Low Expression of TSTD2 Serves as a Biomarker for Poor Prognosis in Kidney Renal Clear Cell Carcinoma

References

• Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9–29. doi:10.3322/caac.21208
   PubMed Web of Science ®Google Scholar
• Srigley JR, Delahunt B, Eble JN, et al. The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia. Am J Surg Pathol. 2013;37(10):782–795. doi:10.1097/PAS.0b013e318299f2d1
   Web of Science ®Google Scholar
• Cui Y, Zhang C, Li Y, et al. HOXD1 functions as a novel tumor suppressor in kidney renal clear cell carcinoma. Cell Biol Int. 2021;45(6):1246–1259. doi:10.1002/cbin.11568
   PubMed Web of Science ®Google Scholar
• Huang Y, Wang J, Jia P, et al. Clonal architectures predict clinical outcome in clear cell renal cell carcinoma. Nat Commun. 2019;10(1):1245. doi:10.1038/s41467-019-09241-7
   PubMedGoogle Scholar
• Barata PC, Rini BI. Treatment of renal cell carcinoma: current status and future directions. CA Cancer J Clin. 2017;67(6):507–524. doi:10.3322/caac.21411
   PubMed Web of Science ®Google Scholar
• Maran S, Lee YY, Xu SH, et al. Towards understanding the low prevalence of Helicobacter pylori in Malays: genetic variants among Helicobacter pylori -negative ethnic Malays in the north-eastern region of Peninsular Malaysia and Han Chinese and South Indians. J Dig Dis. 2013;14(4):196–202. doi:10.1111/1751-2980.12023
   PubMed Web of Science ®Google Scholar
• Wenzel K, Felix SB, Flachmeier C, et al. Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines. Biol Chem. 2003;384(5):763–775. doi:10.1515/BC.2003.085
   PubMed Web of Science ®Google Scholar
• Libiad M, Motl N, Akey DL, et al. Thiosulfate sulfurtransferase-like domain–containing 1 protein interacts with thioredoxin. J Biol Chem. 2018;293(8):2675–2686. doi:10.1074/jbc.RA117.000826
   PubMed Web of Science ®Google Scholar
• Si T, Ning X, Chen H, et al. ANTXR1 as a potential prognostic biomarker for hepatitis B virus-related hepatocellular carcinoma identified by a weighted gene correlation network analysis. J Gastrointest Oncol. 2021;12(6):3079–3092. doi:10.21037/jgo-21-764
   PubMed Web of Science ®Google Scholar
• Kichaev G, Bhatia G, Loh P-R, et al. Leveraging polygenic functional enrichment to improve GWAS power. Am J Hum Genet. 2019;104(1):65–75. doi:10.1016/j.ajhg.2018.11.008
   PubMed Web of Science ®Google Scholar
• Wood AR, Esko T, Yang J, et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet. 2014;46(11):1173–1186. doi:10.1038/ng.3097
   PubMed Web of Science ®Google Scholar
• Weiss B, Eberle B, Roeth R, et al. Evidence that non-syndromic familial tall stature has an oligogenic origin including ciliary genes. Front Endocrinol. 2021;12:660731. doi:10.3389/fendo.2021.660731
   PubMed Web of Science ®Google Scholar
• Li K, Luo H, Luo H, et al. Clinical and prognostic pan-cancer analysis of m6A RNA methylation regulators in four types of endocrine system tumors. Aging. 2020;12(23):23931–23944. doi:10.18632/aging.104064
   PubMedGoogle Scholar
• Goldman MJ, Craft B, Hastie M, et al. Visualizing and interpreting cancer genomics data via the xena platform. Nat Biotechnol. 2020;38(6):675–678. doi:10.1038/s41587-020-0546-8
   PubMed Web of Science ®Google Scholar
• Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. doi:10.1186/s13059-014-0550-8
   PubMed Web of Science ®Google Scholar
• Yu G, Wang L-G, Han Y, et al. clusterProfiler: an R package for comparing biological themes among gene clusters. Omics. 2012;16(5):284–287. doi:10.1089/omi.2011.0118
   PubMed Web of Science ®Google Scholar
• Bindea G, Mlecnik B, Tosolini M, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39(4):782–795. doi:10.1016/j.immuni.2013.10.003
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Gable AL, Lyon D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–D613. doi:10.1093/nar/gky1131
