ΔRDW: A Novel Indicator with Predictive Value for the Diagnosis and Treatment of Multiple Diseases

References

• Feng GH, Li HP, Li QL, Fu Y, Huang RB. Red blood cell distribution width and ischaemic stroke. Stroke Vasc Neurol. 2017;2(3):172–175. doi:10.1136/svn-2017-000071
   PubMedGoogle Scholar
• Kenangil G, Ari B, Kaya F, Demir M, Domac F. Red cell distribution width levels in Parkinson’s disease patients. Acta Neurol Belg. 2020;120(5):1147–1150. doi:10.1007/s13760-019-01197-1
   PubMed Web of Science ®Google Scholar
• Hammons L, Filopei J, Steiger D, Bondarsky E. A narrative review of red blood cell distribution width as a marker for pulmonary embolism. J Thromb Thrombolysis. 2019;48(4):638–647. doi:10.1007/s11239-019-01906-w
   PubMed Web of Science ®Google Scholar
• Zhang F-X, Li Z-L, Zhang Z-D, Ma X-C. Prognostic value of red blood cell distribution width for severe acute pancreatitis. World J Gastroenterol. 2019;25(32):177–186. doi:10.3748/wjg.v25.i32.4739
   Web of Science ®Google Scholar
• Jia L, Cui S, Yang J, et al. Red blood cell distribution width predicts long-term mortality in critically ill patients with acute kidney injury: a retrospective database study. Sci Rep. 2020;10(1):1–11. doi:10.1038/s41598-020-61516-y
   PubMed Web of Science ®Google Scholar
• Hu ZD, Lippi G, Montagnana M. Diagnostic and prognostic value of red blood cell distribution width in sepsis: a narrative review. Clin Biochem. 2020;77:1–6. doi:10.1016/j.clinbiochem.2020.01.001
   PubMed Web of Science ®Google Scholar
• Fan X, Deng H, Wang X, et al. Association of red blood cell distribution width with severity of hepatitis B virus-related liver diseases. Clinica Chimica Acta. 2018;482:155–160. doi:10.1016/j.cca.2018.04.002
   PubMed Web of Science ®Google Scholar
• Hu GP, Zhou YM, Wu ZL, Li YQ, Ran PX. Red blood cell distribution width is an independent predictor of mortality for an acute exacerbation of COPD. Int J Tuberculosis Lung Dis. 2019;23(7):817–823. doi:10.5588/ijtld.18.0429
   PubMed Web of Science ®Google Scholar
• Sotiropoulos K, Yerly P, Monney P, et al. Red cell distribution width and mortality in acute heart failure patients with preserved and reduced ejection fraction. ESC Heart Fail. 2016;3(3):198–204. doi:10.1002/ehf2.12091
   PubMed Web of Science ®Google Scholar
• Th AL, Jda R, Cunanan EL, Mda T, Fer P. Red cell distribution width and mortality in patients with acute coronary syndrome: a meta-analysis on prognosis. Cardiol Res. 2018;9(3):144. doi:10.14740/cr732w
   PubMed Web of Science ®Google Scholar
• Subramanian M, Prabhu MA, Saravanan S, Thachathodiyl R. Bio-width index: a novel biomarker for prognostication of long term outcomes in patients with anaemia and heart failure. Acta Cardiol. 2017;73(4):403–409.
   PubMed Web of Science ®Google Scholar
• Xanthopoulos A, Papamichalis M, Zajichek A, et al. In‐hospital red blood cell distribution width change in patients with heart failure. Eur J Heart Fail. 2019;21(12):1659–1661. doi:10.1002/ejhf.1546
   PubMed Web of Science ®Google Scholar
• Shao Q, Korantzopoulos P, Letsas KP, et al. Red blood cell distribution width as a predictor of atrial fibrillation. J Clin Lab Anal. 2018;32(5):e22378. doi:10.1002/jcla.22378
   PubMed Web of Science ®Google Scholar
• Giuseppe lippi GT, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med. 2009;133(4):628. doi:10.5858/133.4.628
   PubMed Web of Science ®Google Scholar
• He Y, Liu C, Zeng Z, Ye W, Lin J, Ou Q. Red blood cell distribution width: a potential laboratory parameter for monitoring inflammation in rheumatoid arthritis. Clin Rheumatol. 2018;37(1):161–167. doi:10.1007/s10067-017-3871-7
   PubMed Web of Science ®Google Scholar
• Kushang P, Ferrucci V, Ershler L, William B, Dan L. Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med. 2009;169(5):515. doi:10.1001/archinternmed.2009.11
   PubMedGoogle Scholar
• Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: a simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci. 2015;52(2):86. doi:10.3109/10408363.2014.992064
   PubMed Web of Science ®Google Scholar
• Li N, Zhou H, Tang Q. Red blood cell distribution width: a novel predictive indicator for cardiovascular and cerebrovascular diseases. Dis Markers. 2017;2017:1–23.
