112
Views
9
CrossRef citations to date
0
Altmetric
Original Research

Hypoxia-Related Gene-Based Signature Can Evaluate the Tumor Immune Microenvironment and Predict the Prognosis of Colon Adenocarcinoma Patients

, , & ORCID Icon
Pages 9853-9862 | Published online: 16 Dec 2021

References

  • Kostic AD, Chun E, Robertson L, et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 2013;14(2):207–215. PubMed PMID: 23954159; PubMed Central PMCID: PMCPMC3772512. doi: 10.1016/j.chom.2013.07.007
  • Papagiorgis PC, Zizi AE, Tseleni S, Oikonomakis IN, Nikiteas NI. The pattern of epidermal growth factor receptor variation with disease progression and aggressiveness in colorectal cancer depends on tumor location. Oncol Lett. 2012;3(5):1129–1135. PubMed PMID: 22783405; PubMed Central PMCID: PMCPMC3389629. doi:10.3892/ol.2012.621
  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. PubMed PMID: 30207593. doi:10.3322/caac.21492
  • Liu X, Wan X, Kan H, et al. Hypoxia-induced upregulation of Orai1 drives colon cancer invasiveness and angiogenesis. Eur J Pharmacol. 2018;832:1–10. PubMed PMID: 29753044. doi:10.1016/j.ejphar.2018.05.008
  • Liu M, Zhong J, Zeng Z, et al. Hypoxia-induced feedback of HIF-1alpha and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein. Theranostics. 2019;9(16):4795–4810. PubMed PMID: 31367258; PubMed Central PMCID: PMCPMC6643431. doi: 10.7150/thno.30988
  • Gilkes DM, Bajpai S, Wong CC, et al. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol Cancer Res. 2013;11(5):456–466. PubMed PMID: 23378577; PubMed Central PMCID: PMCPMC3656974. doi: 10.1158/1541-7786.MCR-12-0629
  • Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. J Biol Chem. 2013;288(15):10819–10829. PubMed PMID: 23423382; PubMed Central PMCID: PMCPMC3624462. doi:10.1074/jbc.M112.442939
  • Chen J, Ding Z, Peng Y, et al. HIF-1alpha inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein. PLoS One. 2014;9(6):e98882. PubMed PMID: 24901645; PubMed Central PMCID: PMCPMC4047061. doi: 10.1371/journal.pone.0098882
  • Rohwer N, Dame C, Haugstetter A, et al. Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB. PLoS One. 2010;5(8):e12038. PubMed PMID: 20706634; PubMed Central PMCID: PMCPMC2919384. doi: 10.1371/journal.pone.0012038
  • Cubillos-Zapata C, Avendano-Ortiz J, Hernandez-Jimenez E, et al. Hypoxia-induced PD-L1/PD-1 crosstalk impairs T-cell function in sleep apnoea. Eur Respir J. 2017;50(4):1700833. PubMed PMID: 29051270. doi: 10.1183/13993003.00833-2017
  • Chambers AM, Matosevic S. Immunometabolic dysfunction of natural killer cells mediated by the hypoxia-CD73 axis in solid tumors. Front Mol Biosci PubMed PMID: 31396523; PubMed Central PMCID: PMCPMC6668567. 2019;6:60. doi:10.3389/fmolb.2019.00060
  • Westendorf AM, Skibbe K, Adamczyk A, et al. Hypoxia enhances immunosuppression by inhibiting CD4+ effector T cell function and promoting treg activity. Cell Physiol Biochem. 2017;41(4):1271–1284. PubMed PMID: 28278498. doi: 10.1159/000464429
  • Terry S, Buart S, Chouaib S. Hypoxic stress-induced tumor and immune plasticity, suppression, and impact on tumor heterogeneity. Front Immunol 2017;8:1625. PubMed PMID: 29225600; PubMed Central PMCID: PMCPMC5705542. doi:10.3389/fimmu.2017.01625
  • Chen S, Cao GD, Wei W, et al. Prediction and identification of immune genes related to the prognosis of patients with colon adenocarcinoma and its mechanisms. World J Surg Oncol. 2020;18(1):146. PubMed PMID: 32600423; PubMed Central PMCID: PMCPMC7325073. doi: 10.1186/s12957-020-01921-9
  • Newman AM, Liu CL, Green MR, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453–457. PubMed PMID: 25822800; PubMed Central PMCID: PMCPMC4739640. doi: 10.1038/nmeth.3337
  • He C, Wang L, Zhang J, Xu H. Hypoxia-inducible microRNA-224 promotes the cell growth, migration and invasion by directly targeting RASSF8 in gastric cancer. Mol Cancer. 2017;16(1):35. PubMed PMID: 28173803; PubMed Central PMCID: PMCPMC5297251. doi:10.1186/s12943-017-0603-1
