In-Hospital Emergency Treatment Delay Among Chinese Patients with Acute Ischaemic Stroke: Relation to Hospital Arrivals and Implications for Triage Pathways

References

• Disease GBD, Injury I, Prevalence C. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet. 2018;392(10159):1789–1858.
   PubMed Web of Science ®Google Scholar
• Benjamin EJ, Virani SS, Callaway CW, et al. Heart disease and stroke statistics-2018 update: a report from the American heart association. Circulation. 2018;137(12):e67–e492.
   PubMed Web of Science ®Google Scholar
• Lloyd-Jones D, Adams R, Carnethon M, et al. Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119(3):480–486.
   PubMed Web of Science ®Google Scholar
• Roth GA, Mensah GA, Johnson CO, et al.; GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group. Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study. J Am Coll Cardiol. 2020;76(25):2982–3021.
   PubMed Web of Science ®Google Scholar
• Ovbiagele B, Goldstein LB, Higashida RT, et al. Forecasting the future of stroke in the United States: a policy statement from the American Heart Association and American Stroke Association. Stroke. 2013;44(8):2361–2375.
   PubMed Web of Science ®Google Scholar
• Ding Q, Liu S, Yao Y, Liu H, Cai T, Han L. Global, regional, and national burden of ischemic stroke, 1990–2019. Neurology. 2022;98(3):e279–e290.
   PubMed Web of Science ®Google Scholar
• Iso H. Cardiovascular disease, a major global burden: epidemiology of stroke and ischemic heart disease in Japan. Glob Health Med. 2021;3(6):358–364.
   PubMedGoogle Scholar
• Long FQCY, Su QJ. Visiting time of acute ischemic stroke patients and its influencing factors [In Chinese]. J Kunming Med Univ. 2013;34(4):94–97.
   Google Scholar
• Chinese Stroke Association. Guidelines and Consensus on Diagnosis and Treatment of Cerebrovascular Diseases in China (2016 Edition). Beijing, China: People’s Medical Publishing House; 2016.
   Google Scholar
• European Stroke Organisation Executive C, Committee ESOW. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis. 2008;25(5):457–507.
   PubMed Web of Science ®Google Scholar
• Willeit J, Geley T, Schoch J, et al. Thrombolysis and clinical outcome in patients with stroke after implementation of the Tyrol Stroke Pathway: a retrospective observational study. Lancet Neurol. 2015;14(1):48–56.
   PubMed Web of Science ®Google Scholar
• Evenson KR, Foraker RE, Morris DL, Rosamond WD. A comprehensive review of prehospital and in-hospital delay times in acute stroke care. Int J Stroke. 2009;4(3):187–199.
   PubMed Web of Science ®Google Scholar
• Jiang B, Wang WZ, Chen H, et al. Incidence and trends of stroke and its subtypes in China: results from three large cities. Stroke. 2006;37(1):63–68.
   PubMed Web of Science ®Google Scholar
• Yang H. Study on Stroke in-Hospital Emergency Treatment Based on the “Time Window” [In Chinese]. Huazhong University of Science & Technology; 2015.
   Google Scholar
• Marler JR, Jones PW, Emr M Setting new directions for stroke care. Proceedings of a National Symposium onRapid Identification and Treatment of Acute Stroke; 1997.
   Google Scholar
• Kwan J, Hand P, Sandercock P. A systematic review of barriers to delivery of thrombolysis for acute stroke. Age Ageing. 2004;33(2):116–121.
   PubMed Web of Science ®Google Scholar
• Evenson KR, Rosamond WD, Morris DL. Prehospital and in-hospital delays in acute stroke care. Neuroepidemiology. 2001;20(2):65–76.
   PubMed Web of Science ®Google Scholar
• Baskar PS, Chowdhury SZ, Bhaskar SMM. In-hospital systems interventions in acute stroke reperfusion therapy: a meta-analysis. Acta Neurol Scand. 2021;144(4):418–432.
   PubMed Web of Science ®Google Scholar
• Chowdhury SZ, Baskar PS, Bhaskar S. Effect of prehospital workflow optimization on treatment delays and clinical outcomes in acute ischemic stroke: a systematic review and meta-analysis. Acad Emerg Med. 2021;28(7):781–801.
   PubMed Web of Science ®Google Scholar
• Soto-Cámara R, González-Santos J, González-Berna J, Trejo-Gabriel-Galán JM. Factors associated with a rapid call for assistance for patients with ischemic stroke. Emergencias. 2020;32(1):33–39.
