147
Views
4
CrossRef citations to date
0
Altmetric
Original Research

LncRNA UCA1 Accelerates the Progression of Ulcerative Colitis via Mediating the miR-331-3p/BRD4 Axis

, , , &
Pages 2427-2435 | Published online: 10 Jun 2021

References

  • Podolsky DK. Inflammatory bowel disease. N Engl J Med. 2002;347(6):417–429. doi:10.1056/NEJMra020831
  • Farrell RJ, Peppercorn MA. Ulcerative colitis. Lancet. 2002;359(9303):331–340. doi:10.1016/S0140-6736(02)07499-8
  • Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2018;390(10114):2769–2778. doi:10.1016/S0140-6736(17)32448-0
  • Kaplan GG, Ng SC. Globalisation of inflammatory bowel disease: perspectives from the evolution of inflammatory bowel disease in the UK and China. Lancet Gastroenterol Hepatol. 2016;1(4):307–316. doi:10.1016/S2468-1253(16)30077-2
  • Eckburg PB, Relman DA. The role of microbes in Crohn’s disease. Clin Infect Dis. 2007;44(2):256–262. doi:10.1086/510385
  • Weinstock JV. Helminths and mucosal immune modulation. Ann N Y Acad Sci. 2006;1072:356–364. doi:10.1196/annals.1326.033
  • Quinn JJ, Chang HY. Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 2016;17(1):47–62. doi:10.1038/nrg.2015.10
  • Tian Y, Wang Y, Li F, et al. LncRNA TUG1 regulates the balance of HuR and miR-29b-3p and inhibits intestinal epithelial cell apoptosis in a mouse model of ulcerative colitis. Hum Cell. 2021;34(1):37–48. doi:10.1007/s13577-020-00428-5
  • Wang Y. Long Non-coding RNA MEG3 alleviated ulcerative colitis through upregulating miR-98-5p-Sponged IL-10. Inflammation. 2021.
  • Wang XS, Zhang Z, Wang H-C, et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res. 2006;12(16):4851–4858. doi:10.1158/1078-0432.CCR-06-0134
  • Ghafouri-Fard S, Eghtedarian R, Taheri M. The crucial role of non-coding RNAs in the pathophysiology of inflammatory bowel disease. Biomed Pharmacother. 2020;129:110507. doi:10.1016/j.biopha.2020.110507
  • Zhu M, Zhang N, He S, et al. Exosomal miR-106a derived from gastric cancer promotes peritoneal metastasis via direct regulation of Smad7. Cell Cycle. 2020;19(10):1200–1221. doi:10.1080/15384101.2020.1749467
  • Han J, Li Y, Zhang H, et al. MicroRNA-142-5p facilitates the pathogenesis of ulcerative colitis by regulating SOCS1. Int J Clin Exp Pathol. 2018;11(12):5735–5744.
  • Xu X, Zhu X, Wang C, et al. microRNA-650 promotes inflammation induced apoptosis of intestinal epithelioid cells by targeting NLRP6. Biochem Biophys Res Commun. 2019;517(4):551–556. doi:10.1016/j.bbrc.2019.06.077
  • Nie H, Hu Y, Guo W, et al. miR-331-3p inhibits inflammatory response after intracerebral hemorrhage by directly targeting NLRP6. Biomed Res Int. 2020;2020:6182464. doi:10.1155/2020/6182464
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–408. doi:10.1006/meth.2001.1262
  • Qiao C, Yang L, Wan J, et al. Long noncoding RNA ANRIL contributes to the development of ulcerative colitis by miR-323b-5p/TLR4/MyD88/NF-kappaB pathway. Biochem Biophys Res Commun. 2019;508(1):217–224. doi:10.1016/j.bbrc.2018.11.100
  • Murano M, Maemura K, Hirata I, et al. Therapeutic effect of intracolonically administered nuclear factor κ B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis. Clin Exp Immunol. 2000;120(1):51–58. doi:10.1046/j.1365-2249.2000.01183.x
  • Wei S-C, Rosenberg IM, Cao Z, et al. Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling. Inflamm Bowel Dis. 2012;18(5):877–888. doi:10.1002/ibd.22883
  • Molodecky NA. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46–54 e42; quiz e30.