   Web of Science ®Google Scholar
• Xiao C-H, Wan J, Liu H, et al. Red blood cell distribution width is an independent risk factor in the prediction of acute respiratory distress syndrome after severe burns. Burns. 2019;45(5):1158–1163. doi:10.1016/j.burns.2019.01.006
   PubMed Web of Science ®Google Scholar
• Shteinshnaider M, Barchel D, Almoznino-Sarafian D, Tzur I, Tsatsanashvili N. Prognostic significance of changes in red cell distribution width in an internal medicine ward. Eur J Intern Med. 2015;26(8):166–168.
   Web of Science ®Google Scholar
• Schmidt PJ, Ness PM. Hemotherapy: from bloodletting magic to transfusion medicine. Wiley Online Lib. 2006;46(2):166–168.
   Google Scholar
• Spadaro S, Taccone FS, Fogagnolo A, et al. The effects of blood transfusion on red blood cell distribution width in critically ill patients: a pilot study. Transfusion. 2018;58(8):1863–1869. doi:10.1111/trf.14759
   PubMed Web of Science ®Google Scholar
• Nielsen OJ, Andersen LS, Ludwigsen E, et al. Anaemia of rheumatoid arthritis: serum erythropoietin concentrations and red cell distribution width in relation to iron status. Ann Rheum Dis. 1990;49(6):349–353. doi:10.1136/ard.49.6.349
   PubMed Web of Science ®Google Scholar
• Feng L, Wang X, Yan L, Liu D, Yang Z. Red blood cell distribution width in rheumatoid arthritis, ankylosing spondylitis and osteoarthritis: true inflammatory index or effect of anemia? Ann Clin Lab Sci. 2018;48(3):301–307.
   PubMed Web of Science ®Google Scholar
• Weuve J, Mendes D, Bennett DA, Dong X, Evans DA. The red cell distribution width and anemia in association with prevalent dementia. Alzheimer Dis Assoc Disord. 2017;28(2):99. doi:10.1097/WAD.0b013e318299673c
   Web of Science ®Google Scholar
• Winchester LM, John P, Simon L, Nevado-Holgado AJ. Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer’s disease. Genome Med. 2018;10(1):51. doi:10.1186/s13073-018-0556-z
   PubMed Web of Science ®Google Scholar
• Beydoun MA, Hossain S, Maciver PH, Srinivasan D, Waldstein SR. Red cell distribution width, anemia, and brain volumetric outcomes among middle-aged adults. J Alzheimer’s Dis. 2021;81:1–17.
   PubMed Web of Science ®Google Scholar
• Xia Y, Huimian C, He J, Che ZY. Association between red blood cell distribution width (RDW) and carotid artery atherosclerosis (CAS) in patients with primary ischemic stroke. Arch Gerontol Geriatrics. 2015;61(1):72–75. doi:10.1016/j.archger.2015.04.005
   PubMed Web of Science ®Google Scholar
• Hasan K, Selim D, Aysegul B, et al. Red cell distribution width and neurological scoring systems in acute stroke patients. Neuropsychiatr Dis Treat. 2015;11:733–739.
