195
Views
7
CrossRef citations to date
0
Altmetric
Original Research

A Pan-Cancer Analysis of the Oncogenic Role of Integrin Beta4 (ITGB4) in Human Tumors

, , , &
Pages 9629-9645 | Published online: 11 Dec 2021

References

  • Second call for pan-cancer analysis. Nat Genet. 2014;46(12):1251. doi:10.1038/ng.3155
  • Sheppard D. Functions of pulmonary epithelial integrins: from development to disease. Physiol Rev. 2003;83(3):673–686. doi:10.1152/physrev.00033.2002
  • Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol. 2004;5(10):816–826. doi:10.1038/nrm1490
  • Huang W, Yan Y, Liu Y, et al. Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1. Signal Transd Targeted Ther. 2020;5(1):39. doi:10.1038/s41392-020-0133-y
  • Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2002;110(6):673–687. doi:10.1016/s0092-8674(02)00971-6
  • Thuveson M, Gaengel K, Collu GM, Chin ML, Singh J, Mlodzik M. Integrins are required for synchronous ommatidial rotation in the Drosophila eye linking planar cell polarity signalling to the extracellular matrix. Open Biol. 2019;9(8):190148. doi:10.1098/rsob.190148
  • Giancotti FG. Targeting integrin beta4 for cancer and anti-angiogenic therapy. Trends Pharmacol Sci. 2007;28(10):506–511. doi:10.1016/j.tips.2007.08.004
  • Giancotti FG, Tarone G. Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu Rev Cell Dev Biol. 2003;19:173–206. doi:10.1146/annurev.cellbio.19.031103.133334
  • Mercurio AM, Bachelder RE, Rabinovitz I, O’Connor KL, Tani T, Shaw LM. The metastatic odyssey: the integrin connection. Surg Oncol Clin N Am. 2001;10(2):313–328, viii–ix.
  • Mercurio AM, Rabinovitz I. Towards a mechanistic understanding of tumor invasion–lessons from the alpha 6 beta 4 integrin. Semin Cancer Biol. 2001;11(2):129–141. doi:10.1006/scbi.2000.0364
  • Nikolopoulos SN, Blaikie P, Yoshioka T, Guo W, Giancotti FG. Integrin beta4 signaling promotes tumor angiogenesis. Cancer Cell. 2004;6(5):471–483. doi:10.1016/j.ccr.2004.09.029
  • Masugi Y, Yamazaki K, Emoto K, et al. Upregulation of integrin β4 promotes epithelial-mesenchymal transition and is a novel prognostic marker in pancreatic ductal adenocarcinoma. Lab Invest. 2015;95(3):308–319. doi:10.1038/labinvest.2014.166
  • Nieto MA, Huang RY, Jackson RA, Thiery JP. EMT: 2016. Cell. 2016;166(1):21–45. doi:10.1016/j.cell.2016.06.028
  • Diaz LK, Cristofanilli M, Zhou X, et al. Beta4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancer. Mod Pathol. 2005;18(9):1165–1175. doi:10.1038/modpathol.3800411
  • Kitajiri S, Hosaka N, Hiraumi H, Hirose T, Ikehara S. Increased expression of integrin beta-4 in papillary thyroid carcinoma with gross lymph node metastasis. Pathol Int. 2002;52(7):438–441. doi:10.1046/j.1440-1827.2002.01379.x
  • Kurokawa A, Nagata M, Kitamura N, et al. Diagnostic value of integrin alpha3, beta4, and beta5 gene expression levels for the clinical outcome of tongue squamous cell carcinoma. Cancer. 2008;112(6):1272–1281. doi:10.1002/cncr.23295
  • Bierie B, Pierce SE, Kroeger C, et al. Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells. Proc Natl Acad Sci USA. 2017;114(12):E2337–E2346. doi:10.1073/pnas.1618298114
  • Chandrashekar DS, Bashel B, Balasubramanya SAH, et al. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia (New York, NY). 2017;19(8):649–658. doi:10.1016/j.neo.2017.05.002
  • Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2(5):401–404. doi:10.1158/2159-8290.cd-12-0095
  • Bonneville R, Krook MA, Kautto EA, et al. Landscape of microsatellite instability across 39 cancer types. JCO Precision Oncol. 2017;2017. doi:10.1200/po.17.00073
  • Sturm G, Finotello F, Petitprez F, et al. Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology. Bioinformatics (Oxford, England). 2019;35(14):i436–i445. doi:10.1093/bioinformatics/btz363
  • Bardou P, Mariette J, Escudié F, Djemiel C, Klopp C. jvenn: an interactive Venn diagram viewer. BMC Bioinform. 2014;15(1):293. doi:10.1186/1471-2105-15-293
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol. 2006;24(10):1285–1292. doi:10.1038/nbt1240
  • Fridman WH, Galon J, Dieu-Nosjean MC, et al. Immune infiltration in human cancer: prognostic significance and disease control. Curr Top Microbiol Immunol. 2011;344:1–24. doi:10.1007/82_2010_46
  • Wu T, Dai Y. Tumor microenvironment and therapeutic response. Cancer Lett. 2017;387:61–68. doi:10.1016/j.canlet.2016.01.043
  • Chen X, Song E. Turning foes to friends: targeting cancer-associated fibroblasts. Nat Rev Drug Discov. 2019;18(2):99–115. doi:10.1038/s41573-018-0004-1
  • Friedrichs K, Ruiz P, Franke F, Gille I, Terpe HJ, Imhof BA. High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival. Cancer Res. 1995;55(4):901–906.
