5p overexpression attenuates blood–brain barrier disruption in a mouse model of middle cerebral artery occlusion. Stroke. 2020;51:619–627. doi:10.1161/STROKEAHA.119.027531
   PubMed Web of Science ®Google Scholar
• Chamorro A, Vila N, Ascaso C, et al. Early prediction of stroke severity role of the erythrocyte sedimentation rate. Stroke. 1995;26(4):573–576.
   PubMed Web of Science ®Google Scholar
• Singh AS, Atam V, Yathish BE, et al. Role of erythrocyte sedimentation rate in ischemic stroke as an inflammatory marker of carotid atherosclerosis. J Neurosci Rural Pract. 2014;5(1):40–45. doi:10.4103/0976-3147.127870
   PubMedGoogle Scholar
• Escobar T, Yu CR, Muljo SA, Egwuagu CE. STAT3 activates miR-155 in Th17 cells and acts in concert to promote experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2013;54(6):4017–4025. doi:10.1167/iovs.13-11937
   PubMed Web of Science ®Google Scholar
• Perera MN, Ma HK, Arakawa S, et al. Inflammation following stroke. J Clin Neurosci. 2006;13:1–8. doi:10.1016/j.jocn.2005.07.005
   PubMed Web of Science ®Google Scholar
• Li X, Kong D, Chen H, et al. miR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1. Sci Rep. 2016;6:21789. doi:10.1038/srep21789
   PubMed Web of Science ®Google Scholar
• Nazari-Jahantigh M, Wei Y, Schober A. The role of microRNAs in arterial remodelling. Thromb Haemost. 2012;107:611–618. doi:10.1160/TH11-12-0826
   PubMed Web of Science ®Google Scholar
• Vasamsetti SB, Karnewar S, Kanugula AK, Thatipalli AR, Kumar JM, Kotamraju S. Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis. Diabetes. 2015;64:2028–2041. doi:10.2337/db14-1225
   PubMed Web of Science ®Google Scholar
• Min X, Ungureanu D, Maxwell S, et al. Structural and functional characterization of the JH2 pseudokinase domain of JAK family tyrosine kinase 2 (TYK2). J Biol Chem. 2015;290:27261–27270. doi:10.1074/jbc.M115.672048
   PubMed Web of Science ®Google Scholar
• Ceolotto G, Papparella I, Bortoluzzi A, et al. Interplay between miR-155, AT1R A1166C polymorphism, and AT1R expression in young untreated hypertensives. Am J Hypertens. 2011;24(2):241–246. doi:10.1038/ajh.2010.211
   PubMed Web of Science ®Google Scholar
• Johnson AW, Kinzenbaw DA, Modrick ML, Farac FM. Small-molecule inhibitors of signal transducer and activator of transcription 3 protect against angiotensin II–induced vascular dysfunction and hypertension. Hypertension. 2013;61:437–442. doi:10.1161/HYPERTENSIONAHA.111.00299
   PubMed Web of Science ®Google Scholar
• Huang Y, Chen J, Zhou Y, et al. Circulating miR155 expression level is positive with blood pressure parameters: potential markers of target-organ damage. Clin Exp Hypertens. 2016;38:331–336. doi:10.3109/10641963.2015.1116551
   PubMed Web of Science ®Google Scholar
• Huang Y-Q, Huang C, Zhang B, Feng Y-Q. Association of circulating miR-155 expression level and inflammatory markers with white coat hypertension. Hum Hypertens. 2020;34:397–403. doi:10.1038/s41371-019-0250-7
   PubMed Web of Science ®Google Scholar
• Faccini J, Ruidavets J-B, Cordelier P, et al. Circulating miR-155, miR-145 and let-7c as diagnostic biomarkers of the coronary artery disease. Sci Rep. 2017;7:42916. doi:10.1038/srep42916
   PubMed Web of Science ®Google Scholar
• Yang X, Jia J, Yu Z, et al. Inhibition of JAK2/STAT3/SOCS3 signaling attenuates atherosclerosis in rabbit. BMC Cardiovasc Disord. 2020;20:133. doi:10.1186/s12872-020-01391-7
   PubMed Web of Science ®Google Scholar
