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General Medicine

The Association Between Red Cell Distribution Width (RDW) and All-Cause Mortality in Elderly Patients with Hip Fractures: A Retrospective Cohort Study

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Pages 3555-3566 | Received 13 Apr 2023, Accepted 08 Aug 2023, Published online: 17 Aug 2023

References

  • Braithwaite RS, Col NF, Wong JB. Estimating hip fracture morbidity, mortality and costs. J Am Geriatr Soc. 2003;51(3):364–370. doi:10.1046/j.1532-5415.2003.51110.x
  • Hannan MT, Broe KE, Cupples LA, Dufour AB, Rockwell M, Kiel DP. Height loss predicts subsequent Hip fracture in men and women of the Framingham Study. J Bone Miner Res. 2012;27(1):146–152. doi:10.1002/jbmr.557
  • Cooper C, Campion G, Melton LJ. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992;2(6):285–289. doi:10.1007/BF01623184
  • Cummings SR, Rubin SM, Black D. The future of hip fractures in the United States. Numbers, costs, and potential effects of postmenopausal estrogen. Clin Orthop Relat Res. 1990;252:163–166. doi:10.1097/00003086-199003000-00024
  • White SM, Griffiths R. Projected incidence of proximal femoral fracture in England: a report from the NHS Hip Fracture Anaesthesia Network (HIPFAN). Injury. 2011;42(11):1230–1233. doi:10.1016/j.injury.2010.11.010
  • Boufous S, Finch CF, Lord SR. Incidence of hip fracture in New South Wales: are our efforts having an effect? Med J Aust. 2004;180(12):623–626. doi:10.5694/j.1326-5377.2004.tb06124.x
  • Sheehan KJ, Williamson L, Alexander J, et al. Prognostic factors of functional outcome after hip fracture surgery: a systematic review. Age Ageing. 2018;47(5):661–670. doi:10.1093/ageing/afy057
  • Smith T, Pelpola K, Ball M, Ong A, Myint PK. Pre-operative indicators for mortality following hip fracture surgery: a systematic review and meta-analysis. Age Ageing. 2014;43(4):464–471. doi:10.1093/ageing/afu065
  • Hopley C, Stengel D, Ekkernkamp A, Wich M. Primary total hip arthroplasty versus hemiarthroplasty for displaced intracapsular hip fractures in older patients: systematic review. BMJ. 2010;340:c2332. doi:10.1136/bmj.c2332
  • Maggi S, Siviero P, Wetle T, Besdine RW, Saugo M, Crepaldi G. A multicenter survey on profile of care for hip fracture: predictors of mortality and disability. Osteoporos Int. 2010;21(2):223–231. doi:10.1007/s00198-009-0936-8
  • Roche JJ, Wenn RT, Sahota O, Moran CG. Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ. 2005;331(7529):1374. doi:10.1136/bmj.38643.663843.55
  • Seong YJ, Shin WC, Moon NH, Suh KT. Timing of hip-fracture surgery in elderly patients: literature review and recommendations. Hip Pelvis. 2020;32(1):11–16. doi:10.5371/hp.2020.32.1.11
  • Shiga T, Wajima Z, Ohe Y. Is operative delay associated with increased mortality of hip fracture patients? Systematic review, meta-analysis, and meta-regression. Can J Anaesth. 2008;55(3):146–154. doi:10.1007/BF03016088
  • Prestmo A, Hagen G, Sletvold O, et al. Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial. Lancet. 2015;385(9978):1623–1633. doi:10.1016/S0140-6736(14)62409-0
  • Grigoryan KV, Javedan H, Rudolph JL. Orthogeriatric care models and outcomes in Hip fracture patients: a systematic review and meta-analysis. J Orthop Trauma. 2014;28(3):e49–55. doi:10.1097/BOT.0b013e3182a5a045
  • Asplin G, Carlsson G, Zidén L, Kjellby-Wendt G. Early coordinated rehabilitation in acute phase after hip fracture - A model for increased patient participation. BMC Geriatr. 2017;17(1):240. doi:10.1186/s12877-017-0640-z
  • Young Y, Xiong K, Pruzek RM, Brant LJ. Examining heterogeneity of functional recovery among older adults with hip fractures. J Am Med Dir Assoc. 2010;11(2):132–139. doi:10.1016/j.jamda.2009.11.007
  • Penrod JD, Litke A, Hawkes WG, et al. Heterogeneity in hip fracture patients: age, functional status, and comorbidity. J Am Geriatr Soc. 2007;55(3):407–413. doi:10.1111/j.1532-5415.2007.01078.x
  • Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: a simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci. 2015;52(2):86–105. doi:10.3109/10408363.2014.992064
  • Pedrazzani C, Tripepi M, Turri G, et al. Prognostic value of red cell distribution width (RDW) in colorectal cancer. Results from a single-center cohort on 591 patients. Sci Rep. 2020;10(1):1072. doi:10.1038/s41598-020-57721-4
  • Ai L, Mu S, Hu Y. Prognostic role of RDW in hematological malignancies: a systematic review and meta-analysis. Cancer Cell Int. 2018;18:61. doi:10.1186/s12935-018-0558-3
  • Zhao T, Cui L, Li A. The significance of RDW in patients with hepatocellular carcinoma after radical resection. Cancer Biomark. 2016;16(4):507–512. doi:10.3233/CBM-160591
  • Song B, Shi P, Xiao J, et al. Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer. Sci Rep. 2020;10(1):15717. doi:10.1038/s41598-020-72585-4
  • Herraez I, Bento L, Del Campo R, et al. Prognostic role of the red blood cell distribution width (RDW) in Hodgkin Lymphoma. Cancers. 2020;12(11):3262. doi:10.3390/cancers12113262
  • Kim KM, Lui LY, Cauley JA, et al. Red cell distribution width is a risk factor for hip fracture in elderly men without anemia. J Bone Miner Res. 2020;35(5):869–874. doi:10.1002/jbmr.3963
  • Yin P, Lv H, Li Y, et al. Hip fracture patients who experience a greater fluctuation in RDW during hospital course are at heightened risk for all-cause mortality: a prospective study with 2-year follow-up. Osteoporos Int. 2018;29(7):1559–1567. doi:10.1007/s00198-018-4516-7
  • Garbharran U, Chinthapalli S, Hopper I, George M, Back DL, Dockery F. Red cell distribution width is an independent predictor of mortality in hip fracture. Age Ageing. 2012;42(2):258–261. doi:10.1093/ageing/afs176
  • Cheng J, Wang S, Jia J, Chen Q, Song Y, Li J. Association between pre-treatment and post-treatment 3-month red cell distribution width with three-year prognosis of prostate cancer. J Inflamm Res. 2021;14:6115–6127. doi:10.2147/JIR.S342272
  • Förhécz Z, Gombos T, Borgulya G, Pozsonyi Z, Prohászka Z, Jánoskuti L. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J. 2009;158(4):659–666. doi:10.1016/j.ahj.2009.07.024
  • Lippi G, Turcato G, Cervellin G, Sanchis-Gomar F. Red blood cell distribution width in heart failure: a narrative review. World J Cardiol. 2018;10(2):6–14. doi:10.4330/wjc.v10.i2.6
  • Tajuddin SM, Nalls MA, Zonderman AB, Evans MK. Association of red cell distribution width with all-cause and cardiovascular-specific mortality in African American and white adults: a prospective cohort study. J Transl Med. 2017;15(1):208. doi:10.1186/s12967-017-1313-6
  • Li N, Zhou H, Tang Q. Red blood cell distribution width: a novel predictive indicator for cardiovascular and cerebrovascular diseases. Dis Markers. 2017;2017:7089493. doi:10.1155/2017/7089493
  • Sakai Y, Wakao N, Matsui H, Watanabe T, Iida H, Katsumi A. Elevated red blood cell distribution width is associated with poor outcome in osteoporotic vertebral fracture. J Bone Miner Metab. 2021;39(6):1048–1057. doi:10.1007/s00774-021-01242-1
  • Li CM, Chao CT, Chen SI, Han DS, Huang KC. Elevated red cell distribution width is independently associated with a higher frailty risk among 2932 community-dwelling older adults. Front Med. 2020;7:470. doi:10.3389/fmed.2020.00470
  • Marom O, Paz I, Topaz G, Ohana N, Yaacobi E. Red cell distribution width-A mortality predictor in older adults with proximal femoral fracture. Arch Gerontol Geriatr. 2022;100:104623. doi:10.1016/j.archger.2022.104623
  • Lv H, Zhang L, Long A, et al. Red cell distribution width as an independent predictor of long-term mortality in hip fracture patients: a prospective cohort study. J Bone Miner Res. 2016;31(1):223–233. doi:10.1002/jbmr.2597
