Potential Genes and Mechanisms Linking Intracerebral Hemorrhage and Depression: A Bioinformatics-Based Study

References

• Johnson CO, Nguyen M, Roth GA, et al. Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(5):439–458. doi:10.1111/j.1460-9568.2007.05436.x
   PubMed Web of Science ®Google Scholar
• Wu S, Wu B, Liu M, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol. 2019;18(4):394–405. doi:10.1016/S1474-4422(18)30500-3
   PubMed Web of Science ®Google Scholar
• Jokinen H, Melkas S, Ylikoski R, et al. Post-stroke cognitive impairment is common even after successful clinical recovery. Eur J Neurol. 2015;22(9):1288–1294. doi:10.1111/ene.12743
   PubMed Web of Science ®Google Scholar
• Zhao F, Yue Y, Jiang H, Yuan Y. Shared genetic risk factors for depression and stroke. Prog Neuropsychopharmacol Biol Psychiatry. 2019;93:55–70. doi:10.1016/j.pnpbp.2019.03.003
   PubMed Web of Science ®Google Scholar
• Gilsanz P, Walter S, Tchetgen Tchetgen EJ, et al. Changes in depressive symptoms and incidence of first stroke among middle-aged and older US adults. J Am Heart Assoc. 2015;4(5). doi:10.1161/JAHA.115.001923.
   PubMed Web of Science ®Google Scholar
• Stern-Nezer S, Eyngorn I, Mlynash M, et al. Depression one year after hemorrhagic stroke is associated with late worsening of outcomes. NeuroRehabilitation. 2017;41(1):179–187. doi:10.3233/NRE-171470
   PubMed Web of Science ®Google Scholar
• Hackett ML, Pickles K. Part I: frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies. Int J Stroke. 2014;9(8):1017–1025. doi:10.1111/ijs.12357
   PubMed Web of Science ®Google Scholar
• Flaherty ML, Haverbusch M, Sekar P, et al. Long-term mortality after intracerebral hemorrhage. Neurology. 2006;66(8):1182–1186. doi:10.1212/01.wnl.0000208400.08722.7c
   PubMed Web of Science ®Google Scholar
• Lioutas VA, Beiser AS, Aparicio HJ, et al. Assessment of incidence and risk factors of intracerebral hemorrhage among participants in the Framingham Heart Study between 1948 and 2016. JAMA Neurol. 2020;77:1252. doi:10.1001/jamaneurol.2020.1512
   PubMed Web of Science ®Google Scholar
• Fisher OS, Deng H, Liu D, et al. Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun. 2015;6:7937. doi:10.1038/ncomms8937
   PubMed Web of Science ®Google Scholar
• Sun Y, Liu XL, Zhang D, et al. Platelet-derived exosomes affect the proliferation and migration of human umbilical vein endothelial cells via miR-126. Curr Vasc Pharmacol. 2019;17(4):379–387. doi:10.2174/1570161116666180313142139
   PubMed Web of Science ®Google Scholar
• Wang X, Hou Y, Deng K, Zhang Y, Wang DC, Ding J. Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3. Structure. 2015;23(6):1087–1096. doi:10.1016/j.str.2015.04.003
   PubMed Web of Science ®Google Scholar
• Wang Y, Pan L, Moens CB, Appel B. Notch3 establishes brain vascular integrity by regulating pericyte number. Development. 2014;141(2):307–317. doi:10.1242/dev.096107
   PubMed Web of Science ®Google Scholar
• Xing C, Wang X, Cheng C, et al. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke. 2014;45(7):2085–2092. doi:10.1161/STROKEAHA.114.005733
   PubMed Web of Science ®Google Scholar
• Yang J, Wang Y, Zeng Z, et al. Smad4 deletion in blood vessel endothelial cells promotes ovarian cancer metastasis. Int J Oncol. 2017;50(5):1693–1700. doi:10.3892/ijo.2017.3957
   PubMed Web of Science ®Google Scholar
