Tumor DNA Methylation Profiles Enable Diagnosis, Prognosis Prediction, and Screening for Cervical Cancer

References

• Cancer Genome Atlas Research N, Albert Einstein College of M, Analytical Biological S, Barretos Cancer H, Baylor College of M, Beckman Research Institute of City of H, Buck Institute for Research on A, Canada’s Michael Smith Genome Sciences C, Harvard Medical S, Helen FGCC. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543(7645):378–384. doi:10.1038/nature21386
   PubMed Web of Science ®Google Scholar
• Arbyn M, Weiderpass E, Bruni L, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 2020;8(2):e191–e203. doi:10.1016/S2214-109X(19)30482-6
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7–30. doi:10.3322/caac.21590
   PubMed Web of Science ®Google Scholar
• Kagabu M, Nagasawa T, Fukagawa D, et al. Immunotherapy for uterine cervical cancer. Healthcare. 2019;7:108.
   Web of Science ®Google Scholar
• Marret G, Borcoman E, Le Tourneau C. Pembrolizumab for the treatment of cervical cancer. Expert Opin Biol Ther. 2019;19(9):871–877. doi:10.1080/14712598.2019.1646721
   PubMed Web of Science ®Google Scholar
• Pimple SA, Mishra GA. Global strategies for cervical cancer prevention and screening. Minerva Ginecol. 2019;71(4):313–320. doi:10.23736/S0026-4784.19.04397-1
   PubMed Web of Science ®Google Scholar
• Ronco G, Dillner J, Elfstrom KM, et al. Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials. Lancet. 2014;383(9916):524–532. doi:10.1016/S0140-6736(13)62218-7
   PubMed Web of Science ®Google Scholar
• d’Errico M, Alwers E, Zhang Y, Edelmann D, Brenner H, Hoffmeister M. Identification of prognostic DNA methylation biomarkers in patients with gastrointestinal adenocarcinomas: a systematic review of epigenome-wide studies. Cancer Treat Rev. 2020;82:101933. doi:10.1016/j.ctrv.2019.101933
   PubMed Web of Science ®Google Scholar
• Li C, Ke J, Liu J, Su J. DNA methylation data-based molecular subtype classification related to the prognosis of patients with cervical cancer. J Cell Biochem. 2020;121(3):2713–2724. doi:10.1002/jcb.29491
   PubMed Web of Science ®Google Scholar
• Wong CC, Li W, Chan B, Yu J. Epigenomic biomarkers for prognostication and diagnosis of gastrointestinal cancers. Semin Cancer Biol. 2019;55:90–105. doi:10.1016/j.semcancer.2018.04.002
   PubMed Web of Science ®Google Scholar
• Bhat S, Kabekkodu SP, Noronha A, Satyamoorthy K. Biological implications and therapeutic significance of DNA methylation regulated genes in cervical cancer. Biochimie. 2016;121:298–311. doi:10.1016/j.biochi.2015.12.018
   PubMed Web of Science ®Google Scholar
• Urbano A, Smith J, Weeks RJ, Chatterjee A. Gene-specific targeting of DNA methylation in the mammalian genome. Cancers. 2019;11(10):1515. doi:10.3390/cancers11101515
   PubMed Web of Science ®Google Scholar
• Smith ZD, Meissner A. DNA methylation: roles in mammalian development. Nat Rev Genet. 2013;14(3):204–220. doi:10.1038/nrg3354
   PubMed Web of Science ®Google Scholar
• Koch A, Joosten SC, Feng Z, et al. Analysis of DNA methylation in cancer: location revisited. Nat Rev Clin Oncol. 2018;15(7):459–466. doi:10.1038/s41571-018-0004-4
   PubMed Web of Science ®Google Scholar
• Luo H, Zhao Q, Wei W, et al. Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer. Sci Transl Med. 2020;12(524). doi:10.1126/scitranslmed.aax7533.
   Web of Science ®Google Scholar
• Lu Q, Ma D, Zhao S. DNA methylation changes in cervical cancers. Methods Mol Biol. 2012;863:155–176.