   PubMed Web of Science ®Google Scholar
• Soto-Cámara R, González-Santos J, González-Bernal J, Martín-Santidrian A, Cubo E, Trejo-Gabriel-Galán JM. Factors associated with shortening of prehospital delay among patients with acute ischemic stroke. J Clin Med. 2019;8(10):1712.
   PubMed Web of Science ®Google Scholar
• Hacke W, Donnan G, Fieschi C, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet. 2004;363(9411):768–774.
   PubMed Web of Science ®Google Scholar
• Zhang J, Wang XH, Yang HJ, et al. Social determinants of pre-hospital delays after onset of stroke [In Chinese]. Chin J Health Manag. 2014;8(1):40–43.
   Google Scholar
• Santana Baskar P, Cordato D, Wardman D, Bhaskar S. In-hospital acute stroke workflow in acute stroke - Systems-based approaches. Acta Neurol Scand. 2021;143(2):111–120.
   PubMed Web of Science ®Google Scholar
• Soto-Cámara R, Trejo-Gabriel-Galán JM, González-Bernal J, González-Santos J, Cubo E. Factors associated with the activation of emergency medical services in patients with acute stroke: a prospective study. Emergencias. 2019;31(2):86–90.
   PubMed Web of Science ®Google Scholar
• Powers WJ, Rabinstein AA, Ackerson T, et al. 2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2018;49(3):e46–e110.
   PubMed Web of Science ®Google Scholar
• Hu YT, Yang N, Wei XE, et al. Clinic value of reducing in-hospital delay in patients with acute ischemic stroke after intravenous thrombolysis [In Chinese]. Stroke Nerv Dis. 2014;5:280–282.
   Google Scholar
• Kleindorfer DO, Lindsell CJ, Broderick JP, et al. Community socioeconomic status and prehospital times in acute stroke and transient ischemic attack: do poorer patients have longer delays from 911 call to the emergency department? Stroke. 2006;37(6):1508–1513.
   PubMed Web of Science ®Google Scholar
• Lacy CR, Suh DC, Bueno M, Kostis JB. Delay in presentation and evaluation for acute stroke: stroke time registry for outcomes knowledge and epidemiology (S.T.R.O.K.E.). Stroke. 2001;32(1):63–69.
   PubMed Web of Science ®Google Scholar
• Mikulik R, Kadlecova P, Czlonkowska A, et al. Factors influencing in-hospital delay in treatment with intravenous thrombolysis. Stroke. 2012;43(6):1578–1583.
   PubMed Web of Science ®Google Scholar
• Wang XL. Yantai City Hospital of Traditional Chinese Medicine Diagnosis and Treatment of Acute Ischemic Stroke Delay Related Factors Analysis [In Chinese]. DaLian Medical University; 2013.
   Google Scholar
• Wang ZH, Xie LQ, Zhao CM, Liu Q. Pre-hospital and in-hospital delay after acute ischemic stroke among 231 patients [In Chinese]. Chin Gen Pract. 2012;15(8B):2605–2608.
   Google Scholar
• Li JH, Chen L, Chen Z. Analysis of the factors affecting the onset-to-door time of acute ischemic stroke in a primary hospital [In Chinese]. Chin J Neuroimmunol Neurol. 2014;21(5):364–367.
   Google Scholar
• Li K, Gong T, Liu F, Sheng AZ, Chen HB. Intravenous thrombolysis for acute ischemic stroke: analysis of 22 cases [In Chinese]. Chin J Gen Pract. 2012;11(8):607–609.
   Google Scholar
• Abraham SV, Krishnan SV, Thaha F, Balakrishnan JM, Thomas T, Palatty BU. Factors delaying management of acute stroke: an Indian scenario. Int J Crit Illn Inj Sci. 2017;7(4):224–230.
   PubMedGoogle Scholar
• Harrison M, Ryan T, Gardiner C, Jones A. Patients’ and carers’ experiences of gaining access to acute stroke care: a qualitative study. Emerg Med J. 2013;30(12):1033–1037.
   PubMed Web of Science ®Google Scholar
• Shokri HM, El Nahas NM, Aref HM, et al. Factors related to time of stroke onset versus time of hospital arrival: a SITS registry-based study in an Egyptian stroke center. PLoS One. 2020;15(9):e0238305.
   PubMed Web of Science ®Google Scholar
• Sekoranja L, Griesser AC, Wagner G, et al. Factors influencing emergency delays in acute stroke management. Swiss Med Wkly. 2009;139(27–28):393–399.
