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ORIGINAL RESEARCH

The Symptoms of Benign Prostatic Hyperplasia Patients with Stromal-Dominated Hyperplasia Nodules May Be Associated with Prostate Fibrosis

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Pages 1181-1191 | Received 30 Nov 2022, Accepted 03 Mar 2023, Published online: 01 Apr 2023

References

  • Marberger M. Medical management of lower urinary tract symptoms in men with benign prostatic enlargement. Adv Ther. 2013;30:309–319. doi:10.1007/s12325-013-0022-7
  • McConnell JD, Roehrborn CG, Bautista OM, et al. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med. 2003;349:2387–2398. doi:10.1056/NEJMoa030656
  • Rodriguez-Nieves JA, Macoska JA. Prostatic fibrosis, lower urinary tract symptoms, and BPH. Nat Rev Urol. 2013;10:546–550. doi:10.1038/nrurol.2013.149
  • Sciarra A, Voria G, Mariotti G, et al. Histopathological aspects associated with the diagnosis of benign prostatic hyperplasia: clinical implications. Urol Int. 2002;69:253–262. doi:10.1159/000066128
  • Roehrborn CG. Pathology of benign prostatic hyperplasia. Int J Impot Res. 2008;20(Suppl 3):S11–8. doi:10.1038/ijir.2008.55
  • Deering RE, Bigler SA, King J, et al. Morphometric quantitation of stroma in human benign prostatic hyperplasia. Urology. 1994;44:64–70. doi:10.1016/s0090-4295(94)80011-1
  • Foster CS. Pathology of benign prostatic hyperplasia. Prostate Suppl. 2000;9:4–14.
  • Shapiro E, Becich MJ, Hartanto V, et al. The relative proportion of stromal and epithelial hyperplasia is related to the development of symptomatic benign prostate hyperplasia. J Urol. 1992;147:1293–1297. doi:10.1016/s0022-5347(17)37546-8
  • Schuster GA, Schuster TG. The relative amount of epithelium, muscle, connective tissue and lumen in prostatic hyperplasia as a function of the mass of tissue resected. J Urol. 1999;161:1168–1173. doi:10.1016/S0022-5347(01)61620-3
  • Chagas MA, Babinski MA, Costa WS, et al. Stromal and acinar components of the transition zone in normal and hyperplastic human prostate. BJU Int. 2002;89:699–702. doi:10.1046/j.1464-410x.2002.02724.x
  • Lepor H, Shapiro E. This month in investigative urology: alpha adrenergic innervation of the prostate: insights into pharmacotherapy of BPH. J Urol. 1990;143:590–591. doi:10.1016/s0022-5347(17)40035-8
  • Jinjin M, Gharaee-Kermani M, Kunju L, et al. Prostatic fibrosis is associated with lower urinary tract symptoms. J Urol. 2012;188:1375–1381. doi:10.1016/j.juro.2012.06.007
  • Bauman TM, Nicholson TM, Abler LL, et al. Characterization of fibrillar collagens and extracellular matrix of glandular benign prostatic hyperplasia nodules. PLoS One. 2014;9:e109102. doi:10.1371/journal.pone.0109102
  • Robert M, Costa P, Bressolle F, et al. Percentage area density of epithelial and mesenchymal components in benign prostatic hyperplasia: comparison of results between single biopsy, multiple biopsies and multiple tissue specimens. Br J Urol. 1995;75:317–324. doi:10.1111/j.1464-410x.1995.tb07342.x
  • Shapiro E, Hartanto V, Lepor H. Quantifying the smooth muscle content of the prostate using double-immunoenzymatic staining and color assisted image analysis. J Urol. 1992;147:1167–1170. doi:10.1016/s0022-5347(17)37508-0
  • Cantiello F, Cicione A, Salonia A, et al. Periurethral fibrosis secondary to prostatic inflammation causing lower urinary tract symptoms: a prospective cohort study. Urology. 2013;81:1018–1023. doi:10.1016/j.urology.2013.01.053
  • Gelse K, Pöschl E, Aigner T. Collagens: structure, function, and biosynthesis. Adv Drug Deliv Rev. 2003;55:1531–1546. doi:10.1016/j.addr.2003.08.002
  • Péterszegi G, Andrès E, Molinari J, et al. Effect of cellular aging on collagen biosynthesis: i. Methodological considerations and pharmacological applications. Arch Gerontol Geriatr. 2008;47:356–367. doi:10.1016/j.archger.2007.08.019
  • Diaz Encarnacion MM, Griffin MD, Slezak JM, et al. Correlation of quantitative digital image analysis with the glomerular filtration rate in chronic allograft nephropathy. Am J Transplant. 2004;4:248–256. doi:10.1046/j.1600-6143.2003.00311.x
  • Wynn TA. Thomas A Wynn.Integrating mechanisms of pulmonary fibrosis. J Exp Med. 2011;208:1339–1350. doi:10.1084/jem.20110551
  • Grewal P, Martin P. Care of the cirrhotic patient. Clin Liver Dis. 2009;13:331–340. doi:10.1016/j.idc.2012.08.009
  • Kramer G, Mitteregger D, Marberger M. Is benign prostatic hyperplasia (BPH) an immune inflammatory disease? Eur Urol. 2007;51:1202–1216. doi:10.1016/j.eururo.2006.12.011
  • Fibbi B, Penna G, Morelli A, et al. Chronic inflammation in the pathogenesis of benign prostatic hyperplasia. Int J Androl. 2010;33:475–488. doi:10.1111/j.1365-2605.2009.00972.x
  • Penna G, Fibbi B, Amuchastegui S, et al. Human benign prostatic hyperplasia stromal cells as inducers and targets of chronic immuno-mediated inflammation. J Immunol. 2009;182:4056–4064. doi:10.4049/jimmunol.0801875
  • McDowell KL, Begley LA, Mor-Vaknin N, et al. Leukocytic promotion of prostate cellular proliferation. Prostate. 2010;70:377–389. doi:10.1002/pros.21071
  • Gharaee-Kermani M, Kasina S, Moore BB, et al. CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis. PLoS One. 2012;7:e49278. doi:10.1371/journal.pone.0049278
  • Mingfang A, Franco OE, Park D, et al. Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res. 2007;67:4244–4253. doi:10.1158/0008-5472.CAN-06-3946
  • Frangogiannis N. Transforming growth factor-β in tissue fibrosis. J Exp Med. 2020;217:e20190103. doi:10.1084/jem.20190103
  • Bierhoff E, Vogel J, Benz M, et al. Stromal Nodules in Benign Prostatic Hyperplasia. Eur Urol. 1996;29:345–354. doi:10.1159/000473774
  • Verrecchia F, Mauviel A. Transforming growth factor-beta and fibrosis. World J Gastroenterol. 2007;13:3056–3062. doi:10.3748/wjg.v13.i22.3056