Investigation of Diagnostic and Prognostic Value of CLEC4M of Non-Small Cell Lung Carcinoma Associated with Immune Microenvironment

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:182.
   PubMed Web of Science ®Google Scholar
• Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350(21):2129–2139. doi:10.1056/NEJMoa040938
   PubMed Web of Science ®Google Scholar
• Allegretti M, Fabi A, Buglioni S, et al. Tearing down the walls: FDA approves next generation sequencing (NGS) assays for actionable cancer genomic aberrations. J Exp Clin Cancer Res. 2018;37. doi:10.1186/s13046-018-0702-x
   Web of Science ®Google Scholar
• Zhou N, Sepesi B, Leung CH, et al. Impact of genomic aberrations and additional therapies on survival outcomes of patients with operable non-small cell lung cancer (NSCLC) from the NEOSTAR study. J Clin Oncol. 2021;39:8542. doi:10.1200/JCO.2021.39.15_suppl.8542
   Google Scholar
• Postow MA, Sidlow R, Hellmann MD. Immune‐related adverse events associated with immune checkpoint blockade. N Engl J Med. 2018;378:158–168. doi:10.1056/NEJMra1703481
   PubMed Web of Science ®Google Scholar
• Kubli SP, Berger T, Araujo DV, Siu LL, Mak TW. Beyond immune checkpoint blockade: emerging immunological strategies. Nat Rev Drug Discov. 2021;20:899–919. doi:10.1038/s41573-021-00155-y
   PubMed Web of Science ®Google Scholar
• Morad G, Helmink BA, Sharma P, Wargo JA. Hallmarks of response, resistance, and toxicity to immune checkpoint blockade. Cell. 2021;184:5309–5337. doi:10.1016/j.cell.2021.09.020
   PubMed Web of Science ®Google Scholar
• Rizvi NA, Hellmann MD, Snyder A, et al. Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer. Science. 2015;348:124–128. doi:10.1126/science.aaa1348
   PubMed Web of Science ®Google Scholar
• Kim AR, Choi KS, Kim M-S, et al. Absolute quantification of tumor-infiltrating immune cells in high-grade glioma identifies prognostic and radiomics values. Cancer Immunol Immunother. 2021;70:1995–2008. doi:10.1007/s00262-020-02836-w
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang Z. The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Cell Mol Immunol. 2020;17:807–821. doi:10.1038/s41423-020-0488-6
   PubMed Web of Science ®Google Scholar
• Ivetic A, Hoskins Green HL, Hart SJ. L-selectin: a major regulator of leukocyte adhesion, migration and signaling. Front Immunol. 2019;10. doi:10.3389/fimmu.2019.01068
   Web of Science ®Google Scholar
• Pine SR, Mechanic LE, Ambs S, et al. Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene. J Natl Cancer Inst. 2007;99(18):1401–1409. doi:10.1093/jnci/djm128
   PubMedGoogle Scholar
• Zhang Y, Feng Z, Xu Y, et al. Novel roles of LSECtin in gastric cancer cell adhesion, migration, invasion, and lymphatic metastasis. Cell Death Dis. 2022;13:157.
   PubMed Web of Science ®Google Scholar
• Swystun LL, Notley CRP, Georgescu I, James PD, Lillicrap D. The endothelial lectin receptor CLEC4M internalizes factor VIII and von Willebrand factor via a clathrin-coated pit-dependent mechanism. Blood. 2013;122:1091. doi:10.1182/blood.V122.21.1091.1091
   PubMed Web of Science ®Google Scholar
• Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020;367:1444–1448. doi:10.1126/science.abb2762
   PubMed Web of Science ®Google Scholar
• Ishibashi M, Morita N, Nomura-Kawaguchi C, Shimizu YK, Wakita T, Esumi M. CLEC4M-positive and CD81-negative Huh7 cells are not susceptible to JFH-1 HCVcc infection but mediate transinfection. Arch Virol. 2014;159:2949–2955. doi:10.1007/s00705-014-2150-z
   PubMed Web of Science ®Google Scholar
• Tan L-M, Li X, Qiu C-F, et al. CLEC4M is associated with poor prognosis and promotes cisplatin resistance in NSCLC patients. J Cancer. 2019;10:6374–6383. doi:10.7150/jca.30139
   PubMed Web of Science ®Google Scholar
• Yu Q, Gao K. CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma. Mol Med Rep. 2020;22:2245–2252. doi:10.3892/mmr.2020.11336
   PubMed Web of Science ®Google Scholar
• Colaprico A, Silva TC, Olsen C, et al. TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data. Nucleic Acids Res. 2016;44:e71–e71. doi:10.1093/nar/gkv1507
   PubMed Web of Science ®Google Scholar
• Barrett T, Wilhite SE, Ledoux P, et al. NCBI GEO: archive for functional genomics data sets—update. Nucleic Acids Res. 2013;41:D991–D995 . doi:10.1093/nar/gks1193
   PubMed Web of Science ®Google Scholar
• Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019;47:W556–W560 . doi:10.1093/nar/gkz430
   PubMed Web of Science ®Google Scholar
• Chandrashekar DS, Bashel B, Balasubramanya SAH, et al. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 2017;19:649–658. doi:10.1016/j.neo.2017.05.002
   PubMed Web of Science ®Google Scholar
• Deng X, Lin -D-D, Zhang X, et al. Profiles of immune‐related genes and immune cell infiltration in the tumor microenvironment of diffuse lower‐grade gliomas. J Cell Physiol. 2020;235:7321–7331. doi:10.1002/jcp.29633
   PubMed Web of Science ®Google Scholar
• Li T, Fan J, Wang B, et al. TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 2017;77(21):e108–e110. doi:10.1158/0008-5472.CAN-17-0307
   PubMed Web of Science ®Google Scholar
• Nahler G. Pearson correlation coefficient. Definitions. 2020;2020:1–4.