   PubMed Web of Science ®Google Scholar
• Demchak B, Hull T, Reich M, et al. Cytoscape: the network visualization tool for GenomeSpace workflows. F1000Res. 2014;3:151. doi:10.12688/f1000research.4492.2
   PubMedGoogle Scholar
• Bandettini WP, Kellman P, Mancini C, et al. MultiContrast Delayed Enhancement (MCODE) improves detection of subendocardial myocardial infarction by late gadolinium enhancement cardiovascular magnetic resonance: a clinical validation study. J Cardiovasc Magn Reson. 2012;14(1):83. doi:10.1186/1532-429X-14-83
   PubMed Web of Science ®Google Scholar
• Mishanina TV, Libiad M, Banerjee R. Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways. Nat Chem Biol. 2015;11(7):457–464. doi:10.1038/nchembio.1834
   PubMed Web of Science ®Google Scholar
• O’Gara EA, Hill DJ, Maslin DJ. Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori. Appl Environ Microbiol. 2000;66(5):2269–2273. doi:10.1128/AEM.66.5.2269-2273.2000
   PubMed Web of Science ®Google Scholar
• Haristoy X, Angioi-Duprez K, Duprez A, et al. Efficacy of sulforaphane in eradicating Helicobacter pylori in HumanGastric xenografts implanted in NudeMice. Antimicrob Agents Chemother. 2003;47(12):3982–3984. doi:10.1128/AAC.47.12.3982-3984.2003
   PubMed Web of Science ®Google Scholar
• Huang S, Liang S, Chen G, et al. Overexpression of glycosyltransferase 8 domain containing 2 confers ovarian cancer to CDDP resistance by activating FGFR/PI3K signalling axis. Oncogenesis. 2021;10(7):55. doi:10.1038/s41389-021-00343-w
   PubMed Web of Science ®Google Scholar
• Wu Y, Chen X, Wang S, et al. Advances in the relationship between glycosyltransferases and multidrug resistance in cancer. Clin Chim Acta. 2019;495:417–421. doi:10.1016/j.cca.2019.05.015
   PubMed Web of Science ®Google Scholar
• Lairson LL, Henrissat B, Davies GJ, et al. Glycosyltransferases: structures, functions, and mechanisms. Annu Rev Biochem. 2008;77(1):521–555. doi:10.1146/annurev.biochem.76.061005.092322
   PubMedGoogle Scholar
• Song X, Ru M, Steinsnyder Z, et al. SNPs at SMG7 associated with time from biochemical recurrence to prostate cancer death. Cancer Epidemiol Biomarkers Prev. 2022;31(7):1466–1472. doi:10.1158/1055-9965.EPI-22-0053
   PubMed Web of Science ®Google Scholar
• Yang L, Kraft VAN, Pfeiffer S, et al. Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1. Mol Oncol. 2020;14(10):2420–2435. doi:10.1002/1878-0261.12754
   PubMed Web of Science ®Google Scholar
• Jo YS, Song SY, Kim MS, et al. Frameshift mutations of SMG7 essential for nonsense-mediated mRNA decay in gastric and colorectal cancers. Pathol Oncol Res. 2017;23(1):221–222. doi:10.1007/s12253-016-0141-y
   PubMed Web of Science ®Google Scholar
• Cimadamore A, Gasparrini S, Santoni M, et al. Biomarkers of aggressiveness in genitourinary tumors with emphasis on kidney, bladder, and prostate cancer. Expert Rev Mol Diagn. 2018;18(7):645–655. doi:10.1080/14737159.2018.1490179
   PubMed Web of Science ®Google Scholar
• Ramirez NE, Zhang Z, Madamanchi A, et al. The α₂β₁ integrin is a metastasis suppressor in mouse models and human cancer. J Clin Invest. 2011;121(1):226–237. doi:10.1172/JCI42328
   PubMed Web of Science ®Google Scholar
• Damsky CH, Werb Z. Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. Curr Opin Cell Biol. 1992;4(5):772–781. doi:10.1016/0955-0674(92)90100-Q
   PubMedGoogle Scholar
• Dedhar S, Hannigan GE. Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr Opin Cell Biol. 1996;8(5):657–669. doi:10.1016/S0955-0674(96)80107-4
   PubMed Web of Science ®Google Scholar
• Weaver VM, Petersen OW, Wang F, et al. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol. 1997;137(1):231–245. doi:10.1083/jcb.137.1.231
   PubMed Web of Science ®Google Scholar
• Albelda SM. Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab Invest. 1993;68(1):4–17.
