Identification of an miRNA Regulatory Network and Candidate Markers for Ischemic Stroke Related to Diabetes

References

• Li W, Valenzuela JP, Ward R, et al. Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: potential link to hemorrhagic transformation. Exp Neurol. 2019;311:106–114. doi:10.1016/j.expneurol.2018.09.013
   PubMed Web of Science ®Google Scholar
• Ogurtsova K, da Rocha Fernandes JD, Huang Y, et al. IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40–50. doi:10.1016/j.diabres.2017.03.024
   PubMed Web of Science ®Google Scholar
• Mizrahi EH, Waitzman A, Blumstein T, Arad M, Adunsky A. Diabetes mellitus predicts cognitive impairment in patients with ischemic stroke. Am J Alzheimers Dis Other Demen. 2010;25(4):362–366. doi:10.1177/1533317510365343
   PubMed Web of Science ®Google Scholar
• Hong P, Gu RN, Li FX, et al. NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes. J Neuroinflammation. 2019;16(1):121. doi:10.1186/s12974-019-1498-0
   PubMed Web of Science ®Google Scholar
• Benjamin EJ, Virani SS, Callaway CW, et al. Heart disease and stroke statistics-2018 update: a report from the American heart association. Circulation. 2018;137(12):e67–e492.
   PubMed Web of Science ®Google Scholar
• Almdal T, Scharling H, Jensen JS, Vestergaard H. The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13,000 men and women with 20 years of follow-up. Arch Intern Med. 2004;164(13):1422–1426. doi:10.1001/archinte.164.13.1422
   PubMedGoogle Scholar
• Rehni AK, Liu A, Perez-Pinzon MA, Dave KR. Diabetic aggravation of stroke and animal models. Exp Neurol. 2017;292:63–79.
   PubMed Web of Science ®Google Scholar
• Huang Q, Deng G, Wei R, Wang Q, Zou D, Wei J. Comprehensive identification of key genes involved in development of diabetes mellitus-related atherogenesis using weighted gene correlation network analysis. Front Cardiovasc Med. 2020;7:580573. doi:10.3389/fcvm.2020.580573
   PubMed Web of Science ®Google Scholar
• Venkat P, Chopp M, Chen J. Cell-based and exosome therapy in diabetic stroke. Stem Cells Transl Med. 2018;7(6):451–455. doi:10.1002/sctm.18-0014
   PubMed Web of Science ®Google Scholar
• Cai F, Wu F, Cao J, Chen X. MicroRNA-146b-3p regulates the development and progression of cerebral infarction with diabetes through RAF1/P38MAPK/COX-2 signaling pathway. Am J Transl Res. 2018;10(2):618–628.
   PubMed Web of Science ®Google Scholar
• Deng D, Qu Y, Sun L, et al. Fuyuan Xingnao decoction promotes angiogenesis through the Rab1/AT1R pathway in diabetes mellitus complicated with cerebral infarction. Front Pharmacol. 2021;12:616165. doi:10.3389/fphar.2021.616165
   PubMed Web of Science ®Google Scholar
• Phipps MS, Jastreboff AM, Furie K, Kernan WN. The diagnosis and management of cerebrovascular disease in diabetes. Curr Diab Rep. 2012;12(3):314–323. doi:10.1007/s11892-012-0271-x
   PubMed Web of Science ®Google Scholar
• Zhao W, Katzmarzyk PT, Horswell R, et al. Blood pressure and stroke risk among diabetic patients. J Clin Endocrinol Metab. 2013;98(9):3653–3662. doi:10.1210/jc.2013-1757
   PubMed Web of Science ®Google Scholar
• Shi R, Zhang T, Sun H, Hu F. Establishment of clinical prediction model based on the study of risk factors of stroke in patients with type 2 diabetes mellitus. Front Endocrinol. 2020;11:559. doi:10.3389/fendo.2020.00559
   PubMed Web of Science ®Google Scholar
• Hu K, Jiang M, Zhou Q, et al. Association of diabetic retinopathy with stroke: a systematic review and meta-analysis. Front Neurol. 2021;12:626996. doi:10.3389/fneur.2021.626996
   PubMed Web of Science ®Google Scholar
• Yang T, Fan K, Cao Y, Yan J, Han Z. Stroke type, etiology, clinical features and prognosis of diabetic patients in Southern China. Clin Appl Thromb Hemost. 2020;26:1076029620973090. doi:10.1177/1076029620973090
   Web of Science ®Google Scholar
• Bielska A, Niemira M, Kretowski A. Recent highlights of research on miRNAs as early potential biomarkers for cardiovascular complications of type 2 diabetes mellitus. Int J Mol Sci. 2021;22(6):3153. doi:10.3390/ijms22063153