  • Bilotta C, Nicolini P, Casè A, Pina G, Rossi S, Vergani C. Frailty syndrome diagnosed according to the Study of Osteoporotic Fractures (SOF) criteria and adverse health outcomes among community-dwelling older outpatients in Italy. A one-year prospective cohort study. Arch Gerontol Geriatr. 2012;54(2):e23–8. doi:10.1016/j.archger.2011.06.037
  • Chao CT, Wang J, Chien KL. Both pre-frailty and frailty increase healthcare utilization and adverse health outcomes in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2018;17(1):130. doi:10.1186/s12933-018-0772-2
  • Flaatten H, De Lange DW, Morandi A, et al. The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years). Intensive Care Med. 2017;43(12):1820–1828. doi:10.1007/s00134-017-4940-8
  • Low S, Wee E, Dorevitch M. Impact of place of residence, frailty and other factors on rehabilitation outcomes post hip fracture. Age Ageing. 2021;50(2):423–430. doi:10.1093/ageing/afaa131
  • Krishnan M, Beck S, Havelock W, Eeles E, Hubbard RE, Johansen A. Predicting outcome after hip fracture: using a frailty index to integrate comprehensive geriatric assessment results. Age Ageing. 2014;43(1):122–126. doi:10.1093/ageing/aft084
  • Patel KV, Semba RD, Ferrucci L, et al. Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol a Biol Sci Med Sci. 2010;65(3):258–265. doi:10.1093/gerona/glp163
  • Pérez-Ros P, Vila-Candel R, López-Hernández L, Martínez-Arnau FM. Nutritional status and risk factors for frailty in community-dwelling older people: a cross-sectional study. Nutrients. 2020;12(4):1041. doi:10.3390/nu12041041
  • Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Res Rev. 2016;31:1–8. doi:10.1016/j.arr.2016.08.006
  • Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757–772. doi:10.2147/CIA.S158513
  • Roberts SE, Goldacre MJ. Time trends and demography of mortality after fractured neck of femur in an English population, 1968–98: database study. BMJ. 2003;327(7418):771–775. doi:10.1136/bmj.327.7418.771
  • Pereira SR, Puts MT, Portela MC, Sayeg MA. The impact of prefracture and hip fracture characteristics on mortality in older persons in Brazil. Clin Orthop Relat Res. 2010;468(7):1869–1883. doi:10.1007/s11999-009-1147-5
  • Vaseenon T, Luevitoonvechkij S, Wongtriratanachai P, Rojanasthien S. Long-term mortality after osteoporotic hip fracture in Chiang Mai, Thailand. J Clin Densitom. 2010;13(1):63–67. doi:10.1016/j.jocd.2009.10.003
  • Rostagno C, Buzzi R, Campanacci D, et al. In hospital and 3-month mortality and functional recovery rate in patients treated for hip fracture by a multidisciplinary team. PLoS One. 2016;11(7):e0158607. doi:10.1371/journal.pone.0158607
  • Frost SA, Nguyen ND, Black DA, Eisman JA, Nguyen TV. Risk factors for in-hospital post-hip fracture mortality. Bone. 2011;49(3):553–558. doi:10.1016/j.bone.2011.06.002
  • Kim SM, Moon YW, Lim SJ, et al. Prediction of survival, second fracture, and functional recovery following the first hip fracture surgery in elderly patients. Bone. 2012;50(6):1343–1350. doi:10.1016/j.bone.2012.02.633
  • Hou M, Zhang Y, Chen AC, et al. The effects of dementia on the prognosis and mortality of hip fracture surgery: a systematic review and meta-analysis. Aging Clin Exp Res. 2021;33(12):3161–3172. doi:10.1007/s40520-021-01864-5
  • Wang ZC, Chen X, Wu YX, et al. Effect of preoperative waiting time on prognosis of elderly patients with hip fracture. Zhongguo Gu Shang. 2022;35(4):361–366. doi:10.12200/j.issn.1003-0034.2022.04.012
  • Magnusson KA, Gunnarsson B, Sigurdsson GH, Mogensen B, Olafsson Y, Karason S. Treatment and outcome of patients with hip fracture. Laeknabladid. 2016;102(3):119–125. doi:10.17992/lbl.2016.03.69
  • Kalemci S, Akin F, Sarihan A, Sahin C, Zeybek A, Yilmaz N. The relationship between hematological parameters and the severity level of chronic obstructive lung disease. Pol Arch Intern Med. 2018;128(3):171–177. doi:10.20452/pamw.4198
  • Chen J, Liu Z, Gao G, et al. Efficacy of circulating microRNA-130b and blood routine parameters in the early diagnosis of gastric cancer. Oncol Lett. 2021;22(4):725. doi:10.3892/ol.2021.12986