185
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury

, , &
Pages 2933-2941 | Received 16 Apr 2023, Accepted 04 Jul 2023, Published online: 10 Jul 2023

References

  • Cavaillon JM, Singer M, Skirecki T. Sepsis therapies: learning from 30 years of failure of translational research to propose new leads. EMBO Mol Med. 2020;12(4):e10128. doi:10.15252/emmm.201810128
  • Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–810. doi:10.1001/jama.2016.0287
  • Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200–211. doi:10.1016/S0140-6736(19)32989-7
  • Fleischmann C, Thomas–Rueddel DO, Hartmann M, et al. Hospital incidence and mortality rates of sepsis: an analysis of hospital episode (DRG) statistics in Germany from 2007 to 2013. Deutsches Ärzteblatt Int. 2016;113(10):159. doi:10.3238/arztebl.2016.0159
  • Teggert A, Datta H, Ali Z. Biomarkers for point-of-care diagnosis of sepsis. Micromachines. 2020;11(3):286. doi:10.3390/mi11030286
  • Vincent JL, Sakr Y, Sprung CL, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006;34(2):344–353. doi:10.1097/01.CCM.0000194725.48928.3A
  • X. X, Nie S, Liu Z, et al. Epidemiology and clinical correlates of AKI in Chinese hospitalized adults. Clin J Am Soc Nephrol. 2015;10(9):1510–1518. doi:10.2215/CJN.02140215
  • Boron M, Hauzer-Martin T, Keil J, Sun X-L. Circulating thrombomodulin: release mechanisms, measurements, and levels in diseases and medical procedures. TH Open. 2022;6(03):e194–e212. doi:10.1055/a-1801-2055
  • Califano F, Giovanniello T, Pantone P, et al. Clinical importance of thrombomodulin serum levels. Eur Rev Med Pharmacol Sci. 2000;4(3):59–66.
  • Khan KA, McMurray JL, Mohammed F, Bicknell R. C‐type lectin domain group 14 proteins in vascular biology, cancer and inflammation. FEBS J. 2019;286(17):3299–3332. doi:10.1111/febs.14985
  • Watanabe-Kusunoki K, Nakazawa D, Ishizu A, Atsumi T. Thrombomodulin as a physiological modulator of intravascular injury. Front Immunol. 2020;11:575890. doi:10.3389/fimmu.2020.575890
  • Khattab AA, Dawood AAER, Saleh NY. Value of thrombomodulin as a marker for sepsis in critically ill children. Indian J Pediatr. 2021;88:864–871. doi:10.1007/s12098-020-03564-w
  • Mihajlovic DM, Lendak DF, Draskovic BG, et al. Thrombomodulin is a strong predictor of multiorgan dysfunction syndrome in patients with sepsis. Clin Appl Thromb Hemost. 2015;21(5):469–474. doi:10.1177/1076029613508600
  • Katayama S, Nunomiya S, Koyama K, et al. Markers of acute kidney injury in patients with sepsis: the role of soluble thrombomodulin. Crit Care. 2017;21(1):1–9. doi:10.1186/s13054-017-1815-x
  • Zhou J, Wang L, Guo J, et al. Correlation between sTREM-1 and serum sTM in patients with AKI and the predictive value of their joint evalution in AKI occurrence and patients’ death. Int J Clin Exp Med. 2020;13(4):2798–2806.
  • Kellum JA, Lameire N, Aspelin P, et al. Kidney disease: improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2(1):1–138.
  • Inkinen N, Pettilä V, Lakkisto P, et al. Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study. Ann Intensive Care. 2019;9(1):1–11. doi:10.1186/s13613-019-0575-y
  • Vucelić V, Klobučar I, Đuras Cuculić B, et al. Sepsis and septic shock–an observational study of the incidence, management, and mortality predictors in a medical intensive care unit. Croat Med J. 2020;61(5):429–439. doi:10.3325/cmj.2020.61.429
  • Gameiro J, Carreiro C, Fonseca JA, et al. Acute kidney disease and long-term outcomes in critically ill acute kidney injury patients with sepsis: a cohort analysis. Clin Kidney J. 2021;14(5):1379–1387. doi:10.1093/ckj/sfaa130
  • Luhr R, Cao Y, Soederquist B, Cajander S. Trends in sepsis mortality over time in randomised sepsis trials: a systematic literature review and meta-analysis of mortality in the control arm, 2002–2016. Crit Care. 2019;23(1):1–9. doi:10.1186/s13054-019-2528-0
  • Kellum JA, Artigas A, Gunnerson KJ, et al. Use of biomarkers to identify acute kidney injury to help detect sepsis in patients with infection. Crit Care Med. 2021;49(4):e360. doi:10.1097/CCM.0000000000004845
  • Liu J, Bai C, B. L, et al. Mortality prediction using a novel combination of biomarkers in the first day of sepsis in intensive care units. Sci Rep. 2021;11(1):1275. doi:10.1038/s41598-020-79843-5
  • Jiang L, Zhu Y, Luo X, et al. Epidemiology of acute kidney injury in intensive care units in Beijing: the multi-center BAKIT study. BMC Nephrol. 2019;20(1):1–10. doi:10.1186/s12882-019-1660-z
  • Bouchard J, Malhotra R, Shah S, et al. Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study. PLoS One. 2015;10(3):e0120770. doi:10.1371/journal.pone.0120770
  • Rodrigues AT, Rodrigues JT, Rodrigues CT, et al. Association between thrombomodulin and high mobility group box 1 in sepsis patients. World J Crit Care Med. 2020;9(4):63–73. doi:10.5492/wjccm.v9.i4.63
  • Nozaki Y, Ri J, Sakai K, Niki K, Funauchi M, Matsumura I. Protective effects of recombinant human soluble thrombomodulin on lipopolysaccharide-induced acute kidney injury. Int J Mol Sci. 2020;21(7):2519. doi:10.3390/ijms21072519
  • Goshua G, Pine AB, Meizlish ML, et al. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. Lancet Haematol. 2020;7(8):e575–e582. doi:10.1016/S2352-3026(20)30216-7
  • Lin JJ, Hsiao HJ, Chan OW, Wang Y, Hsia S-H, Chiu C-H. Increased serum thrombomodulin level is associated with disease severity and mortality in pediatric sepsis. PLoS One. 2017;12(8):e0182324. doi:10.1371/journal.pone.0182324
  • Iba T, Yagi Y, Kidokoro A, Fukunaga M, Fukunaga T. Increased plasma levels of soluble thrombomodulin in patients with sepsis and organ failure. Surg Today. 1995;25(7):585–590. doi:10.1007/BF00311430