   PubMed Web of Science ®Google Scholar
• Ghafouri-Fard S, Shoorei H, Taheri M. Non-coding RNAs participate in the ischemia-reperfusion injury. Biomed Pharmacother. 2020;129:110419. doi:10.1016/j.biopha.2020.110419
   PubMed Web of Science ®Google Scholar
• Zou D, Liu C, Zhang Q, et al. Association between polymorphisms in microRNAs and ischemic stroke in an Asian population: evidence based on 6,083 cases and 7,248 controls. Clin Interv Aging. 2018;13:1709–1726. doi:10.2147/CIA.S174000
   PubMed Web of Science ®Google Scholar
• Cai G, Cai G, Zhou H, et al. Mesenchymal stem cell-derived exosome miR-542-3p suppresses inflammation and prevents cerebral infarction. Stem Cell Res Ther. 2021;12(1):2. doi:10.1186/s13287-020-02030-w
   PubMed Web of Science ®Google Scholar
• Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinform. 2008;9:559. doi:10.1186/1471-2105-9-559
   PubMed Web of Science ®Google Scholar
• Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47. doi:10.1093/nar/gkv007
   PubMed Web of Science ®Google Scholar
• Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. doi:10.1186/s13059-014-0550-8
   PubMed Web of Science ®Google Scholar
• Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–287. doi:10.1089/omi.2011.0118
   PubMed Web of Science ®Google Scholar
• Ito K, Murphy D. Application of ggplot2 to pharmacometric graphics. CPT Pharmacometrics Syst Pharmacol. 2013;2:e79. doi:10.1038/psp.2013.56
   PubMedGoogle Scholar
• Sergushichev AA. An algorithm for fast preranked gene set enrichment analysis using cumulative statistic calculation. BioRxiv. 2016;060012.
   Google Scholar
• Robin X, Turck N, Hainard A, et al. pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinform. 2011;12:77. doi:10.1186/1471-2105-12-77
   PubMed Web of Science ®Google Scholar
• López-de-andrés A, Jimenez-Garcia R, Hernández-Barrera V, et al. Sex-related disparities in the incidence and outcomes of ischemic stroke among type 2 diabetes patients. A matched-pair analysis using the Spanish national hospital discharge database for years 2016–2018. Int J Environ Res Public Health. 2021;18(7):3659. doi:10.3390/ijerph18073659
   PubMed Web of Science ®Google Scholar
• Weisenburger-Lile D, Dong Y, Yger M, et al. Harmful neutrophil subsets in patients with ischemic stroke: association with disease severity. Neurol Neuroimmunol Neuroinflamm. 2019;6(4):e571. doi:10.1212/NXI.0000000000000571
   PubMed Web of Science ®Google Scholar
• Lin SK, Chen PY, Chen GC, et al. Association of a high neutrophil-to-lymphocyte ratio with hyperdense artery sign and unfavorable short-term outcomes in patients with acute ischemic stroke. J Inflamm Res. 2021;14:313–324. doi:10.2147/JIR.S293825
   PubMed Web of Science ®Google Scholar
• Maida CD, Norrito RL, Daidone M, Tuttolomondo A, Pinto A. Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches. Int J Mol Sci. 2020;21(18):6454. doi:10.3390/ijms21186454
   PubMed Web of Science ®Google Scholar
• Blasco MP, Chauhan A, Honarpisheh P, et al. Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation. J Neuroinflammation. 2020;17(1):160. doi:10.1186/s12974-020-01833-1
   PubMed Web of Science ®Google Scholar
• Bot I, Velden DV, Bouwman M, et al. Local mast cell activation promotes neovascularization. Cells. 2020;9:3. doi:10.3390/cells9030701
   Web of Science ®Google Scholar
• Carandina A, Lazzeri G, Villa D, et al. Targeting the autonomic nervous system for risk stratification, outcome prediction and neuromodulation in ischemic stroke. Int J Mol Sci. 2021;22(5):2357. doi:10.3390/ijms22052357
   PubMed Web of Science ®Google Scholar
• De Rosa S, Arcidiacono B, Chiefari E, Brunetti A, Indolfi C, Foti DP. Type 2 diabetes mellitus and cardiovascular disease: genetic and epigenetic links. Front Endocrinol. 2018;9:2. doi:10.3389/fendo.2018.00002
   PubMed Web of Science ®Google Scholar
• Eyileten C, Wicik Z, De Rosa S, et al. MicroRNAs as diagnostic and prognostic biomarkers in ischemic stroke-a comprehensive review and bioinformatic analysis. Cells. 2018;7:12. doi:10.3390/cells7120249