   Google Scholar
• Ashburner M, Ball CA, Blake JA, et al. Gene ontology: tool for the unification of biology. Nat Genet. 2000;25:25–29. doi:10.1038/75556
   PubMed Web of Science ®Google Scholar
• Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M. KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 2012;40:D109–D114 . doi:10.1093/nar/gkr988
   PubMed Web of Science ®Google Scholar
• Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102:15545–15550. doi:10.1073/pnas.0506580102
   PubMed Web of Science ®Google Scholar
• Groeneveld CS, Chagas VS, Jones SJM, et al. RTNsurvival: an R/Bioconductor package for regulatory network survival analysis. Bioinformatics. 2019;35:4488–4489. doi:10.1093/bioinformatics/btz229
   PubMed Web of Science ®Google Scholar
• Routledge RD. Fisher’s exact test. Definitions. 2020;2020:524–525.
   Google Scholar
• Zhang Y, Wei H, Fan L, et al. CLEC4s as potential therapeutic targets in hepatocellular carcinoma microenvironment. Front Cell. 2021;9:54.
   Google Scholar
• Pees B, Yang W, Kloock A, et al. Effector and regulator: diverse functions of C. elegans C-type lectin-like domain proteins. PLoS Pathog. 2021;17:e1009454. doi:10.1371/journal.ppat.1009454
   PubMed Web of Science ®Google Scholar
• Binnewies M, Roberts EW, Kersten K, et al. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. 2018;24:541–550. doi:10.1038/s41591-018-0014-x
   PubMed Web of Science ®Google Scholar
• Baghban R, Roshangar L, Jahanban-Esfahlan R, et al. Tumor microenvironment complexity and therapeutic implications at a glance. Cell Commun Signal. 2020;18:147.
   PubMed Web of Science ®Google Scholar
• Gajewski TF, Schreiber H, Fu Y-X. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14:1014–1022. doi:10.1038/ni.2703
   PubMed Web of Science ®Google Scholar
• Liu Y, Sun Z. Turning cold tumors into hot tumors by improving T-cell infiltration. Theranostics. 2021;11:5365–5386. doi:10.7150/thno.58390
   PubMed Web of Science ®Google Scholar
• Banchereau JF, Steinman RM. Dendritic cells and the control of immunity. Nat Genet. 1998;392:245–252.
   Google Scholar
• Németh T, Sperandio M, Mócsai A. Neutrophils as emerging therapeutic targets. Nat Rev Drug Discov. 2020;19:253–275. doi:10.1038/s41573-019-0054-z
   PubMed Web of Science ®Google Scholar
• Martínez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. Prime Rep. 2014;6:24.
   Google Scholar
• Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5:953–964. doi:10.1038/nri1733
   PubMed Web of Science ®Google Scholar
• Shapouri-Moghaddam A, Mohammadian S, Vazini H, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233:6425–6440. doi:10.1002/jcp.26429
   PubMed Web of Science ®Google Scholar
• Li J, Liu S, Zhou H, Qu L, Yang J. starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 2014;42:D92–D97 . doi:10.1093/nar/gkt1248
   PubMed Web of Science ®Google Scholar
• Laliotis GI, Chavdoula ED, Paraskevopoulou MD, et al. RETRACTED ARTICLE: AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing. Nat Commun. 2021;12. doi:10.1038/s41467-021-24795-1
   PubMed Web of Science ®Google Scholar
• Chen C, Lin T, Huang J. MP01-06 exosome-transmitted long non-coding RNA PLAT1 recruits HNRNPA1 to promote lymphatic metastasis of bladder cancer. J Urol. 2020;205:1415–1420. doi:10.1097/JU.0000000000001545
   PubMedGoogle Scholar
• Lv Y, Zhang W, Zhao J, et al. SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer. Signal Transduct. 2021;6:36.
   Google Scholar
• Flucke UE, van Noesel MM, Siozopoulou V, et al. EWSR1—the most common rearranged gene in soft tissue lesions, which also occurs in different bone lesions: an updated review. Diagnostics. 2021;11:1093. doi:10.3390/diagnostics11061093
   Web of Science ®Google Scholar
• Liu S, Yang N, Jiang X, Wang J, Dong J, Gao Y. FUS‐induced circular RNA ZNF609 promotes tumorigenesis and progression via sponging miR‐142‐3p in lung cancer. J Cell Physiol. 2021;236:79–92. doi:10.1002/jcp.29481
   PubMed Web of Science ®Google Scholar
• Ye Q, Guo NL. Hub genes in non-small cell lung cancer regulatory networks. Biomolecules. 2022;12(12):1782. doi:10.3390/biom12121782
   PubMed Web of Science ®Google Scholar
• Yu L, Liang X, Wang J, et al. Identification of key biomarkers and candidate molecules in non-small-cell lung cancer by integrated bioinformatics analysis. Genet Res (Camb). 2023;2023:6782732. doi:10.1155/2023/6782732
   PubMed Web of Science ®Google Scholar
• Qiu A, Xu H, Mao L, et al. A novel apaQTL-SNP for the modification of non-small-cell lung cancer susceptibility across histological subtypes. Cancers. 2022;14(21):5309. doi:10.3390/cancers14215309
   PubMed Web of Science ®Google Scholar