   PubMedGoogle Scholar
• Xu RH, Wei W, Krawczyk M, et al. Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma. Nat Mater. 2017;16(11):1155–1161. doi:10.1038/nmat4997
   PubMed Web of Science ®Google Scholar
• Schoonjans F, Zalata A, Depuydt CE, Comhaire FH. MedCalc: a new computer program for medical statistics. Comput Methods Programs Biomed. 1995;48(3):257–262. doi:10.1016/0169-2607(95)01703-8
   PubMed Web of Science ®Google Scholar
• Lu J, Song E, Ghoneim A, Alrashoud M. Machine learning for assisting cervical cancer diagnosis: an ensemble approach. Future Gener Comput Syst. 2020;106:199–205. doi:10.1016/j.future.2019.12.033
   Web of Science ®Google Scholar
• van Leeuwen RW, Ostrbenk A, Poljak M, van der Zee AGJ, Schuuring E, Wisman GBA. DNA methylation markers as a triage test for identification of cervical lesions in a high risk human papillomavirus positive screening cohort. Int J Cancer. 2019;144(4):746–754. doi:10.1002/ijc.31897
   PubMed Web of Science ®Google Scholar
• Liu B, Ricarte-Filho J, Mallisetty A, et al. Detection of promoter DNA methylation in urine and plasma aids the detection of non-small cell lung cancer. Clin Cancer Res. 2020;26(16):4339–4348.
   PubMed Web of Science ®Google Scholar
• Liu X, Wen J, Li C, Wang H, Wang J, Zou H. High-Yield methylation markers for stool-based detection of colorectal cancer. Dig Dis Sci. 2020;65(6):1710–1719. doi:10.1007/s10620-019-05908-9
   PubMed Web of Science ®Google Scholar
• Rosenquist R, Esteller M, Plass C. Introduction: epigenetics in cancer. Semin Cancer Biol. 2018;51:iv–v. doi:10.1016/j.semcancer.2018.07.002
   PubMed Web of Science ®Google Scholar
• Roy D, Tiirikainen M. Diagnostic power of DNA methylation classifiers for early detection of cancer. Trends Cancer. 2020;6(2):78–81. doi:10.1016/j.trecan.2019.12.006
   PubMed Web of Science ®Google Scholar
• Lorincz AT. Cancer diagnostic classifiers based on quantitative DNA methylation. Expert Rev Mol Diagn. 2014;14(3):293–305. doi:10.1586/14737159.2014.897610
   PubMed Web of Science ®Google Scholar
• Farkas SA, Milutin-Gasperov N, Grce M, Nilsson TK. Genome-wide DNA methylation assay reveals novel candidate biomarker genes in cervical cancer. Epigenetics. 2013;8(11):1213–1225. doi:10.4161/epi.26346
   PubMed Web of Science ®Google Scholar
• Vrba L, Futscher BW. A suite of DNA methylation markers that can detect most common human cancers. Epigenetics. 2018;13(1):61–72. doi:10.1080/15592294.2017.1412907
   PubMed Web of Science ®Google Scholar
• von Knebel Doeberitz M, Meijer CJLM, Lorincz A, Doorbar J, Leeman A: Infection to Cancer—Finding useful biomarkers for predicting risk of progression to cancer. 2020:269–282.
   Google Scholar
• Eijsink JJ, Lendvai A, Deregowski V, et al. A four-gene methylation marker panel as triage test in high-risk human papillomavirus positive patients. Int J Cancer. 2012;130(8):1861–1869. doi:10.1002/ijc.26326
   PubMed Web of Science ®Google Scholar
• Hao X, Luo H, Krawczyk M, et al. DNA methylation markers for diagnosis and prognosis of common cancers. Proc Natl Acad Sci U S A. 2017;114(28):7414–7419. doi:10.1073/pnas.1703577114
   PubMed Web of Science ®Google Scholar
• Jiang H, Ou Z, He Y, et al. DNA methylation markers in the diagnosis and prognosis of common leukemias. Signal Transduct Target Ther. 2020;5(1). doi:10.1038/s41392-019-0090-5.
   Web of Science ®Google Scholar
• Ying J, Xu T, Wang Q, Ye J, Lyu J. Exploration of DNA methylation markers for diagnosis and prognosis of patients with endometrial cancer. Epigenetics. 2018;13(5):490–504. doi:10.1080/15592294.2018.1474071
   PubMed Web of Science ®Google Scholar
• Fiano V, Trevisan M, Fasanelli F, et al. Methylation in host and viral genes as marker of aggressiveness in cervical lesions: analysis in 543 unscreened women. Gynecol Oncol. 2018;151(2):319–326. doi:10.1016/j.ygyno.2018.08.031
   PubMed Web of Science ®Google Scholar
• Yang HJ. Aberrant DNA methylation in cervical carcinogenesis. Chin J Cancer. 2013;32(1):42–48. doi:10.5732/cjc.012.10033
   PubMedGoogle Scholar
• Li F, Wang T, Tang S. SOX14 promotes proliferation and invasion of cervical cancer cells through Wnt/beta-catenin pathway. Int J Clin Exp Pathol. 2015;8(2):1698–1704.