   PubMed Web of Science ®Google Scholar
• Bulygin KV, Beeraka NM, Saitgareeva AR, et al. Can miRNAs be considered as diagnostic and therapeutic molecules in ischemic stroke pathogenesis?-Current status. Int J Mol Sci. 2020;21(18):6728. doi:10.3390/ijms21186728
   PubMed Web of Science ®Google Scholar
• Cakmak HA, Coskunpinar E, Ikitimur B, et al. The prognostic value of circulating microRNAs in heart failure: preliminary results from a genome-wide expression study. J Cardiovasc Med. 2015;16(6):431–437. doi:10.2459/JCM.0000000000000233
   Google Scholar
• Naveen V, Vengamma B, Mohan A, Vanajakshamma V. N-terminal pro-brain natriuretic peptide levels and short term prognosis in acute ischemic stroke. Ann Indian Acad Neurol. 2015;18(4):435–440. doi:10.4103/0972-2327.165478
   PubMed Web of Science ®Google Scholar
• Benameur T, Osman A, Parray A, Ait Hssain A, Munusamy S, Agouni A. Molecular mechanisms underpinning microparticle-mediated cellular injury in cardiovascular complications associated with diabetes. Oxid Med Cell Longev. 2019;2019:6475187. doi:10.1155/2019/6475187
   PubMed Web of Science ®Google Scholar
• Tan KS, Armugam A, Sepramaniam S, et al. Expression profile of MicroRNAs in young stroke patients. PLoS One. 2009;4(11):e7689. doi:10.1371/journal.pone.0007689
   PubMed Web of Science ®Google Scholar
• Meydan C, Madrer N, Soreq H. The Neat Dance of COVID-19: NEAT1, DANCR, and co-modulated cholinergic RNAs link to inflammation. Front Immunol. 2020;11:590870. doi:10.3389/fimmu.2020.590870
   PubMed Web of Science ®Google Scholar
• Wanve M, Kaur H, Sarmah D, et al. Therapeutic spectrum of interferon-beta in ischemic stroke. J Neurosci Res. 2019;97(2):116–127. doi:10.1002/jnr.24333
   PubMed Web of Science ®Google Scholar
• Yang ZM, Chen LH, Hong M, et al. Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population. Mol Med Rep. 2017;15(4):2143–2153. doi:10.3892/mmr.2017.6239
   PubMed Web of Science ®Google Scholar
• Jamaluddin MS, Weakley SM, Zhang L, et al. miRNAs: roles and clinical applications in vascular disease. Expert Rev Mol Diagn. 2011;11(1):79–89. doi:10.1586/erm.10.103
   PubMed Web of Science ®Google Scholar
• Geisler S, Vollmer S, Golombek S, Kahle PJ. The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy. J Cell Sci. 2014;127(Pt 15):3280–3293. doi:10.1242/jcs.146035
   PubMed Web of Science ®Google Scholar
• Yin P, Tu Z, Yin A, et al. Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin. Hum Mol Genet. 2015;24(5):1350–1362. doi:10.1093/hmg/ddu544
   PubMed Web of Science ®Google Scholar
• Rath D, Chatterjee M, Muller I, et al. Platelet expression of transforming growth factor beta 1 is enhanced and associated with cardiovascular prognosis in patients with acute coronary syndrome. Atherosclerosis. 2014;237(2):754–759. doi:10.1016/j.atherosclerosis.2014.10.021
   PubMed Web of Science ®Google Scholar
• Yang C, Hawkins KE, Dore S, Candelario-Jalil E. Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke. Am J Physiol Cell Physiol. 2019;316(2):C135–C153. doi:10.1152/ajpcell.00136.2018
   PubMed Web of Science ®Google Scholar
• Park HK, Kim DH, Yun DH, Ban JY. Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population. Mol Biol Rep. 2013;40(2):1785–1790. doi:10.1007/s11033-012-2232-5
   PubMed Web of Science ®Google Scholar
• Dykstra-Aiello C, Jickling GC, Ander BP, et al. Intracerebral hemorrhage and ischemic stroke of different etiologies have distinct alternatively spliced mRNA profiles in the blood: a pilot RNA-seq study. Transl Stroke Res. 2015;6(4):284–289. doi:10.1007/s12975-015-0407-9
   PubMed Web of Science ®Google Scholar
• Martha SR, Cheng Q, Fraser JF, et al. Expression of cytokines and chemokines as predictors of stroke outcomes in acute ischemic stroke. Front Neurol. 2019;10:1391. doi:10.3389/fneur.2019.01391
   PubMed Web of Science ®Google Scholar
• Jayaraj RL, Azimullah S, Beiram R, Jalal FY, Rosenberg GA. Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflammation. 2019;16(1):142.
   PubMed Web of Science ®Google Scholar