Overexpression of NRP1 is Associated with Poor Prognosis via Accelerating Immunosuppression in Head and Neck Squamous Cell Carcinoma

References

• Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Deleyiannis FW, Thomas DB, Vaughan TL, Davis S. Alcoholism: independent predictor of survival in patients with head and neck cancer. J Natl Cancer Inst. 1996;88(8):542–549. doi:10.1093/jnci/88.8.542
   PubMedGoogle Scholar
• Kashigar A, Habbous S, Eng L, et al. Social environment, secondary smoking exposure, and smoking cessation among head and neck cancer patients. Cancer. 2013;119(15):2701–2709. doi:10.1002/cncr.28088
   PubMed Web of Science ®Google Scholar
• Labarge B, Hennessy M, Zhang L, et al. Human papillomavirus integration strictly correlates with global genome instability in head and neck cancer. Mol Cancer Res. 2022;20(9):1420–1428. doi:10.1158/1541-7786.MCR-21-0831
   PubMed Web of Science ®Google Scholar
• Pinatti LM, Walline HM, Carey TE. Human papillomavirus genome integration and head and neck cancer. J Dent Res. 2018;97(6):691–700. doi:10.1177/0022034517744213
   PubMed Web of Science ®Google Scholar
• Seiwert TY, Zuo Z, Keck MK, et al. Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Clin Cancer Res. 2015;21(3):632–641. doi:10.1158/1078-0432.CCR-13-3310
   PubMed Web of Science ®Google Scholar
• Gan LL, Hii LW, Wong SF, Leong CO, Mai CW. Molecular mechanisms and potential therapeutic reversal of pancreatic cancer-induced immune evasion. Cancers. 2020;12(7). doi:10.3390/cancers12071872
   PubMed Web of Science ®Google Scholar
• Qin A, Coffey DG, Warren EH, Ramnath N. Mechanisms of immune evasion and current status of checkpoint inhibitors in non-small cell lung cancer. Cancer Med. 2016;5(9):2567–2578. doi:10.1002/cam4.819
   PubMed Web of Science ®Google Scholar
• Fantin A, Vieira JM, Plein A, et al. NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis. Blood. 2013;121(12):2352–2362. doi:10.1182/blood-2012-05-424713
   PubMed Web of Science ®Google Scholar
• Koch S, van Meeteren LA, Morin E, et al. NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation. Dev Cell. 2014;28(6):633–646. doi:10.1016/j.devcel.2014.02.010
   PubMed Web of Science ®Google Scholar
• Chen Z, Gao H, Dong Z, et al. NRP1 regulates radiation-induced EMT via TGF-beta/Smad signaling in lung adenocarcinoma cells. Int J Radiat Biol. 2020;96(10):1281–1295. doi:10.1080/09553002.2020.1793015
   PubMed Web of Science ®Google Scholar
• Ding Z, Du W, Lei Z, et al. Neuropilin 1 modulates TGF‑beta1‑induced epithelial‑mesenchymal transition in non‑small cell lung cancer. Int J Oncol. 2020;56(2):531–543. doi:10.3892/ijo.2019.4938
   PubMed Web of Science ®Google Scholar
• Dong Z, Zhang H, Gong X, et al. The role of the tumor microenvironment in neuropilin 1-induced radiation resistance in lung cancer cells. J Cancer. 2019;10(17):4017–4030. doi:10.7150/jca.28163
   PubMed Web of Science ®Google Scholar
• Stockl S, Reichart J, Zborilova M, Johnstone B, Grassel S. Semaphorin 3A-Neuropilin-1 signaling modulates MMP13 expression in human osteoarthritic chondrocytes. Int J Mol Sci. 2022;23(22). doi:10.3390/ijms232214180
   Web of Science ®Google Scholar
• Glinka Y, Mohammed N, Subramaniam V, Jothy S, Prud’homme GJ. Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NF-kappaB activation and tumor sphere formation. Biochem Biophys Res Commun. 2012;425(4):775–780. doi:10.1016/j.bbrc.2012.07.151
   PubMed Web of Science ®Google Scholar
• Luo M, Hou L, Li J, et al. VEGF/NRP-1 axis promotes progression of breast cancer via enhancement of epithelial-mesenchymal transition and activation of NF-kappaB and beta-catenin. Cancer Lett. 2016;373(1):1–11. doi:10.1016/j.canlet.2016.01.010
   PubMed Web of Science ®Google Scholar
• Cantuti-Castelvetri L, Ojha R, Pedro LD, et al. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020;370(6518):856–860. doi:10.1126/science.abd2985
   PubMed Web of Science ®Google Scholar
• Li B, Severson E, Pignon JC, et al. Comprehensive analyses of tumor immunity: implications for cancer immunotherapy. Genome Biol. 2016;17(1):174. doi:10.1186/s13059-016-1028-7
