156
Views
7
CrossRef citations to date
0
Altmetric
Original Research

Increased Platelet-to-Lymphocyte Ratio is an Independent Predictor of Hemorrhagic Transformation and In-Hospital Mortality Among Acute Ischemic Stroke with Large-Artery Atherosclerosis Patients

, &
Pages 7545-7555 | Published online: 01 Nov 2021

References

  • Adams HP Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in acute stroke treatment. Stroke. 1993;24(1):35–41.
  • Rovira A, Grive E, Rovira A, Alvarez-Sabin J. Distribution territories and causative mechanisms of ischemic stroke. Eur Radiol. 2005;15:416–426.
  • Von Kummer R, Broderick JP, Campbell BCV, et al. The Heidelberg bleeding classification: classification of bleeding events after ischemic stroke and reperfusion therapy. Stroke. 2015;46(10):2981–2986. doi:10.1161/STROKEAHA.115.010049
  • Jickling GC, Liu D, Stamova B, et al. Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow Metab. 2014;34:185–199. doi:10.1038/jcbfm.2013.203
  • Lu GF, He QW, Shen Y, Cao F. Potential biomarkers for predicting hemorrhagic transformation of ischemic stroke. Int J Neurosci. 2018;128:179–189. doi:10.1080/00207454.2017.1349766
  • Lee SJ, Lee DG. Distribution of atherosclerotic stenosis determining early neurologic deterioration in acute ischemic stroke. PloS One. 2017;12(9):e0185314. doi:10.1371/journal.pone.0185314
  • Wolf D, Ley K. Immunity and inflammation in atherosclerosis. Circ Res. 2019;124(2):315–327. doi:10.1161/CIRCRESAHA.118.313591
  • Schaftenaar F, Frodermann V, Kuiper J, Lutgens E. Atherosclerosis: the interplay between lipids and immune cells. Curr Opin Lipidol. 2016;27(3):209–215.
  • Song QH, Pan RS, Jin YX, et al. Lymphocyte-to-monocyte ratio and risk of hemorrhagic transformation in patients with acute ischemic stroke. Neurol Sci. 2020;41(9):2511–2520. doi:10.1007/s10072-020-04355-z
  • He WW, Ruan YT, Yuan CX, et al. High neutrophil-to-platelet ratio is associated with hemorrhagic transformation in patients with acute ischemic stroke. Front Neurol. 2019;10:1310. doi:10.3389/fneur.2019.01310
  • Zhang WB, Zeng YY, Wang F, Cheng L, Tang WJ, Wang XQ. A high neutrophil-to-lymphocyte ratio predicts hemorrhagic transformation of large atherosclerotic infarction in patients with acute ischemic stroke. Aging. 2020;12(3):2428–2439. doi:10.18632/aging.102752
  • Zhang RR, Wu XD, Hu WJ, et al. Neutrophil‐to‐lymphocyte ratio predicts hemorrhagic transformation in ischemic stroke: a meta‐analysis. Brain Behav. 2019;9(9):e01382. doi:10.1002/brb3.1382
  • Song QH, Li YS, Wang YN, Wei CC, Liu JF, Liu M. Increased neutrophil-to-lymphocyte ratios are associated with greater risk of hemorrhagic transformation in patients with acute ischemic stroke. Curr Neurovasc Res. 2018;15(4):326–335. doi:10.2174/1567202616666181204122457
  • Gong PY, Xie Y, Jiang T, et al. Neutrophil-lymphocyte ratio predicts post-thrombolysis early neurological deterioration in acute ischemic stroke patients. Brain Behav. 2019;9(10):e01426. doi:10.1002/brb3.1426
  • Duan ZH, Wang HM, Wang Z, et al. Neutrophil-lymphocyte ratio predicts functional and safety outcomes after endovascular treatment for acute ischemic stroke. Cerebrovasc Dis. 2018;45(5–6):221–227. doi:10.1159/000489401
  • Brooks SD, Spears C, Cummings C, et al. Admission neutrophil‐lymphocyte ratio predicts 90 day outcome after endovascular stroke therapy. J Neurointerv Surg. 2014;6(8):578–583. doi:10.1136/neurintsurg-2013-010780
  • Xu JH, He XW, Li Q, et al. Higher platelet-to-lymphocyte ratio is associated with worse outcomes after intravenous thrombolysis in acute ischaemic stroke. Front Neurol. 2019;10:1192. doi:10.3389/fneur.2019.01192
  • Maimaiti A, Li Y, Wang YT, et al. Association of platelet-to-lymphocyte count ratio with myocardial reperfusion and major adverse events in patients with acute myocardial infarction: a two-center retrospective cohort study. BMJ Open. 2019;9(9):e025628. doi:10.1136/bmjopen-2018-025628
  • Zhang YF, Jiang L, Yang P, Zhang YZ. Comparison of lymphocyte count, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting the severity and the clinical outcomes of acute cerebral infarction patients. Clin Lab. 2019;65(7). doi:10.7754/Clin.Lab.2019.190102
  • Huang GQ, Chen HJ, Wang QZ, et al. High platelet-to-lymphocyte ratio are associated with post-stroke depression. J Affect Disord. 2019;246:105–111. doi:10.1016/j.jad.2018.12.012
  • Hatano S. Experience from a multicenter stroke register: a preliminary report. Bull World Health Organ. 1976;54(5):541–553.