• Tran KV, Majka J, Sanghai S, et al. Micro-RNAs are related to epicardial adipose tissue in participants with atrial fibrillation: data from the MiRhythm study. Front Cardiovasc Med. 2019;6:115. doi:10.3389/fcvm.2019.00115
   PubMed Web of Science ®Google Scholar
• Komal S, Yin -J-J, Wang S-H, Huang C-Z, Tao H-L, Dong J-Z. MicroRNAs: emerging biomarkers for atrial fibrillation. J Cardiol. 2019;74(6):475–482. doi:10.1016/j.jjcc.2019.05.018
   PubMed Web of Science ®Google Scholar
• McManus DD, Tanriverdi K, Lin H, et al. Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study). Heart Rhythm. 2015;12(1):3–10. doi:10.1016/j.hrthm.2014.09.050
   PubMed Web of Science ®Google Scholar
• Xue XD, Huang JH, Wang HS. Angiotensin II activates signal transducers and activators of transcription 3 via Rac1 in the atrial tissue in permanent atrial fibrillation patients with rheumatic heart disease. Cell Biochem Biophys. 2015;71:205–213. doi:10.1007/s12013-014-0186-z
   PubMed Web of Science ®Google Scholar
• Chen Y, Surinkaew S, Naud P. JAK-STAT signalling and the atrial fibrillation promoting fibrotic substrate. Cardiovasc Res. 2017;113:310–320. doi:10.1093/cvr/cvx004
   PubMed Web of Science ®Google Scholar
• Yang S, Zhao J, Chen Y, Lei M. Biomarkers associated with ischemic stroke in diabetes mellitus patients. Cardiovasc Toxicol. 2016;16:213–222. doi:10.1007/s12012-015-9329-8
   PubMed Web of Science ®Google Scholar
• Fichtlscherer S, Zeiher AM, Dimmeler S. Circulating microRNAs: biomarkers or mediators of cardiovascular diseases? Arterioscler Thromb Vasc Biol. 2011;31:2383–2390. doi:10.1161/ATVBAHA.111.226696
   PubMed Web of Science ®Google Scholar
• Yang M, Tian M, Zhang X. Role of the JAK2/STAT3 signaling pathway in the pathogenesis of type 2 diabetes mellitus with macrovascular complications. Oncotarget. 2017;8:96958–96969. doi:10.18632/oncotarget.18555
   PubMedGoogle Scholar
• Pan B, Jin X, Jun L, Qiu S, Zheng Q, Pan M. The relationship between smoking and stroke. Medicine. 2019;98(12):e14872. doi:10.1097/MD.0000000000014872
   PubMed Web of Science ®Google Scholar
• Frati G, Forte M, Di Nonno F, Bordin A, Chimenti I, Picchio V. inhibition of miR‐155 attenuates detrimental vascular effects of tobacco cigarette smoking. J Am Heart Assoc. 2020;9:e017000. doi:10.1161/JAHA.120.017000
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xie Y, Zhang L, Zhao H. MicroRNA-155 participates in smoke-inhalation-induced acute lung injury through inhibition of SOCS-1. Molecules. 2020;25(5):1022. doi:10.3390/molecules25051022
   PubMed Web of Science ®Google Scholar
• De Smet EG, Van Eeckhoutte HP, Avila Cobos F, et al. The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD. Mucosal Immunol. 2020;13(3):423–436.
   PubMed Web of Science ®Google Scholar
• Xu S, Ni H, Chen H, Dai Q. The interaction between STAT3 and nAChRα1 interferes with nicotine-induced atherosclerosis via Akt/mTOR signaling cascade. AGING. 2019;11(19):8120. doi:10.18632/aging.102296
   PubMedGoogle Scholar
• Kim JM, Jung KH, Chu K, et al. Atherosclerosis-related circulating microRNAs as a predictor of stroke recurrence. Transl Stroke Res. 2015;6:191–197. doi:10.1007/s12975-015-0390-1
   PubMed Web of Science ®Google Scholar
• Zhang Z, Xu G, Cai B, Zhang H, Zhu W, Liu X. Genetic variants in microRNAs predict recurrence of ischemic stroke. Mol Neurobiol. 2017;54(4):2776–2780. doi:10.1007/s12035-016-9865-7
   PubMed Web of Science ®Google Scholar
• Ryu CS, Oh SH, Lee KO, et al. MiR-10a, 27a, 34b/c, and 300 polymorphisms are associated with ischemic stroke susceptibility and post-stroke mortality. Life. 2020;10(12):309. doi:10.3390/life10120309
   PubMedGoogle Scholar