Analysis of Communal Molecular Mechanism and Potential Therapeutic Targets in Heart Failure and Type 2 Diabetes Mellitus

References

• Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129–2200.
   PubMed Web of Science ®Google Scholar
• Ziaeian B, Fonarow GC. Epidemiology and aetiology of heart failure. Nat Rev Cardiol. 2016;13(6):368–378. doi:10.1038/nrcardio.2016.25
   PubMed Web of Science ®Google Scholar
• Ponikowski P, Anker SD, AlHabib KF, et al. Heart failure: preventing disease and death worldwide. ESC Heart Fail. 2014;1(1):4–25. doi:10.1002/ehf2.12005
   PubMedGoogle Scholar
• Berbudi A, Rahmadika N, Tjahjadi AI, Ruslami R. Type 2 diabetes and its impact on the immune system. Curr Diabetes Rev. 2020;16(5):442–449. doi:10.2174/1573399815666191024085838
   PubMed Web of Science ®Google Scholar
• Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14(2):88–98. doi:10.1038/nrendo.2017.151
   PubMed Web of Science ®Google Scholar
• Dunlay SM, Givertz MM, Aguilar D, et al. Type 2 diabetes mellitus and heart failure: a scientific statement from the American Heart Association and the Heart Failure Society of America: this statement does not represent an update of the 2017 ACC/AHA/HFSA heart failure guideline update. Circulation. 2019;140(7):e294–e324. doi:10.1161/CIR.0000000000000691
   PubMed Web of Science ®Google Scholar
• Seferović PM, Fragasso G, Petrie M, et al. Sodium-glucose co-transporter 2 inhibitors in heart failure: beyond glycaemic control. A position paper of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2020;22(9):1495–1503. doi:10.1002/ejhf.1954
   PubMed Web of Science ®Google Scholar
• Nichols GA, Gullion CM, Koro CE, Ephross SA, Brown JB. The incidence of congestive heart failure in type 2 diabetes: an update. Diabetes Care. 2004;27(8):1879–1884. doi:10.2337/diacare.27.8.1879
   PubMed Web of Science ®Google Scholar
• Aguilar D, Solomon SD, Køber L, et al. Newly diagnosed and previously known diabetes mellitus and 1-year outcomes of acute myocardial infarction: the VALsartan in Acute myocardial iNfarcTion (VALIANT) trial. Circulation. 2004;110(12):1572–1578. doi:10.1161/01.CIR.0000142047.28024.F2
   PubMed Web of Science ®Google Scholar
• MacDonald MR, Petrie MC, Varyani F, et al. Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure: an analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programme. Eur Heart J. 2008;29(11):1377–1385. doi:10.1093/eurheartj/ehn153
   PubMed Web of Science ®Google Scholar
• Preiss D, Zetterstrand S, McMurray JJ, et al. Predictors of development of diabetes in patients with chronic heart failure in the Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM) program. Diabetes Care. 2009;32(5):915–920. doi:10.2337/dc08-1709
   PubMed Web of Science ®Google Scholar
• Preiss D, van Veldhuisen DJ, Sattar N, et al. Eplerenone and new-onset diabetes in patients with mild heart failure: results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF). Eur J Heart Fail. 2012;14(8):909–915. doi:10.1093/eurjhf/hfs067
   PubMed Web of Science ®Google Scholar
• Levelt E, Rodgers CT, Clarke WT, et al. Cardiac energetics, oxygenation, and perfusion during increased workload in patients with type 2 diabetes mellitus. Eur Heart J. 2016;37(46):3461–3469. doi:10.1093/eurheartj/ehv442
   PubMed Web of Science ®Google Scholar
• Levelt E, Pavlides M, Banerjee R, et al. Ectopic and visceral fat deposition in lean and obese patients with type 2 diabetes. J Am Coll Cardiol. 2016;68(1):53–63. doi:10.1016/j.jacc.2016.03.597
   PubMed Web of Science ®Google Scholar
• Lehrke M, Marx N. Diabetes mellitus and heart failure. Am J Cardiol. 2017;120(1s):S37–s47. doi:10.1016/j.amjcard.2017.05.014
   PubMed Web of Science ®Google Scholar
• Doehner W, Frenneaux M, Anker SD. Metabolic impairment in heart failure: the myocardial and systemic perspective. J Am Coll Cardiol. 2014;64(13):1388–1400. doi:10.1016/j.jacc.2014.04.083
   PubMed Web of Science ®Google Scholar
• Hallow KM, Helmlinger G, Greasley PJ, McMurray JJV, Boulton DW. Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis. Diabetes Obes Metab. 2018;20(3):479–487. doi:10.1111/dom.13126
