261
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Plasma Exosome-Derived microRNAs Profiles in Patients with Serofast Status: A Cross-Sectional Study

ORCID Icon, , , , &
Pages 1455-1469 | Received 01 Feb 2023, Accepted 07 Apr 2023, Published online: 20 Apr 2023

References

  • World Health Organization. Sexually transmitted infections (STIs). Available from: https://www.who.int/news-room/fact-sheets/detail/sexually-transmitted-infections-(stis). Accessed November 22, 2021.
  • Chinese Center for Disease Control and Prevention. An overview of the epidemic situation of notifiable infectious diseases in China in 2018; 2019.
  • Peeling RW, Mabey D, Kamb ML, Chen XS, Radolf JD, Benzaken AS. Syphilis. Nat Rev Dis Primers. 2017;3(Suppl):17073. doi:10.1038/nrdp.2017.73
  • World Health Organization. WHO Guidelines for the Treatment of Treponema Pallidum (Syphilis). Geneva Switzerland: World Health Organization; 2016.
  • Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021;70(4):1–187. doi:10.15585/mmwr.rr7004a1
  • Arlene C. A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy. BMC Infect Dis. 2015; 2015:1.
  • Seña AC, Wolff M, Martin DH, et al. Predictors of serological cure and Serofast State after treatment in HIV-negative persons with early syphilis. Clin Infect Dis. 2011;53(11):1092–1099. doi:10.1093/cid/cir671
  • Tong ML, Lin LR, Liu GL, et al. Factors associated with serological cure and the serofast state of HIV-negative patients with primary, secondary, latent, and tertiary syphilis. PLoS One. 2013;8(7):e70102. doi:10.1371/journal.pone.0070102
  • Wang Z-S, Liu X-K LJ, Li J. Serological response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin. J Antimicrob Chemother. 2018;73(5):1348–1351. doi:10.1093/jac/dky006
  • Seña AC, Wolff M, Behets F, et al. Response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin. Clin Infect Dis. 2013;56(3):420–422. doi:10.1093/cid/cis918
  • Seña AC, Zhang XH, Li T, et al. A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy. BMC Infect Dis. 2015;15:479. doi:10.1186/s12879-015-1209-0
  • Pastuszczak M, Gozdzialska A, Jakiela B, Obtulowicz A, Jaskiewicz J, Wojas-Pelc A. Robust pro-inflammatory immune response is associated with serological cure in patients with syphilis: an observational study. Sex Transm Infect. 2017;93(1):11–14. doi:10.1136/sextrans-2016-052681
  • Li J, Wang LN, Zuo YG, et al. 梅毒血清抵抗患者临床分析及免疫功能研究 [Clinical analysis and study of immunological function in syphilis patients with seroresistance]. Zhonghua Yi Xue Za Zhi. 2009;89(12):813–816. Chinese.
  • Chaudhari P, Ghate V, Nampoothiri M, Lewis S. Multifunctional role of exosomes in viral diseases: from transmission to diagnosis and therapy. Cell Signal. 2022;94:110325. doi:10.1016/j.cellsig.2022.110325
  • Yang J, Shin TS, Kim JS, Jee YK, Kim YK. A new horizon of precision medicine: combination of the microbiome and extracellular vesicles. Exp Mol Med. 2022;54(4):466–482. doi:10.1038/s12276-022-00748-6
  • Tkach M, Kowal J, Théry C. Why the need and how to approach the functional diversity of extracellular vesicles. Biol Sci. 2018;373(1737). doi:10.1098/rstb.2016.0479
  • Villarroya-Beltri C, Gutiérrez-Vázquez C, Sánchez-Cabo F, et al. Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun. 2013;4:2980. doi:10.1038/ncomms3980
  • Anfossi S, Babayan A, Pantel K, Calin GA. Clinical utility of circulating non-coding RNAs - an update. Nat Rev Clin Oncol. 2018;15(9):541–563. doi:10.1038/s41571-018-0035-x
  • Zhang H, Li QY, Guo ZZ, et al. Serum levels of microRNAs can specifically predict liver injury of chronic hepatitis B. World J Gastroenterol. 2012;18(37):5188–5196. doi:10.3748/wjg.v18.i37.5188
  • Mourenza Á, Lorente-Torres B, Durante E, et al. Understanding microRNAs in the context of infection to find new treatments against human bacterial pathogens. Antibiotics. 2022;11(3):356. doi:10.3390/antibiotics11030356
  • Yuan S, Wu Q, Wang Z, et al. miR-223: an immune regulator in infectious disorders. Front Immunol. 2021;12:781815. doi:10.3389/fimmu.2021.781815
  • He X, Pan W. Host-parasite interactions mediated by cross-species microRNAs. Trends Parasitol. 2022;38(6):478–488. doi:10.1016/j.pt.2022.02.011
  • Jia X, Wang Z, Liu X, Zheng H, Li J. Peripheral blood mononuclear cell microRNA profiles in syphilitic patients with serofast status. Mol Biol Rep. 2020;47(5):3407–3421. doi:10.1007/s11033-020-05421-7