  • de Silva S, Ma C, Proulx M, et al. Postoperative complications and mortality following colectomy for ulcerative colitis. Clin Gastroenterol Hepatol. 2011;9(11):972–980. doi:10.1016/j.cgh.2011.07.016
  • Bewtra M, Kaiser LM, TenHave T, et al. Crohn’s disease and ulcerative colitis are associated with elevated standardized mortality ratios: a meta-analysis. Inflamm Bowel Dis. 2013;19(3):599–613. doi:10.1097/MIB.0b013e31827f27ae
  • Yu T, Meng F, Xie M, et al. LncRNA PMS2L2 downregulates miR-24 through methylation to suppress cell apoptosis in ulcerative colitis. Dig Dis. 2020. doi:10.1159/000513330
  • Tian Y, Cui L, Lin C, et al. LncRNA CDKN2B-AS1 relieved inflammation of ulcerative colitis via sponging miR-16 and miR-195. Int Immunopharmacol. 2020;88:106970. doi:10.1016/j.intimp.2020.106970
  • Gao H. Long noncoding RNA UCA1 promotes proliferation and metastasis of thyroid cancer cells by sponging miR-497-3p. Eur Rev Med Pharmacol Sci. 2020;24(14):7555.
  • Liu T. Long Noncoding RNA UCA1 facilitates endometrial cancer development by regulating KLF5 and RXFP1 Gene Expressions. Cancer Biother Radiopharm. 2020.
  • Hu X, Ma R, Fu W, et al. LncRNA UCA1 sponges miR-206 to exacerbate oxidative stress and apoptosis induced by ox-LDL in human macrophages. J Cell Physiol. 2019;234(8):14154–14160. doi:10.1002/jcp.28109
  • Zhao YJ. LncRNA UCA1 remits LPS-engendered inflammatory damage through deactivation of miR-499b-5p/TLR4 axis. IUBMB Life. 2020.
  • Wang LX. Integrative analysis of long noncoding RNA (lncRNA), microRNA (miRNA) and mRNA expression and construction of a competing endogenous RNA (ceRNA) Network in Metastatic Melanoma. Med Sci Monit. 2019;25:2896–2907. doi:10.12659/MSM.913881
  • Li R. LncRNA SOX2OT knockdown alleviates lipopolysaccharide-induced damage of PC12 Cells by Regulating miR-331-3p/Neurod1 Axis. World Neurosurg. 2020.
  • Kong L, Wu P, Li J. miR-331 inhibits CLDN2 expression and may alleviate the vascular endothelial injury induced by sepsis. Exp Ther Med. 2020;20(2):1343–1352. doi:10.3892/etm.2020.8854
  • Li XM, Jiao -Y-Y, Luan B-H, et al. Long non-coding RNA MIAT promotes gastric cancer proliferation and metastasis via modulating the miR-331-3p/RAB5B pathway. Oncol Lett. 2020;20(6):355. doi:10.3892/ol.2020.12219
  • Adlakha YK, Saini N. Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128. Mol Cancer. 2014;13:33. doi:10.1186/1476-4598-13-33
  • Zhou Y, Gu Y, Liu J. BRD4 suppression alleviates cerebral ischemia-induced brain injury by blocking glial activation via the inhibition of inflammatory response and pyroptosis. Biochem Biophys Res Commun. 2019;519(3):481–488. doi:10.1016/j.bbrc.2019.07.097
  • Wang J, Chen J, Jin H, et al. BRD4 inhibition attenuates inflammatory response in microglia and facilitates recovery after spinal cord injury in rats. J Cell Mol Med. 2019;23(5):3214–3223. doi:10.1111/jcmm.14196
  • Wang H, Gu J, Hou X, et al. Anti-inflammatory effect of miltirone on inflammatory bowel disease via TLR4/NF-kappaB/IQGAP2 signaling pathway. Biomed Pharmacother. 2017;85:531–540. doi:10.1016/j.biopha.2016.11.061
  • Gao L, Zhao H, Sun H, et al. TAB3 overexpression promotes NF-kappaB activation and inflammation in acute pancreatitis. Am J Blood Res. 2020;10(4):118–123.
  • Yang Q, Zhang D, Li Y, et al. Paclitaxel alleviated liver injury of septic mice by alleviating inflammatory response via microRNA-27a/TAB3/NF-kappaB signaling pathway. Biomed Pharmacother. 2018;97:1424–1433. doi:10.1016/j.biopha.2017.11.003