Advanced search
Publication Cover
International Journal of General Medicine Volume 15, 2022 - Issue
Submit an article Journal homepage
141
Views
2
CrossRef citations to date
0
Altmetric
Original Research

Independent and Interactive Effects of Sex and CYP2C9 Variant rs4918758 on Ischemic Stroke Risk in Taiwan Biobank

Jui-Wen Peng1 Institute of Medicine, Chung Shan Medical University, Taichung, 40201, TaiwanView further author information
,
Oswald Ndi Nfor2 Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, 40201, TaiwanView further author information
,
Chien-Chang Ho3 Department of Physical Education, Fu-Jen Catholic University, New Taipei City, 24205, Taiwan;4 Research and Development Center for Physical Education, Health, and Information Technology, Fu Jen Catholic University, New Taipei, 24205, TaiwanView further author information
,
Shu-Yi Hsu2 Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, 40201, TaiwanView further author information
,
Ming-Chih Chou1 Institute of Medicine, Chung Shan Medical University, Taichung, 40201, TaiwanCorrespondence[email protected]
View further author information
&
Yung-Po Liaw2 Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, 40201, Taiwan;5 Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City, 40201, TaiwanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2046-4964View further author information
ORCID Icon
Pages 3583-3589 | Published online: 01 Apr 2022

References

  • Mandalenakis Z, Rosengren A, Lappas G, Eriksson P, Hansson PO, Dellborg M. Ischemic stroke in children and young adults with congenital heart disease. J Am Heart Assoc. 2016;5(2):e003071. doi:10.1161/JAHA.115.003071
  • Hsieh FI, Lien LM, Chen ST, et al. Get with the guidelines-stroke performance indicators: surveillance of stroke care in the Taiwan stroke registry: get with the guidelines-stroke in Taiwan. Circulation. 2010;122:1116–1123. doi:10.1161/CIRCULATIONAHA.110.936526
  • Putaala J, Metso AJ, Metso TM, et al. Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: the Helsinki young stroke registry. Stroke. 2009;40(4):1195–1203. doi:10.1161/STROKEAHA.108.529883
  • Holliday EG, Maguire JM, Evans TJ, et al. Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nat Genet. 2012;44(10):1147–1151. doi:10.1038/ng.2397
  • Bellenguez C, Bevan S, Gschwendtner A, et al. Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet. 2012;44(3):328–333. doi:10.1038/ng.1081
  • Smith JG, Melander O, Lövkvist H, et al. Common genetic variants on chromosome 9p21 confers risk of ischemic stroke. Circ Cardiovasc Genet. 2009;2(2):159–164. doi:10.1161/CIRCGENETICS.108.835173
  • Polonikov A, Kharchenko A, Bykanova M, et al. Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population. Gene. 2017;627:451–459. doi:10.1016/j.gene.2017.07.004
  • Sreedharan S, Churilov L, Chan J, et al. Association between CYP2C9 polymorphisms and ischemic stroke following endovascular neurointervention. J Stroke Cerebrovasc Dis. 2020;29(8):104901. doi:10.1016/j.jstrokecerebrovasdis.2020.104901
  • Cullell N, Carrera C, Muiño E, et al. Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain. Sci Rep. 2020;10(1):2806. doi:10.1038/s41598-020-59641-9
  • Gu S, Sun Y, Han R, et al. Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese. BMC Med Genet. 2014;15(1):83. doi:10.1186/1471-2350-15-83
  • Park YA, Song YB, Yee J, Yoon H-Y, Gwak H-S. Influence of CYP2C9 genetic polymorphisms on the pharmacokinetics of losartan and its active metabolite E-3174: a systematic review and meta-analysis. J Pers Med. 2021;11(7):617. doi:10.3390/jpm11070617
  • Kaithoju S. Ischemic Stroke: risk Stratification, Warfarin Treatment and Outcome Measure. J Atr Fibrillation. 2015;8(4):1144. doi:10.4022/jafib.1144
  • Polonikov A, Sirotina S, Bykanova M, Bocharova A, Stepanov V, Solodilova M. AB026. Genetic variation in CYP2C8, CYP2C9 and CYP2C19 and the risk of coronary artery disease. Ann Transl Med. 2017;5:24. doi:10.21037/atm.2017.s026
  • Wang T-H, Hsiong C-H, Ho H-T, et al. Genetic polymorphisms of metabolic enzymes and the pharmacokinetics of indapamide in Taiwanese subjects. AAPS J. 2014;16(2):206–213. doi:10.1208/s12248-013-9535-x
  • Daly AK, Rettie AE, Fowler DM, Miners JO. Pharmacogenomics of CYP2C9: functional and clinical considerations. J Pers Med. 2018;8(1):1. doi:10.3390/jpm8010001
  • Hauer AJ, Ruigrok YM, Algra A, et al. Age‐Specific vascular risk factor profiles according to stroke subtype. J Am Heart Assoc. 2017;6(5):e005090. doi:10.1161/JAHA.116.005090
  • Raynaud FI. Chapter 9 - drug development. In: Adamski J, editor. Metabolomics for Biomedical Research. Academic Press; 2020:159–199.
  • Hald EM, Rinde LB, Løchen ML, et al. Atrial fibrillation and cause‐specific risks of pulmonary embolism and ischemic stroke. J Am Heart Assoc. 2018;7(3):e006502. doi:10.1161/JAHA.117.006502
  • Olesen KK, Madsen M, Gyldenkerne C, et al. Diabetes mellitus is associated with increased risk of ischemic stroke in patients with and without coronary artery disease. Stroke. 2019;50(12):3347–3354. doi:10.1161/STROKEAHA.119.026099
  • Kivioja R, Pietilä A, Martinez‐Majander N, et al. Risk factors for early‐onset ischemic stroke: a case‐control study. J Am Heart Assoc. 2018;7(21):e009774. doi:10.1161/JAHA.118.009774
  • Paul SL, Thrift AG, Donnan GA. Smoking as a crucial independent determinant of stroke. Tob Induc Dis. 2004;2(2):67. doi:10.1186/1617-9625-2-2-67
  • Hawkins BT, Brown RC, Davis TP. Smoking and ischemic stroke: a role for nicotine? Trends Pharmacol Sci. 2002;23(2):78–82. doi:10.1016/S0165-6147(02)01893-X
  • Pan B, Jin X, Jun L, Qiu S, Zheng Q, Pan M. The relationship between smoking and stroke: a meta-analysis. Medicine. 2019;98(12):e14872. doi:10.1097/MD.0000000000014872
  • Tung JM, Mamdani MM, Juurlink DN, Paterson JM, Kapral MK, Gomes T. Rates of ischemic stroke during warfarin treatment for atrial fibrillation. Stroke. 2015;46(4):1120–1122. doi:10.1161/STROKEAHA.114.007852

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.