Molecular Mechanism of Sphingosine-1-Phosphate Receptor 1 Regulating CD4⁺ Tissue Memory in situ T Cells in Primary Sjogren’s Syndrome

References

• Borchers AT, Naguwa SM, Keen CL, et al. Immunopathogenesis of Sjögren’s syndrome. Clin Rev Allergy Immunol. 2003;25(1):89–104. doi:10.1385/CRIAI:25:1:89
   PubMed Web of Science ®Google Scholar
• Peri Y, Agmon-Levin N, Theodor E, et al. Sjögren’s syndrome, the old and the new. Best practice & research. Clin Rheumatol. 2012;26(1):105–117.
   Google Scholar
• Gao C-Y, Yao Y, Li L, et al. Tissue-Resident Memory CD 8+ T Cells Acting as Mediators of Salivary Gland Damage in a Murine Model of Sjögren’s Syndrome. Arthritis Rheumatol. 2019;71(1):121–132. doi:10.1002/art.40676
   PubMed Web of Science ®Google Scholar
• Mingueneau M, Boudaoud S, Haskett S, et al. Cytometry by time-of-flight immunophenotyping identifies a blood Sjögren’s signature correlating with disease activity and glandular inflammation. J Allergy Clin Immunol. 2016;137(6):1809–1821.e12. doi:10.1016/j.jaci.2016.01.024
   PubMed Web of Science ®Google Scholar
• Nocturne G, Mariette X. Advances in understanding the pathogenesis of primary Sjögren’s syndrome. Nat Rev Rheumatol. 2013;9(9):544–556. doi:10.1038/nrrheum.2013.110
   PubMed Web of Science ®Google Scholar
• Qin B, Wang J, Yang Z, et al. Epidemiology of primary Sjögren’s syndrome: a systematic review and meta-analysis. Ann Rheum Dis. 2015;74(11):1983–1989. doi:10.1136/annrheumdis-2014-205375
   PubMed Web of Science ®Google Scholar
• Mariette X, Criswell LA. Primary Sjögren’s Syndrome. N Engl J Med. 2018;378(10):931–939. doi:10.1056/NEJMcp1702514
   PubMed Web of Science ®Google Scholar
• Chatzis L, Pezoulas VC, Ferro F, et al. Sjögren’s syndrome: the clinical spectrum of male patients. J Clin Med. 2020;9(8):2620. doi:10.3390/jcm9082620
   PubMed Web of Science ®Google Scholar
• Stefanski A-L, Tomiak C, Pleyer U, et al. The diagnosis and treatment of Sjögren’s syndrome. Dtsch Arztebl Int. 2017;114(20):354–361.
   PubMed Web of Science ®Google Scholar
• Christodoulou MI, Kapsogeorgou EK, Moutsopoulos.Characteristics HM. of the minor salivary gland infiltrates in Sjögren’s syndrome. J Autoimmun. 2010;34(4):400–407. doi:10.1016/j.jaut.2009.10.004
   PubMed Web of Science ®Google Scholar
• Verstappen GM, Kroese FGM, Bootsma H. T cells in primary Sjögren’s syndrome: targets for early intervention. Rheumatology. 2019; 60(7):3088.
   Web of Science ®Google Scholar
• Schenkel JM, Masopust D. Tissue-resident memory T cells. Immunity. 2014;41(6):886–897. doi:10.1016/j.immuni.2014.12.007
   PubMed Web of Science ®Google Scholar
• Zundler S, Becker E, Spocinska M, et al. Hobit- and Blimp-1-driven CD4 tissue-resident memory T cells control chronic intestinal inflammation. Nat Immunol. 2019;20(3):288–300. doi:10.1038/s41590-018-0298-5
   PubMed Web of Science ®Google Scholar
• Teijaro JR, Turner D, Pham Q, et al. Cutting edge: tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. J Immunol. 2011;187(11):5510–5514. doi:10.4049/jimmunol.1102243
   PubMed Web of Science ®Google Scholar
• Turner DL, Bickham KL, Thome JJ, et al. Lung niches for the generation and maintenance of tissue-resident memory T cells. Mucosal Immunol. 2014;7(3):501–510. doi:10.1038/mi.2013.67
   PubMed Web of Science ®Google Scholar
• Iijima N, Iwasaki A. T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Science. 2014;346(6205):93–98. doi:10.1126/science.1257530
   PubMed Web of Science ®Google Scholar
• Smith CJ, Caldeira-Dantas S, Turula H, et al. Murine CMV infection induces the continuous production of mucosal resident T cells. Cell Rep. 2015;13(6):1137–1148. doi:10.1016/j.celrep.2015.09.076
   PubMed Web of Science ®Google Scholar
• Thom JT, Weber TC, Walton SM, et al. The salivary gland acts as a sink for tissue-resident memory CD8(+) T cells, facilitating protection from local cytomegalovirus infection. Cell Rep. 2015;13(6):1125–1136. doi:10.1016/j.celrep.2015.09.082
   PubMed Web of Science ®Google Scholar
• Collins N, Jiang X, Zaid A, et al. Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation. Nat Commun. 2016;7:11514. doi:10.1038/ncomms11514