• Zhou HJ, Tang T, Zhong JH, et al. Electroacupuncture improves recovery after hemorrhagic brain injury by inducing the expression of angiopoietin-1 and −2 in rats. BMC Complement Altern Med. 2014;14:127. doi:10.1186/1472-6882-14-127
   PubMed Web of Science ®Google Scholar
• Woo D, Falcone GJ, Devan WJ, et al. Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. Am J Hum Genet. 2014;94(4):511–521. doi:10.1016/j.ajhg.2014.02.012
   PubMed Web of Science ®Google Scholar
• Koivunen RJ, Harno H, Tatlisumak T, Putaala J. Depression, anxiety, and cognitive functioning after intracerebral hemorrhage. Acta Neurol Scand. 2015;132(3):179–184. doi:10.1111/ane.12367
   PubMed Web of Science ®Google Scholar
• Wu Y, Wang L, Hu K, et al. Mechanisms and therapeutic targets of depression after intracerebral hemorrhage. Front Psychiatry. 2018;9:682. doi:10.3389/fpsyt.2018.00682
   PubMed Web of Science ®Google Scholar
• Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47. doi:10.1093/nar/gkv007
   PubMed Web of Science ®Google Scholar
• Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–287. doi:10.1089/omi.2011.0118
   PubMed Web of Science ®Google Scholar
• Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545–15550. doi:10.1073/pnas.0506580102
   PubMed Web of Science ®Google Scholar
• Liberzon A, Birger C, Thorvaldsdottir H, Ghandi M, Mesirov JP, Tamayo P. The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst. 2015;1(6):417–425. doi:10.1016/j.cels.2015.12.004
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Morris JH, Cook H, et al. The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 2017;45(D1):D362–D368. doi:10.1093/nar/gkw937
   PubMed Web of Science ®Google Scholar
• Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–2504. doi:10.1101/gr.1239303
   PubMed Web of Science ®Google Scholar
• Yu G, Li F, Qin Y, Bo X, Wu Y, Wang S. GOSemSim: an R package for measuring semantic similarity among GO terms and gene products. Bioinformatics. 2010;26(7):976–978. doi:10.1093/bioinformatics/btq064
   PubMed Web of Science ®Google Scholar
• Rahman MS, Yang J, Luan Y, et al. Attenuation of acute intracerebral hemorrhage-induced microglial activation and neuronal death mediated by the blockade of metabotropic glutamate receptor 5 in vivo. Neurochem Res. 2020;45(5):1230–1243. doi:10.1007/s11064-020-03006-1
   PubMed Web of Science ®Google Scholar
• Wang W, Qin X, Wang R, et al. EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice. J Affect Disord. 2020;272:452–464. doi:10.1016/j.jad.2020.03.154
   PubMed Web of Science ®Google Scholar
• Wen H, Weymann KB, Wood L, Wang QM. Inflammatory signaling in post-stroke fatigue and depression. Eur Neurol. 2018;80(3–4):138–148. doi:10.1159/000494988
   PubMed Web of Science ®Google Scholar
• Nguyen VA, Carey LM, Giummarra L, et al. A pathway proteomic profile of ischemic stroke survivors reveals innate immune dysfunction in association with mild symptoms of depression - a pilot study. Front Neurol. 2016;7:85. doi:10.3389/fneur.2016.00085
   PubMed Web of Science ®Google Scholar
• Jiang JL, El Mansari M, Blier P. Triple reuptake inhibition of serotonin, norepinephrine, and dopamine increases the tonic activation of alpha2-adrenoceptors in the rat hippocampus and dopamine levels in the nucleus accumbens. Prog Neuropsychopharmacol Biol Psychiatry. 2020;103:109987. doi:10.1016/j.pnpbp.2020.109987