   PubMed Web of Science ®Google Scholar
• Kwang CY, Danai K, Anastasios D, et al. Inhibition of renin angiotensin axis may be associated with reduced risk of developing venous thromboembolism in patients with atherosclerotic disease. PLoS One. 2014;9(1):e87813. doi:10.1371/journal.pone.0087813
   PubMed Web of Science ®Google Scholar
• Kato H, Ishida J, Imagawa S, et al. Enhanced erythropoiesis mediated by activation of the renin‐angiotensin system via angiotensin II type 1a receptor. FASEB J. 2005;19(14):2023–2025. doi:10.1096/fj.05-3820fje
   PubMed Web of Science ®Google Scholar
• Ashley C, Bradley R, Frazee W. Community-acquired pneumonia. Emerg Med Clin North Am. 2018;36(4):665–683. doi:10.1016/j.emc.2018.07.001
   PubMed Web of Science ®Google Scholar
• Nascimento arvalho CM. Community acquired pneumonia among children: the latest evidence for an updated management. Jornal de Pediatria (Versão Em Português). 2020;96:29–38. doi:10.1016/j.jpedp.2019.08.002
   Google Scholar
• Leung AK, Wong AH, Hon KL. Community-acquired pneumonia in children. Recent Pat Inflamm Allergy Drug Discov. 2018;12(2):136–144. doi:10.2174/1872213X12666180621163821
   PubMed Web of Science ®Google Scholar
• MandellLionel A. Community-acquired pneumonia: an overview. Postgrad Med. 2015;127(6):607–615. doi:10.1080/00325481.2015.1074030
   PubMed Web of Science ®Google Scholar
• Ge Y, Liu C, Al-Masud M, Xiao R. Elevated Red blood cell distribution width combined white blood cell in peripheral blood routine have a better sensitivity than CURB-65 scores in predicting ICU admission and mortality in adult community-acquired pneumonia patients. Clin Lab. 2019;65(3). doi:10.7754/Clin.Lab.2018.180828
   Web of Science ®Google Scholar
• Lee SM, Lee JH, Kim K, You HJ, Park H. The clinical significance of changes in red blood cell distribution width in patients with community-acquired pneumonia. Clin Exp Emerg Med. 2016;3(3):139–147. doi:10.15441/ceem.15.081
   PubMed Web of Science ®Google Scholar
• Celli BR, Wedzicha JA. Update on clinical aspects of chronic obstructive pulmonary disease. N Engl J Med. 2019;381(13):1257–1266. doi:10.1056/NEJMra1900500
   PubMed Web of Science ®Google Scholar
• Zhu M, Dai L, Wan L, Zhang S, Peng H. Dynamic increase of red cell distribution width predicts increased risk of 30-day readmission in patients with acute exacerbation of chronic obstructive pulmonary disease. Int J COPD. 2021;16:393–400. doi:10.2147/COPD.S291833
   Google Scholar
• Otero TM, Yeh DD, Bajwa EK, et al. Elevated red cell distribution width is associated with decreased ventilator-free days in critically ill patients. J Intensive Care Med. 2018;33(4):241–247. doi:10.1177/0885066616652612
   PubMed Web of Science ®Google Scholar
• Henry BM, Benoit JL, Benoit S, Pulvino C, Lippi G. Red Blood Cell Distribution Width (RDW) predicts COVID-19 severity: a prospective, observational study from the Cincinnati SARS-CoV-2 emergency department cohort. Diagnostics. 2020;10(9):618. doi:10.3390/diagnostics10090618
   Web of Science ®Google Scholar
• Hornick A, Tashtish N, Osnard M, Shah B, Al-Kindi SG. Anisocytosis is associated with short-term mortality in COVID-19 and may reflect proinflammatory signature in uninfected ambulatory adults. Pathogens Immun. 2020;5(1):312–326. doi:10.20411/pai.v5i1.391
   PubMedGoogle Scholar
• Lorente L, Martín M, Argueso M, Solé-Violán J, Jiménez A. Association between red blood cell distribution width and mortality of COVID-19 patients. Anaesth Crit Care Pain Med. 2020;40(1):100777. doi:10.1016/j.accpm.2020.10.013
   PubMed Web of Science ®Google Scholar
• Foy BH, Carlson JC, Reinertsen E, et al. Association of red blood cell distribution width with mortality risk in hospitalized adults with SARS-CoV-2 infection. JAMA Net Open. 2020;3(9):e2022058–e2022058. doi:10.1001/jamanetworkopen.2020.22058
