The Association Between Red Cell Distribution Width (RDW) and All-Cause Mortality in Elderly Patients with Hip Fractures: A Retrospective Cohort Study

References

• Braithwaite RS, Col NF, Wong JB. Estimating hip fracture morbidity, mortality and costs. J Am Geriatr Soc. 2003;51(3):364–370. doi:10.1046/j.1532-5415.2003.51110.x
   PubMed Web of Science ®Google Scholar
• Hannan MT, Broe KE, Cupples LA, Dufour AB, Rockwell M, Kiel DP. Height loss predicts subsequent Hip fracture in men and women of the Framingham Study. J Bone Miner Res. 2012;27(1):146–152. doi:10.1002/jbmr.557
   PubMed Web of Science ®Google Scholar
• Cooper C, Campion G, Melton LJ. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992;2(6):285–289. doi:10.1007/BF01623184
   PubMed Web of Science ®Google Scholar
• Cummings SR, Rubin SM, Black D. The future of hip fractures in the United States. Numbers, costs, and potential effects of postmenopausal estrogen. Clin Orthop Relat Res. 1990;252:163–166. doi:10.1097/00003086-199003000-00024
   PubMed Web of Science ®Google Scholar
• White SM, Griffiths R. Projected incidence of proximal femoral fracture in England: a report from the NHS Hip Fracture Anaesthesia Network (HIPFAN). Injury. 2011;42(11):1230–1233. doi:10.1016/j.injury.2010.11.010
   PubMed Web of Science ®Google Scholar
• Boufous S, Finch CF, Lord SR. Incidence of hip fracture in New South Wales: are our efforts having an effect? Med J Aust. 2004;180(12):623–626. doi:10.5694/j.1326-5377.2004.tb06124.x
   PubMed Web of Science ®Google Scholar
• Sheehan KJ, Williamson L, Alexander J, et al. Prognostic factors of functional outcome after hip fracture surgery: a systematic review. Age Ageing. 2018;47(5):661–670. doi:10.1093/ageing/afy057
   PubMed Web of Science ®Google Scholar
• Smith T, Pelpola K, Ball M, Ong A, Myint PK. Pre-operative indicators for mortality following hip fracture surgery: a systematic review and meta-analysis. Age Ageing. 2014;43(4):464–471. doi:10.1093/ageing/afu065
   PubMed Web of Science ®Google Scholar
• Hopley C, Stengel D, Ekkernkamp A, Wich M. Primary total hip arthroplasty versus hemiarthroplasty for displaced intracapsular hip fractures in older patients: systematic review. BMJ. 2010;340:c2332. doi:10.1136/bmj.c2332
   PubMed Web of Science ®Google Scholar
• Maggi S, Siviero P, Wetle T, Besdine RW, Saugo M, Crepaldi G. A multicenter survey on profile of care for hip fracture: predictors of mortality and disability. Osteoporos Int. 2010;21(2):223–231. doi:10.1007/s00198-009-0936-8
   PubMed Web of Science ®Google Scholar
• Roche JJ, Wenn RT, Sahota O, Moran CG. Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ. 2005;331(7529):1374. doi:10.1136/bmj.38643.663843.55
   PubMed Web of Science ®Google Scholar
• Seong YJ, Shin WC, Moon NH, Suh KT. Timing of hip-fracture surgery in elderly patients: literature review and recommendations. Hip Pelvis. 2020;32(1):11–16. doi:10.5371/hp.2020.32.1.11
   PubMedGoogle Scholar
• Shiga T, Wajima Z, Ohe Y. Is operative delay associated with increased mortality of hip fracture patients? Systematic review, meta-analysis, and meta-regression. Can J Anaesth. 2008;55(3):146–154. doi:10.1007/BF03016088
   PubMed Web of Science ®Google Scholar
• Prestmo A, Hagen G, Sletvold O, et al. Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial. Lancet. 2015;385(9978):1623–1633. doi:10.1016/S0140-6736(14)62409-0
   PubMed Web of Science ®Google Scholar
