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Original Research

The Impact of Diabetes Mellitus and Hyperglycemia on the Severity and Outcome of Patients with COVID-19 Disease: A Single-Center Experience

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Pages 9445-9457 | Published online: 06 Dec 2021

References

  • COVID-19 Coronavirus – update. Available from: https://virusncov.com/. Accessed October 29, 2021.
  • World Health organization. Saudi Arabia: WHO Coronavirus Disease (COVID-19) Dashboard. Available from: https://covid19.who.int/region/emro/country/sa. Accessed June 6, 2021.
  • Wu Z, McGoogan J. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China Summary of a Report of 72 314 Cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–1242. doi:10.1001/jama.2020.2648
  • Lim S, Bae JH, Kwon HS, Nauck MA. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol. 2021;17:11–30. doi:10.1038/s41574-020-00435-4
  • Pearson-Stuttard J, Blundell S, Harris T, Cook DG, Critchley J. Diabetes and infection: assessing the association with glycaemic control in population-based studies. Lancet Diabetes Endocrinol. 2016;4(2):148–158. doi:10.1016/S2213-8587(15)00379-4
  • Codo AC, Davanzo GG, Monteiro LB, et al. Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis. Cell Metab. 2020;32(3):437–446.e5. doi:10.1016/j.cmet.2020.07.007
  • Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–1062. doi:10.1016/S0140-6736(20)30566-3
  • McMichael T, Currie D, Clark S, et al. Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington. N Engl J Med. 2020;382:2005–2011. doi:10.1056/NEJMoa2005412
  • Li X, Xu S, Yu M, et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol. 2020;146(1):110–118. doi:10.1016/j.jaci.2020.04.006
  • Du Y, Tu L, Zhu P, et al. Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study. Am J Respir Crit Care Med. 2020;201(11):1372–1379. doi:10.1164/rccm.202003-0543OC
  • Zhu L, She ZG, Cheng X, et al. Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes. Cell Metab. 2020;31(6):1068–1077. doi:10.1016/j.cmet.2020.04.021
  • Roncon L, Zuin M, Rigatelli G, Zuliani G. Diabetic patients with COVID-19 infection are at higher risk of ICU admission and poor short-term outcome. J Clin Virol. 2020;127:104354. doi:10.1016/j.jcv.2020.104354
  • Aleanizy FS, Alqahtani FY, Alanazi MS, et al. Clinical characteristics and risk factors of patients with severe COVID-19 in Riyadh, Saudi Arabia: a retrospective study. J Infect Public Health. 2021;14(9):1133–1138. doi:10.1016/j.jiph.2021.07.014
  • Iroungou BA, Mangouka LG, Bivigou-Mboumba B, et al. Demographic and Clinical Characteristics Associated With Severity, Clinical Outcomes, and Mortality of COVID-19 Infection in Gabon. JAMA Netw Open. 2021;4(9):e2124190. doi:10.1001/jamanetworkopen.2021.24190
  • Patone M, Thomas K, Hatch R, et al. Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study. Lancet Infect Dis. 2021;21:1518–1528. doi:10.1016/S1473-3099(21)00318-2
  • Meo SA. Prevalence and future prediction of type 2 diabetes mellitus in the Kingdom of Saudi Arabia: a systematic review of published studies. J Pak Med Assoc. 2016;66(6):722–725.
  • Villar J, Ariff S, Gunier RB, et al. Maternal and Neonatal Morbidity and Mortality Among Pregnant Women with and Without COVID-19 Infection: the INTERCOVID Multinational Cohort Study. JAMA Pediatr. 2021;175(8):817–826. doi:10.1001/jamapediatrics.2021.1050
  • Qeadan F, Mensah NA, Tingey B, et al. The risk of clinical complications and death among pregnant women with COVID-19 in the Cerner COVID-19 cohort: a retrospective analysis. BMC Pregnancy Childbirth. 2021;21:305. doi:10.1186/s12884-021-03772-y
  • Saudi Arabian Ministry of Health. Saudi MOH Protocol for Patients Suspected of/Confirmed with COVID-19. Supportive care and antiviral treatment of suspected or confirmed COVID-19 infection. (Version 2.9) May 19th, 2021. Available from: https://www.moh.gov.sa/Ministry/MediaCenter/Publications/Documents/MOH-therapeutic-protocol-for-COVID-19.pdf. Accessed June 3, 2021.
  • Umpierrez GE, Hellman R, Korytkowski MT, et al. Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(1):16–38. doi:10.1210/jc.2011-2098
  • American diabetes Association. Diabetes Care in the Hospital: standards of medical Care in Diabetes-2021. Diabetes Care. 2021;44(Suppl 1):S211–S220. doi:10.2337/dc21-S015