   PubMed Web of Science ®Google Scholar
• Lu G, Wang J. Dynamic changes in routine blood parameters of a severe COVID-19 case. Clinica Chimica Acta. 2020;508:98–102. doi:10.1016/j.cca.2020.04.034
   PubMed Web of Science ®Google Scholar
• Liang J, Nong S, Jiang L, et al. Correlations of disease severity and age with hematology parameter variations in patients with COVID‐19 pre‐and post‐treatment. J Clin Lab Anal. 2021;35(1):e23609. doi:10.1002/jcla.23609
   PubMed Web of Science ®Google Scholar
• Horta‐Baas G, Romero‐Figueroa MD. Clinical utility of red blood cell distribution width in inflammatory and non‐inflammatory joint diseases. Int J Rheum Dis. 2019;22(1):47–54. doi:10.1111/1756-185X.13332
   PubMed Web of Science ®Google Scholar
• Gupta M, Yadav G, Singh Y, Bhalekar A. Correlation of the changing trends of red cell distribution width and serum lactate as a prognostic factor in sepsis and septic shock. J Anaesthesiol Clin Pharmacol. 2020;36(4):531. doi:10.4103/joacp.JOACP_105_19
   PubMed Web of Science ®Google Scholar
• Fan YW, Liu D, Chen JM, Li WJ, Gao CJ. Fluctuation in red cell distribution width predicts disseminated intravascular coagulation morbidity and mortality in sepsis: a retrospective single-center study. Minerva Anestesiol. 2021;87(1):52–64. doi:10.23736/S0375-9393.20.14420-1
   PubMed Web of Science ®Google Scholar
• Stacher E, Graham BB, Hunt JM, et al. Modern age pathology of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012;186(3):261. doi:10.1164/rccm.201201-0164OC
   PubMed Web of Science ®Google Scholar
• Ulrich A, Wharton J, Thayer T, et al. Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension. Eur Respir J. 2019;55(2):1901486. doi:10.1183/13993003.01486-2019
   Web of Science ®Google Scholar
• Alamri B, Bahabri A, Aldereihim A, et al. Hyperglycemia effect on red blood cells indices. Eur Rev Med Pharmacol Sci. 2019;23(5):2139–2150.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhang Y, Wan Y, Fan Z, Xu R. The relationship between red blood cell distribution width and incident diabetes in Chinese adults: a cohort study. J Diabetes Res. 2020;27:1623247.
   Google Scholar
• Atalay H, Boyuk B, Ates M, Guzel S, Celebi A, Ekizoglu I. Red cell distribution width and acute complications of diabetes. Acta Endocrinol. 2018;14(4):514. doi:10.4183/aeb.2018.514
   Google Scholar
• Ma Y, Li S, Zhang A, et al. Association between red blood cell distribution width and diabetic retinopathy: a 5-year retrospective case-control study. J Ophthalmol. 2021;2021:6653969.
   PubMed Web of Science ®Google Scholar
• Evans MA, Sano S, Walsh K. Cardiovascular disease, aging, and clonal hematopoiesis. Ann Rev Pathol. 2020;15:419–438. doi:10.1146/annurev-pathmechdis-012419-032544
   PubMed Web of Science ®Google Scholar
• Pilling LC, Atkins JL, Kuchel GA, Luigi F, David M, Ru KY. Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years. PLoS One. 2018;13(9):e0203504. doi:10.1371/journal.pone.0203504
   PubMed Web of Science ®Google Scholar
• Veeranna V, Zalawadiya SK, Panaich S, Patel KV, Afonso L. Comparative analysis of red cell distribution width and high sensitivity C-reactive protein for coronary heart disease mortality prediction in multi-ethnic population: findings from the 1999–2004 NHANES. Int J Cardiol. 2013;168(6):5156–5161. doi:10.1016/j.ijcard.2013.07.109
   PubMed Web of Science ®Google Scholar
• Lee SI, Lee SY, Choi CH, Park C-H, Park KY, Son KH. Relation between changes in red blood cell distribution width after coronary artery bypass grafting and early postoperative morbidity. J Thorac Dis. 2018;10(7):4244. doi:10.21037/jtd.2018.06.108
   PubMed Web of Science ®Google Scholar
• Turcato G, Zorzi E, Prati D, et al. Early in-hospital variation of red blood cell distribution width predicts mortality in patients with acute heart failure. Int J Cardiol. 2017;243:306–310.
