93
Views
2
CrossRef citations to date
0
Altmetric
Original Research

Plasma Levels of Homocysteine is Associated with Liver Fibrosis in Health Check-Up Population

, , , &
Pages 5175-5181 | Published online: 03 Sep 2021

References

  • Tung H-C, Hsu S-J, Tsai M-H, et al. Homocysteine deteriorates intrahepatic derangement and portal-systemic collaterals in cirrhotic rats. Clin Sci. 2016;131:69–86. doi:10.1042/cs20160470
  • Jud P, Hafner F, Verheyen N, et al. Age-dependent effects of homocysteine and dimethylarginines on cardiovascular mortality in claudicant patients with lower extremity arterial disease. Heart Vessels. 2018;33:1453–1462. doi:10.1007/s00380-018-1210-9
  • Bukharaeva E, Shakirzyanova A, Khuzakhmetova V, Sitdikova G, Giniatullin R. Homocysteine aggravates ROS-induced depression of transmitter release from motor nerve terminals: potential mechanism of peripheral impairment in motor neuron diseases associated with hyperhomocysteinemia. Front Cell Neurosci. 2015;9:391. doi:10.3389/fncel.2015.00391
  • Xie D, Yuan Y, Guo J, et al. Hyperhomocysteinemia predicts renal function decline: a prospective study in hypertensive adults. Sci Rep. 2015;5(1):16268. doi:10.1038/srep16268
  • Joseph J, Kennedy RH, Devi S, Wang J, Joseph L, Hauer-Jensen M. Protective role of mast cells in homocysteine-induced cardiac remodeling. Am J Physiol Heart Circ Physiol. 2005;288(5):H2541–H2545. doi:10.1152/ajpheart.00806.2004
  • Cao L, Lou X, Zou Z, et al. Folic acid attenuates hyperhomocysteinemia-induced glomerular damage in rats. Microvasc Res. 2013;89:146–152. doi:10.1016/j.mvr.2013.07.002
  • Tan H, Shi C, Jiang X, et al. Hyperhomocysteinemia promotes vascular remodeling and fibrosis in carotid vein graph in mice. Front Biosci. 2014;19:958. doi:10.2741/4260
  • García-Tevijano ER, Berasain C, Rodríguez JA, et al. Hyperhomocysteinemia in liver cirrhosis. Hypertension. 2001;38:1217–1221. doi:10.1161/hy1101.099499
  • Deffieux T, Gennisson J-L, Bousquet L, et al. Investigating liver stiffness and viscosity for fibrosis, steatosis and activity staging using shear wave elastography. J Hepatol. 2015;62(2):317–324. doi:10.1016/j.jhep.2014.09.020
  • Yoon KT, Lim SM, Park JY, et al. Liver stiffness measurement using Acoustic Radiation Force Impulse (ARFI) elastography and effect of necroinflammation. Dig Dis Sci. 2012;57(6):1682–1691. doi:10.1007/s10620-012-2044-4
  • Sini M, Sorbello O, Civolani A, Liggi M, Demelia L. Non-invasive assessment of hepatic fibrosis in a series of patients with Wilson’s disease. Dig Liver Dis. 2012;44(6):487–491. doi:10.1016/j.dld.2011.12.010
  • Lee J, Kim MY, Kang SH, et al. The gamma-glutamyl transferase to platelet ratio and the FIB-4 score are noninvasive markers to determine the severity of liver fibrosis in chronic hepatitis B infection. Br J Biomed Sci. 2018;75(3):128–132. doi:10.1080/09674845.2018.1459147
  • Boursier J, Zarski J-P, de Ledinghen V, et al. Determination of reliability criteria for liver stiffness evaluation by transient elastography. Hepatology. 2013;57(3):1182–1191. doi:10.1002/hep.25993
  • Roulot D, Roudot-Thoraval F, Nkontchou G, et al. Concomitant screening for liver fibrosis and steatosis in French type 2 diabetic patients using fibroscan. Liver Int. 2017;37(12):1897–1906. doi:10.1111/liv.13481
  • Cassinotto C, Boursier J, de Lédinghen V, et al. Liver stiffness in nonalcoholic fatty liver disease: a comparison of supersonic shear imaging, FibroScan, and ARFI with liver biopsy. Hepatology. 2016;63(6):1817–1827. doi:10.1002/hep.28394
  • Eddowes PJ, Sasso M, Allison M, et al. Accuracy of FibroScan controlled attenuation parameter and liver stiffness measurement in assessing steatosis and fibrosis in patients with nonalcoholic fatty liver disease. Gastroenterology. 2019;156(6):1717–1730. doi:10.1053/j.gastro.2019.01.042