  • Jya B, Tao HB, Pz B, et al. MicroRNA-101-3p, MicroRNA-195-5p, and MicroRNA-223-3p in peripheral blood mononuclear cells may serve as novel biomarkers for syphilis diagnosis. Microb Pathog. 2021;152:104769.
  • Huang T, Zhang J, Ke W, et al. MicroRNA expression profiling of peripheral blood mononuclear cells associated with syphilis. BMC Infect Dis. 2020;20(1):165. doi:10.1186/s12879-020-4846-x
  • Chen H, Zhou Y, Wang ZY, et al. Exosomal microRNA profiles from serum and cerebrospinal fluid in neurosyphilis. Sex Transm Infect. 2019;95(4):246–250. doi:10.1136/sextrans-2018-053813
  • Hu W, Xu B, Zhang J, et al. Exosomal miR-146a-5p from Treponema pallidum-stimulated macrophages reduces endothelial cells permeability and monocyte transendothelial migration by targeting JAM-C. Exp Cell Res. 2020;388(1):111823. doi:10.1016/j.yexcr.2020.111823
  • ICS. National Standard of the People’s Republic of China: Diagnosis for Syphilis(WS 273—2018). Beijing: Standards Press of China; 2018.
  • Mehta N, Bhari N, Gupta S. Asian guidelines for syphilis. J Infect Chemother. 2022;28(8):1084–1091. doi:10.1016/j.jiac.2022.04.023
  • Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 2010;59(Rr–12):1–110.
  • Kingston M, French P, Higgins S, et al. UK national guidelines on the management of syphilis 2015. Int J STD AIDS. 2016;27(6):421–446. doi:10.1177/0956462415624059
  • Dieckmann K, Radtke A, Geczi L, et al. Serum levels of MicroRNA-371a-3p (M371 test) as a new biomarker of testicular germ cell tumors: results of a prospective multicentric study. J Clin Oncol. 2019;37(16):1412–1423. doi:10.1200/jco.18.01480
  • Thomou T, Mori M, Dreyfuss J, et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature. 2017;542(7642):450–455. doi:10.1038/nature21365
  • Shan Z, Qin S, Li W, et al. An endocrine genetic signal between blood cells and vascular smooth muscle cells: role of MicroRNA-223 in smooth muscle function and atherogenesis. J Am Coll Cardiol. 2015;65(23):2526–2537. doi:10.1016/j.jacc.2015.03.570
  • Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci. 2008;105(30):10513–10518. doi:10.1073/pnas.0804549105
  • Yang Z, Yang X, Gan Z, Yuan L, Liu W, Si C. Genome-wide MicroRNA analysis of peripheral blood mononuclear cells reveals elevated miR-142-3p expression as a potential biomarker for secondary syphilis. Biomed Res Int. 2021;2021:5520053. doi:10.1155/2021/5520053
  • Yang J, Huang T, Zhao P, et al. MicroRNA-101-3p, MicroRNA-195-5p, and MicroRNA-223-3p in peripheral blood mononuclear cells may serve as novel biomarkers for syphilis diagnosis. Microb Pathog. 2021;152:104769. doi:10.1016/j.micpath.2021.104769
  • Lin LR, Tong ML, Fu ZG, et al. Evaluation of a colloidal gold immunochromatography assay in the detection of Treponema pallidum specific IgM antibody in syphilis serofast reaction patients: a serologic marker for the relapse and infection of syphilis. Diagn Microbiol Infect Dis. 2011;70(1):10–16. doi:10.1016/j.diagmicrobio.2010.11.015
  • Yang WL, Lin WS, Yang J, Zheng HP. Relationship between seroresistance and molecular subtypes of treponema pallidum repeat gene. China J Mod Med. 2011 2011:1.
  • Leader BT, Hevner K, Molini BJ, Barrett LK, Van Voorhis WC, Lukehart SA. Antibody responses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pallidum subsp. pallidum. Infect Immun. 2003;71(10):6054–6057. doi:10.1128/iai.71.10.6054-6057.2003
  • Morgan CA, Lukehart SA, Van Voorhis WC. Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K. Infect Immun. 2003;71(10):5605–5612. doi:10.1128/iai.71.10.5605-5612.2003
  • Huang Q, Ma B, Su Y, et al. miR-197-3p represses the proliferation of prostate cancer by regulating the VDAC1/AKT/β-catenin signaling axis. Int J Biol Sci. 2020;16(8):1417–1426. doi:10.7150/ijbs.42019
  • Xie W, Shui C, Fang X, Peng Y, Qin L. miR-197-3p reduces epithelial-mesenchymal transition by targeting ABCA7 in ovarian cancer cells. Biotech. 2020;10(8):375. doi:10.1007/s13205-020-02362-7
  • Li Y, Wu X, Gao F, Wang X. MiR-197-3p regulates endothelial cell proliferation and migration by targeting IGF1R and BCL2 in Kawasaki disease. Int J Clin Exp Pathol. 2019;12(11):4181–4192.
  • Akkaya-Ulum YZ, Akbaba TH, Tavukcuoglu Z, et al. Familial Mediterranean fever-related miR-197-3p targets IL1R1 gene and modulates inflammation in monocytes and synovial fibroblasts. Sci Rep. 2021;11(1):685. doi:10.1038/s41598-020-80097-4