• Grigoryan KV, Javedan H, Rudolph JL. Orthogeriatric care models and outcomes in Hip fracture patients: a systematic review and meta-analysis. J Orthop Trauma. 2014;28(3):e49–55. doi:10.1097/BOT.0b013e3182a5a045
   PubMed Web of Science ®Google Scholar
• Asplin G, Carlsson G, Zidén L, Kjellby-Wendt G. Early coordinated rehabilitation in acute phase after hip fracture - A model for increased patient participation. BMC Geriatr. 2017;17(1):240. doi:10.1186/s12877-017-0640-z
   PubMedGoogle Scholar
• Young Y, Xiong K, Pruzek RM, Brant LJ. Examining heterogeneity of functional recovery among older adults with hip fractures. J Am Med Dir Assoc. 2010;11(2):132–139. doi:10.1016/j.jamda.2009.11.007
   PubMed Web of Science ®Google Scholar
• Penrod JD, Litke A, Hawkes WG, et al. Heterogeneity in hip fracture patients: age, functional status, and comorbidity. J Am Geriatr Soc. 2007;55(3):407–413. doi:10.1111/j.1532-5415.2007.01078.x
   PubMed Web of Science ®Google Scholar
• Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: a simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci. 2015;52(2):86–105. doi:10.3109/10408363.2014.992064
   PubMed Web of Science ®Google Scholar
• Pedrazzani C, Tripepi M, Turri G, et al. Prognostic value of red cell distribution width (RDW) in colorectal cancer. Results from a single-center cohort on 591 patients. Sci Rep. 2020;10(1):1072. doi:10.1038/s41598-020-57721-4
   PubMed Web of Science ®Google Scholar
• Ai L, Mu S, Hu Y. Prognostic role of RDW in hematological malignancies: a systematic review and meta-analysis. Cancer Cell Int. 2018;18:61. doi:10.1186/s12935-018-0558-3
   PubMed Web of Science ®Google Scholar
• Zhao T, Cui L, Li A. The significance of RDW in patients with hepatocellular carcinoma after radical resection. Cancer Biomark. 2016;16(4):507–512. doi:10.3233/CBM-160591
   PubMed Web of Science ®Google Scholar
• Song B, Shi P, Xiao J, et al. Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer. Sci Rep. 2020;10(1):15717. doi:10.1038/s41598-020-72585-4
   PubMed Web of Science ®Google Scholar
• Herraez I, Bento L, Del Campo R, et al. Prognostic role of the red blood cell distribution width (RDW) in Hodgkin Lymphoma. Cancers. 2020;12(11):3262. doi:10.3390/cancers12113262
   PubMed Web of Science ®Google Scholar
• Kim KM, Lui LY, Cauley JA, et al. Red cell distribution width is a risk factor for hip fracture in elderly men without anemia. J Bone Miner Res. 2020;35(5):869–874. doi:10.1002/jbmr.3963
   PubMed Web of Science ®Google Scholar
• Yin P, Lv H, Li Y, et al. Hip fracture patients who experience a greater fluctuation in RDW during hospital course are at heightened risk for all-cause mortality: a prospective study with 2-year follow-up. Osteoporos Int. 2018;29(7):1559–1567. doi:10.1007/s00198-018-4516-7
   PubMed Web of Science ®Google Scholar
• Garbharran U, Chinthapalli S, Hopper I, George M, Back DL, Dockery F. Red cell distribution width is an independent predictor of mortality in hip fracture. Age Ageing. 2012;42(2):258–261. doi:10.1093/ageing/afs176
   PubMed Web of Science ®Google Scholar
• Cheng J, Wang S, Jia J, Chen Q, Song Y, Li J. Association between pre-treatment and post-treatment 3-month red cell distribution width with three-year prognosis of prostate cancer. J Inflamm Res. 2021;14:6115–6127. doi:10.2147/JIR.S342272
   PubMed Web of Science ®Google Scholar