  • Wang R-Q, Zhang Q-S, Zhao S-X, et al. Gamma-glutamyl transpeptidase to platelet ratio index is a good noninvasive biomarker for predicting liver fibrosis in Chinese chronic hepatitis B patients. J Int Med Res. 2016;44(6):1302–1313. doi:10.1177/0300060516664638
  • Cengiz M, Ozenirler S. Comparative diagnostic accuracy of red cell distribution width-to-platelet ratio versus noninvasive fibrosis scores for the diagnosis of liver fibrosis in biopsy-proven nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2015;27(11):1293–1299. doi:10.1097/meg.0000000000000445
  • Chrysant SG, Chrysant GS. The current status of homocysteine as a risk factor for cardiovascular disease: a mini review. Expert Rev Cardiovasc Ther. 2018;16(8):559–565. doi:10.1080/14779072.2018.1497974
  • Sharma M, Tiwari M, Tiwari RK. Hyperhomocysteinemia: impact on neurodegenerative diseases. Basic Clin Pharmacol Toxicol. 2015;117:287–296. doi:10.1111/bcpt.12424
  • Audelin MC, Genest J. Homocysteine and cardiovascular disease in diabetes mellitus. Atherosclerosis. 2001;159:497–511. doi:10.1016/s0021-9150(01)00531-7
  • Zhang J-S, Hou Y-L, Lu -W-W, et al. Intermedin(1–53) protects against myocardial fibrosis by inhibiting endoplasmic reticulum stress and inflammation induced by homocysteine in apolipoprotein E-deficient mice. J Atheroscler Thromb. 2016;23:1294–1306. doi:10.5551/jat.34082
  • Ding H, Gan H-Z, Fan W-J, Cao L-Y, Xu J-M, Mei Q. Homocysteine promotes intestinal fibrosis in rats with trinitrobenzene sulfonic acid-induced colitis. Dig Dis Sci. 2014;60:375–381. doi:10.1007/s10620-014-3379-9
  • Ghoul A, Moudilou E, Cherifi MEH, et al. The role of homocysteine in seminal vesicles remodeling in rat. Folia Histochem Cytobiol. 2017;55:62–73. doi:10.5603/fhc.a2017.0010
  • Culafic D, Markovic M, Obrenovic R, Mijac D. Plasma homocysteine levels in patients with liver cirrhosis. Vojnosanit Pregl. 2013;70(1):57–60. doi:10.2298/vsp110823032c
  • Bhanji RA, Ma M, Bain VG, Montano-Loza AJ. Hyperhomocysteinemia is associated with severity of cirrhosis and negative impact after liver transplantation. Liver Int. 2015;36:696–704. doi:10.1111/liv.12979
  • Yao L, Wang C, Zhang X, et al. Hyperhomocysteinemia activates the aryl hydrocarbon receptor/CD36 pathway to promote hepatic steatosis in mice. Hepatology. 2016;64(1):92–105. doi:10.1002/hep.28518
  • Zou C-G, Gao S-Y, Zhao Y-S, et al. Homocysteine enhances cell proliferation in hepatic myofibroblastic stellate cells. J Mol Med. 2009;87(1):75–84. doi:10.1007/s00109-008-0407-2
  • El Serafy MA, Kassem AM, Omar H, Mahfouz MS, El Said El Raziky M. APRI test and hyaluronic acid as non-invasive diagnostic tools for post HCV liver fibrosis: systematic review and meta-analysis. Arab J Gastroenterol. 2017;18(2):51–57. doi:10.1016/j.ajg.2017.05.005
  • Papadopoulos N, Vasileiadi S, Papavdi M, et al. Liver fibrosis staging with combination of APRI and FIB-4 scoring systems in chronic hepatitis C as an alternative to transient elastography. Ann Gastroenterol. 2019;32:498–503. doi:10.20524/aog.2019.0406
  • Imai H, Kamei H, Onishi Y, et al. Diagnostic usefulness of APRI and FIB-4 for the prediction of liver fibrosis after liver transplantation in patients infected with hepatitis C virus. Transplant Proc. 2018;50(5):1431–1436. doi:10.1016/j.transproceed.2018.03.005
  • Ding D, Li H, Liu P, et al. FibroScan, aspartate aminotransferase and alanine aminotransferase ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factor (FIB-4), and their combinations in the assessment of liver fibrosis in patients with hepatitis B. Int J Clin Exp Med. 2015;8:20876.