  • Gao S, Jia B, Feng G, et al. First-in-human pilot study of an integrin α6-targeted radiotracer for SPECT imaging of breast cancer. Signal Transd Targeted Ther. 2020;5(1)):147. doi:10.1038/s41392-020-00266-9
  • Takada Y, Ye X, Simon S. The integrins. Genome Biol. 2007;8(5):215. doi:10.1186/gb-2007-8-5-215
  • Chen Y, Zhang H, Han F, et al. The depletion of MARVELD1 leads to murine placenta accreta via integrin β4-dependent trophoblast cell invasion. J Cell Physiol. 2018;233(3):2257–2269. doi:10.1002/jcp.26098
  • Fabre S, Chantepie L, Plisson-Petit F, et al. A novel homozygous nonsense mutation in ITGB4 gene causes epidermolysis bullosa in Mouton Vendéen sheep. Anim Genet. 2021;52(1):138–139. doi:10.1111/age.13026
  • Mueller CK, Thorwarth M, Chen J, Schultze-Mosgau S. A laboratory study comparing the effect of ridge exposure using tissue punch versus mucoperiosteal flap on the formation of the implant-epithelial junction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(5 Suppl):S41–45. doi:10.1016/j.tripleo.2011.08.019
  • Van der Zee CE, Kreft M, Beckers G, Kuipers A, Sonnenberg A. Conditional deletion of the Itgb4 integrin gene in Schwann cells leads to delayed peripheral nerve regeneration. J Neurosci. 2008;28(44):11292–11303. doi:10.1523/jneurosci.3068-08.2008
  • Li M, Jiang X, Wang G, et al. ITGB4 is a novel prognostic factor in colon cancer. J Cancer. 2019;10(21):5223–5233. doi:10.7150/jca.29269
  • Wang S, Li J, Xie J, et al. Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway. Oncogene. 2018;37(30):4164–4180. doi:10.1038/s41388-018-0252-x
  • Wilkinson EJ, Woodworth AM, Parker M, et al. Epigenetic regulation of the ITGB4 gene in prostate cancer. Exp Cell Res. 2020;392(2):112055. doi:10.1016/j.yexcr.2020.112055
  • Li GS, Hou W, Chen G, et al. Clinical significance of integrin subunit Beta 4 in head and neck squamous cell carcinoma. Cancer Biother Radiopharm. 2020. doi:10.1089/cbr.2020.3943
  • Wu P, Wang Y, Wu Y, Jia Z, Song Y, Liang N. Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer. PeerJ. 2019;7:e8299. doi:10.7717/peerj.8299
  • Li XL, Liu L, Li DD, et al. Integrin β4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma. Sci Rep. 2017;7:40464. doi:10.1038/srep40464
  • Tagliabue E, Ghirelli C, Squicciarini P, Aiello P, Colnaghi MI, Ménard S. Prognostic value of alpha 6 beta 4 integrin expression in breast carcinomas is affected by laminin production from tumor cells. Clin Cancer Res. 1998;4(2):407–410.
