186
Views
9
CrossRef citations to date
0
Altmetric
Original Research

Altered Expression of Angiogenic Biomarkers in Pregnancy Associated with Gestational Diabetes

, ORCID Icon, , &
Pages 3367-3375 | Published online: 13 Jul 2021

References

  • Troncoso F, Acurio J, Herlitz K, et al. Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1. PLoS One. 2017;12(8):e0182509. doi:10.1371/journal.pone.0182509
  • Loegl J, Nussbaumer E, Cvitic S, Huppertz B, Desoye G, Hiden U. GDM alters paracrine regulation of feto-placental angiogenesis via the trophoblast. Lab Invest. 2017;97(4):409–418. doi:10.1038/labinvest.2016.149
  • Sobrevia L, Salsoso R, Fuenzalida B, et al. Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus. Front Physiol. 2016;7:119. doi:10.3389/fphys.2016.00119
  • Betz C, Lenard A, Belting HG, Affolter M. Cell behaviors and dynamics during angiogenesis. Development. 2016;143(13):2249–2260. doi:10.1242/dev.135616
  • Conway EM, Collen D, Carmeliet P. Molecular mechanisms of blood vessel growth. Cardiovasc Res. 2001;49(3):507–521. doi:10.1016/S0008-6363(00)00281-9
  • Umapathy A, Chamley LW, James JL. Reconciling the distinct roles of angiogenic/anti-angiogenic factors in the placenta and maternal circulation of normal and pathological pregnancies. Angiogenesis. 2020;23(2):105–117. doi:10.1007/s10456-019-09694-w
  • Chen DB, Zheng J. Regulation of placental angiogenesis. Microcirculation. 2014;21(1):15–25. doi:10.1111/micc.12093
  • Suganya N, Bhakkiyalakshmi E, Sarada DV, Ramkumar KM. Reversibility of endothelial dysfunction in diabetes: role of polyphenols. Br J Nutr. 2016;116(2):223–246. doi:10.1017/S0007114516001884
  • Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology. 2005;69(Suppl 3):4–10. doi:10.1159/000088478
  • Padmanabhan S, Lee VW, McLean M, et al. The Association of Falling Insulin Requirements With Maternal Biomarkers and Placental Dysfunction: a Prospective Study of Women With Preexisting Diabetes in Pregnancy. Diabetes Care. 2017;40(10):1323–1330. doi:10.2337/dc17-0391
  • Li L, Juan-Yu H, Jian-Yong X, et al. Association between interleukin-19 and angiopoietin-2 with vascular complications in type 2 diabetes. J Diabetes Investig. 2016;7(6):895–900.
  • Melincovici CS, Bosca AB, Susman S, et al. Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. Rom J Morphol Embryol. 2018;59(2):455–467.
  • Bus P, Gerrits T, Heemskerk SAC, et al. Endoglin Mediates Vascular Endothelial Growth Factor-A-Induced Endothelial Cell Activation by Regulating Akt Signaling. Am J Pathol. 2018;188(12):2924–2935. doi:10.1016/j.ajpath.2018.08.005
  • Szentpeteri I, Rab A, Kornya L, Kovacs P, Brubel R, Joo JG. Placental gene expression patterns of endoglin (CD105) in intrauterine growth restriction. J Matern Fetal Neonatal Med. 2014;27(4):350–354. doi:10.3109/14767058.2013.818125
  • Gillis EE, Sasser JM, Sullivan JC. Endothelin, sex, and pregnancy: unique considerations for blood pressure control in females. Am J Physiol Regul Integr Comp Physiol. 2016;310(8):R691–6. doi:10.1152/ajpregu.00427.2015
  • Horinouchi T, Hoshi A, Harada T, et al. Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells. Br J Pharmacol. 2016;173(6):1018–1032. doi:10.1111/bph.13406
  • Eftekhar M, Naghshineh E, Khani P. Role of granulocyte colony-stimulating factor in human reproduction. J Res Med Sci. 2018;23(1):7. doi:10.4103/jrms.JRMS_628_17
  • Lacko LA, Hurtado R, Hinds S, Poulos MG, Butler JM, Stuhlmann H. Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function. Development. 2017;144(13):2469–2479. doi:10.1242/dev.147025
  • Rizov M, Andreeva P, Dimova I. Molecular regulation and role of angiogenesis in reproduction. Taiwan J Obstet Gynecol. 2017;56(2):127–132. doi:10.1016/j.tjog.2016.06.019