  • Siddiqui MS, Yamada G, Vuppalanchi R, et al. Diagnostic accuracy of noninvasive fibrosis models to detect change in fibrosis stage. Clin Gastroenterol Hepatol. 2019;17(9):1877–1885. e1875. doi:10.1016/j.cgh.2018.12.031
  • Săftoiu A, Gilja OH, Sidhu PS, et al. The EFSUMB guidelines and recommendations for the clinical practice of elastography in non-hepatic applications: update 2018. Ultraschall Med. 2019;40(04):425–453. doi:10.1055/a-0838-9937
  • Nierhoff J, Chávez Ortiz AA, Herrmann E, Zeuzem S, Friedrich-Rust M. The efficiency of acoustic radiation force impulse imaging for the staging of liver fibrosis: a meta-analysis. Eur Radiol. 2013;23(11):3040–3053. doi:10.1007/s00330-013-2927-6
  • Bota S, Herkner H, Sporea I, et al. Meta-analysis: ARFI elastography versus transient elastography for the evaluation of liver fibrosis. Liver Int. 2013;33(8):1138–1147. doi:10.1111/liv.12240
  • Ferraioli G, Tinelli C, Dal Bello B, Zicchetti M, Filice G, Filice C. Accuracy of real-time shear wave elastography for assessing liver fibrosis in chronic hepatitis C: a pilot study. Hepatology. 2012;56(6):2125–2133. doi:10.1002/hep.25936
  • Cassinotto C, Lapuyade B, Mouries A, et al. Non-invasive assessment of liver fibrosis with impulse elastography: comparison of supersonic shear imaging with ARFI and FibroScan®. J Hepatol. 2014;61(3):550–557. doi:10.1016/j.jhep.2014.04.044
  • Boursier J, Vergniol J, Guillet A, et al. Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease. J Hepatol. 2016;65(3):570–578. doi:10.1016/j.jhep.2016.04.023
  • de Lédinghen V, Wong VW-S, Vergniol J, et al. Diagnosis of liver fibrosis and cirrhosis using liver stiffness measurement: comparison between M and XL probe of FibroScan. J Hepatol. 2012;56:833–839. doi:10.1016/j.jhep.2011.10.017
  • Verveer C, Zondervan PE, Ten Kate FJW, Hansen BE, Janssen HLA, de Knegt RJ. Evaluation of transient elastography for fibrosis assessment compared with large biopsies in chronic hepatitis B and C. Liver Int. 2011;32:622–628. doi:10.1111/j.1478-3231.2011.02663.x
  • Zeng X, Xu C, He D, et al. Influence of hepatic inflammation on FibroScan findings in diagnosing fibrosis in patients with chronic hepatitis B. Ultrasound Med Biol. 2015;41:1538–1544. doi:10.1016/j.ultrasmedbio.2015.01.011