   PubMed Web of Science ®Google Scholar
• Stanisavljevic D, Petrovic I, Vukovic V, et al. SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. PLoS One. 2017;12(9):e0184686. doi:10.1371/journal.pone.0184686
   PubMed Web of Science ®Google Scholar
• Wang R, van Leeuwen RW, Boers A, et al. Genome-wide methylome analysis using MethylCap-seq uncovers 4 hypermethylated markers with high sensitivity for both adeno- and squamous-cell cervical carcinoma. Oncotarget. 2016;7(49):80735–80750. doi:10.18632/oncotarget.12598
   PubMedGoogle Scholar
• Mousavi Ardehaie R, Hashemzadeh S, Behrouz Sharif S, Ghojazadeh M, Teimoori-Toolabi L, Sakhinia E. Aberrant methylated EDNRB can act as a potential diagnostic biomarker in sporadic colorectal cancer while KISS1 is controversial. Bioengineered. 2017;8(5):555–564. doi:10.1080/21655979.2017.1283458
   PubMed Web of Science ®Google Scholar
• Yuan Y, Du Y, Wang L, Liu X. The value of endothelin receptor type B promoter methylation as a biomarker for the risk assessment and diagnosis of prostate cancer: a meta-analysis. Pathol Res Pract. 2020;216(2):152796. doi:10.1016/j.prp.2019.152796
   PubMed Web of Science ®Google Scholar
• Chen C, Wang L, Liao Q, et al. Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer. Diagn Pathol. 2013;8(1):199. doi:10.1186/1746-1596-8-199
   PubMed Web of Science ®Google Scholar
• Tao K, Wu C, Wu K, et al. Quantitative analysis of promoter methylation of the EDNRB gene in gastric cancer. Med Oncol. 2012;29(1):107–112. doi:10.1007/s12032-010-9805-8
   PubMed Web of Science ®Google Scholar
• Schussel J, Zhou XC, Zhang Z, et al. EDNRB and DCC salivary rinse hypermethylation has a similar performance as expert clinical examination in discrimination of oral cancer/dysplasia versus benign lesions. Clin Cancer Res. 2013;19:3268–3275. doi:10.1158/1078-0432.CCR-12-3496
   PubMed Web of Science ®Google Scholar
• Liang Y, He L, Yuan H, Jin Y, Yao Y. Association between RUNX3 promoter methylation and non-small cell lung cancer: a meta-analysis. J Thorac Dis. 2014;6(6):694–705. doi:10.3978/j.issn.2072-1439.2014.04.09
   PubMed Web of Science ®Google Scholar
• Steponaitis G, Kazlauskas A, Vaitkiene P, Deltuva VP, Mikuciunas M, Skiriute D. Oncosuppressive Role of RUNX3 in Human Astrocytomas. J Oncol. 2019;2019:1232434. doi:10.1155/2019/1232434
   PubMed Web of Science ®Google Scholar
• Hideura E, Suehiro Y, Nishikawa J, et al. Blood free-circulating DNA testing of methylated RUNX3 is useful for diagnosing early gastric cancer. Cancers. 2020;12(4):789. doi:10.3390/cancers12040789
   PubMed Web of Science ®Google Scholar
• Xu L, He J, Cai Q, Li M, Pu X, Guo Y. An effective seven-CpG-based signature to predict survival in renal clear cell carcinoma by integrating DNA methylation and gene expression. Life Sci. 2020;243:117289. doi:10.1016/j.lfs.2020.117289
   PubMed Web of Science ®Google Scholar
• Peng Y, Wu Q, Wang L, Wang H, Yin F. A DNA methylation signature to improve survival prediction of gastric cancer. Clin Epigenetics. 2020;12(1):15. doi:10.1186/s13148-020-0807-x
   PubMed Web of Science ®Google Scholar
• Yang J, Tian G, Pan Z, et al. Nomograms for predicting the survival rate for cervical cancer patients who undergo radiation therapy: a SEER analysis. Future Oncol. 2019;15:3033–3045.
   PubMed Web of Science ®Google Scholar
• Polterauer S, Grimm C, Hofstetter G, et al. Nomogram prediction for overall survival of patients diagnosed with cervical cancer. Br J Cancer. 2012;107(6):918–924. doi:10.1038/bjc.2012.340
   PubMed Web of Science ®Google Scholar