Patients, Prescribers, and Institutional Factors Associated with Inappropriate Use of Acid Suppressive Therapy in Medical Wards: An Experience of a Single-Center in Saudi Arabia

References

• American Society of Health Pharmacy. ASHP therapeutic guidelines on stress ulcer prophylaxis developed through the ashp commission on therapeutics and approved by the ashp board of directors on; 1998. Available from: https://academic.oup.com/ajhp/article-abstract/56/4/347/5150704. Accessed August 18, 2021.
   Google Scholar
• Li T, Xie Y, Al-Aly Z. The association of proton pump inhibitors and chronic kidney disease. Curr Opin Nephrol Hypertens. 2018;27(3):182–187. doi:10.1097/MNH.0000000000000406
   PubMed Web of Science ®Google Scholar
• Muheim L, Signorell A, Markun S, et al. Potentially inappropriate proton-pump inhibitor prescription in the general population: a claims-based retrospective time trend analysis. Therap Adv Gastroenterol. 2021;14:175628482199892. doi:10.1177/1756284821998928
   Web of Science ®Google Scholar
• Zink DA, Pohlman M, Barnes M, Cannon ME. Long-term use of acid suppression started inappropriately during hospitalization. Aliment Pharmacol Ther. 2005;21(10):1203–1209. doi:10.1111/j.1365-2036.2005.02454.x
   PubMed Web of Science ®Google Scholar
• Yap MH, Yip G, Edwards A, D’Intini V, Tong E. Appropriateness of proton pump inhibitor use in patients admitted under the general medical unit. J Pharmacy Practice Res. 2019;49(5):447–453. doi:10.1002/jppr.1548
   Google Scholar
• Ladd AM, Panagopoulos G, Cohen J, Mar N, Graham R. Potential Costs of Inappropriate Use of Proton Pump Inhibitors. Am J Med Sci. 2014;347(6):446–451. doi:10.1097/MAJ.0b013e31829f87d5
   PubMed Web of Science ®Google Scholar
• Malhis A, Alghamdi T, Alfandi R, et al. Appropriateness of acid-suppressing agents for stress ulcer prophylaxis in non-intensive care unit setting in Saudi Arabia. J Pharmacy Bioallied Sci. 2019;11(1):25. doi:10.4103/JPBS.JPBS_173_18
   Web of Science ®Google Scholar
• Mayet A, Malhani A, Alshaikh M, Alsultan M. Pattern of intravenous proton pump inhibitors use in ICU and Non-ICU setting: a prospective observational study. Saudi J Gastroenterol. 2010;16(4):275. doi:10.4103/1319-3767.70614
   PubMedGoogle Scholar
• Kumbhani DJ, Cannon CP, Beavers CJ, et al. 2020 ACC Expert Consensus Decision Pathway for Anticoagulant and Antiplatelet Therapy in Patients With Atrial Fibrillation or Venous Thromboembolism Undergoing Percutaneous Coronary Intervention or With Atherosclerotic Cardiovascular Disease. J Am Coll Cardiol. 2021;77(5):629–658. doi:10.1016/j.jacc.2020.09.011
   PubMed Web of Science ®Google Scholar
• Abraham NS, Hlatky MA, Antman EM, et al. ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: a Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. Circulation. 2010;122(24):478. doi:10.1161/CIR.0b013e318202f701
   PubMed Web of Science ®Google Scholar
• Lanza FL, Chan FKL, Quigley EMM. Guidelines for Prevention of NSAID-Related Ulcer Complications. Am J Gastroenterol. 2009;104(3):115. doi:10.1038/ajg.2009.115
   Web of Science ®Google Scholar
• Voukelatou P, Vrettos I, Emmanouilidou G, et al. Predictors of Inappropriate Proton Pump Inhibitors Use in Elderly Patients. Current Gerontology and Geriatrics Research: Hindawi Limited; 2019. Vol. 2019.
   Google Scholar
• Palkovic LB, Coley KC, Sokos DR. Factors associated with inappropriate inpatient prescribing of acid-suppressive therapy. Int J Pharmacy Practice. 2010;17(1):73–75. doi:10.1211/ijpp.17.1.0011
   Google Scholar
• Redfern RE, Brown M, Karhoff KL, Middleton JL. Overuse of Acid-Suppression Therapy at an Urban Tertiary Hospital. South Med J. 2015;108(12):732–738. doi:10.14423/SMJ.0000000000000383
   PubMed Web of Science ®Google Scholar
• Barrison AF, Jarboe LA, Weinberg BM, Nimmagadda K, Sullivan LM, Wolfe MM. Patterns of proton pump inhibitor use in clinical practice. Am J Med. 2001;111(6):469–473. doi:10.1016/S0002-9343(01)00901-9
   PubMed Web of Science ®Google Scholar
• Batuwitage BT, Kingham JGC, Morgan NE, Bartlett RL. Inappropriate prescribing of proton pump inhibitors in primary care. Postgrad Med J. 2007;83(975):66–68. doi:10.1136/pgmj.2006.051151
   PubMed Web of Science ®Google Scholar
• Shin S. Evaluation of costs accrued through inadvertent continuation of hospital-initiated proton pump inhibitor therapy for stress ulcer prophylaxis beyond hospital discharge: a retrospective chart review. Ther Clin Risk Manag. 2015;649. doi:10.2147/TCRM.S81759
   PubMed Web of Science ®Google Scholar
• Dharmarajan TS, Use T. Misuse of Proton Pump Inhibitors: an Opportunity for Deprescribing. J Am Med Dir Assoc. 2021;22(1):15–22. doi:10.1016/j.jamda.2020.09.046
   PubMed Web of Science ®Google Scholar
• Sattayalertyanyong O, Thitilertdecha P, Auesomwang C. The inappropriate use of proton pump inhibitors during admission and after discharge: a prospective cross-sectional study. Int J Clin Pharm. 2020;42(1):174–183. doi:10.1007/s11096-019-00955-8
   PubMed Web of Science ®Google Scholar
• Wahking RA, Steele RL, Hanners RE, Lockwood SM, Davis KW. Outcomes from a pharmacist - led proton pump inhibitor stewardship program at a single institution. Hosp Pharm. 2018;53(1):59–67. doi:10.1177/0018578717747192
   PubMedGoogle Scholar
• Padhy BM, Bhadauria HS, Gupta YK. Attitude and Knowledge of Indian Emergency Care Residents towards Use of Proton Pump Inhibitors. Int Scholarly Res Notices. 2014;2014:1–6. doi:10.1155/2014/968430
   Google Scholar
• Luo H, Fan Q, Bian T, et al. Awareness, attitude and behavior regarding proton pump inhibitor among medical staff in the Southwest of China. BMC Health Serv Res. 2019;19(1). doi:10.1186/s12913-019-4725-6
   Web of Science ®Google Scholar
• Nachnani JS, Bulchandani D, Moormeier J, Foxworth J. Patient and physician predictors of inappropriate acid-suppressive therapy (AST) use in hospitalized patients. J Hospital Med. 2009;4(8):E10–E14. doi:10.1002/jhm.492
   PubMedGoogle Scholar
• Davis KW, Hanners RE, Lockwood SM. Implementation of a proton pump inhibitor stewardship program. Am J Health System Pharmacy. 2017;74(12):54. doi:10.2146/ajhp160670
   PubMed Web of Science ®Google Scholar