• Förhécz Z, Gombos T, Borgulya G, Pozsonyi Z, Prohászka Z, Jánoskuti L. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J. 2009;158(4):659–666. doi:10.1016/j.ahj.2009.07.024
   PubMed Web of Science ®Google Scholar
• Lippi G, Turcato G, Cervellin G, Sanchis-Gomar F. Red blood cell distribution width in heart failure: a narrative review. World J Cardiol. 2018;10(2):6–14. doi:10.4330/wjc.v10.i2.6
   PubMed Web of Science ®Google Scholar
• Tajuddin SM, Nalls MA, Zonderman AB, Evans MK. Association of red cell distribution width with all-cause and cardiovascular-specific mortality in African American and white adults: a prospective cohort study. J Transl Med. 2017;15(1):208. doi:10.1186/s12967-017-1313-6
   PubMedGoogle Scholar
• Li N, Zhou H, Tang Q. Red blood cell distribution width: a novel predictive indicator for cardiovascular and cerebrovascular diseases. Dis Markers. 2017;2017:7089493. doi:10.1155/2017/7089493
   PubMed Web of Science ®Google Scholar
• Sakai Y, Wakao N, Matsui H, Watanabe T, Iida H, Katsumi A. Elevated red blood cell distribution width is associated with poor outcome in osteoporotic vertebral fracture. J Bone Miner Metab. 2021;39(6):1048–1057. doi:10.1007/s00774-021-01242-1
   PubMed Web of Science ®Google Scholar
• Li CM, Chao CT, Chen SI, Han DS, Huang KC. Elevated red cell distribution width is independently associated with a higher frailty risk among 2932 community-dwelling older adults. Front Med. 2020;7:470. doi:10.3389/fmed.2020.00470
   Web of Science ®Google Scholar
• Marom O, Paz I, Topaz G, Ohana N, Yaacobi E. Red cell distribution width-A mortality predictor in older adults with proximal femoral fracture. Arch Gerontol Geriatr. 2022;100:104623. doi:10.1016/j.archger.2022.104623
   PubMed Web of Science ®Google Scholar
• Lv H, Zhang L, Long A, et al. Red cell distribution width as an independent predictor of long-term mortality in hip fracture patients: a prospective cohort study. J Bone Miner Res. 2016;31(1):223–233. doi:10.1002/jbmr.2597
   PubMed Web of Science ®Google Scholar
• Bilotta C, Nicolini P, Casè A, Pina G, Rossi S, Vergani C. Frailty syndrome diagnosed according to the Study of Osteoporotic Fractures (SOF) criteria and adverse health outcomes among community-dwelling older outpatients in Italy. A one-year prospective cohort study. Arch Gerontol Geriatr. 2012;54(2):e23–8. doi:10.1016/j.archger.2011.06.037
   PubMed Web of Science ®Google Scholar
• Chao CT, Wang J, Chien KL. Both pre-frailty and frailty increase healthcare utilization and adverse health outcomes in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2018;17(1):130. doi:10.1186/s12933-018-0772-2
   PubMed Web of Science ®Google Scholar
• Flaatten H, De Lange DW, Morandi A, et al. The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years). Intensive Care Med. 2017;43(12):1820–1828. doi:10.1007/s00134-017-4940-8
   PubMed Web of Science ®Google Scholar
• Low S, Wee E, Dorevitch M. Impact of place of residence, frailty and other factors on rehabilitation outcomes post hip fracture. Age Ageing. 2021;50(2):423–430. doi:10.1093/ageing/afaa131
   PubMed Web of Science ®Google Scholar
• Krishnan M, Beck S, Havelock W, Eeles E, Hubbard RE, Johansen A. Predicting outcome after hip fracture: using a frailty index to integrate comprehensive geriatric assessment results. Age Ageing. 2014;43(1):122–126. doi:10.1093/ageing/aft084
   PubMed Web of Science ®Google Scholar