   PubMed Web of Science ®Google Scholar
• Tanaka A, Sakaguchi S. Regulatory T cells in cancer immunotherapy. Cell Res. 2017;27(1):109–118. doi:10.1038/cr.2016.151
   PubMed Web of Science ®Google Scholar
• Wang SS, Liu W, Ly D, Xu H, Qu L, Zhang L. Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer. Cell Mol Immunol. 2019;16(1):6–18. doi:10.1038/s41423-018-0027-x
   PubMed Web of Science ®Google Scholar
• Huang A, Garraway LA, Ashworth A, Weber B. Synthetic lethality as an engine for cancer drug target discovery. Nat Rev Drug Discov. 2020;19(1):23–38. doi:10.1038/s41573-019-0046-z
   PubMed Web of Science ®Google Scholar
• Mantovani A, Marchesi F, Malesci A, Laghi L, Allavena P. Tumour-associated macrophages as treatment targets in oncology. Nat Rev Clin Oncol. 2017;14(7):399–416. doi:10.1038/nrclinonc.2016.217
   PubMed Web of Science ®Google Scholar
• Chiorean EG, Coveler AL. Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies. Drug Des Devel Ther. 2015;9:3529–3545. doi:10.2147/DDDT.S60328
   PubMed Web of Science ®Google Scholar
• Napolitano V, Russo D, Morra F, et al. Neuropilin-1 expression associates with poor prognosis in HNSCC and elicits EGFR activation upon CDDP-induced cytotoxic stress. Cancers. 2021;13(15):56.
   Web of Science ®Google Scholar
• Shi F, Shang L, Yang LY, et al. Neuropilin-1 contributes to esophageal squamous cancer progression via promoting P65-dependent cell proliferation. Oncogene. 2018;37(7):935–943. doi:10.1038/onc.2017.399
   PubMed Web of Science ®Google Scholar
• Jin Q, Ren Q, Chang X, et al. Neuropilin-1 predicts poor prognosis and promotes tumor metastasis through epithelial-mesenchymal transition in gastric cancer. J Cancer. 2021;12(12):3648–3659. doi:10.7150/jca.52851
   PubMed Web of Science ®Google Scholar
• Yang B, Chen J, Teng Y. TNPO1-mediated nuclear import of FUBP1 contributes to tumor immune evasion by increasing NRP1 expression in cervical cancer. J Immunol Res. 2021;2021:9994004. doi:10.1155/2021/9994004
   PubMed Web of Science ®Google Scholar
• Jimenez-Hernandez LE, Vazquez-Santillan K, Castro-Oropeza R, et al. NRP1-positive lung cancer cells possess tumor-initiating properties. Oncol Rep. 2018;39(1):349–357. doi:10.3892/or.2017.6089
   PubMed Web of Science ®Google Scholar
• Chen C, Zhang R, Ma L, et al. Neuropilin-1 is up-regulated by cancer-associated fibroblast-secreted IL-8 and associated with cell proliferation of gallbladder cancer. J Cell Mol Med. 2020;24(21):12608–12618. doi:10.1111/jcmm.15825
   PubMed Web of Science ®Google Scholar
• Hansen W, Hutzler M, Abel S, et al. Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J Exp Med. 2012;209(11):2001–2016. doi:10.1084/jem.20111497
   PubMed Web of Science ®Google Scholar
• Roy S, Bag AK, Singh RK, Talmadge JE, Batra SK, Datta K. Multifaceted role of neuropilins in the immune system: potential targets for immunotherapy. Front Immunol. 2017;8:1228. doi:10.3389/fimmu.2017.01228
   PubMed Web of Science ®Google Scholar
• Liu C, Somasundaram A, Manne S, et al. Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity. Nat Immunol. 2020;21(9):1010–1021. doi:10.1038/s41590-020-0733-2
   PubMed Web of Science ®Google Scholar
• Tavares MC, Sampaio CD, Lima GE, et al. A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma. BMC Cancer. 2021;21(1):901. doi:10.1186/s12885-021-08636-4
   PubMed Web of Science ®Google Scholar
• Ruan P, Tao Z, Tan A. Low expression of miR-30a-5p induced the proliferation and invasion of oral cancer via promoting the expression of FAP. Biosci Rep. 2018;38(1). doi:10.1042/BSR20171027
   Google Scholar
• Connor EV, Saygin C, Braley C, et al. Thy-1 predicts poor prognosis and is associated with self-renewal in ovarian cancer. J Ovarian Res. 2019;12(1):112. doi:10.1186/s13048-019-0590-5
   PubMed Web of Science ®Google Scholar
• Yang C, Wei C, Wang S, et al. Elevated CD163(+)/CD68(+) ratio at tumor invasive front is closely associated with aggressive phenotype and poor prognosis in colorectal cancer. Int J Biol Sci. 2019;15(5):984–998. doi:10.7150/ijbs.29836
   PubMed Web of Science ®Google Scholar