Effectiveness and Safety of Favipiravir Compared to Hydroxychloroquine for Management of Covid-19: A Retrospective Study

References

• Horby P, Mafham M, Linsell L, et al. Effect of hydroxychloroquine in hospitalized patients with COVID-19: preliminary results from a multi-center, randomized, controlled trial. MedRxiv. 2020. https://www.semanticscholar.org/paper/Effect-of-Hydroxychloroquine-in-Hospitalized-with-a-Horby-Mafham/9019fe8a10a26e412af464eda3a54320ed179dbf
   Google Scholar
• Furtado RH, Berwanger O, Fonseca HA, et al. Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial. Lancet. 2020;396(10256):959–967. doi:10.1016/S0140-6736(20)31862-6
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang D, Du G, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet. 2020;395(10236):1569–1578. doi:10.1016/S0140-6736(20)31022-9
   PubMed Web of Science ®Google Scholar
• Nasir M, Perveen RA, Saha SK, Talha KA, Selina F, Islam MA. Systematic review on repurposing use of Favipiravir against SARS-CoV-2. Mymensingh Med J. 2020;29(3):747–754.
   PubMedGoogle Scholar
• Lu R. Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2019:395(10224):566–568.
   Google Scholar
• Gao J, Tian Z, Yang X. Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends. 2020;14(1):72–73. doi:10.5582/bst.2020.01047
   PubMed Web of Science ®Google Scholar
• Wang M, Cao R, Zhang L, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30(3):269–271. doi:10.1038/s41422-020-0282-0
   PubMed Web of Science ®Google Scholar
• Commission NH. Diagnosis and treatment protocol for novel coronavirus pneumonia (Trial version 8); 2020.
   Google Scholar
• Chen C, Huang J, Cheng Z, et al. Favipiravir versus arbidol for COVID-19: a randomized clinical trial. MedRxiv. 2020. https://www.medrxiv.org/content/10.1101/2020.03.17.20037432v4#:~:text=Conclusions%20Among%20patients%20with%20COVID,Favipiravir%20are%20mild%20and%20manageable.
   Google Scholar
• Cai Q, Yang M, Liu D, et al. Experimental treatment with favipiravir for COVID-19: an open-label control study. Engineering. 2020;6(10):1192–1198. doi:10.1016/j.eng.2020.03.007
   Web of Science ®Google Scholar
• Saudi MoH protocol for patients suspected of/confirmed with COVID‐19 supportive care and antiviral treatment of suspected or confirmed COVID‐19 infection (version 1.4) AtS; 2020 Available from: https://www.moh.gov.sa/en/Ministry/MediaCenter/Publications/Pages/covid19.aspx. Accessed September 3, 2021.
   Google Scholar
• Chen J, Liu D, Liu L, et al. A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19). J Zhejiang Univ. 2020;49(1):215–219
   Google Scholar
• Tablet A. 200 mg. Report on the Deliberation Results. Evaluation and Licensing Division, Pharmaceutical and Food Safety Bureau. Ministry of Health. Labour and Welfare; 2014.