• Patel KV, Semba RD, Ferrucci L, et al. Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol a Biol Sci Med Sci. 2010;65(3):258–265. doi:10.1093/gerona/glp163
   PubMed Web of Science ®Google Scholar
• Pérez-Ros P, Vila-Candel R, López-Hernández L, Martínez-Arnau FM. Nutritional status and risk factors for frailty in community-dwelling older people: a cross-sectional study. Nutrients. 2020;12(4):1041. doi:10.3390/nu12041041
   PubMed Web of Science ®Google Scholar
• Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Res Rev. 2016;31:1–8. doi:10.1016/j.arr.2016.08.006
   PubMed Web of Science ®Google Scholar
• Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757–772. doi:10.2147/CIA.S158513
   PubMed Web of Science ®Google Scholar
• Roberts SE, Goldacre MJ. Time trends and demography of mortality after fractured neck of femur in an English population, 1968–98: database study. BMJ. 2003;327(7418):771–775. doi:10.1136/bmj.327.7418.771
   PubMed Web of Science ®Google Scholar
• Pereira SR, Puts MT, Portela MC, Sayeg MA. The impact of prefracture and hip fracture characteristics on mortality in older persons in Brazil. Clin Orthop Relat Res. 2010;468(7):1869–1883. doi:10.1007/s11999-009-1147-5
   PubMed Web of Science ®Google Scholar
• Vaseenon T, Luevitoonvechkij S, Wongtriratanachai P, Rojanasthien S. Long-term mortality after osteoporotic hip fracture in Chiang Mai, Thailand. J Clin Densitom. 2010;13(1):63–67. doi:10.1016/j.jocd.2009.10.003
   PubMed Web of Science ®Google Scholar
• Rostagno C, Buzzi R, Campanacci D, et al. In hospital and 3-month mortality and functional recovery rate in patients treated for hip fracture by a multidisciplinary team. PLoS One. 2016;11(7):e0158607. doi:10.1371/journal.pone.0158607
   PubMed Web of Science ®Google Scholar
• Frost SA, Nguyen ND, Black DA, Eisman JA, Nguyen TV. Risk factors for in-hospital post-hip fracture mortality. Bone. 2011;49(3):553–558. doi:10.1016/j.bone.2011.06.002
   PubMed Web of Science ®Google Scholar
• Kim SM, Moon YW, Lim SJ, et al. Prediction of survival, second fracture, and functional recovery following the first hip fracture surgery in elderly patients. Bone. 2012;50(6):1343–1350. doi:10.1016/j.bone.2012.02.633
   PubMed Web of Science ®Google Scholar
• Hou M, Zhang Y, Chen AC, et al. The effects of dementia on the prognosis and mortality of hip fracture surgery: a systematic review and meta-analysis. Aging Clin Exp Res. 2021;33(12):3161–3172. doi:10.1007/s40520-021-01864-5
   PubMed Web of Science ®Google Scholar
• Wang ZC, Chen X, Wu YX, et al. Effect of preoperative waiting time on prognosis of elderly patients with hip fracture. Zhongguo Gu Shang. 2022;35(4):361–366. doi:10.12200/j.issn.1003-0034.2022.04.012
   PubMedGoogle Scholar
• Magnusson KA, Gunnarsson B, Sigurdsson GH, Mogensen B, Olafsson Y, Karason S. Treatment and outcome of patients with hip fracture. Laeknabladid. 2016;102(3):119–125. doi:10.17992/lbl.2016.03.69
   PubMed Web of Science ®Google Scholar
• Kalemci S, Akin F, Sarihan A, Sahin C, Zeybek A, Yilmaz N. The relationship between hematological parameters and the severity level of chronic obstructive lung disease. Pol Arch Intern Med. 2018;128(3):171–177. doi:10.20452/pamw.4198
   PubMedGoogle Scholar
• Chen J, Liu Z, Gao G, et al. Efficacy of circulating microRNA-130b and blood routine parameters in the early diagnosis of gastric cancer. Oncol Lett. 2021;22(4):725. doi:10.3892/ol.2021.12986
   PubMed Web of Science ®Google Scholar