   PubMed Web of Science ®Google Scholar
• Shibue T, Weinberg RA. Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A. 2009;106(25):10290–10295. doi:10.1073/pnas.0904227106
   PubMed Web of Science ®Google Scholar
• White DE, Muller WJ. Multifaceted roles of integrins in breast cancer metastasis. J Mammary Gland Biol Neoplasia. 2007;12(2–3):135–142. doi:10.1007/s10911-007-9045-5
   PubMed Web of Science ®Google Scholar
• Ho W-C, Heinemann C, Hangan D, et al. Modulation of in vivo migratory function of α2β1 integrin in mouse liver. Mol Biol Cell. 1997;8(10):1863–1875. doi:10.1091/mbc.8.10.1863
   PubMed Web of Science ®Google Scholar
• Yang C, Zeisberg M, Lively JC, et al. Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironment. Cancer Res. 2003;63(23):8312–8317.
   PubMed Web of Science ®Google Scholar
• Yoshimura K, Meckel KF, Laird LS, et al. Integrin α2 mediates selective metastasis to the liver. Cancer Res. 2009;69(18):7320–7328. doi:10.1158/0008-5472.CAN-09-0315
   PubMed Web of Science ®Google Scholar
• Kumar V, Stellrecht K, Sercarz E. Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE). J Exp Med. 1996;184(5):1609–1617. doi:10.1084/jem.184.5.1609
   PubMed Web of Science ®Google Scholar
• Schaerli P, Willimann K, Lang AB, et al. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med. 2000;192(11):1553–1562. doi:10.1084/jem.192.11.1553
   PubMed Web of Science ®Google Scholar
• Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235–238. doi:10.1038/nature04753
   PubMed Web of Science ®Google Scholar
• Mangan PR, Harrington LE, O’Quinn DB, et al. Transforming growth factor-β induces development of the TH17 lineage. Nature. 2006;441(7090):231–234. doi:10.1038/nature04754
   PubMed Web of Science ®Google Scholar
• Veldhoen M, Hocking RJ, Atkins CJ, et al. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24(2):179–189. doi:10.1016/j.immuni.2006.01.001
   PubMed Web of Science ®Google Scholar
• Accogli T, Bruchard M, Végran F. Modulation of CD4 T cell response according to tumor cytokine microenvironment. Cancers. 2021;13(3):373.
   PubMed Web of Science ®Google Scholar
• Charych DH, Hoch U, Langowski JL, et al. NKTR-214, an engineered cytokine with biased IL2 receptor binding, increased tumor exposure, and marked efficacy in mouse tumor models. Clin Cancer Res. 2016;22(3):680–690. doi:10.1158/1078-0432.CCR-15-1631
   PubMed Web of Science ®Google Scholar
• Diab A, Tannir NM, Bentebibel S-E, et al. Bempegaldesleukin (NKTR-214) plus nivolumab in patients with advanced solid tumors: phase I dose-escalation study of safety, efficacy, and immune activation (PIVOT-02). Cancer Discov. 2020;10(8):1158–1173. doi:10.1158/2159-8290.CD-19-1510
   PubMed Web of Science ®Google Scholar
• Bentebibel S-E, Hurwitz ME, Bernatchez C, et al. A first-in-human study and biomarker analysis of NKTR-214, a novel IL2Rβγ-biased cytokine, in patients with advanced or metastatic solid tumors. Cancer Discov. 2019;9(6):711–721. doi:10.1158/2159-8290.CD-18-1495
   PubMed Web of Science ®Google Scholar
• Skak K, Frederiksen KS, Lundsgaard D. Interleukin-21 activates human natural killer cells and modulates their surface receptor expression. Immunology. 2008;123(4):575–583. doi:10.1111/j.1365-2567.2007.02730.x
   PubMed Web of Science ®Google Scholar