   PubMed Web of Science ®Google Scholar
• Jin HQ, Zhu SN, Hao HJ, Sun YA, Huang YN. An analysis of stroke subtypes and influencing factors in different regions of China [In Chinese]. Zhonghua Nei Ke Za Zhi. 2012;51(3):201–205.
   PubMedGoogle Scholar
• Mosley I, Nicol M, Donnan G, Patrick I, Kerr F, Dewey H. The impact of ambulance practice on acute stroke care. Stroke. 2007;38(10):2765–2770.
   PubMed Web of Science ®Google Scholar
• Kwan J, Hand P, Sandercock P. Improving the efficiency of delivery of thrombolysis for acute stroke: a systematic review. QJM. 2004;97(5):273–279.
   PubMed Web of Science ®Google Scholar
• Sobesky J, Frackowiak M, Zaro Weber O, et al. The Cologne stroke experience: safety and outcome in 450 patients treated with intravenous thrombolysis. Cerebrovasc Dis. 2007;24(1):56–65.
   PubMed Web of Science ®Google Scholar
• Lachkhem Y, Rican S, Minvielle E. Understanding delays in acute stroke care: a systematic review of reviews. Eur J Public Health. 2018;28(3):426–433.
   PubMed Web of Science ®Google Scholar
• Liu L, Kong FJ. Factors affecting the time window of thrombolytic therapy in acute ischemic stroke and intervention measures [In Chinese]. J Neurosci Ment Health. 2007;7(1):52–54.
   Google Scholar
• Feng LY, Gui XX, Wang CS. Analysis of influential factors of delayed diagnosis of acute cerebral infarction [In Chinese]. Chin J Gen Pract. 2004;3(1):64.
   Google Scholar
• Huang CX, Zhao SH. The effect of process management on quality control of community nursing in stroke patients [In Chinese]. Chin Gen Pract. 2011;14(35):4028–4031.
   Google Scholar
• Yang HJ, Huang X, Yang CY, et al. Time window for acute stroke management: a cross-sectional study among community healthcare practitioners in primary care. Int J Gen Med. 2022;15:4483–4493.
   PubMed Web of Science ®Google Scholar
• Bhaskar S, Thomas P, Cheng Q, et al. Trends in acute stroke presentations to an emergency department: implications for specific communities in accessing acute stroke care services. Postgrad Med J. 2019;95(1123):258–264.
   PubMed Web of Science ®Google Scholar
• Nepal G, Yadav JK, Basnet B, Shrestha TM, Kharel G, Ojha R. Status of prehospital delay and intravenous thrombolysis in the management of acute ischemic stroke in Nepal. BMC Neurol. 2019;19(1):155.
   PubMedGoogle Scholar
• Bhaskar S, Stanwell P, Bivard A, et al. The influence of initial stroke severity on mortality, overall functional outcome and in-hospital placement at 90 days following acute ischemic stroke: a tertiary hospital stroke register study. Neurol India. 2017;65(6):1252–1259.
   PubMed Web of Science ®Google Scholar
• Acker JE 3rd, Pancioli AM, Crocco TJ, et al. Implementation strategies for emergency medical services within stroke systems of care: a policy statement from the American Heart Association/American Stroke Association expert panel on emergency medical services systems and the stroke council. Stroke. 2007;38(11):3097–3115.
   PubMed Web of Science ®Google Scholar
• Yang H, Zhang J, Xie J, et al. Factors influencing pre-hospital delay among acute ischemic stroke patients in the midlands of China. Int J Cardiol. 2014;172(2):533–534.
   PubMed Web of Science ®Google Scholar
• Zakaria MF, Aref H, Abd ElNasser A, et al. Egyptian experience in increasing utilization of reperfusion therapies in acute ischemic stroke. Int J Stroke. 2018;13(5):525–529.
   PubMed Web of Science ®Google Scholar
• Wang HHX, Li YT, Wong MCS. Leveraging the power of health communication: messaging matters not only in clinical practice but also in public health. Hong Kong Med J. 2022;28(2):103–105.
   PubMed Web of Science ®Google Scholar
• El Nahas NM, Shokri HM, Roushdy TM, et al. Door to needle count down: a 3-years experience in an Egyptian University Stroke Center. Neurologist. 2021;27(2):61–64.
   PubMed Web of Science ®Google Scholar
• Aref HM, Shokri H, Roushdy TM, Fathalla F, El Nahas NM. Pre-hospital causes for delayed arrival in acute ischemic stroke before and during the COVID-19 pandemic: a study at two stroke centers in Egypt. PLoS One. 2021;16(7):e0254228.
   PubMed Web of Science ®Google Scholar