   PubMed Web of Science ®Google Scholar
• Barrett T, Wilhite S, Ledoux P, et al. NCBI GEO: archive for functional genomics data sets–update. Nucleic Acids Res. 2013;41(D1):D991–995. doi:10.1093/nar/gks1193
   PubMed Web of Science ®Google Scholar
• Laugier L, Frade A, Ferreira F, et al. Whole-genome cardiac DNA methylation fingerprint and gene expression analysis provide new insights in the pathogenesis of chronic Chagas disease cardiomyopathy. Clin Infect Dis. 2017;65(7):1103–1111. doi:10.1093/cid/cix506
   PubMed Web of Science ®Google Scholar
• Luo L, Zhou WH, Cai JJ, et al. Gene expression profiling identifies downregulation of the neurotrophin-MAPK signaling pathway in female diabetic peripheral neuropathy patients. J Diabetes Res. 2017;2017:8103904. doi:10.1155/2017/8103904
   PubMed Web of Science ®Google Scholar
• Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44–57. doi:10.1038/nprot.2008.211
   PubMed Web of Science ®Google Scholar
• Wu J, Mao X, Cai T, Luo J, Wei L. KOBAS server: a web-based platform for automated annotation and pathway identification. Nucleic Acids Res. 2006;34(1):W720–724. doi:10.1093/nar/gkl167
   PubMed Web of Science ®Google Scholar
• Franceschini A, Szklarczyk D, Frankild S, et al. STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 2013;41(D1):D808–815. doi:10.1093/nar/gks1094
   PubMed Web of Science ®Google Scholar
• Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T. Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics. 2011;27(3):431–432. doi:10.1093/bioinformatics/btq675
   PubMed Web of Science ®Google Scholar
• Bader GD, Hogue CW. An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinform. 2003;4(1):2. doi:10.1186/1471-2105-4-2
   PubMed Web of Science ®Google Scholar
• Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY. cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 2014;8(Suppl S4):S11. doi:10.1186/1752-0509-8-S4-S11
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhou B, Pache L, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523. doi:10.1038/s41467-019-09234-6
   PubMed Web of Science ®Google Scholar
• Warde-Farley D, Donaldson SL, Comes O, et al. The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 2010;38(suppl_2):W214–220. doi:10.1093/nar/gkq537
   PubMed Web of Science ®Google Scholar
• Cotto KC, Wagner AH, Feng YY, et al. DGIdb 3.0: a redesign and expansion of the drug-gene interaction database. Nucleic Acids Res. 2018;46(D1):D1068–d1073. doi:10.1093/nar/gkx1143
   PubMedGoogle Scholar
• Sticht C, De La Torre C, Parveen A, Gretz N. miRWalk: an online resource for prediction of microRNA binding sites. PLoS One. 2018;13(10):e0206239. doi:10.1371/journal.pone.0206239
   PubMed Web of Science ®Google Scholar
• Mortensen RM. Immune cell modulation of cardiac remodeling. Circulation. 2012;125(13):1597–1600. doi:10.1161/CIRCULATIONAHA.112.097832
   PubMed Web of Science ®Google Scholar
• Swirski FK, Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science. 2013;339(6116):161–166. doi:10.1126/science.1230719
   PubMed Web of Science ®Google Scholar
• Zhang Y, Bauersachs J, Langer HF. Immune mechanisms in heart failure. Eur J Heart Fail. 2017;19(11):1379–1389. doi:10.1002/ejhf.942
   PubMed Web of Science ®Google Scholar
• Anand IS, Latini R, Florea VG, et al. C-reactive protein in heart failure: prognostic value and the effect of valsartan. Circulation. 2005;112(10):1428–1434. doi:10.1161/CIRCULATIONAHA.104.508465
   PubMed Web of Science ®Google Scholar
• Mielniczuk LM, Baughman KL. Immune modulation therapy in heart failure. Congest Heart Fail. 2006;12(2):91–96; quiz 97–98. doi:10.1111/j.1527-5299.2006.04630.x
   PubMedGoogle Scholar
• Zhou T, Hu Z, Yang S, Sun L, Yu Z, Wang G. Role of adaptive and innate immunity in type 2 diabetes mellitus. J Diabetes Res. 2018;2018:7457269. doi:10.1155/2018/7457269
   PubMed Web of Science ®Google Scholar
• Xu X, Lin S, Chen Y, et al. The effect of metformin on the expression of GPR109A, NF-κB and IL-1β in peripheral blood leukocytes from patients with type 2 diabetes mellitus. Ann Clin Lab Sci. 2017;47(5):556–562.