   Google Scholar
• Rattanaumpawan P, Jirajariyavej S, Lerdlamyong K, Palavutitotai N, Saiyarin J. Real-world experience with favipiravir for treatment of COVID-19 in Thailand: results from a multi-center observational study. MedRxiv. 2020. https://www.medrxiv.org/content/10.1101/2020.06.24.20133249v3
   Google Scholar
• Perveen RA, Nasir M, Murshed M, Nazneen R, Ahmad SN. Remdesivir and favipiravir changes hepato-renal profile in COVID-19 patients: a cross sectional observation in Bangladesh. Int J Med Sci Clin Invent. 2021;8(1):5196–5201. doi:10.18535/ijmsci/v8i01.03
   Google Scholar
• Kaur RJ, Charan J, Dutta S, et al. Favipiravir use in COVID-19: analysis of suspected adverse drug events reported in the WHO database. Infect Drug Resist. 2020;13:4427. doi:10.2147/IDR.S287934
   PubMed Web of Science ®Google Scholar
• Dabbous HM, El-Sayed MH, El Assal G, et al. Safety and efficacy of favipiravir versus hydroxychloroquine in management of COVID-19: a randomised controlled trial. Sci Rep. 2021;11(1):1–7. doi:10.1038/s41598-021-85227-0
   PubMed Web of Science ®Google Scholar
• Lagier J-C, Million M, Gautret P, et al. Outcomes of 3737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: a retrospective analysis. Travel Med Infect Dis. 2020;36:101791. doi:10.1016/j.tmaid.2020.101791
   PubMed Web of Science ®Google Scholar
• Guner R, Hasanoglu I, Kayaaslan B, et al. Comparing ICU admission rates of mild/moderate COVID-19 patients treated with hydroxychloroquine, favipiravir, and hydroxychloroquine plus favipiravir. J Infect Public Health. 2021;14(3):365–370. doi:10.1016/j.jiph.2020.12.017
   PubMed Web of Science ®Google Scholar
• Udwadia ZF, Singh P, Barkate H, et al. Efficacy and safety of favipiravir, an oral RNA-dependent RNA polymerase inhibitor, in mild-to-moderate COVID-19: a randomized, comparative, open-label, multi-center, Phase 3 clinical trial. Int J Infect Dis. 2021;103:62–71. doi:10.1016/j.ijid.2020.11.142
   PubMed Web of Science ®Google Scholar
• Alzeer A, BaHammam A, Masood M, Basha SJ, Alhamad E, Sohail S. Outcome of patients with severe asthma in the intensive care unit. Ann Saudi Med. 2006;26(6):461–465. doi:10.5144/0256-4947.2006.461
   PubMed Web of Science ®Google Scholar
• Mamary AJ, Kondapaneni S, Vance GB, Gaughan JP, Martin UJ, Criner GJ. Survival in patients receiving prolonged ventilation: factors that influence outcome. Clin Med Insights Circ Respir Pulm Med. 2011;5:S6649.
   Google Scholar
• Thai PQ, Son DT, Van HTH, et al. Factors associated with the duration of hospitalisation among COVID-19 patients in Vietnam: a survival analysis. Epidemiol Infect. 2020;148. https://pubmed.ncbi.nlm.nih.gov/32517822/
   Web of Science ®Google Scholar
• Madelain V, Nguyen THT, Olivo A, et al. Ebola virus infection: review of the pharmacokinetic and pharmacodynamic properties of drugs considered for testing in human efficacy trials. Clin Pharmacokinet. 2016;55(8):907–923. doi:10.1007/s40262-015-0364-1
   PubMed Web of Science ®Google Scholar
• Joshi S, Parkar J, Ansari A, et al. Role of favipiravir in the treatment of COVID-19. Int J Infect Dis. 2020;102:501–508. doi:10.1016/j.ijid.2020.10.069
   PubMed Web of Science ®Google Scholar
• Chen C-Y, Wang F-L, Lin -C-C. Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia. Clinical Toxicol. 2006;44(2):173–175.
   PubMed Web of Science ®Google Scholar
• Negoescu A, Thornback A, Wong E, Ostor A. Long QT and hydroxychloroquine; A poorly recognised problem in rheumatology patients.: 2045. Arthritis Rheum. 2013;65. https://acrabstracts.org/abstract/long-qt-and-hydroxychloroquine-a-poorly-recognised-problem-in-rheumatology-patients/
   Google Scholar
• Çap M, Bilge Ö, Işık F, et al. The effect of favipiravir on QTc interval in patients hospitalized with coronavirus disease 2019. J Electrocardiol. 2020;63:115–119. doi:10.1016/j.jelectrocard.2020.10.015
   PubMed Web of Science ®Google Scholar
• Kumagai Y, Murakawa Y, Hasunuma T, et al. Lack of effect of favipiravir, a novel antiviral agent, on QT interval in healthy Japanese adults. Int J Clin Pharmacol Ther. 2015;53(10):866–874. doi:10.5414/CP202388
   PubMed Web of Science ®Google Scholar