  • Yang H, Geng YH, Wang P, et al. Extracellular ATP promotes breast cancer invasion and epithelial-mesenchymal transition via hypoxia-inducible factor 2alpha signaling. Cancer Sci. 2019;110(8):2456–2470. PubMed PMID: 31148343; PubMed Central PMCID: PMCPMC6676128. doi: 10.1111/cas.14086
  • Jubb AM, Buffa FM, Harris AL. Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis. J Cell Mol Med. 2010;14(1–2):18–29. PubMed PMID: 19840191; PubMed Central PMCID: PMCPMC3837600. doi:10.1111/j.1582-4934.2009.00944.x
  • Heller S, Maurer GD, Wanka C, et al. Gene suppression of Transketolase-Like Protein 1 (TKTL1) sensitizes glioma cells to hypoxia and ionizing radiation. Int J Mol Sci. 2018;19(8):2168. PubMed PMID: 30044385; PubMed Central PMCID: PMCPMC6121283. doi: 10.3390/ijms19082168
  • Starska K, Forma E, Jozwiak P, et al. Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal cancer-the relationship with regulatory hypoxia-inducible factor-1alpha expression, tumor invasiveness, and patient prognosis. Tumour Biol. 2015;36(4):2309–2321. PubMed PMID: 25412955; PubMed Central PMCID: PMCPMC4428538. doi: 10.1007/s13277-014-2838-4
  • He J, Jin Y, Chen Y, et al. Downregulation of ALDOB is associated with poor prognosis of patients with gastric cancer. Onco Targets Ther. 2016;9:6099–6109. PubMed PMID: 27785057; PubMed Central PMCID: PMCPMC5065259. doi:10.2147/OTT.S110203
  • Pan X, Wu H, Chen G, Li W. Prognostic value of enolase gene family in colon cancer. Med Sci Monit PubMed PMID: 32703926; PubMed Central PMCID: PMCPMC7401828. 2020;26:e922980. doi:10.12659/MSM.922980
  • Kumar V, Gabrilovich DI. Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment. Immunology. 2014;143(4):512–519. PubMed PMID: 25196648; PubMed Central PMCID: PMCPMC4253499. doi:10.1111/imm.12380
  • Elia AR, Cappello P, Puppo M, et al. Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile. J Leukoc Biol. 2008;84(6):1472–1482. PubMed PMID: 18725395. doi: 10.1189/jlb.0208082
  • Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood. 2004;104(8):2224–2234. PubMed PMID: 15231578. doi:10.1182/blood-2004-03-1109
  • Barsoum IB, Hamilton TK, Li X, et al. Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide. Cancer Res. 2011;71(24):7433–7441. PubMed PMID: 22006996. doi: 10.1158/0008-5472.CAN-11-2104
  • Noman MZ, Chouaib S. Targeting hypoxia at the forefront of anticancer immune responses. Oncoimmunology. 2014;3(12):e954463. PubMed PMID: 25964858; PubMed Central PMCID: PMCPMC4353170. doi:10.4161/21624011.2014.954463
  • Noman MZ, Janji B, Hu S, et al. Tumor-promoting effects of myeloid-derived suppressor cells are potentiated by hypoxia-induced expression of miR-210. Cancer Res. 2015;75(18):3771–3787. PubMed PMID: 26206559. doi: 10.1158/0008-5472.CAN-15-0405
  • Damgaci S, Ibrahim-Hashim A, Enriquez-Navas PM, Pilon-Thomas S, Guvenis A, Gillies RJ. Hypoxia and acidosis: immune suppressors and therapeutic targets. Immunology. 2018;154(3):354–362. PubMed PMID: 29485185; PubMed Central PMCID: PMCPMC6002221. doi:10.1111/imm.12917
  • Moeller BJ, Dewhirst MW. HIF-1 and tumour radiosensitivity. Br J Cancer. 2006;95(1):1–5. PubMed PMID: 16735998; PubMed Central PMCID: PMCPMC2360497. doi:10.1038/sj.bjc.6603201
  • Rohwer N, Cramer T. Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist Updat. 2011;14(3):191–201. PubMed PMID: 21466972. doi:10.1016/j.drup.2011.03.001
  • Liu L, Ning X, Sun L, et al. Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer. Cancer Sci. 2008;99(1):121–128. PubMed PMID: 17953712. doi: 10.1111/j.1349-7006.2007.00643.x
  • Ruan K, Song G, Ouyang G. Role of hypoxia in the hallmarks of human cancer. J Cell Biochem. 2009;107(6):1053–1062. PubMed PMID: 19479945. doi:10.1002/jcb.22214