   PubMed Web of Science ®Google Scholar
• Yin G, Yang X, Li Q, Guo Z. SYK protects cardiocytes against anoxia and hypoglycemia-induced injury in ischemic heart failure. Mol Immunol. 2017;91:35–41. doi:10.1016/j.molimm.2017.08.018
   PubMed Web of Science ®Google Scholar
• Wei W, Li XX, Xu M. Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice. Atherosclerosis. 2019;289:132–142. doi:10.1016/j.atherosclerosis.2019.08.017
   PubMed Web of Science ®Google Scholar
• Liu L, Pang X, Shang W, Feng G, Wang Z, Wang J. miR-136 improves renal fibrosis in diabetic rats by targeting down-regulation of tyrosine kinase SYK and inhibition of TGF-β1/Smad3 signaling pathway. Ren Fail. 2020;42(1):513–522. doi:10.1080/0886022X.2020.1764854
   PubMed Web of Science ®Google Scholar
• Königsberger S, Prodöhl J, Stegner D, et al. Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state. EMBO J. 2012;31(15):3363–3374. doi:10.1038/emboj.2012.169
   PubMed Web of Science ®Google Scholar
• Yamagishi SI, Edelstein D, Du XL, Brownlee M. Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction. Diabetes. 2001;50(6):1491–1494. doi:10.2337/diabetes.50.6.1491
   PubMed Web of Science ®Google Scholar
• Calverley DC, Hacker MR, Loda KA, et al. Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus. Br J Haematol. 2003;121(1):139–142. doi:10.1046/j.1365-2141.2003.04233.x
   PubMed Web of Science ®Google Scholar
• Lanzavecchia A, Sallusto F. Toll-like receptors and innate immunity in B-cell activation and antibody responses. Curr Opin Immunol. 2007;19(3):268–274. doi:10.1016/j.coi.2007.04.002
   PubMed Web of Science ®Google Scholar
• Satoh M, Akatsu T, Ishikawa Y, Minami Y, Takahashi Y, Nakamura M. Association between toll-like receptor 8 expression and adverse clinical outcomes in patients with enterovirus-associated dilated cardiomyopathy. Am Heart J. 2007;154(3):581–588. doi:10.1016/j.ahj.2007.05.010
   PubMed Web of Science ®Google Scholar
• Pereira NS, Queiroga TBD, Nunes DF, et al. Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients. PLoS Negl Trop Dis. 2018;12(7):e0006589. doi:10.1371/journal.pntd.0006589
   PubMed Web of Science ®Google Scholar
• Ahmad R, Kochumon S, Thomas R, Atizado V, Sindhu S. Increased adipose tissue expression of TLR8 in obese individuals with or without type-2 diabetes: significance in metabolic inflammation. J Inflamm. 2016;13(1):38. doi:10.1186/s12950-016-0147-y
   Google Scholar
• Meier DT, Morcos M, Samarasekera T, Zraika S, Hull RL, Kahn SE. Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice. Diabetologia. 2014;57(9):1884–1888. doi:10.1007/s00125-014-3304-y
   PubMed Web of Science ®Google Scholar
• Hannibal TD, Schmidt-Christensen A, Nilsson J, Fransén-Pettersson N, Hansen L, Holmberg D. Deficiency in plasmacytoid dendritic cells and type I interferon signalling prevents diet-induced obesity and insulin resistance in mice. Diabetologia. 2017;60(10):2033–2041. doi:10.1007/s00125-017-4341-0
   PubMed Web of Science ®Google Scholar
• Ivetic A, Hoskins Green HL, Hart SJ. L-selectin: a major regulator of leukocyte adhesion, migration and signaling. Front Immunol. 2019;10:1068.
   PubMed Web of Science ®Google Scholar
• Chen C, Ba X, Xu T, Cui L, Hao S, Zeng X. c-Abl is involved in the F-actin assembly triggered by L-selectin crosslinking. J Biochem. 2006;140(2):229–235. doi:10.1093/jb/mvj149
   PubMed Web of Science ®Google Scholar
• Liu J, Liu JX, Xu SN, et al. Association of P213S polymorphism of the L-selectin gene with type 2 diabetes and insulin resistance in Chinese population. Gene. 2012;509(2):286–290. doi:10.1016/j.gene.2012.07.086
   PubMed Web of Science ®Google Scholar
• Kamiuchi K, Hasegawa G, Obayashi H, et al. Leukocyte-endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus. J Diabetes Complicat. 2002;16(5):333–337. doi:10.1016/S1056-8727(01)00226-4
   PubMed Web of Science ®Google Scholar
• Sokup A. [Adhesion molecules in type 2 diabetes]. Przegl Lek. 2005;62(4):234–237. Polish
   PubMedGoogle Scholar
• Sandoval-Pinto E, Padilla-Gutiérrez JR, Hernández-Bello J, et al. Influence of haplotypes, gene expression and soluble levels of L-selectin on the risk of acute coronary syndrome. Gene. 2017;625:31–41. doi:10.1016/j.gene.2017.05.005
   PubMed Web of Science ®Google Scholar
• Arrington ME, Temple B, Schaefer A, Campbell SL. The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2. J Biol Chem. 2020;295(34):12130–12142. doi:10.1074/jbc.RA120.012915
   PubMed Web of Science ®Google Scholar
• Fløyel T, Mirza AH, Kaur S, et al. The Rac2 GTPase contributes to cathepsin H-mediated protection against cytokine-induced apoptosis in insulin-secreting cells. Mol Cell Endocrinol. 2020;518:110993. doi:10.1016/j.mce.2020.110993
   PubMed Web of Science ®Google Scholar