   PubMed Web of Science ®Google Scholar
• Zou XH, Sun LH, Yang W, Li BJ, Cui RJ. Potential role of insulin on the pathogenesis of depression. Cell Prolif. 2020;53(5):e12806. doi:10.1111/cpr.12806
   PubMed Web of Science ®Google Scholar
• Jin J, Bhatti DL, Lee KW, et al. Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior. Mol Psychiatry. 2020;25(5):1035–1049. doi:10.1038/s41380-019-0371-y
   PubMed Web of Science ®Google Scholar
• Weiss R, Bitton A, Ben Shimon M, et al. Annexin A2, autoimmunity, anxiety and depression. J Autoimmun. 2016;73:92–99. doi:10.1016/j.jaut.2016.06.011
   PubMed Web of Science ®Google Scholar
• Hedhli N, Falcone DJ, Huang B, et al. The annexin A2/S100A10 system in health and disease: emerging paradigms. J Biomed Biotechnol. 2012;2012:406273. doi:10.1155/2012/406273
   PubMedGoogle Scholar
• Sayad A, Akbari MT, Inoko H, et al. Association between human leucocyte antigen alleles and risk of stroke in Iranian population. Int J Immunogenet. 2019;46(3):179–191. doi:10.1111/iji.12421
   PubMed Web of Science ®Google Scholar
• Glanville KP, Coleman JRI, Hanscombe KB, et al. Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression. Biol Psychiatry. 2020;87(5):419–430. doi:10.1016/j.biopsych.2019.06.031
   PubMed Web of Science ®Google Scholar
• Majsky A, Dvorakova M, Zvolsky P. [Modifications of lymphocyte HL-A antigens as a consequence of therapy in patients with manic-depressive psychosis]. Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(4):509–517. German.
   PubMedGoogle Scholar
• Tran NQV, Nguyen AN, Takabe K, Yamagata Z, Miyake K. Pre-treatment with amitriptyline causes epigenetic up-regulation of neuroprotection-associated genes and has anti-apoptotic effects in mouse neuronal cells. Neurotoxicol Teratol. 2017;62:1–12. doi:10.1016/j.ntt.2017.05.002
   PubMed Web of Science ®Google Scholar
• Yang Y, Dong B, Lu J, Wang G, Yu Y. Hemopexin reduces blood-brain barrier injury and protects synaptic plasticity in cerebral ischemic rats by promoting EPCs through the HO-1 pathway. Brain Res. 2018;1699:177–185. doi:10.1016/j.brainres.2018.08.008
   PubMed Web of Science ®Google Scholar
• Leclerc JL, Li C, Jean S, et al. Temporal and age-dependent effects of haptoglobin deletion on intracerebral hemorrhage-induced brain damage and neurobehavioral outcomes. Exp Neurol. 2019;317:22–33. doi:10.1016/j.expneurol.2019.01.011
   PubMed Web of Science ®Google Scholar
• Chen-Roetling J, Kamalapathy P, Cao Y, Song W, Schipper HM, Regan RF. Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage. Neurobiol Dis. 2017;102:140–146. doi:10.1016/j.nbd.2017.03.008
   PubMed Web of Science ®Google Scholar
• Zheng J, Dai Q, Han K, et al. JNK-IN-8, a c-Jun N-terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke. J Cell Physiol. 2020;235(3):2792–2799. doi:10.1002/jcp.29183
   PubMed Web of Science ®Google Scholar
• Zhang J, Lin W, Tang M, et al. Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation. Psychoneuroendocrinology. 2020;113:104580. doi:10.1016/j.psyneuen.2019.104580
   PubMed Web of Science ®Google Scholar
• Lu H, Ning X, Tao X, et al. MEKK1 associated with neuronal apoptosis following intracerebral hemorrhage. Neurochem Res. 2016;41(12):3308–3321. doi:10.1007/s11064-016-2063-1
   PubMed Web of Science ®Google Scholar
