128
Views
3
CrossRef citations to date
0
Altmetric
Original Research

ROCK2 Polymorphism and Expression Contribute to Increased Susceptibility and Poor Prognosis in Hepatocellular Carcinoma

ORCID Icon, , &
Pages 1295-1306 | Published online: 09 Feb 2022

References

  • Kulik L, El-Serag H. Epidemiology and management of hepatocellular carcinoma. Gastroenterology. 2019;156(2):477–491. doi:10.1053/j.gastro.2018.08.065
  • Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. Ca Cancer J Clin. 2016;66(2):115–132. doi:10.3322/caac.21338
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7–30. doi:10.3322/caac.21590
  • Liu J, Liu M. Research progress on relevant diseases of RhoA/ROCK signaling pathway. J Hainan Med Coll. 2019;25(06):78–82. doi:10.13210/j.cnki.jhmu.20190129.002
  • Hua Y, Wang K, He J, et al. Overexpression of rho-associated coiled-coil containing protein kinase 2 is correlated with clinical progression and poor prognosis in breast cancer. Med Sci Mon. 2018;24:4776–4781. doi:10.12659/MSM.908507
  • Luo J, Lou Z, Zheng J. Targeted regulation by ROCK2 on bladder carcinoma via Wnt signaling under hypoxia. Cancer Biomark. 2019;24(1):109–116. doi:10.3233/CBM-181949
  • Pranatharthi A, Thomas P, Udayashankar AH, Bhavani C, Srivastava S. RhoC regulates radioresistance via crosstalk of ROCK2 with the DNA repair machinery in cervical cancer. J Exp Clin Cancer Res. 2019;38(1):392. doi:10.1186/s13046-019-1385-7
  • Zhou J, Sun H, Wang Z, Cong W, Fan J. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 edition). Liver Cancer. 2020;9(6):682–720. doi:10.1159/000509424
  • Fukui H, Saito H, Ueno Y, et al. Evidence-based clinical practice guidelines for liver cirrhosis 2015. J Gastroenterol. 2016;51(7):629–650. doi:10.1007/s00535-016-1216-y
  • Hou J, Wang G, Wang F, et al. Guideline of prevention and treatment for chronic hepatitis B (2015 update). J Clin Transl Hepatol. 2017;5(4):297–318. doi:10.14218/JCTH.2016.00019
  • Forner A, Reig ME, Lope CRD, Bruix J. Current strategy for staging and treatment: the BCLC update and future prospects. Semin Liver Dis. 2010;30(1):61–74. doi:10.1055/s-0030-1247133
  • Qin L, Qin J, Zhen X, Qian Y, Huang L. Curcumin protects against hepatic stellate cells activation and migration by inhibiting the CXCL12/CXCR4 biological axis in liver fibrosis: a study in vitro and in vivo. Biomed Pharmacother. 2018;101:599–607. doi:10.1016/j.biopha.2018.02.091
  • Qin L, Qin J, Lv X, Yin C, Zhang J. MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma. Oncol Lett. 2021;22(1):549. doi:10.3892/ol.2021.12810
  • Julian L, Olson MF. Rho-associated coiled-coil containing kinases (ROCK) structure, regulation, and functions. Small GTPases. 2014;5:e29846. doi:10.4161/sgtp.29846
  • Pan P, Shen M, Yu H, Li Y, Hou T. Advances in the development of Rho-associated protein kinase (ROCK) inhibitors. Drug Discov Today. 2013;18(23–24):1323–1333. doi:10.1016/j.drudis.2013.09.010
  • Pelosi M, Marampon F, Zani BM, Prudente S, Rosenthal N. ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program. Mol Cell Biol. 2007;27(17):6163–6176. doi:10.1128/MCB.01735-06
  • Chen W, Mao K, Liu Z, Dinh-Xuan A. The role of the RhoA/Rho kinase pathway in angiogenesis and its potential value in prostate cancer (Review). Oncol Lett. 2014;8(5):1907–1911. doi:10.3892/ol.2014.2471
  • Inaba N, Ishizawa S, Kimura M, Fujioka K, Manome Y. Effect of inhibition of the ROCK isoform on RT2 malignant glioma cells. Anticancer Res. 2010;30(9):3509–3514. doi:10.1097/CAD.0b013e32833d19f0
  • Jeong KJ, Park SY, Cho KH, et al. The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion. Oncogene. 2012;31(39):4279–4289. doi:10.1038/onc.2011.595
  • Jiang L, Liu X, Kolokythas A, et al. Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. Int J Cancer. 2010;127(3):505–512. doi:10.1002/ijc.25320
  • Kale VP, Hengst JA, Desai DH, et al. A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion. Cancer Lett. 2014;354(2):299–310. doi:10.1016/j.canlet.2014.08.032
  • Lane J, Martin TA, Watkins G, Mansel RE, Jiang WG. The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer. Int J Oncol. 2008;33(3):585–593. doi:10.1002/app.11859
  • Wong CCL, Wong CM, Tung EKK, Man K, Ng IOL. Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion. Hepatology. 2010;49(5):1583–1594. doi:10.1002/hep.22836
  • Huang D, Du X, Yuan R, Chen L, Liu T. Rock2 promotes the invasion and metastasis of hepatocellular carcinoma by modifying MMP2 ubiquitination and degradation. Biochem Biophys Res Commun. 2014;453(1):49–56. doi:10.1016/j.bbrc.2014.09.061
  • Li G, Liu T, Yu X, et al. Protective effect and regulation mechanism of Rock2 on ultraviolet-induced DNA damage in liver cancer cells. China Oncol. 2012;22(7):505–509. doi:10.3969/j.issn.1007-3969.2012.07.005
  • Du Y, Lu S, Ge J, Long D, Zhou W. ROCK2 disturbs MKP1 expression to promote invasion and metastasis in hepatocellular carcinoma. Am J Cancer Res. 2020;10(3):884–896.
  • Niu Y, Tang G. miR-185-5p targets ROCK2 and inhibits cell migration and invasion of hepatocellular carcinoma. Oncol Lett. 2019;17(6):5087–5093. doi:10.3892/ol.2019.10144
  • Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM. Genetic landscape and biomarkers of hepatocellular carcinoma. Gastroenterology. 2015;149:1226–1239. doi:10.1053/j.gastro.2015.05.061
  • Seasholtz TM, Wessel J, Rao F, et al. Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity. Hypertension. 2006;47(5):937–947. doi:10.1161/01.HYP.0000217364.45622.f0
  • Kalender ME, Demiryürek S, Oztuzcu S, et al. Association between the Thr431Asn polymorphism of the ROCK2 gene and risk of developing metastases of breast cancer. Oncol Res. 2010;18(11):583–591. doi:10.3727/096504010X12767359113767
  • Sari I, Berberoglu B, Ozkara E, Oztuzcu S, Demiryurek AT. Role of Rho-kinase gene polymorphisms and protein expressions in colorectal cancer development. Pathobiology. 2013;80(3):138–145. doi:10.1159/000341395
  • Açık DY, Yılmaz M, Sarı İ, Öztuzcu S, Sayıner ZA. Investigation of Rho-kinase expressions and polymorphisms in mantle cell lymphoma patients. Turk J Haematol. 2016;33(2):141–147. doi:10.4274/tjh.2015.0193