  • Brendle A, Lei H, Brandt A, et al. Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. Carcinogenesis. 2008;29(7):1394–1399. doi:10.1093/carcin/bgn126
  • Menyhárt O, Nagy Á, Győrffy B. Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma. R Soc Open Sci. 2018;5(12):181006. doi:10.1098/rsos.181006
  • Mohanty A, Nam A, Pozhitkov A, et al. A non-genetic mechanism involving the integrin β4/paxillin axis contributes to chemoresistance in lung cancer. iScience. 2020;23(9):101496. doi:10.1016/j.isci.2020.101496
  • Huafeng J, Deqing Z, Yong D, Yulian Z, Ailing H. A cross-talk between integrin β4 and epidermal growth factor receptor induces gefitinib chemoresistance to gastric cancer. Cancer Cell Int. 2018;18:50. doi:10.1186/s12935-018-0548-5
  • Gan L, Meng J, Xu M, et al. Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin β4/FAK/SOX2/HIF-1α signaling pathway in gastric cancer. Oncogene. 2018;37(6):744–755. doi:10.1038/onc.2017.363
  • Hong D, Zhang X, Li R, et al. Deletion of TMEM268 inhibits growth of gastric cancer cells by downregulating the ITGB4 signaling pathway. Cell Death Differ. 2019;26(8):1453–1466. doi:10.1038/s41418-018-0223-3
  • Chen Q, Xu R, Zeng C, et al. Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin β4-mediated FAK signaling. PLoS One. 2014;9(2):e88386. doi:10.1371/journal.pone.0088386
  • Choi YP, Kim BG, Gao MQ, Kang S, Cho NH, Targeting ILK and β4 integrin abrogates the invasive potential of ovarian cancer. Biochem Biophys Res Commun. 2012;427(3):642–648. doi:10.1016/j.bbrc.2012.09.114
  • Lee JG, Ahn JH, Jin kim T, Ho lee J, Choi JH. Mutant p53 promotes ovarian cancer cell adhesion to mesothelial cells via integrin β4 and Akt signals. Sci Rep. 2015;5:12642. doi:10.1038/srep12642
  • Jeffers MD, Paxton J, Bolger B, Richmond JA, Kennedy JH, McNicol AM. E-cadherin and integrin cell adhesion molecule expression in invasive and in situ carcinoma of the cervix. Gynecol Oncol. 1997;64(3):481–486. doi:10.1006/gyno.1996.4578
  • Abramov IS, Emelyanova MA, Ryabaya OO, Krasnov GS, Zasedatelev AS, Nasedkina TV. Somatic mutations associated with metastasis in acral melanoma. Mol Biol (Mosk). 2019;53(4):648–653. doi:10.1134/s0026898419040025
  • Litjens SH, de Pereda JM, Sonnenberg A. Current insights into the formation and breakdown of hemidesmosomes. Trends Cell Biol. 2006;16(7):376–383. doi:10.1016/j.tcb.2006.05.004
  • Hamidi H, Ivaska J. Every step of the way: integrins in cancer progression and metastasis. Nat Rev Cancer. 2018;18(9):533–548. doi:10.1038/s41568-018-0038-z
  • Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 2010;10(1):9–22. doi:10.1038/nrc2748
  • Sung JS, Kang CW, Kang S, et al. ITGB4-mediated metabolic reprogramming of cancer-associated fibroblasts. Oncogene. 2020;39(3):664–676. doi:10.1038/s41388-019-1014-0
  • Klutstein M, Nejman D, Greenfield R, Cedar H. DNA methylation in cancer and aging. Cancer Res. 2016;76(12):3446–3450. doi:10.1158/0008-5472.can-15-3278
  • Zhuang H, Zhou Z, Ma Z, et al. Characterization of the prognostic and oncologic values of ITGB superfamily members in pancreatic cancer. J Cell Mol Med. 2020;24(22):13481–13493. doi:10.1111/jcmm.15990
  • Li L, Gao Y, Wu Q, Cheng ASL, Yip KY. New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation. Genome Res. 2019;29(4):543–553. doi:10.1101/gr.240036.118
  • Anastasiadi D, Esteve-Codina A, Piferrer F. Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species. Epigenetics Chromatin. 2018;11(1):37. doi:10.1186/s13072-018-0205-1
  • Yamashita K, Hosoda K, Nishizawa N, Katoh H, Watanabe M. Epigenetic biomarkers of promoter DNA methylation in the new era of cancer treatment. Cancer Sci. 2018;109(12):3695–3706. doi:10.1111/cas.13812
  • Meng X, Liu P, Wu Y, et al. Integrin beta 4 (ITGB4) and its tyrosine-1510 phosphorylation promote pancreatic tumorigenesis and regulate the MEK1-ERK1/2 signaling pathway. Bosnian J Basic Med Sci. 2020;20(1):106–116. doi:10.17305/bjbms.2019.4255