   PubMed Web of Science ®Google Scholar
• Uemura Y, Shibata R, Takemoto K, et al. Elevation of red blood cell distribution width during hospitalization predicts mortality in patients with acute decompensated heart failure. J Cardiol. 2016;67(3):268–273. doi:10.1016/j.jjcc.2015.05.011
   PubMed Web of Science ®Google Scholar
• Jian Y, Li W, Peng Y, Xiong M, Zhang M. Dynamic Monitoring of Erythrocyte Distribution Width (RDW) and Platelet Distribution Width (PDW) in treatment of acute myocardial infarction. Medical Sci Monitor Int Med J Exp Clin Res. 2017;23:5899–5906.
   Google Scholar
• Carluccio E, Biagioli P, Alunni G, et al. Non-cardiac factors for prediction of response to cardiac resynchronization therapy: the value of baseline, and of serial changes, in red cell distribution width. Int J Cardiol. 2017;243:347–353. doi:10.1016/j.ijcard.2017.05.123
   PubMed Web of Science ®Google Scholar
• Geenen LW, de Assis LU, Baggen VJ, et al. Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults. IJC Heart Vasculature. 2020;30:100582. doi:10.1016/j.ijcha.2020.100582
   PubMed Web of Science ®Google Scholar
• Reinhart WH, Piety NZ, Goede JS, Shevkoplyas SS. Effect of osmolality on erythrocyte rheology and perfusion of an artificial microvascular network. Microvasc Res. 2015;98:102–107. doi:10.1016/j.mvr.2015.01.010
   PubMed Web of Science ®Google Scholar
• Patel KV,  Mohanty JG,  Kanapuru B,  Hesdorffer C,  Ershler WB, Rifkind JM. Association of the red cell distribution width with red blood cell deformability. Adv Exp Med Biol. 2013,765:211–216. doi:10.1007/978-1-4614-4989-8_29.
   Google Scholar
• Zyga S, Kolovos P. Cardiovascular disease and chronic inflammation in end stage kidney disease. Int J Caring Sci. 2013;6(1):29–36.
   Google Scholar
• Tziakas DN, Chalikias GK, Boudoulas H. Significance of the Cholesterol Content of Erythrocyte Membranes in Atherosclerosis. Taylor & Francis; 2010:449–452.
   Google Scholar
• Chalikias G, Kikas P, Drosos I, et al. Sphingomyelin content of erythrocyte membranes is in linear association with membranes’ loading with cholesterol in coronary artery disease patients. Atherosclerosis. 2016;252:e119–e120. doi:10.1016/j.atherosclerosis.2016.07.634
   Web of Science ®Google Scholar
• Vayá A, Sarnago A, Fuster O, Alis R, Romagnoli M. Influence of inflammatory and lipidic parameters on red blood cell distribution width in a healthy population. Clin Hemorheol Microcirc. 2015;59(4):379–385. doi:10.3233/CH-141862
   PubMed Web of Science ®Google Scholar
• Han F, Liu Y, Cheng S, Sun Z, Ju Y. Diagnosis and survival values of neutrophil-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) in esophageal cancer. Clinica Chimica Acta. 2018;488:150–158.
   PubMed Web of Science ®Google Scholar
• Wu J, Zhang X, Liu H, Guo N, Pan Q, Wang Y. RDW, NLR and RLR in predicting liver failure and prognosis in patients with hepatitis E virus infection. Clin Biochem. 2019;63:24–31. doi:10.1016/j.clinbiochem.2018.11.012
   PubMed Web of Science ®Google Scholar
• May JE, Marques MB, Reddy VVB, Gangaraju R. Three neglected numbers in the CBC: the RDW, MPV, and NRBC count. Cleve Clin J Med. 2019;86(3):167–172. doi:10.3949/ccjm.86a.18072
   PubMed Web of Science ®Google Scholar
• Wang X, Wu CY, Zeng PY, Li LL, Chai Y. Value of red blood cell distribution width and fibrinogen level for evaluation of the therapeutic efficacy and prognosis in patients with diffuse large B-cell lymphoma. Zhongguo Shi yan Xue ye Xue Za Zhi/Zhongguo Bing li Sheng Li Xue Hui/J Exp Hematol/Chin Assoc Pathophysiol. 2020;28(1):153–159.
   PubMedGoogle Scholar
• Ahin F, Koar AF, Aslan AF, Yiitba B, Uslu B. Serum biomarkers in patients with stable and acute exacerbation of chronic obstructive pulmonary disease: a comparative study. J Med Biochem. 2019;38(4):503–511. doi:10.2478/jomb-2018-0050
   PubMed Web of Science ®Google Scholar