  • Alguwaihes AM, Al-Sofiani ME, Megdad M, et al. Diabetes and Covid-19 among hospitalized patients in Saudi Arabia: a single-centre retrospective study. Cardiovasc Diabetol. 2020;19(1):205. doi:10.1186/s12933-020-01184-4
  • Bode B, Garrett V, Messler J, et al. Glycemic Characteristics and Clinical Outcomes of COVID-19 Patients Hospitalized in the United States. J Diabetes Sci Technol. 2020;14(4):813–821. doi:10.1177/1932296820924469
  • Ciceri F, Castagna A, Rovere-Querini P, et al. Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy. Clin Immunol. 2020;217:108509. doi:10.1016/j.clim.2020.108509
  • Wang X, Liu Z, Li J, et al. Impacts of Type 2 Diabetes on Disease Severity, Therapeutic Effect, and Mortality of Patients With COVID-19. J Clin Endocrinol Metab. 2020;105(12):e4219–e4229. doi:10.1210/clinem/dgaa535
  • Zhang N, Wang C, Zhu F, et al. Risk Factors for Poor Outcomes of Diabetes Patients With COVID-19: a Single-Center, Retrospective Study in Early Outbreak in China. Front Endocrinol. 2020;24(11):571037. doi:10.3389/fendo.2020.571037
  • Gupta S, Hayek SS, Wang W, et al. Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US [published correction appears in JAMA Intern Med. JAMA Intern Med. 2020;180(11):1436–1447. doi:10.1001/jamainternmed.2020.3596
  • Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708–1720. doi:10.1056/NEJMoa2002032
  • McGurnaghan SJ, Weir A, Bishop J, et al. Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland. Lancet Diabetes Endocrinol. 2021;9(2):82–93. doi:10.1016/S2213-8587(20)30405-8
  • Kumar A, Arora A, Sharma P, et al. Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis. Diabetes Metab Syndr. 2020;14(4):535–545. doi:10.1016/j.dsx.2020.04.044
  • Cai Y, Shi S, Yang F, et al. Fasting blood glucose level is a predictor of mortality in patients with COVID-19 independent of diabetes history. Diabetes Res Clin Pract. 2020;169:108437. doi:10.1016/j.diabres.2020.108437
  • Raoufi M, Khalili S, Mansouri M, Mahdavi A, Khalili N. Well-controlled vs poorly-controlled diabetes in patients with COVID-19: are there any differences in outcomes and imaging findings? Diabetes Res Clin Pract. 2020;166:108286. doi:10.1016/j.diabres.2020.108286
  • Zhang Y, Li H, Zhang J, et al. The clinical characteristics and outcomes of patients with diabetes and secondary hyperglycaemia with coronavirus disease 2019: a single-centre, retrospective, observational study in Wuhan. Diabetes Obes Metab. 2020;22(8):1443–1454. doi:10.1111/dom.14086
  • Petrilli CM, Jones SA, Yang J, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020;369:m1966. doi:10.1136/bmj.m1966
  • Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844–847. doi:10.1111/jth.14768
  • Natale V, Paola R, Chiara C, Giovanni D. Diabetes mellitus and thrombosis. Thromb Res. 2012;129(3):371–377. doi:10.1016/j.thromres.2011.11.052
  • Apicella M, Campopiano MC, Mantuano M, Mazoni L, Coppelli A, Del Prato S. COVID-19 in people with diabetes: understanding the reasons for worse outcomes. Lancet Diabetes Endocrinol. 2020;8(9):782–792. doi:10.1016/S2213-8587(20)30238-2
  • Knowler WC, Pettitt DJ, Savage PJ, Bennett PH. Diabetes incidence in Pima Indians: contributions of obesity and parental diabetes. Am J Epidemiol. 1981;113(2):144–156. doi:10.1093/oxfordjournals.aje.a113079
  • Hendren NS, de Lemos JA, Ayers C, et al. Association of Body Mass Index and Age With Morbidity and Mortality in Patients Hospitalized With COVID-19: results From the American Heart Association COVID-19 Cardiovascular. Circulation. 2021;143(2):135–144. doi:10.1161/CIRCULATIONAHA.120.051936
  • Critchley JA, Carey IM, Harris T, deWilde S, Hosking FJ, Cook DG. Glycemic control and risk of infections among people with type 1 or type 2 diabetes in a large primary care cohort study. Diabetes Care. 2018;41:2127–2135. doi:10.2337/dc18-0287
  • Peckham H, de Gruijter NM, Raine C, et al. Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. Nat Commun. 2020;11:6317. doi:10.1038/s41467-020-19741-6
  • Menon T, Gandhi SAQ, Tariq W, et al. Impact of Chronic Kidney Disease on Severity and Mortality in COVID-19 Patients: a Systematic Review and Meta-analysis. Cureus. 2021;13(4):e14279. doi:10.7759/cureus.14279