   PubMed Web of Science ®Google Scholar
• Glennie ND, Yeramilli VA, Beiting DP, et al. Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection. J Exp Med. 2015;212(9):1405–1414. doi:10.1084/jem.20142101
   PubMed Web of Science ®Google Scholar
• Mackay LK, Kallies A. Transcriptional Regulation of tissue-resident lymphocytes. Trends Immunol. 2017;38(2):94–103. doi:10.1016/j.it.2016.11.004
   PubMed Web of Science ®Google Scholar
• Yao Y, Ma J-F, Chang C, et al. Immunobiology of T Cells in Sjögren’s Syndrome. Clin Rev Allergy Immunol. 2021;60(1):111–131. doi:10.1007/s12016-020-08793-7
   PubMed Web of Science ®Google Scholar
• Kumar BV, Ma W, Miron M, et al. Human Tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites. Cell Rep. 2017;20(12):2921–2934. doi:10.1016/j.celrep.2017.08.078
   PubMed Web of Science ®Google Scholar
• Matloubian M, Lo CG, Cinamon G, et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004;427(6972):355–360. doi:10.1038/nature02284
   PubMed Web of Science ®Google Scholar
• Spiegel S, Milstien S. The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol. 2011;11(6):403–415. doi:10.1038/nri2974
   PubMed Web of Science ®Google Scholar
• Skon CN, Lee J-Y, Anderson KG, et al. Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells. Nat Immunol. 2013;14(12):1285–1293. doi:10.1038/ni.2745
   PubMed Web of Science ®Google Scholar
• Xiao L, Zhou Y, Friis T, et al. S1P-S1PR1 Signaling: the “Sphinx” in Osteoimmunology. Front Immunol. 2019;10:1409. doi:10.3389/fimmu.2019.01409
   PubMed Web of Science ®Google Scholar
• Tsai H-C, Nguyen K, Hashemi E, et al. Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation. J Autoimmun. 2019;105:102290. doi:10.1016/j.jaut.2019.06.001
   PubMed Web of Science ®Google Scholar
• Lankadasari MB, Aparna JS, Mohammed S, et al. Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine. Theranostics. 2018;8(14):3824–3840. doi:10.7150/thno.25308
   PubMed Web of Science ®Google Scholar
• Lin Q, Ren L, Jian M, et al. The mechanism of the premetastatic niche facilitating colorectal cancer liver metastasis generated from myeloid-derived suppressor cells induced by the S1PR1-STAT3 signaling pathway. Cell Death Dis. 2019;10(10):693. doi:10.1038/s41419-019-1922-5
   PubMed Web of Science ®Google Scholar
• Kappos L, Radue E-W, O’Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010;362(5):387–401. doi:10.1056/NEJMoa0909494
   PubMed Web of Science ®Google Scholar
• Doolen S, Iannitti T, Donahue RR, et al. Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn. Pain. 2018;159(2):224–238. doi:10.1097/j.pain.0000000000001106
   PubMed Web of Science ®Google Scholar
• Nielsen OH, Li Y, Johansson-Lindbom B, et al. Sphingosine-1-phosphate signaling in inflammatory bowel disease. Trends Mol Med. 2017;23(4):362–374. doi:10.1016/j.molmed.2017.02.002
   PubMed Web of Science ®Google Scholar
• Wang R-H, Dai X-J, Wu H, et al. Anti-Inflammatory Effect of Geniposide on Regulating the Functions of Rheumatoid Arthritis Synovial Fibroblasts via Inhibiting Sphingosine-1-Phosphate Receptors1/3 Coupling Gαi/Gαs Conversion. Front Pharmacol. 2020;11:584176. doi:10.3389/fphar.2020.584176
   PubMed Web of Science ®Google Scholar
• Sekiguchi M, Iwasaki T, Kitano M, et al. Role of sphingosine 1-phosphate in the pathogenesis of Sjögren’s syndrome. J Immunol. 2008;180(3):1921–1928. doi:10.4049/jimmunol.180.3.1921
   PubMed Web of Science ®Google Scholar
• Ramos-Casals M, Font J. Primary Sjögren’s syndrome: current and emergent aetiopathogenic concepts. Rheumatology. 2005;44(11):1354–1367. doi:10.1093/rheumatology/keh714
   PubMed Web of Science ®Google Scholar
• Zajac AJ, Harrington LE. Tissue-resident T cells lose their S1P1 exit visas. Cell Mol Immunol. 2014;11(3):221–223. doi:10.1038/cmi.2014.7
   PubMed Web of Science ®Google Scholar
• Mandl T, Bredberg A, Jacobsson LT, et al. CD4+ T-lymphocytopenia–a frequent finding in anti-SSA antibody seropositive patients with primary Sjögren’s syndrome. J Rheumatol. 2004;31(4):726–728.