  • de Los Rios la Rosa F, Khoury J, Kissela BM, et al. Eligibility for intravenous recombinant tissue-type plasminogen activator within a population: the effect of the European Cooperative Acute Stroke Study (ECASS) III trial. Stroke. 2012;43(6):1591–1595. doi:10.1161/STROKEAHA.111.645986
  • Yuksel M, Yildiz A, Oylumlu M, et al. The association between platelet/lymphocyte ratio and coronary artery disease severity. Anatol J Cardiol. 2015;15:640–647. doi:10.5152/akd.2014.5565
  • Rust R, Grönnert L, Schwab ME. Inflammation after stroke: a local rather than systemic response? Trends Neurosci. 2018;41(12):877–879. doi:10.1016/j.tins.2018.09.011
  • Xu XR, Zhang D, Oswald BE, et al. Platelets are versatile cells: new discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond. Crit Rev Clin Lab Sci. 2016;53:409–430. doi:10.1080/10408363.2016.1200008
  • Mercuri M, Cinffetti G, Lombardini R, Neri C, Robinson M. Do leukocytes have a role in the cerebrovascular no-reflow phenomenon? J Neurol Neurosurg Psychiatry. 1990;53(6):536.
  • Arumugam TV, Granger DN, Mattson MP. Stroke and T-cells. Neuromolecular Med. 2015;7(3):229–242. doi:10.1385/NMM:7:3:229
  • Huang J, Upadhyay UM, Tamargo RJ. Inflammation in stroke and focal cerebral ischemia. Surg Neurol. 2006;66(3):232–245.
  • Perera MN, Ma HK, Arakawa S, et al. Inflammation following stroke. J Clin Neurosci. 2006;13(1):1–8. doi:10.1016/j.jocn.2005.07.005
  • Jin R, Yang G, Li G. Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator. Neurobiol Dis. 2010;38:376–385. doi:10.1016/j.nbd.2010.03.008
  • Turner RJ, Sharp FR. Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke. Front Cell Neurosci. 2016;10:56. doi:10.3389/fncel.2016.00056
  • Macrez R, Ali C, Toutirais O, et al. Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol. 2011;10(5):471–480. doi:10.1016/S1474-4422(11)70066-7
  • Salas-Perdomo A, Miró-Mur F, Urra X, et al. T cells prevent hemorrhagic transformation in ischemic stroke by P-selectin binding. Arterioscler Thromb Vasc Biol. 2018;38(8):1761–1771. doi:10.1161/ATVBAHA.118.311284
  • Yip HK, Chen SS, Liu JS, et al. Serial changes in platelet activation in patients after ischemic stroke: role of pharmacodynamic modulation. Stroke. 2004;35(7):1683–1687. doi:10.1161/01.STR.0000131658.80951.c3
  • Fateh-Moghadam S, Htun P, Tomandl B, et al. Hyperresponsiveness of platelets in ischemic stroke. Thromb Haemost. 2007;97(6):974–978. doi:10.1160/TH06-12-0725
  • Marquardt L, Ruf A, Mansmann U, et al. Course of platelet activation markers after ischemic stroke. Stroke. 2002;33(11):2570–2574. doi:10.1161/01.STR.0000034398.34938.20
  • Yilmaz G, Arumugam TV, Stokes KY, Granger DN. Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation. 2006;113(17):2105–2112. doi:10.1161/CIRCULATIONAHA.105.593046
  • Gorelick PB, Wong KS, Bae HJ, Pandey DK. Large artery intracranial occlusive disease: a large worldwide burden but a relatively neglected frontier. Stroke. 2008;39:2396–2399. doi:10.1161/STROKEAHA.107.505776
  • Bang OY. Intracranial atherosclerosis: current understanding and perspectives. J Stroke. 2014;16(1):27. doi:10.5853/jos.2014.16.1.27
  • Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 2010;9(7):689–701. doi:10.1016/S1474-4422(10)70104-6
  • Yang Y, Han YF, Sun WD, Zhang YB. Increased systemic immune-inflammation index predicts hemorrhagic transformation in anterior circulation acute ischemic stroke due to large-artery atherosclerotic. Int J Neurosci. 2021;Jul 22:1–7. doi:10.1080/00207454.2021.1953021
  • Yang M, Pan Y, Li Z, et al. Platelet count predicts adverse clinical outcomes after ischemic stroke or TIA: subgroup analysis of CNSR II. Front Neurol. 2019;10:370. doi:10.3389/fneur.2019.00370
  • Zierath D, Tanzi P, Shibata D, Becker KJ. Cortisol is more important than metanephrines in driving changes in leukocyte counts after stroke. J Stroke Cerebrovasc Dis. 2018;27:555–562. doi:10.1016/j.jstrokecerebrovasdis.2017.09.048
  • Cetin EHO, Cetin MS, Aras D, et al. Platelet to lymphocyte ratio as a prognostic marker of in-hospital and long term major adverse cardiovascular events in ST-segment elevation myocardial infarction. Angiology. 2016;67:336–345. doi:10.1177/0003319715591751
  • Bodi V, Sanchis J, Nunez J, et al. Post-reperfusion lymphopenia and microvascular obstruction in ST-segment elevation acute myocardial infarction. Rev Esp Cardiol. 2009;62:1109–1117.