• Yang Y, Zhang K, Zhong J, et al. Stably maintained microtubules protect dopamine neurons and alleviate depression-like behavior after intracerebral hemorrhage. Sci Rep. 2018;8(1):12647. doi:10.1038/s41598-018-31056-7
   PubMed Web of Science ®Google Scholar
• Sharaf A, Bock HH, Spittau B, Bouche E, Krieglstein K. ApoER2 and VLDLr are required for mediating reelin signalling pathway for normal migration and positioning of mesencephalic dopaminergic neurons. PLoS One. 2013;8(8):e71091. doi:10.1371/journal.pone.0071091
   PubMed Web of Science ®Google Scholar
• Xiao MF, Xu JC, Tereshchenko Y, Novak D, Schachner M, Kleene R. Neural cell adhesion molecule modulates dopaminergic signaling and behavior by regulating dopamine D2 receptor internalization. J Neurosci. 2009;29(47):14752–14763. doi:10.1523/JNEUROSCI.4860-09.2009
   PubMed Web of Science ®Google Scholar
• Castillo-Gomez E, Gomez-Climent MA, Varea E, et al. Dopamine acting through D2 receptors modulates the expression of PSA-NCAM, a molecule related to neuronal structural plasticity, in the medial prefrontal cortex of adult rats. Exp Neurol. 2008;214(1):97–111. doi:10.1016/j.expneurol.2008.07.018
   PubMed Web of Science ®Google Scholar
• Chocyk A, Dudys D, Przyborowska A, Mackowiak M, Wedzony K. Impact of maternal separation on neural cell adhesion molecules expression in dopaminergic brain regions of juvenile, adolescent and adult rats. Pharmacol Rep. 2010;62(6):1218–1224. doi:10.1016/S1734-1140(10)70385-6
   PubMed Web of Science ®Google Scholar
• Ditlevsen DK, Berezin V, Bock E. Signalling pathways underlying neural cell adhesion molecule-mediated survival of dopaminergic neurons. Eur J Neurosci. 2007;25(6):1678–1684.
   PubMed Web of Science ®Google Scholar
• Bodea LG, Wang Y, Linnartz-Gerlach B, et al. Neurodegeneration by activation of the microglial complement-phagosome pathway. J Neurosci. 2014;34(25):8546–8556. doi:10.1523/JNEUROSCI.5002-13.2014
   PubMed Web of Science ®Google Scholar
• Kotowski SJ, Hopf FW, Seif T, Bonci A, von Zastrow M. Endocytosis promotes rapid dopaminergic signaling. Neuron. 2011;71(2):278–290. doi:10.1016/j.neuron.2011.05.036
   PubMed Web of Science ®Google Scholar
• von Zastrow M. Endocytosis and downregulation of G protein-coupled receptors. Parkinsonism Relat Disord. 2001;7(3):265–271. doi:10.1016/S1353-8020(00)00069-9
   PubMed Web of Science ®Google Scholar
• Yun HM, Baik JH, Kang I, Jin C, Rhim H. Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival. J Biol Chem. 2010;285(13):10016–10029. doi:10.1074/jbc.M109.068759
   PubMed Web of Science ®Google Scholar
• Pernhorst K, van Loo KM, von Lehe M, et al. Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue. Brain Res. 2013;1499:136–144. doi:10.1016/j.brainres.2012.12.045
   PubMed Web of Science ®Google Scholar
• Yang CR, Ning L, Zhou FH, et al. Downregulation of adhesion molecule CHL1 in B cells but not T cells of patients with major depression and in the brain of mice with chronic stress. Neurotox Res. 2020;38(4):914–928. doi:10.1007/s12640-020-00234-9
   PubMed Web of Science ®Google Scholar
• Kumar GA, Sarkar P, Jafurulla M, et al. Exploring endocytosis and intracellular trafficking of the human Serotonin1A receptor. Biochemistry. 2019;58(22):2628–2641. doi:10.1021/acs.biochem.9b00033
   PubMed Web of Science ®Google Scholar