  • Chi C, Loy SL, Chan SY, et al. Impact of adopting the 2013 World Health Organization criteria for diagnosis of gestational diabetes in a multi-ethnic Asian cohort: a prospective study. BMC Pregnancy Childbirth. 2018;18(1):69. doi:10.1186/s12884-018-1707-3
  • Geurtsen ML, van Soest EEL, Voerman E, Steegers EAP, Jaddoe VWV, Gaillard R. High maternal early-pregnancy blood glucose levels are associated with altered fetal growth and increased risk of adverse birth outcomes. Diabetologia. 2019;62(10):1880–1890. doi:10.1007/s00125-019-4957-3
  • Shi Y, Qian J, Zhang F, et al. Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors. Mol Med Rep. 2020;21(2):623–630. doi:10.3892/mmr.2019.10868
  • Boulanger E, Grossin N, Wautier MP, Taamma R, Wautier JL. Mesothelial RAGE activation by AGEs enhances VEGF release and potentiates capillary tube formation. Kidney Int. 2007;71(2):126–133. doi:10.1038/sj.ki.5002016
  • Meng Q, Shao L, Luo X, et al. Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies. Reprod Biol Endocrinol. 2016;14(1):61. doi:10.1186/s12958-016-0191-8
  • Abdullah B, Deveci K, Atilgan R, Kilicli F, Soylemez MS. Serum angiopoietin-related growth factor (AGF) levels are elevated in gestational diabetes mellitus and associated with insulin resistance. Ginekol Pol. 2012;83(10):749–753.
  • Findley CM, Cudmore MJ, Ahmed A, Kontos CD. VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling. Arterioscler Thromb Vasc Biol. 2007;27(12):2619–2626. doi:10.1161/ATVBAHA.107.150482
  • Kappou D, Sifakis S, Konstantinidou A, Papantoniou N, Spandidos DA. Role of the angiopoietin/Tie system in pregnancy (Review). Exp Ther Med. 2015;9(4):1091–1096. doi:10.3892/etm.2015.2280
  • Yu Y, Jenkins AJ, Nankervis AJ, et al. Anti-angiogenic factors and pre-eclampsia in type 1 diabetic women. Diabetologia. 2009;52(1):160–168. doi:10.1007/s00125-008-1182-x
  • Masuyama H, Nakatsukasa H, Takamoto N, Hiramatsu Y. Correlation between soluble endoglin, vascular endothelial growth factor receptor-1, and adipocytokines in preeclampsia. J Clin Endocrinol Metab. 2007;92(7):2672–2679. doi:10.1210/jc.2006-2349
  • Schneider JG, Tilly N, Hierl T, et al. Elevated plasma endothelin-1 levels in diabetes mellitus. Am J Hypertens. 2002;15(11):967–972. doi:10.1016/S0895-7061(02)03060-1
  • Dieber-Rotheneder M, Beganovic S, Desoye G, Lang U, Cervar-Zivkovic M. Complex expression changes of the placental endothelin system in early and late onset preeclampsia, fetal growth restriction and gestational diabetes. Life Sci. 2012;91(13–14):710–715. doi:10.1016/j.lfs.2012.04.040
  • Swiderski S, Celewicz Z, Miazgowski T, Ogonowski J. Maternal endothelin-1 and cyclic guanosine monophosphate concentrations in pregnancies complicated by pregravid and gestational diabetes mellitus. Gynecol Obstet Invest. 2010;69(1):46–50. doi:10.1159/000253851
  • Telejko B, Zonenberg A, Kuzmicki M, et al. Circulating asymmetric dimethylarginine, endothelin-1 and cell adhesion molecules in women with gestational diabetes. Acta Diabetol. 2009;46(4):303–308. doi:10.1007/s00592-008-0088-x
  • Surendar J, Mohan V, Pavankumar N, Babu S, Aravindhan V. Increased levels of serum granulocyte-macrophage colony-stimulating factor is associated with activated peripheral dendritic cells in type 2 diabetes subjects (CURES-99). Diabetes Technol Ther. 2012;14(4):344–349. doi:10.1089/dia.2011.0182
  • Alaa HAO, Hussein D, Raheem M, Hasanain S, Noor K. Impact of Serum Granulocyte-Macrophage Colony-Stimulating Factor Levels among Diabetes Patients in Hilla City - Iraq. Adv Life Sci. 2014;4(6):260–264. doi:10.5923/j.als.20140406.02
  • Giaglis S, Stoikou M, Sur Chowdhury C, et al. Multimodal Regulation of NET Formation in Pregnancy: progesterone Antagonizes the Pro-NETotic Effect of Estrogen and G-CSF. Front Immunol. 2016;7:565. doi:10.3389/fimmu.2016.00565