   PubMed Web of Science ®Google Scholar
• Nocturne G, Mariette X. Sjögren Syndrome-associated lymphomas: an update on pathogenesis and management. Br J Haematol. 2015;168(3):317–327. doi:10.1111/bjh.13192
   PubMed Web of Science ®Google Scholar
• Casey KA, Fraser KA, Schenkel JM, et al. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J Immunol. 2012;188(10):4866–4875. doi:10.4049/jimmunol.1200402
   PubMed Web of Science ®Google Scholar
• Mackay LK, Rahimpour A, Ma JZ, et al. The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. Nat Immunol. 2013;14(12):1294–1301. doi:10.1038/ni.2744
   PubMed Web of Science ®Google Scholar
• Awada A, Nicaise C, Ena S, et al. Potential involvement of the IL-33-ST2 axis in the pathogenesis of primary Sjogren’s syndrome. Ann Rheum Dis. 2014;73(6):1259–1263. doi:10.1136/annrheumdis-2012-203187
   PubMed Web of Science ®Google Scholar
• Conti P, Stellin L, Caraffa A, et al. Advances in Mast Cell Activation by IL-1 and IL-33 in Sjögren’s Syndrome: promising Inhibitory Effect of IL-37. Int J Mol Sci. 2020;21(12):12. doi:10.3390/ijms21124297
   Web of Science ®Google Scholar
• McCarthy PC, Phair IR, Greger C, et al. IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3. Immunol Cell Biol. 2019;97(1):54–71. doi:10.1111/imcb.12200
   PubMed Web of Science ®Google Scholar
• Limaye A, Hall BE, Zhang L, et al. Targeted TNF-α overexpression drives salivary gland inflammation. J Dent Res. 2019;98(6):713–719. doi:10.1177/0022034519837240
   PubMed Web of Science ®Google Scholar
• Patrussi L, Capitani N, Martini V, et al. Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia. Cancer Res. 2015;75(19):4153–4163. doi:10.1158/0008-5472.CAN-15-0986
   PubMed Web of Science ®Google Scholar
• Katsifis GE, Rekka S, Moutsopoulos NM, et al. Systemic and local interleukin-17 and linked cytokines associated with Sjögren’s syndrome immunopathogenesis. Am J Pathol. 2009;175(3):1167–1177. doi:10.2353/ajpath.2009.090319
   PubMed Web of Science ®Google Scholar
• Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235–238. doi:10.1038/nature04753
   PubMed Web of Science ®Google Scholar
• Sisto M, Lorusso L, Tamma R, et al. Interleukin-17 and −22 synergy linking inflammation and EMT-dependent fibrosis in Sjögren’s syndrome. Clin Exp Immunol. 2019;198(2):261–272. doi:10.1111/cei.13337
   PubMed Web of Science ®Google Scholar
• Sisto M, Lorusso L, Ingravallo G, et al. The TGF-β 1 Signaling pathway as an attractive target in the fibrosis pathogenesis of Sjögren’s syndrome. Mediators Inflamm. 2018;2018:1965935. doi:10.1155/2018/1965935
   PubMed Web of Science ®Google Scholar
• Leehan KM, Pezant NP, Rasmussen A, et al. Minor salivary gland fibrosis in Sjögren’s syndrome is elevated, associated with focus score and not solely a consequence of aging. Clin Exp Rheumatol. 2018;36 Suppl 112(3):80–88.
   PubMed Web of Science ®Google Scholar
• Dörner T, Hucko M, Mayet WJ, et al. Enhanced membrane expression of the 52 kDa Ro(SS-A) and La(SS-B) antigens by human keratinocytes induced by TNF alpha. Ann Rheum Dis. 1995;54(11):904–909. doi:10.1136/ard.54.11.904
   PubMed Web of Science ®Google Scholar